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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TBX5
Z-value: 0.96
Motif logo
Transcription factors associated with TBX5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TBX5
|
ENSG00000089225.20 | TBX5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX5 | hg38_v1_chr12_-_114406133_114406150 | 0.48 | 7.1e-03 | Click! |
Activity profile of TBX5 motif
Sorted Z-values of TBX5 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0060032 | notochord regression(GO:0060032) |
| 0.7 | 2.2 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.6 | 1.8 | GO:0034653 | diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) regulation of skeletal muscle fiber differentiation(GO:1902809) |
| 0.5 | 4.9 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.5 | 6.7 | GO:0021840 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.5 | 4.3 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.5 | 1.4 | GO:0007308 | oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719) |
| 0.5 | 1.9 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.5 | 1.4 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.5 | 1.4 | GO:0051714 | natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714) |
| 0.4 | 5.5 | GO:2001300 | ductus arteriosus closure(GO:0097070) lipoxin metabolic process(GO:2001300) |
| 0.4 | 1.7 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
| 0.4 | 4.2 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.4 | 1.9 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.4 | 2.2 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.4 | 4.6 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.3 | 0.3 | GO:0051710 | regulation of cytolysis in other organism(GO:0051710) |
| 0.3 | 1.3 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 1.4 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.3 | 0.8 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.3 | 1.3 | GO:0019087 | transformation of host cell by virus(GO:0019087) |
| 0.2 | 1.8 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.2 | 1.1 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.2 | 1.4 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.2 | 0.6 | GO:0045014 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) |
| 0.2 | 1.1 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 0.2 | 0.2 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 0.2 | 0.8 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919) |
| 0.2 | 0.8 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.2 | 0.8 | GO:0090095 | regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.2 | 0.8 | GO:0002913 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.2 | 0.6 | GO:0031247 | actin rod assembly(GO:0031247) |
| 0.2 | 1.3 | GO:2000490 | negative regulation of hepatic stellate cell activation(GO:2000490) |
| 0.2 | 0.9 | GO:0010193 | response to ozone(GO:0010193) |
| 0.2 | 0.9 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.2 | 3.7 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.2 | 0.7 | GO:0042335 | cuticle development(GO:0042335) |
| 0.2 | 1.2 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.2 | 0.6 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.2 | 0.8 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.2 | 0.5 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.2 | 1.6 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.2 | 0.6 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.1 | 0.6 | GO:0060574 | intestinal epithelial cell maturation(GO:0060574) |
| 0.1 | 0.8 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.1 | 0.6 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 0.1 | 0.4 | GO:1900195 | positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 0.1 | 1.1 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 1.2 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.1 | 0.4 | GO:0042938 | dipeptide transport(GO:0042938) |
| 0.1 | 0.4 | GO:1901877 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
| 0.1 | 0.5 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.1 | 1.4 | GO:0030091 | protein repair(GO:0030091) |
| 0.1 | 0.3 | GO:1904328 | regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764) |
| 0.1 | 0.3 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 0.1 | 0.3 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.1 | 0.5 | GO:0032903 | viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472) |
| 0.1 | 1.0 | GO:0010533 | regulation of activation of Janus kinase activity(GO:0010533) |
| 0.1 | 0.6 | GO:1904073 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.1 | 1.0 | GO:0032364 | oxygen homeostasis(GO:0032364) |
| 0.1 | 0.5 | GO:0032185 | septin cytoskeleton organization(GO:0032185) |
| 0.1 | 2.4 | GO:0048757 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.1 | 0.4 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.1 | 0.9 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.1 | 0.6 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
| 0.1 | 0.4 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.1 | 1.7 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.1 | 0.2 | GO:0003241 | growth involved in heart morphogenesis(GO:0003241) |
| 0.1 | 0.5 | GO:0098838 | reduced folate transmembrane transport(GO:0098838) |
| 0.1 | 0.5 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.5 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.1 | 0.3 | GO:0090222 | centrosome-templated microtubule nucleation(GO:0090222) |
| 0.1 | 0.6 | GO:0032971 | regulation of muscle filament sliding(GO:0032971) |
| 0.1 | 0.2 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.1 | 1.0 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 0.4 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.1 | 0.6 | GO:0072564 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 0.2 | GO:0001207 | histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039) |
| 0.1 | 0.8 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.1 | 0.5 | GO:1905247 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 0.1 | 1.1 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.3 | GO:0097325 | melanocyte proliferation(GO:0097325) |
| 0.1 | 0.3 | GO:1904823 | pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 0.1 | 0.8 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.1 | 1.0 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 0.2 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 0.1 | 0.2 | GO:0061536 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.1 | 0.3 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
| 0.1 | 0.4 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 0.1 | 0.2 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.1 | 0.3 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.1 | 0.2 | GO:0043396 | corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) |
| 0.1 | 0.2 | GO:0032848 | negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.1 | 0.5 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 0.2 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) |
| 0.1 | 0.4 | GO:0070272 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
| 0.1 | 0.2 | GO:0030221 | basophil differentiation(GO:0030221) |
| 0.1 | 0.5 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
| 0.1 | 0.2 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
| 0.1 | 0.3 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.0 | 0.3 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.0 | 0.2 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.0 | 0.6 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.0 | 0.1 | GO:0021722 | pons maturation(GO:0021586) superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.0 | 0.2 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 0.0 | 0.3 | GO:0051673 | membrane disruption in other organism(GO:0051673) |
| 0.0 | 0.3 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.0 | 0.4 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.0 | 0.3 | GO:0030421 | defecation(GO:0030421) |
| 0.0 | 1.0 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 0.0 | 0.3 | GO:0000066 | mitochondrial ornithine transport(GO:0000066) |
| 0.0 | 0.7 | GO:1903764 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.0 | 0.2 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.0 | 0.6 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.1 | GO:0099557 | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission(GO:0099557) |
| 0.0 | 0.3 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.0 | 0.1 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.0 | 0.2 | GO:0061760 | antifungal innate immune response(GO:0061760) |
| 0.0 | 0.1 | GO:0042137 | sequestering of neurotransmitter(GO:0042137) |
| 0.0 | 0.2 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 0.0 | 0.9 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 0.9 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.0 | 0.7 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.0 | GO:1903937 | response to acrylamide(GO:1903937) |
| 0.0 | 0.6 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 0.0 | 0.3 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.0 | 0.9 | GO:0007567 | parturition(GO:0007567) |
| 0.0 | 1.4 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 0.2 | GO:0052651 | monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651) |
| 0.0 | 0.3 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.0 | 1.5 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 5.6 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.0 | 0.1 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.0 | 3.0 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.1 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.0 | 1.8 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 1.0 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 0.7 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.0 | 0.2 | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 0.0 | 0.3 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.0 | 0.5 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.2 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 0.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 8.2 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.0 | 0.5 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 0.3 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 0.6 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 0.5 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.0 | 0.2 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.0 | 1.0 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 0.2 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.0 | 0.4 | GO:0015732 | prostaglandin transport(GO:0015732) |
| 0.0 | 0.3 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.0 | 0.2 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.0 | 0.1 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
| 0.0 | 0.3 | GO:0002335 | mature B cell differentiation(GO:0002335) |
| 0.0 | 0.0 | GO:2000851 | positive regulation of glucocorticoid secretion(GO:2000851) |
| 0.0 | 0.5 | GO:0009595 | detection of biotic stimulus(GO:0009595) |
| 0.0 | 0.3 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 0.1 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.0 | 0.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.0 | 0.4 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 0.8 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 1.0 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 0.0 | 0.2 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
| 0.0 | 0.2 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) |
| 0.0 | 0.2 | GO:2000346 | negative regulation of hepatocyte proliferation(GO:2000346) |
| 0.0 | 1.1 | GO:1901222 | regulation of NIK/NF-kappaB signaling(GO:1901222) |
| 0.0 | 0.2 | GO:0042354 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.0 | 0.5 | GO:0010996 | response to auditory stimulus(GO:0010996) |
| 0.0 | 0.2 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 1.2 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
| 0.0 | 1.0 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.0 | 0.1 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.0 | 0.9 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.0 | 2.2 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.0 | 0.3 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.5 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.0 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 0.0 | 0.3 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
| 0.0 | 0.8 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.9 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.7 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.0 | 0.2 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.0 | 0.3 | GO:0032094 | response to food(GO:0032094) |
| 0.0 | 0.3 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.0 | 0.2 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.9 | GO:0045143 | homologous chromosome segregation(GO:0045143) |
| 0.0 | 0.5 | GO:0046320 | regulation of fatty acid oxidation(GO:0046320) |
| 0.0 | 0.5 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.0 | 0.3 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
| 0.0 | 1.9 | GO:0034605 | cellular response to heat(GO:0034605) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.9 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.4 | 4.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.4 | 1.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.3 | 1.9 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.2 | 2.5 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.2 | 1.4 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.2 | 1.4 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 0.2 | 1.0 | GO:0030934 | anchoring collagen complex(GO:0030934) |
| 0.2 | 1.4 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.2 | 1.4 | GO:0071546 | pi-body(GO:0071546) |
| 0.1 | 0.4 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.1 | 6.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 0.4 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.1 | 0.6 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.1 | 1.2 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 6.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.9 | GO:0061200 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
| 0.1 | 0.5 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 0.3 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 0.5 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.1 | 1.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 0.9 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 1.4 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.1 | 0.6 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.1 | 1.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.2 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.1 | 0.7 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.1 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.1 | 0.2 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.1 | 1.3 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 4.1 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 1.1 | GO:0043219 | lateral loop(GO:0043219) |
| 0.0 | 3.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 1.1 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 2.1 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 0.2 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.0 | 2.3 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.8 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 0.7 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 0.5 | GO:0031088 | platelet dense granule membrane(GO:0031088) zymogen granule membrane(GO:0042589) |
| 0.0 | 1.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.2 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.0 | 0.3 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.1 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 2.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.2 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 0.4 | GO:0071203 | WASH complex(GO:0071203) |
| 0.0 | 0.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.3 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
| 0.0 | 0.9 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.3 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.2 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.0 | 0.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.3 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 1.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.6 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.9 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.0 | 1.2 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.5 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.3 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 1.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.6 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 1.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.4 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 0.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.2 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 8.5 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 0.0 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 0.0 | 0.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.5 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.6 | 1.8 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
| 0.5 | 1.4 | GO:0036134 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.5 | 4.3 | GO:0043426 | MRF binding(GO:0043426) |
| 0.4 | 2.2 | GO:0034040 | lipid-transporting ATPase activity(GO:0034040) |
| 0.4 | 2.2 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.4 | 1.3 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.4 | 6.7 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.3 | 1.4 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
| 0.3 | 1.3 | GO:0047888 | fatty acid peroxidase activity(GO:0047888) |
| 0.3 | 2.2 | GO:0008481 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.3 | 1.2 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.3 | 1.3 | GO:0033906 | hyaluronoglucuronidase activity(GO:0033906) |
| 0.3 | 0.8 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.2 | 1.9 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.2 | 1.4 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.2 | 2.2 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.2 | 0.8 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.2 | 1.2 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.2 | 1.0 | GO:0016749 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 0.2 | 1.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 1.4 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.1 | 0.6 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 0.4 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.1 | 0.4 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.1 | 0.9 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 4.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.4 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.1 | 0.6 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.1 | 1.0 | GO:0038049 | transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) |
| 0.1 | 1.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 1.4 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 0.3 | GO:0015389 | pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389) |
| 0.1 | 0.4 | GO:0001632 | leukotriene B4 receptor activity(GO:0001632) |
| 0.1 | 0.9 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.1 | 0.8 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 0.5 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 0.1 | 0.8 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 0.9 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 1.8 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 0.3 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.1 | 1.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.6 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 0.7 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.1 | 2.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.4 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 1.1 | GO:0098960 | postsynaptic neurotransmitter receptor activity(GO:0098960) |
| 0.1 | 5.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 1.5 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.1 | 0.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 0.8 | GO:0030911 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) TPR domain binding(GO:0030911) |
| 0.1 | 0.3 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.1 | 0.6 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.1 | 0.5 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 0.8 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 0.8 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 0.3 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.2 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.0 | 5.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.9 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 0.2 | GO:0003875 | ADP-ribosylarginine hydrolase activity(GO:0003875) |
| 0.0 | 0.1 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.0 | 1.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.2 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.0 | 1.2 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 1.1 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 0.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.0 | 0.7 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.0 | 0.7 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.2 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.0 | 0.3 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.0 | 0.5 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.6 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.0 | 0.2 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 0.0 | 0.3 | GO:0008517 | folic acid transporter activity(GO:0008517) |
| 0.0 | 0.2 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.0 | 0.4 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 0.1 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.0 | 0.2 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.0 | 0.3 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.0 | 0.2 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.0 | 0.1 | GO:0098988 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988) |
| 0.0 | 0.4 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 0.2 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.0 | 0.6 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 1.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.8 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.8 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 0.4 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 0.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 0.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 0.4 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.0 | 0.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.1 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.0 | 0.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 0.2 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 0.3 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.0 | 1.1 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.3 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.0 | 2.0 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.5 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.0 | 0.4 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 3.3 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.2 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.0 | 0.2 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.0 | 0.1 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.0 | 0.2 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.4 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.0 | 0.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.3 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.0 | 0.5 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.2 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.0 | 0.3 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 1.4 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.2 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.0 | 0.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 5.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 1.1 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 0.2 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.0 | 3.9 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 1.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 1.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.8 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 6.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 1.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.2 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.2 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 0.1 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 0.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 1.0 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.0 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 6.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 4.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 3.0 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 1.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 3.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 0.4 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 0.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 5.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 3.2 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 3.1 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.0 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 3.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.0 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 1.1 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.8 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.6 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 1.3 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.8 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.3 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 0.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 4.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 6.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 2.3 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.4 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 4.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 0.9 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 4.2 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 2.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 0.8 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 1.4 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.2 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.9 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 2.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.8 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 1.0 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.6 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 0.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.0 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.1 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 0.2 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.8 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.2 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 1.4 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.5 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.7 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.3 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.0 | 0.5 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.8 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 1.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.6 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 2.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.4 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.0 | 0.3 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 0.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.2 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.7 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.5 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.2 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.0 | 0.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.2 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.3 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 2.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |