Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TBP
Z-value: 1.77
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Transcription factors associated with TBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBP | hg38_v1_chr6_+_170554333_170554396 | 0.19 | 3.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBP
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_50984028 Show fit | 6.93 |
ENST00000597707.5
|
kallikrein related peptidase 7 |
|
| chr8_-_23404076 Show fit | 6.46 |
ENST00000524168.1
ENST00000389131.8 ENST00000523833.2 ENST00000519243.1 |
lysyl oxidase like 2 |
|
| chr8_-_132085655 Show fit | 6.26 |
ENST00000262283.5
|
novel protein |
|
| chr1_-_153041111 Show fit | 5.94 |
ENST00000360379.4
|
small proline rich protein 2D |
|
| chr15_+_45430579 Show fit | 5.72 |
ENST00000558435.5
ENST00000344300.3 ENST00000396650.7 |
chromosome 15 open reading frame 48 |
|
| chr12_-_52452139 Show fit | 4.91 |
ENST00000252252.4
|
keratin 6B |
|
| chr7_+_107660819 Show fit | 4.40 |
ENST00000644269.2
|
solute carrier family 26 member 4 |
|
| chr19_+_6531018 Show fit | 4.24 |
ENST00000245817.5
|
TNF superfamily member 9 |
|
| chr8_-_6877928 Show fit | 4.15 |
ENST00000297439.4
|
defensin beta 1 |
|
| chr1_+_152908538 Show fit | 4.14 |
ENST00000368764.4
|
involucrin |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 1.3 | 7.8 | GO:0060356 | leucine import(GO:0060356) |
| 0.2 | 7.0 | GO:0046688 | response to copper ion(GO:0046688) |
| 1.1 | 6.7 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.1 | 6.7 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.1 | 6.6 | GO:0070268 | cornification(GO:0070268) |
| 0.5 | 5.9 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.3 | 5.7 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.6 | 5.3 | GO:2000332 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.2 | 4.9 | GO:0048240 | sperm capacitation(GO:0048240) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 10.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 9.8 | GO:0005604 | basement membrane(GO:0005604) |
| 1.0 | 6.9 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 6.9 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 5.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 5.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.3 | 5.0 | GO:0097229 | sperm end piece(GO:0097229) |
| 1.0 | 4.2 | GO:1990742 | microvesicle(GO:1990742) |
| 0.1 | 4.0 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 7.8 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 7.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 7.5 | GO:0005179 | hormone activity(GO:0005179) |
| 1.1 | 6.5 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.2 | 5.7 | GO:0016918 | retinal binding(GO:0016918) |
| 0.2 | 5.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.7 | 5.3 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.0 | 5.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 4.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 11.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 7.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 7.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 6.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 5.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 4.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 4.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 4.1 | PID TRAIL PATHWAY | TRAIL signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 8.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 6.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 6.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.4 | 6.1 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.0 | 5.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 4.4 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.1 | 4.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 3.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 3.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |