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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for STAT6

Z-value: 0.85

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Transcription factors associated with STAT6

Gene Symbol Gene ID Gene Info
ENSG00000166888.12 STAT6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT6hg38_v1_chr12_-_57111338_571114330.115.7e-01Click!

Activity profile of STAT6 motif

Sorted Z-values of STAT6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT6

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_205422050 10.05 ENST00000367153.9
LEM domain containing 1
chrX_+_136169624 3.23 ENST00000394153.6
four and a half LIM domains 1
chrX_+_136169833 3.17 ENST00000628032.2
four and a half LIM domains 1
chrX_+_136169664 2.93 ENST00000456445.5
four and a half LIM domains 1
chr10_+_100347225 2.69 ENST00000370355.3
stearoyl-CoA desaturase
chr2_+_113127588 2.66 ENST00000409930.4
interleukin 1 receptor antagonist
chrX_+_136169891 2.25 ENST00000449474.5
four and a half LIM domains 1
chr17_-_17836997 2.23 ENST00000395757.6
sterol regulatory element binding transcription factor 1
chr11_-_128587551 2.09 ENST00000392668.8
ETS proto-oncogene 1, transcription factor
chr1_-_160646958 1.86 ENST00000538290.2
signaling lymphocytic activation molecule family member 1
chr11_+_70078291 1.77 ENST00000355303.9
anoctamin 1
chr4_+_54100161 1.75 ENST00000326902.7
ENST00000503800.1
GS homeobox 2
chr3_+_50269140 1.62 ENST00000616701.5
ENST00000433753.4
ENST00000611067.4
semaphorin 3B
chr17_-_17836973 1.59 ENST00000261646.11
ENST00000355815.8
sterol regulatory element binding transcription factor 1
chr9_+_36572854 1.59 ENST00000543751.5
ENST00000536860.5
ENST00000541717.4
ENST00000536329.5
ENST00000536987.5
ENST00000298048.7
ENST00000495529.5
ENST00000545008.5
maternal embryonic leucine zipper kinase
chr13_+_48653921 1.53 ENST00000682523.1
cysteinyl leukotriene receptor 2
chr12_-_27971970 1.50 ENST00000395872.5
ENST00000201015.8
parathyroid hormone like hormone
chr11_-_68213577 1.45 ENST00000402789.5
ENST00000402185.6
ENST00000458496.1
lysine methyltransferase 5B
chr2_-_189179754 1.41 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chr1_-_8026283 1.39 ENST00000474874.5
ENST00000469499.5
ENST00000377482.10
ERBB receptor feedback inhibitor 1
chrX_-_107717054 1.37 ENST00000503515.1
ENST00000372397.6
TSC22 domain family member 3
chr5_-_151686908 1.35 ENST00000231061.9
secreted protein acidic and cysteine rich
chr14_-_68979314 1.27 ENST00000684713.1
ENST00000683198.1
ENST00000684598.1
ENST00000682331.1
ENST00000682291.1
ENST00000683342.1
actinin alpha 1
chr14_-_68979436 1.26 ENST00000193403.10
actinin alpha 1
chr8_+_49072335 1.26 ENST00000399653.8
ENST00000522267.6
ENST00000303202.8
pancreatic progenitor cell differentiation and proliferation factor like
chr12_+_8992029 1.26 ENST00000543895.1
killer cell lectin like receptor G1
chr22_+_44069043 1.24 ENST00000404989.1
parvin beta
chr11_+_65314853 1.21 ENST00000279249.3
CDC42 effector protein 2
chr2_+_190927649 1.19 ENST00000409428.5
ENST00000409215.5
glutaminase
chr15_-_29822028 1.18 ENST00000545208.6
tight junction protein 1
chr15_-_29822077 1.10 ENST00000677774.1
tight junction protein 1
chr15_+_66453418 1.04 ENST00000566326.1
mitogen-activated protein kinase kinase 1
chr1_-_75932392 1.04 ENST00000284142.7
ankyrin repeat and SOCS box containing 17
chr17_-_41350824 1.02 ENST00000007735.4
keratin 33A
chr10_+_74176741 0.97 ENST00000673027.1
ENST00000372734.5
ENST00000541550.6
adenosine kinase
chr8_+_11809135 0.97 ENST00000528643.5
ENST00000525777.5
farnesyl-diphosphate farnesyltransferase 1
chr16_+_30064142 0.93 ENST00000562168.5
ENST00000569545.5
aldolase, fructose-bisphosphate A
chr1_-_160647037 0.92 ENST00000302035.11
signaling lymphocytic activation molecule family member 1
chr15_-_29822418 0.91 ENST00000614355.5
ENST00000495972.6
ENST00000346128.10
tight junction protein 1
chr1_-_120100688 0.91 ENST00000652264.1
notch receptor 2
chr4_+_72031902 0.90 ENST00000344413.6
ENST00000308744.12
neuropeptide FF receptor 2
chr1_+_156282917 0.88 ENST00000295694.9
ENST00000357501.6
transmembrane protein 79
chr3_-_73624840 0.86 ENST00000308537.4
ENST00000263666.9
PDZ domain containing ring finger 3
chr20_+_59676661 0.84 ENST00000355648.8
phosphatase and actin regulator 3
chr1_+_150272772 0.84 ENST00000369098.3
ENST00000369099.8
chromosome 1 open reading frame 54
chr6_-_116829037 0.83 ENST00000368549.7
ENST00000530250.1
ENST00000310357.8
G protein-coupled receptor class C group 6 member A
chr2_+_68734773 0.82 ENST00000409202.8
Rho GTPase activating protein 25
chr4_+_6693870 0.82 ENST00000296370.4
S100 calcium binding protein P
chr1_-_40862354 0.81 ENST00000372638.4
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
chr16_+_30064274 0.79 ENST00000563060.6
aldolase, fructose-bisphosphate A
chr1_-_160647287 0.79 ENST00000235739.6
signaling lymphocytic activation molecule family member 1
chr3_-_10108231 0.78 ENST00000524279.1
ENST00000450660.3
FANCD2 opposite strand
chr3_-_98517096 0.78 ENST00000513873.1
claudin domain containing 1
chr19_+_2785481 0.75 ENST00000307741.11
ENST00000585338.1
thimet oligopeptidase 1
chr11_-_60952559 0.74 ENST00000538739.2
solute carrier family 15 member 3
chr16_+_30064462 0.72 ENST00000412304.6
aldolase, fructose-bisphosphate A
chr3_+_189789734 0.71 ENST00000437221.5
ENST00000392463.6
ENST00000392461.7
ENST00000449992.5
ENST00000456148.1
tumor protein p63
chr6_-_27912396 0.70 ENST00000303324.4
olfactory receptor family 2 subfamily B member 2
chr3_+_159069252 0.70 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1 readthrough
chr2_+_201451711 0.69 ENST00000194530.8
ENST00000392249.6
STE20 related adaptor beta
chr2_-_133568393 0.68 ENST00000317721.10
ENST00000405974.7
ENST00000409261.6
ENST00000409213.5
NCK associated protein 5
chr3_+_159273235 0.67 ENST00000638749.1
IQCJ-SCHIP1 readthrough
chr6_+_30557287 0.66 ENST00000376560.8
proline rich 3
chr12_-_54385727 0.66 ENST00000551109.5
ENST00000546970.5
zinc finger protein 385A
chr11_-_60952067 0.65 ENST00000681275.1
solute carrier family 15 member 3
chr8_-_42768602 0.63 ENST00000534622.5
cholinergic receptor nicotinic alpha 6 subunit
chr6_+_30557274 0.63 ENST00000376557.3
proline rich 3
chr8_-_42768781 0.63 ENST00000276410.7
cholinergic receptor nicotinic alpha 6 subunit
chr1_+_213989691 0.62 ENST00000607425.1
prospero homeobox 1
chr10_+_96304392 0.60 ENST00000630152.1
DNA nucleotidylexotransferase
chr10_+_96304425 0.60 ENST00000371174.5
DNA nucleotidylexotransferase
chr3_+_189789643 0.59 ENST00000354600.10
tumor protein p63
chr19_-_54100792 0.59 ENST00000391761.5
ENST00000356532.7
ENST00000616447.4
ENST00000359649.8
ENST00000358375.8
ENST00000391760.1
ENST00000351806.8
osteoclast associated Ig-like receptor
chr9_-_128724088 0.57 ENST00000406904.2
ENST00000452105.5
ENST00000372667.9
ENST00000372663.9
zinc finger DHHC-type palmitoyltransferase 12
chr5_+_127649018 0.55 ENST00000379445.7
cortexin 3
chr18_-_26865732 0.54 ENST00000672188.1
aquaporin 4
chr18_-_26865689 0.54 ENST00000675739.1
ENST00000383168.9
ENST00000672981.2
ENST00000578776.1
aquaporin 4
chr6_-_41201128 0.54 ENST00000483722.2
triggering receptor expressed on myeloid cells like 2
chr11_-_60952134 0.53 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
solute carrier family 15 member 3
chr2_+_131011683 0.51 ENST00000355771.7
Rho guanine nucleotide exchange factor 4
chr6_-_41286665 0.51 ENST00000589614.5
ENST00000244709.9
ENST00000334475.10
ENST00000591620.1
triggering receptor expressed on myeloid cells 1
chr7_+_129375643 0.51 ENST00000490911.5
adenosylhomocysteinase like 2
chr3_+_35641421 0.51 ENST00000449196.5
cAMP regulated phosphoprotein 21
chr1_+_159437845 0.50 ENST00000642080.1
olfactory receptor family 10 subfamily J member 1
chr10_+_12068945 0.49 ENST00000263035.9
dehydrogenase E1 and transketolase domain containing 1
chr9_+_87497222 0.49 ENST00000358077.9
death associated protein kinase 1
chr11_+_112961402 0.47 ENST00000613217.4
ENST00000316851.12
ENST00000620046.4
ENST00000531044.5
ENST00000529356.5
neural cell adhesion molecule 1
chr12_+_43758936 0.47 ENST00000440781.6
ENST00000431837.5
ENST00000550616.5
ENST00000613694.5
ENST00000551736.5
interleukin 1 receptor associated kinase 4
chr12_-_70637405 0.46 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
protein tyrosine phosphatase receptor type B
chr15_-_23687290 0.45 ENST00000649030.2
necdin, MAGE family member
chr9_+_87497675 0.45 ENST00000472284.5
ENST00000469640.6
death associated protein kinase 1
chr4_-_120066777 0.44 ENST00000296509.11
mitotic arrest deficient 2 like 1
chr1_+_26432803 0.43 ENST00000430232.5
dehydrodolichyl diphosphate synthase subunit
chr2_-_203535253 0.43 ENST00000457812.5
ENST00000319170.10
ENST00000630330.2
ENST00000308091.8
ENST00000453034.5
ENST00000420371.2
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr15_+_91100194 0.40 ENST00000394232.6
synaptic vesicle glycoprotein 2B
chrX_-_139832235 0.40 ENST00000327569.7
ENST00000361648.6
ATPase phospholipid transporting 11C
chr11_-_59212869 0.40 ENST00000361050.4
macrophage expressed 1
chr7_+_32979445 0.38 ENST00000418354.5
ENST00000490776.3
FKBP prolyl isomerase 9
chr13_-_74133892 0.38 ENST00000377669.7
Kruppel like factor 12
chr3_+_141262614 0.38 ENST00000504264.5
2-phosphoxylose phosphatase 1
chr17_+_7481332 0.38 ENST00000412468.3
solute carrier family 35 member G6
chr3_-_57199938 0.38 ENST00000473921.2
ENST00000295934.8
HESX homeobox 1
chr9_+_137742957 0.36 ENST00000637318.1
ENST00000478940.1
euchromatic histone lysine methyltransferase 1
chr11_+_65333834 0.36 ENST00000528416.6
ENST00000415073.6
ENST00000252268.8
double PHD fingers 2
chr7_-_77199808 0.35 ENST00000248598.6
fibrinogen like 2
chr4_-_115113822 0.35 ENST00000613194.4
N-deacetylase and N-sulfotransferase 4
chr9_+_87497852 0.34 ENST00000408954.8
death associated protein kinase 1
chr1_-_67833448 0.34 ENST00000370982.4
G protein subunit gamma 12
chr16_-_29745951 0.34 ENST00000329410.4
chromosome 16 open reading frame 54
chr11_+_112961247 0.33 ENST00000621518.4
ENST00000618266.4
ENST00000615112.4
ENST00000615285.4
ENST00000619839.4
ENST00000401611.6
ENST00000621128.4
neural cell adhesion molecule 1
chrX_-_101291325 0.32 ENST00000356784.2
TATA-box binding protein associated factor 7 like
chr14_-_37172553 0.32 ENST00000331299.6
solute carrier family 25 member 21
chr12_-_52703522 0.31 ENST00000341809.8
keratin 77
chr12_+_56041893 0.31 ENST00000552361.1
ENST00000646449.2
ribosomal protein S26
chr7_+_112480853 0.30 ENST00000439068.6
ENST00000312849.4
leucine rich single-pass membrane protein 1
chr1_-_108192818 0.30 ENST00000370041.4
solute carrier family 25 member 24
chr2_+_233778330 0.30 ENST00000389758.3
maestro heat like repeat family member 2A
chr8_+_10095704 0.30 ENST00000382490.9
methionine sulfoxide reductase A
chr17_+_36211055 0.29 ENST00000617405.5
ENST00000617416.4
ENST00000613173.4
ENST00000620732.4
ENST00000620098.4
ENST00000620576.4
ENST00000620055.4
ENST00000610565.4
ENST00000620250.1
C-C motif chemokine ligand 4 like 2
chr6_+_116529013 0.29 ENST00000628083.1
ENST00000368597.6
ENST00000452373.5
ENST00000405399.5
calcium homeostasis modulator family member 4
chr6_-_11232658 0.29 ENST00000379433.5
ENST00000379446.10
ENST00000620854.4
neural precursor cell expressed, developmentally down-regulated 9
chr1_+_42153399 0.28 ENST00000372581.2
guanylate cyclase activator 2B
chr2_+_196639686 0.28 ENST00000389175.9
coiled-coil domain containing 150
chr7_-_75772172 0.28 ENST00000005180.9
C-C motif chemokine ligand 26
chr20_+_43945677 0.27 ENST00000358131.5
TOX high mobility group box family member 2
chr13_-_51845169 0.27 ENST00000627246.3
ENST00000629372.3
transmembrane protein 272
chr2_+_167248638 0.27 ENST00000295237.10
xin actin binding repeat containing 2
chr8_+_10095551 0.26 ENST00000522907.5
ENST00000528246.5
methionine sulfoxide reductase A
chr16_-_67660694 0.26 ENST00000219251.13
ENST00000620338.4
ACD shelterin complex subunit and telomerase recruitment factor
chr12_-_124495252 0.26 ENST00000405201.5
nuclear receptor corepressor 2
chr9_-_70869076 0.26 ENST00000677594.1
transient receptor potential cation channel subfamily M member 3
chrX_-_50643649 0.26 ENST00000460112.3
shroom family member 4
chr17_+_36210924 0.25 ENST00000615418.4
C-C motif chemokine ligand 4 like 2
chr15_+_84981981 0.25 ENST00000339708.9
phosphodiesterase 8A
chrX_+_149929573 0.25 ENST00000457775.3
heat shock transcription factor family, X-linked member 4
chr14_+_38207893 0.25 ENST00000267377.3
somatostatin receptor 1
chr5_+_150671588 0.25 ENST00000523553.1
myozenin 3
chr1_-_153312919 0.25 ENST00000683862.1
peptidoglycan recognition protein 3
chr12_-_32755876 0.24 ENST00000324868.13
tyrosyl-tRNA synthetase 2
chr8_-_81447428 0.24 ENST00000256103.3
ENST00000519260.1
peripheral myelin protein 2
chrX_+_102937272 0.24 ENST00000218249.7
RAB40A like
chr5_-_88823763 0.23 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
myocyte enhancer factor 2C
chr18_+_35581734 0.23 ENST00000591924.5
ENST00000269195.6
polypeptide N-acetylgalactosaminyltransferase 1
chr19_+_14941489 0.23 ENST00000248072.3
olfactory receptor family 7 subfamily C member 2
chr14_-_77423517 0.22 ENST00000555603.1
NADP dependent oxidoreductase domain containing 1
chr15_+_84981834 0.22 ENST00000394553.6
phosphodiesterase 8A
chr12_+_51888217 0.22 ENST00000340970.8
ankyrin repeat domain 33
chr6_+_83512501 0.22 ENST00000369700.4
serine protease 35
chr14_+_22052503 0.21 ENST00000390449.3
T cell receptor alpha variable 21
chr6_-_32853813 0.21 ENST00000643049.2
transporter 1, ATP binding cassette subfamily B member
chr12_+_51888083 0.21 ENST00000301190.11
ankyrin repeat domain 33
chr12_-_81758665 0.21 ENST00000549325.5
ENST00000550584.6
PTPRF interacting protein alpha 2
chr6_+_28080565 0.20 ENST00000377325.2
ENST00000683778.1
zinc finger protein 165
chr15_+_67548992 0.20 ENST00000354498.9
mitogen-activated protein kinase kinase 5
chr20_-_56525925 0.20 ENST00000243913.8
glucosaminyl (N-acetyl) transferase family member 7
chr7_-_139716980 0.20 ENST00000342645.7
homeodomain interacting protein kinase 2
chr6_-_32853618 0.20 ENST00000354258.5
transporter 1, ATP binding cassette subfamily B member
chr5_+_7396099 0.20 ENST00000338316.9
adenylate cyclase 2
chr1_+_77918128 0.20 ENST00000342754.5
nexilin F-actin binding protein
chr2_-_202870761 0.19 ENST00000420558.5
ENST00000418208.5
islet cell autoantigen 1 like
chr5_+_147878703 0.19 ENST00000296694.5
secretoglobin family 3A member 2
chr17_-_64230727 0.19 ENST00000583097.5
ENST00000615733.4
testis expressed 2
chr3_+_121593363 0.18 ENST00000338040.6
F-box protein 40
chr9_-_132079856 0.18 ENST00000651555.1
ENST00000651950.1
ENST00000357028.6
ENST00000474263.1
ENST00000292035.10
mediator complex subunit 27
chr1_+_192636121 0.17 ENST00000543215.5
ENST00000391995.7
regulator of G protein signaling 13
chr12_-_6342066 0.17 ENST00000162749.7
ENST00000440083.6
TNF receptor superfamily member 1A
chr7_-_123199960 0.17 ENST00000194130.7
solute carrier family 13 member 1
chr12_+_6384144 0.16 ENST00000228918.9
ENST00000536876.5
ENST00000543190.5
lymphotoxin beta receptor
chrX_-_135764444 0.16 ENST00000597510.6
cancer/testis antigen family 45 member A3
chr8_-_116874746 0.15 ENST00000297338.7
RAD21 cohesin complex component
chr6_+_31571957 0.15 ENST00000454783.5
lymphotoxin alpha
chr11_-_790062 0.15 ENST00000330106.5
cell cycle exit and neuronal differentiation 1
chr19_+_13118235 0.15 ENST00000292431.5
nucleus accumbens associated 1
chr2_-_229921316 0.13 ENST00000428959.5
ENST00000675423.1
thyroid hormone receptor interactor 12
chr2_+_27217361 0.12 ENST00000264705.9
ENST00000403525.5
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr14_+_21918161 0.11 ENST00000390439.2
T cell receptor alpha variable 13-2
chr5_+_139273752 0.11 ENST00000509990.5
ENST00000506147.5
ENST00000512107.5
matrin 3
chr12_-_81759307 0.11 ENST00000547623.5
ENST00000549396.6
PTPRF interacting protein alpha 2
chr4_+_70472189 0.10 ENST00000304887.6
mucin 7, secreted
chr14_-_24609660 0.10 ENST00000557220.6
ENST00000216338.9
ENST00000382548.4
granzyme H
chrX_-_73214793 0.10 ENST00000373517.4
nucleosome assembly protein 1 like 2
chr17_-_3298360 0.09 ENST00000323404.2
olfactory receptor family 3 subfamily A member 1
chr22_-_29061831 0.09 ENST00000216071.5
chromosome 22 open reading frame 31
chr3_-_185938006 0.09 ENST00000342294.4
ENST00000453386.7
ENST00000382191.4
transformer 2 beta homolog
chrX_-_140784366 0.09 ENST00000674533.1
cerebellar degeneration related protein 1
chr10_-_59362460 0.08 ENST00000422313.6
ENST00000435852.6
ENST00000614220.4
ENST00000618804.5
ENST00000621119.4
family with sequence similarity 13 member C
chr12_-_81758641 0.08 ENST00000552948.5
ENST00000548586.5
PTPRF interacting protein alpha 2
chr8_+_103298836 0.08 ENST00000523739.5
ENST00000358755.5
frizzled class receptor 6
chr1_-_173603041 0.08 ENST00000367714.4
solute carrier family 9 member C2 (putative)
chr1_-_17045219 0.08 ENST00000491274.5
succinate dehydrogenase complex iron sulfur subunit B
chr1_-_115841116 0.07 ENST00000320238.3
nescient helix-loop-helix 2
chr3_+_141402322 0.07 ENST00000510338.5
ENST00000504673.5
zinc finger and BTB domain containing 38
chr10_-_95693893 0.07 ENST00000371209.5
ENST00000680144.1
ENST00000430368.6
ENST00000371217.10
tectonic family member 3
chr17_+_7558296 0.07 ENST00000438470.5
ENST00000436057.5
TNF superfamily member 13
chr20_-_23086316 0.07 ENST00000246006.5
CD93 molecule
chr11_+_63888515 0.07 ENST00000509502.6
ENST00000512060.1
microtubule affinity regulating kinase 2
chr1_+_202462730 0.07 ENST00000290419.9
ENST00000491336.5
protein phosphatase 1 regulatory subunit 12B
chr15_+_91099943 0.07 ENST00000545111.6
synaptic vesicle glycoprotein 2B
chr12_+_26011713 0.06 ENST00000542004.5
Ras association domain family member 8
chr17_-_35880350 0.06 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
C-C motif chemokine ligand 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0035744 T-helper 1 cell cytokine production(GO:0035744)
0.6 3.2 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.5 1.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 2.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 3.8 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.3 1.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.2 1.0 GO:0006175 adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175)
0.2 1.8 GO:0015705 iodide transport(GO:0015705)
0.2 0.9 GO:0042335 cuticle development(GO:0042335)
0.2 1.8 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.2 0.6 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 1.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.4 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.2 1.5 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.2 2.3 GO:0030578 PML body organization(GO:0030578)
0.2 0.7 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) platelet alpha granule organization(GO:0070889) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2 1.0 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.2 1.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 1.0 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.1 0.4 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 1.4 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) skin morphogenesis(GO:0043589) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.1 0.4 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 2.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.2 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.1 11.3 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 2.5 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.3 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.1 0.5 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1 0.2 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.1 1.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.2 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.1 0.3 GO:1904744 positive regulation of telomeric DNA binding(GO:1904744)
0.1 0.3 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.1 0.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 0.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.4 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.2 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.2 GO:2000342 negative regulation of interleukin-8 biosynthetic process(GO:0045415) negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.6 GO:0030091 protein repair(GO:0030091)
0.0 1.5 GO:0002076 osteoblast development(GO:0002076)
0.0 1.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 2.7 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.0 0.4 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.1 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 1.1 GO:0006833 water transport(GO:0006833)
0.0 0.1 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.2 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.0 0.2 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.4 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.4 GO:0060992 response to fungicide(GO:0060992)
0.0 0.3 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 1.3 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.2 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 1.2 GO:0033198 response to ATP(GO:0033198)
0.0 1.6 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.3 GO:0015866 ADP transport(GO:0015866)
0.0 0.6 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0 0.5 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.2 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 1.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 0.5 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.1 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.2 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.7 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.4 GO:2000678 negative regulation of transcription regulatory region DNA binding(GO:2000678)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.3 GO:0006968 cellular defense response(GO:0006968)
0.0 0.3 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.2 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.3 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.4 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 1.8 GO:0015992 proton transport(GO:0015992)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.5 GO:0031143 pseudopodium(GO:0031143)
0.1 2.9 GO:0005921 gap junction(GO:0005921)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.1 1.5 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 3.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 2.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.2 GO:0000791 euchromatin(GO:0000791)
0.0 3.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.3 GO:0070187 telosome(GO:0070187)
0.0 0.6 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 13.8 GO:0005925 focal adhesion(GO:0005925)
0.0 0.1 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.8 3.8 GO:0032810 sterol response element binding(GO:0032810)
0.7 2.7 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.4 1.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.3 1.9 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.2 1.0 GO:0004001 adenosine kinase activity(GO:0004001)
0.2 2.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.5 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.2 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.0 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.2 1.4 GO:0043426 MRF binding(GO:0043426)
0.1 0.4 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 0.6 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.9 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.1 2.5 GO:0017166 vinculin binding(GO:0017166)
0.1 0.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.1 GO:0015250 water channel activity(GO:0015250)
0.1 0.6 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 0.6 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.3 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 0.4 GO:0015440 peptide-transporting ATPase activity(GO:0015440) MHC class Ib protein binding(GO:0023029) TAP2 binding(GO:0046979)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0051373 FATZ binding(GO:0051373)
0.0 2.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.8 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 10.2 GO:0044325 ion channel binding(GO:0044325)
0.0 0.4 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.9 GO:0031628 opioid receptor binding(GO:0031628)
0.0 1.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 4.2 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.1 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.2 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.0 0.3 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0060002 microfilament motor activity(GO:0000146) plus-end directed microfilament motor activity(GO:0060002)
0.0 0.3 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 3.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0004383 guanylate cyclase activity(GO:0004383) adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.0 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.9 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 5.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.1 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 2.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.8 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 3.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.0 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 1.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.9 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 3.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 2.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall