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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for STAT5B
Z-value: 0.85
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Transcription factors associated with STAT5B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5B | hg38_v1_chr17_-_42276341_42276443 | -0.27 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT5B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.3 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 3.3 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.0 | 3.3 | GO:0007602 | phototransduction(GO:0007602) |
| 0.1 | 3.1 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.1 | 2.3 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.2 | 2.2 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 1.8 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.6 | 1.7 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.3 | 1.2 | GO:0003095 | pressure natriuresis(GO:0003095) |
| 0.0 | 1.2 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.3 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.1 | 2.2 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 1.8 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.2 | 1.7 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 1.3 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 1.1 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 1.0 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 0.9 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.8 | GO:0043194 | axon initial segment(GO:0043194) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.8 | GO:0019864 | IgG binding(GO:0019864) |
| 1.1 | 3.3 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.3 | 2.3 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.7 | 2.2 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.0 | 2.2 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.1 | 2.0 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 1.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 1.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 1.2 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) leukotriene-B4 20-monooxygenase activity(GO:0050051) |
| 0.1 | 1.1 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.6 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 2.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 1.8 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 1.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.2 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 1.2 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 1.0 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.1 | 0.9 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.9 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |