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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SRF

Z-value: 1.20

Motif logo

Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
ENSG00000112658.8 SRF

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg38_v1_chr6_+_43171260_431712810.077.1e-01Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_+_151240368 8.18 ENST00000253332.5
A-kinase anchoring protein 12
chr5_+_138465472 6.56 ENST00000239938.5
early growth response 1
chr6_+_151239951 5.85 ENST00000402676.7
A-kinase anchoring protein 12
chr11_-_65900375 5.71 ENST00000312562.7
FOS like 1, AP-1 transcription factor subunit
chr11_-_65900413 4.89 ENST00000448083.6
ENST00000531493.5
ENST00000532401.1
FOS like 1, AP-1 transcription factor subunit
chr2_-_207166818 4.78 ENST00000423015.5
Kruppel like factor 7
chr14_-_93976550 4.45 ENST00000555019.6
ankyrin repeat and SOCS box containing 2
chr14_+_75278820 4.00 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
Fos proto-oncogene, AP-1 transcription factor subunit
chr2_+_73892967 3.87 ENST00000409731.7
ENST00000409918.5
ENST00000442912.5
ENST00000345517.8
ENST00000409624.1
actin gamma 2, smooth muscle
chr10_-_17617235 3.74 ENST00000466335.1
3-hydroxyacyl-CoA dehydratase 1
chr2_-_160200289 3.67 ENST00000409872.1
integrin subunit beta 6
chr19_+_53869384 3.49 ENST00000391769.2
myeloid associated differentiation marker
chr2_-_160200251 3.18 ENST00000428609.6
ENST00000409967.6
ENST00000283249.7
integrin subunit beta 6
chr10_+_110497898 3.12 ENST00000369583.4
dual specificity phosphatase 5
chr19_+_16067526 3.11 ENST00000646974.2
tropomyosin 4
chr10_-_17617326 3.00 ENST00000326961.6
ENST00000361271.8
3-hydroxyacyl-CoA dehydratase 1
chr2_-_160200310 2.89 ENST00000620391.4
integrin subunit beta 6
chr5_+_151025343 2.67 ENST00000521632.1
glutathione peroxidase 3
chr10_-_88952763 2.56 ENST00000224784.10
actin alpha 2, smooth muscle
chr12_+_75480800 2.56 ENST00000456650.7
GLI pathogenesis related 1
chr1_-_168137430 2.44 ENST00000546300.5
ENST00000271357.9
ENST00000367835.1
ENST00000537209.5
G protein-coupled receptor 161
chr12_+_75480745 2.38 ENST00000266659.8
GLI pathogenesis related 1
chr2_-_207167220 2.23 ENST00000421199.5
ENST00000457962.5
Kruppel like factor 7
chr10_-_29634964 2.11 ENST00000375398.6
ENST00000355867.8
supervillin
chr4_+_87006988 2.10 ENST00000307808.10
AF4/FMR2 family member 1
chr7_-_108003122 2.00 ENST00000393559.2
ENST00000222399.11
ENST00000676777.1
ENST00000439976.6
ENST00000393560.5
ENST00000677793.1
ENST00000679244.1
laminin subunit beta 1
chr1_+_167630093 1.95 ENST00000537350.5
ENST00000361496.3
ENST00000367854.8
RCSD domain containing 1
chr9_+_128882502 1.92 ENST00000259324.5
leucine rich repeat containing 8 VRAC subunit A
chr1_-_229434086 1.85 ENST00000366684.7
ENST00000684723.1
ENST00000366683.4
actin alpha 1, skeletal muscle
chr15_+_45114324 1.77 ENST00000323030.6
dual oxidase maturation factor 2
chr1_+_15758768 1.64 ENST00000483633.6
ENST00000502739.5
ENST00000375766.8
ENST00000431771.6
filamin binding LIM protein 1
chr19_+_45467988 1.61 ENST00000615753.4
ENST00000585836.5
ENST00000417353.6
ENST00000591858.5
ENST00000443841.6
ENST00000590335.1
ENST00000353609.8
FosB proto-oncogene, AP-1 transcription factor subunit
chr2_+_190927649 1.56 ENST00000409428.5
ENST00000409215.5
glutaminase
chr22_-_35961623 1.55 ENST00000408983.2
RNA binding fox-1 homolog 2
chr11_-_65859282 1.53 ENST00000526975.1
ENST00000531413.5
ENST00000525451.6
cofilin 1
chrX_-_153674325 1.53 ENST00000370142.5
ENST00000447676.6
pregnancy up-regulated nonubiquitous CaM kinase
chr2_-_105438503 1.53 ENST00000393352.7
ENST00000607522.1
four and a half LIM domains 2
chr4_+_94489030 1.49 ENST00000510099.5
PDZ and LIM domain 5
chr7_+_143381561 1.48 ENST00000354434.8
zyxin
chr3_-_99876193 1.46 ENST00000383694.3
filamin A interacting protein 1 like
chr17_-_42979993 1.41 ENST00000409103.5
ENST00000360221.8
ENST00000454303.1
ENST00000591916.7
ENST00000451885.3
PTGES3L-AARSD1 readthrough
prostaglandin E synthase 3 like
chr6_-_87702221 1.39 ENST00000257787.6
akirin 2
chr5_-_177496845 1.37 ENST00000506537.1
PDZ and LIM domain 7
chr3_-_123620571 1.36 ENST00000583087.5
myosin light chain kinase
chr12_-_11395556 1.31 ENST00000565533.1
ENST00000389362.6
ENST00000546254.3
proline rich protein BstNI subfamily 2
proline rich protein BstNI subfamily 1
chr4_+_87006736 1.31 ENST00000544085.6
AF4/FMR2 family member 1
chr3_-_123620496 1.30 ENST00000578202.1
myosin light chain kinase
chr5_-_177496802 1.26 ENST00000506161.5
PDZ and LIM domain 7
chr7_+_143381286 1.25 ENST00000449630.5
ENST00000322764.10
ENST00000457235.5
zyxin
chr17_-_74361860 1.23 ENST00000375366.4
BTB domain containing 17
chr17_-_42980393 1.21 ENST00000409446.8
ENST00000409399.6
ENST00000421990.7
prostaglandin E synthase 3 like
PTGES3L-AARSD1 readthrough
chr16_-_11281322 1.14 ENST00000312511.4
protamine 1
chr20_+_36541484 1.14 ENST00000346786.2
myosin light chain 9
chr21_-_46142701 1.13 ENST00000494498.2
formimidoyltransferase cyclodeaminase
chr15_+_83107572 1.13 ENST00000379390.10
ENST00000322019.14
ENST00000565774.5
ENST00000565982.1
transmembrane 6 superfamily member 1
chr10_+_69318831 1.11 ENST00000359426.7
hexokinase 1
chr1_+_11934651 1.07 ENST00000449038.5
ENST00000196061.5
ENST00000429000.6
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
chr3_-_99876104 1.06 ENST00000471562.1
ENST00000495625.2
filamin A interacting protein 1 like
chr11_-_2141238 1.04 ENST00000434045.6
insulin like growth factor 2
chr7_-_27143672 1.02 ENST00000222726.4
homeobox A5
chr3_-_9792691 1.02 ENST00000343450.2
transcriptional adaptor 3
chr19_-_17245889 1.01 ENST00000291442.4
nuclear receptor subfamily 2 group F member 6
chr11_-_2140967 0.95 ENST00000381389.5
insulin like growth factor 2
chr7_-_122304738 0.93 ENST00000442488.7
FEZ family zinc finger 1
chr12_+_18242955 0.91 ENST00000676171.1
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr7_-_94656197 0.88 ENST00000643903.1
ENST00000644122.1
ENST00000447873.6
ENST00000644816.1
ENST00000644375.1
sarcoglycan epsilon
chr5_+_66958870 0.87 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
microtubule associated serine/threonine kinase family member 4
chr19_+_1026566 0.84 ENST00000562015.5
ENST00000263097.9
ENST00000348419.7
ENST00000565096.6
ENST00000562958.6
ENST00000568865.3
ENST00000606983.5
ENST00000562075.6
ENST00000607102.1
calponin 2
chr7_-_94656160 0.80 ENST00000644609.1
ENST00000643272.1
ENST00000646137.1
ENST00000646098.1
ENST00000643193.1
ENST00000437425.7
ENST00000644551.1
ENST00000415788.3
sarcoglycan epsilon
chr6_+_157981826 0.79 ENST00000355585.9
ENST00000640338.1
ENST00000367113.5
synaptojanin 2
chr5_-_179623659 0.79 ENST00000519056.5
ENST00000506721.5
ENST00000503105.5
ENST00000504348.5
ENST00000508103.5
ENST00000510431.5
ENST00000515158.5
ENST00000393432.8
ENST00000442819.6
heterogeneous nuclear ribonucleoprotein H1
chr12_-_50222348 0.76 ENST00000552823.5
ENST00000552909.5
LIM domain and actin binding 1
chr1_-_11848345 0.76 ENST00000376476.1
natriuretic peptide A
chr6_-_123636923 0.76 ENST00000334268.9
triadin
chr2_-_105398978 0.75 ENST00000408995.5
ENST00000530340.6
ENST00000393353.7
ENST00000322142.13
ENST00000344213.9
ENST00000358129.8
four and a half LIM domains 2
chr7_-_94655993 0.71 ENST00000647110.1
ENST00000647048.1
ENST00000643020.1
ENST00000644682.1
ENST00000646119.1
ENST00000646265.1
ENST00000645445.1
ENST00000647334.1
ENST00000645262.1
ENST00000428696.7
ENST00000647096.1
ENST00000642394.1
ENST00000645725.1
ENST00000647351.1
ENST00000646943.1
ENST00000648936.2
ENST00000642707.1
ENST00000645109.1
ENST00000646489.1
ENST00000642933.1
ENST00000643128.1
ENST00000445866.7
ENST00000645101.1
ENST00000644116.1
ENST00000642441.1
ENST00000646879.1
ENST00000647018.1
sarcoglycan epsilon
chr1_-_41662298 0.71 ENST00000643665.1
HIVEP zinc finger 3
chr12_-_50222694 0.71 ENST00000552783.5
LIM domain and actin binding 1
chr12_+_62260338 0.70 ENST00000353364.7
ENST00000549523.5
ubiquitin specific peptidase 15
chr2_-_208254232 0.67 ENST00000415913.5
ENST00000415282.5
ENST00000446179.5
isocitrate dehydrogenase (NADP(+)) 1
chr3_-_46863435 0.65 ENST00000395869.5
ENST00000653454.1
ENST00000292327.6
myosin light chain 3
chr5_+_138439020 0.64 ENST00000378339.7
ENST00000254901.9
ENST00000506158.5
receptor accessory protein 2
chr15_-_34795541 0.64 ENST00000290378.6
actin alpha cardiac muscle 1
chr10_+_73998104 0.63 ENST00000372755.7
ENST00000211998.10
vinculin
chr19_+_13151975 0.61 ENST00000588173.1
immediate early response 2
chr8_-_22693469 0.61 ENST00000317216.3
early growth response 3
chr11_+_117199363 0.58 ENST00000392951.9
ENST00000525531.5
ENST00000278968.10
transgelin
chr5_-_170389634 0.57 ENST00000521859.1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
chr10_-_129964240 0.56 ENST00000440978.2
ENST00000355311.10
EBF transcription factor 3
chr19_-_4518465 0.54 ENST00000633942.1
perilipin 4
chr4_-_108166715 0.54 ENST00000510624.5
lymphoid enhancer binding factor 1
chr7_+_112480853 0.53 ENST00000439068.6
ENST00000312849.4
leucine rich single-pass membrane protein 1
chr1_+_50108856 0.53 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAV like RNA binding protein 4
chr11_-_72112068 0.52 ENST00000537644.5
ENST00000538919.5
ENST00000539395.1
ENST00000542531.5
anaphase promoting complex subunit 15
chr8_+_96584920 0.51 ENST00000521590.5
syndecan 2
chr12_+_62260374 0.51 ENST00000312635.10
ENST00000280377.10
ENST00000549237.5
ubiquitin specific peptidase 15
chr6_-_99349647 0.50 ENST00000389677.6
failed axon connections homolog, metaxin like GST domain containing
chr6_-_3751703 0.49 ENST00000380283.5
PX domain containing 1
chr7_-_44141074 0.49 ENST00000457314.5
ENST00000447951.1
ENST00000431007.1
myosin light chain 7
chr11_+_4704782 0.48 ENST00000380390.6
matrix metallopeptidase 26
chr12_+_54033026 0.48 ENST00000312492.3
homeobox C5
chr17_-_4987624 0.48 ENST00000572543.5
ENST00000381311.9
ENST00000348066.8
calmodulin binding transcription activator 2
chr17_+_3475959 0.47 ENST00000263080.3
aspartoacylase
chr6_-_123636979 0.47 ENST00000662930.1
triadin
chr17_-_4987354 0.43 ENST00000361571.9
calmodulin binding transcription activator 2
chr5_-_142621318 0.43 ENST00000359370.10
fibroblast growth factor 1
chr18_-_56651122 0.42 ENST00000590954.5
thioredoxin like 1
chr7_-_44141285 0.42 ENST00000458240.5
ENST00000223364.7
myosin light chain 7
chr1_-_248755754 0.40 ENST00000590317.4
LY6/PLAUR domain containing 8
chr17_-_29622893 0.39 ENST00000345068.9
ENST00000584602.1
ENST00000388767.8
ENST00000580212.6
coronin 6
chr11_-_72112669 0.38 ENST00000545944.5
ENST00000502597.2
anaphase promoting complex subunit 15
chr7_-_5530581 0.38 ENST00000676397.1
ENST00000645576.1
ENST00000674681.1
ENST00000646664.1
ENST00000493945.6
ENST00000676319.1
ENST00000473257.3
ENST00000647275.1
ENST00000432588.6
actin beta
chr11_-_72112750 0.38 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
anaphase promoting complex subunit 15
chr2_-_171231314 0.37 ENST00000521943.5
tousled like kinase 1
chr8_-_100953331 0.37 ENST00000353245.7
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr1_-_11847772 0.35 ENST00000376480.7
ENST00000610706.1
natriuretic peptide A
chr8_-_100952918 0.35 ENST00000395957.6
ENST00000395948.6
ENST00000457309.2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr10_+_6144883 0.33 ENST00000379789.8
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr3_-_190449782 0.32 ENST00000354905.3
transmembrane protein 207
chr12_-_11310420 0.31 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
proline rich protein BstNI subfamily 4
chrX_-_104254921 0.31 ENST00000372588.4
ESX homeobox 1
chrX_-_11265975 0.30 ENST00000303025.10
ENST00000657361.1
Rho GTPase activating protein 6
chr19_-_47471886 0.29 ENST00000236877.11
ENST00000597014.1
solute carrier family 8 member A2
chr15_-_65067938 0.28 ENST00000421977.7
ENST00000220062.9
RAS like family 12
chr3_+_9792495 0.27 ENST00000498623.6
actin related protein 2/3 complex subunit 4
chr19_+_35856885 0.27 ENST00000347900.10
ENST00000360202.10
kirre like nephrin family adhesion molecule 2
chr1_+_47416280 0.26 ENST00000335071.4
forkhead box E3
chr17_-_4967790 0.26 ENST00000575142.5
ENST00000206020.8
sperm associated antigen 7
chr2_-_96145431 0.26 ENST00000288943.5
dual specificity phosphatase 2
chr13_+_42040036 0.26 ENST00000379274.6
diacylglycerol kinase eta
chr17_-_81512671 0.25 ENST00000679480.1
ENST00000644774.2
ENST00000571721.6
ENST00000575842.5
ENST00000575087.5
ENST00000573283.7
ENST00000571691.6
ENST00000570382.2
actin gamma 1
chr1_+_76074698 0.25 ENST00000328299.4
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr1_-_207911384 0.24 ENST00000356522.4
CD34 molecule
chr2_+_206159580 0.24 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
eukaryotic translation elongation factor 1 beta 2
chr16_+_30065777 0.24 ENST00000395240.7
ENST00000566846.5
aldolase, fructose-bisphosphate A
chr2_+_218419114 0.24 ENST00000454069.5
ENST00000392114.6
ENST00000248444.10
villin 1
chr2_-_127675065 0.24 ENST00000545738.6
ENST00000409808.6
LIM zinc finger domain containing 2
chr19_-_47471847 0.24 ENST00000594353.1
ENST00000542837.2
solute carrier family 8 member A2
chr9_+_137877773 0.23 ENST00000371372.6
ENST00000277551.6
ENST00000277549.9
ENST00000371363.5
ENST00000371355.8
ENST00000371357.5
calcium voltage-gated channel subunit alpha1 B
chr2_+_206159884 0.23 ENST00000392222.7
eukaryotic translation elongation factor 1 beta 2
chr1_+_6045914 0.22 ENST00000378083.7
potassium voltage-gated channel subfamily A regulatory beta subunit 2
chr22_+_37608826 0.20 ENST00000405147.7
ENST00000343632.9
ENST00000429218.5
ENST00000325180.12
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr16_+_30065753 0.20 ENST00000642816.3
ENST00000643777.4
ENST00000569798.5
aldolase, fructose-bisphosphate A
chr20_-_35147285 0.20 ENST00000374491.3
ENST00000374492.8
ER degradation enhancing alpha-mannosidase like protein 2
chr17_+_80170012 0.19 ENST00000573882.5
ENST00000648509.2
ENST00000575465.6
ENST00000651672.1
caspase recruitment domain family member 14
chr3_-_185923893 0.14 ENST00000259043.11
transformer 2 beta homolog
chr8_+_85438850 0.13 ENST00000285381.3
carbonic anhydrase 3
chr13_+_27251545 0.13 ENST00000311549.11
ribosomal protein L21
chr1_+_19644284 0.13 ENST00000375136.8
NBL1, DAN family BMP antagonist
chr19_-_45322867 0.12 ENST00000221476.4
creatine kinase, M-type
chr5_-_33891941 0.11 ENST00000352040.7
ENST00000504830.6
ADAM metallopeptidase with thrombospondin type 1 motif 12
chr1_-_152360004 0.11 ENST00000388718.5
filaggrin family member 2
chr18_-_3219961 0.09 ENST00000356443.9
myomesin 1
chr6_-_159045104 0.08 ENST00000326965.7
T cell activation RhoGTPase activating protein
chr3_+_9793074 0.08 ENST00000397261.8
ENST00000485273.1
ENST00000433034.1
ENST00000397256.5
actin related protein 2/3 complex subunit 4
ARPC4-TTLL3 readthrough
chr1_-_207911027 0.08 ENST00000310833.12
CD34 molecule
chr3_+_143971784 0.08 ENST00000315691.8
divergent protein kinase domain 2A
chr12_+_59596010 0.07 ENST00000547379.6
ENST00000552432.5
solute carrier family 16 member 7
chr5_-_54310545 0.04 ENST00000504924.6
ENST00000620747.4
ENST00000507646.2
ENST00000502271.5
ADP ribosylation factor like GTPase 15
chr10_-_16817443 0.04 ENST00000602389.1
Ras suppressor protein 1
chr1_-_23014024 0.03 ENST00000440767.2
ENST00000622840.1
testis expressed 46
chr10_-_16817362 0.03 ENST00000377921.7
ENST00000345264.10
Ras suppressor protein 1
chr19_-_35757009 0.03 ENST00000587965.1
ENST00000004982.6
heat shock protein family B (small) member 6
chrX_-_32412220 0.02 ENST00000619831.5
dystrophin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182)
1.8 8.9 GO:0090131 mesenchyme migration(GO:0090131)
1.8 10.6 GO:0007296 vitellogenesis(GO:0007296)
1.2 14.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.2 3.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.9 9.7 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.6 2.3 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.4 2.7 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.4 4.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.4 2.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 1.0 GO:0060435 bronchiole development(GO:0060435)
0.3 6.7 GO:0030497 fatty acid elongation(GO:0030497)
0.3 1.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.3 2.0 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.3 1.1 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.3 1.6 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.9 GO:0002329 pre-B cell differentiation(GO:0002329)
0.2 1.1 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.2 0.7 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.5 GO:0051511 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.2 3.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 1.8 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.2 1.1 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.2 1.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 0.5 GO:0006533 aspartate catabolic process(GO:0006533)
0.2 1.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 2.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 0.4 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 1.6 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 2.0 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.6 GO:1903413 cellular response to bile acid(GO:1903413)
0.1 1.1 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.1 0.5 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.6 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 0.3 GO:1901258 mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.1 0.9 GO:0043696 forebrain anterior/posterior pattern specification(GO:0021797) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 0.5 GO:0008218 bioluminescence(GO:0008218)
0.1 0.6 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.1 0.3 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.2 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.1 1.3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.2 GO:0060327 cytoplasmic actin-based contraction involved in cell motility(GO:0060327)
0.1 1.6 GO:0051412 response to corticosterone(GO:0051412)
0.1 0.7 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.4 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 4.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.0 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.4 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0030167 proteoglycan catabolic process(GO:0030167)
0.0 2.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.0 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.4 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 7.0 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.5 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.2 GO:0070995 NADPH oxidation(GO:0070995)
0.0 1.1 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 2.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.9 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.5 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.6 GO:0003299 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 3.0 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.6 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 1.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 3.1 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 1.4 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.9 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.8 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 1.5 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.7 2.0 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.5 4.0 GO:0035976 AP1 complex(GO:0035976)
0.4 4.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.4 2.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 2.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 3.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 2.1 GO:0036449 microtubule minus-end(GO:0036449)
0.1 14.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.6 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 1.2 GO:0030314 junctional membrane complex(GO:0030314)
0.1 10.6 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.6 GO:0005916 fascia adherens(GO:0005916)
0.1 4.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.2 GO:1990031 pinceau fiber(GO:1990031)
0.0 3.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 1.1 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 17.1 GO:0005938 cell cortex(GO:0005938)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.1 GO:0042629 mast cell granule(GO:0042629)
0.0 4.1 GO:0030175 filopodium(GO:0030175)
0.0 1.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 6.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 1.1 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.4 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.8 GO:0005884 actin filament(GO:0005884)
0.0 1.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:0046930 pore complex(GO:0046930)
0.0 0.8 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
1.1 6.6 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.7 14.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 2.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 1.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.3 1.6 GO:0004359 glutaminase activity(GO:0004359)
0.2 2.7 GO:0008430 selenium binding(GO:0008430)
0.2 0.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.2 1.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.2 3.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.4 GO:0098918 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 1.1 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.9 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.6 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 0.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.8 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.1 9.7 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.6 GO:0031005 filamin binding(GO:0031005)
0.1 1.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 4.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 2.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 20.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0043199 sulfate binding(GO:0043199)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.9 GO:0043531 ADP binding(GO:0043531)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 1.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 4.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.5 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 14.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 6.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 7.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 2.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 4.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 2.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.7 PID IGF1 PATHWAY IGF1 pathway
0.0 1.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 3.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.1 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 4.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 11.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 5.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 7.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.7 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 4.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions