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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TBX20

Z-value: 0.33

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Transcription factors associated with TBX20

Gene Symbol Gene ID Gene Info
TBX20
ENSG00000164532.11 TBX20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX20hg38_v1_chr7_-_35254074_352541060.115.8e-01Click!

Activity profile of TBX20 motif

Sorted Z-values of TBX20 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX20

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_57628507 0.79 ENST00000456916.5
ENST00000567154.5
ENST00000388813.9
ENST00000562558.6
ENST00000566271.6
ENST00000563374.5
ENST00000673126.2
ENST00000562631.7
ENST00000568234.5
ENST00000565770.5
ENST00000566164.5
ADGRG1
adhesion G protein-coupled receptor G1
chr5_+_136059151 0.67 ENST00000503087.1
TGFBI
transforming growth factor beta induced
chr15_-_74212219 0.49 ENST00000449139.6
STRA6
signaling receptor and transporter of retinol STRA6
chr15_-_74212256 0.46 ENST00000416286.7
STRA6
signaling receptor and transporter of retinol STRA6
chr12_-_84912783 0.44 ENST00000680892.1
ENST00000266682.10
ENST00000680714.1
ENST00000552192.5
SLC6A15
solute carrier family 6 member 15
chr12_-_121039204 0.41 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like
chr12_-_121039236 0.41 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr6_-_32407123 0.40 ENST00000374993.4
ENST00000544175.2
ENST00000454136.7
ENST00000446536.2
BTNL2
butyrophilin like 2
chr12_-_121039156 0.39 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr20_+_45881218 0.35 ENST00000372523.1
ZSWIM1
zinc finger SWIM-type containing 1
chr19_+_56404314 0.34 ENST00000333201.13
ENST00000391778.3
ZNF583
zinc finger protein 583
chr12_-_121038967 0.34 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
OASL
2'-5'-oligoadenylate synthetase like
chr15_+_75724034 0.33 ENST00000332145.3
ODF3L1
outer dense fiber of sperm tails 3 like 1
chr15_-_22160868 0.28 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr12_+_15322257 0.27 ENST00000674316.1
PTPRO
protein tyrosine phosphatase receptor type O
chr1_-_11058839 0.26 ENST00000465788.1
SRM
spermidine synthase
chr3_+_187197486 0.26 ENST00000312295.5
RTP1
receptor transporter protein 1
chrX_+_68693629 0.24 ENST00000374597.3
STARD8
StAR related lipid transfer domain containing 8
chr11_+_15114912 0.22 ENST00000379556.8
INSC
INSC spindle orientation adaptor protein
chr3_+_40387175 0.22 ENST00000301825.8
ENTPD3
ectonucleoside triphosphate diphosphohydrolase 3
chr19_-_40714641 0.22 ENST00000678467.1
COQ8B
coenzyme Q8B
chr12_+_15322529 0.21 ENST00000348962.7
PTPRO
protein tyrosine phosphatase receptor type O
chrX_-_101617921 0.21 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
ARMCX6
armadillo repeat containing X-linked 6
chr15_-_21718245 0.20 ENST00000630556.1
ENSG00000281179.1
novel gene identicle to IGHV1OR15-1
chr8_+_27325516 0.18 ENST00000346049.10
ENST00000420218.3
PTK2B
protein tyrosine kinase 2 beta
chr5_+_134525649 0.15 ENST00000282605.8
ENST00000681547.2
ENST00000361895.6
ENST00000402835.5
JADE2
jade family PHD finger 2
chr16_+_57628684 0.14 ENST00000567397.5
ENST00000568979.5
ENST00000672974.1
ADGRG1
adhesion G protein-coupled receptor G1
chr12_+_15322480 0.12 ENST00000674188.1
ENST00000281171.9
ENST00000543886.6
PTPRO
protein tyrosine phosphatase receptor type O
chrX_+_78945332 0.11 ENST00000544091.1
ENST00000171757.3
P2RY10
P2Y receptor family member 10
chr19_-_39320839 0.11 ENST00000248668.5
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr3_-_15099122 0.10 ENST00000507357.1
ENST00000449050.5
ENST00000253699.7
ENST00000476527.6
RBSN
rabenosyn, RAB effector
chr9_+_107306459 0.09 ENST00000457811.1
RAD23B
RAD23 homolog B, nucleotide excision repair protein
chr11_-_64935882 0.09 ENST00000532246.1
ENST00000279168.7
GPHA2
glycoprotein hormone subunit alpha 2
chrX_+_52369014 0.08 ENST00000286049.3
XAGE2
X antigen family member 2
chr7_+_142424942 0.07 ENST00000426318.2
TRBV10-2
T cell receptor beta variable 10-2
chr16_+_31033513 0.06 ENST00000313843.8
STX4
syntaxin 4
chr7_-_33100886 0.06 ENST00000448915.1
RP9
RP9 pre-mRNA splicing factor
chr13_+_113105782 0.06 ENST00000541084.5
ENST00000346342.8
ENST00000375581.3
F7
coagulation factor VII
chr3_-_139678011 0.06 ENST00000646611.1
ENST00000645290.1
ENST00000647257.1
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chrX_+_55089052 0.06 ENST00000374965.5
ENST00000449097.1
PAGE2
PAGE family member 2
chr6_-_2841853 0.05 ENST00000380739.6
SERPINB1
serpin family B member 1
chr11_+_6259806 0.05 ENST00000532715.5
ENST00000334619.7
ENST00000525014.1
ENST00000531712.5
ENST00000525462.1
CCKBR
cholecystokinin B receptor
chr2_+_176107272 0.04 ENST00000249504.7
HOXD11
homeobox D11
chr3_-_131502946 0.04 ENST00000512877.1
ENST00000264995.8
ENST00000511168.5
ENST00000425847.6
MRPL3
mitochondrial ribosomal protein L3
chr3_-_50359480 0.03 ENST00000266025.4
TMEM115
transmembrane protein 115
chr15_-_84716153 0.03 ENST00000455959.7
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr15_-_84716384 0.03 ENST00000559729.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr1_-_158330957 0.03 ENST00000451207.5
CD1B
CD1b molecule
chr4_-_26490453 0.03 ENST00000295589.4
CCKAR
cholecystokinin A receptor
chr5_+_162067500 0.03 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr1_-_17054015 0.03 ENST00000375499.8
SDHB
succinate dehydrogenase complex iron sulfur subunit B
chr2_+_153871909 0.02 ENST00000392825.8
ENST00000434213.1
GALNT13
polypeptide N-acetylgalactosaminyltransferase 13
chr2_+_60881515 0.02 ENST00000295025.12
REL
REL proto-oncogene, NF-kB subunit
chr15_-_84716099 0.02 ENST00000560266.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr11_-_14337074 0.02 ENST00000531421.5
RRAS2
RAS related 2
chr2_+_60881553 0.02 ENST00000394479.4
REL
REL proto-oncogene, NF-kB subunit
chr15_-_84716063 0.02 ENST00000558217.5
ENST00000558196.1
ENST00000558134.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr19_+_7680822 0.01 ENST00000596148.3
ENST00000317378.5
ENST00000426877.2
TRAPPC5
trafficking protein particle complex 5
chr6_-_106629472 0.01 ENST00000369063.8
RTN4IP1
reticulon 4 interacting protein 1
chr6_-_136466858 0.01 ENST00000544465.5
MAP7
microtubule associated protein 7
chr1_+_22637580 0.01 ENST00000402322.1
C1QA
complement C1q A chain
chr5_+_162067458 0.01 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr17_-_3696133 0.00 ENST00000225328.10
P2RX5
purinergic receptor P2X 5
chr22_+_41560973 0.00 ENST00000306149.12
CSDC2
cold shock domain containing C2
chr19_+_45668191 0.00 ENST00000652180.1
ENST00000590918.6
ENST00000263281.7
ENST00000304207.12
GIPR
gastric inhibitory polypeptide receptor
chr2_+_63840982 0.00 ENST00000480679.5
ENST00000613823.2
ENST00000677841.1
UGP2
UDP-glucose pyrophosphorylase 2
chr2_+_85133376 0.00 ENST00000282111.4
TCF7L1
transcription factor 7 like 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 0.6 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.2 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.4 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.3 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.2 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.1 GO:0033594 response to hydroxyisoflavone(GO:0033594)
0.0 1.5 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0097451 glial limiting end-foot(GO:0097451)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.3 GO:0004766 spermidine synthase activity(GO:0004766)
0.1 0.4 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.1 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.0 0.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines