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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TCF21

Z-value: 0.95

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Transcription factors associated with TCF21

Gene Symbol Gene ID Gene Info
ENSG00000118526.7 TCF21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF21hg38_v1_chr6_+_133889105_133889120-0.029.1e-01Click!

Activity profile of TCF21 motif

Sorted Z-values of TCF21 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF21

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_205422050 4.44 ENST00000367153.9
LEM domain containing 1
chr17_-_7590072 4.29 ENST00000538513.6
ENST00000570788.1
ENST00000250055.3
SRY-box transcription factor 15
chrX_+_70290077 4.04 ENST00000374403.4
kinesin family member 4A
chr1_+_171185293 3.63 ENST00000209929.10
flavin containing dimethylaniline monoxygenase 2
chr7_-_41703062 3.24 ENST00000242208.5
inhibin subunit beta A
chr4_+_8182066 3.19 ENST00000508641.2
SH3 domain and tetratricopeptide repeats 1
chr20_+_31739260 3.12 ENST00000340513.4
ENST00000300403.11
TPX2 microtubule nucleation factor
chr22_+_37675629 3.09 ENST00000215909.10
galectin 1
chr7_-_76626127 2.73 ENST00000454397.1
POM121 and ZP3 fusion
chr7_+_134565098 2.63 ENST00000652743.1
aldo-keto reductase family 1 member B15
chr17_-_44947637 2.52 ENST00000587309.5
ENST00000593135.6
kinesin family member 18B
chr17_+_6444441 2.51 ENST00000250056.12
ENST00000571373.5
ENST00000570337.6
ENST00000572595.6
ENST00000572447.6
ENST00000576056.5
PICALM interacting mitotic regulator
chr5_-_60700094 2.50 ENST00000453022.6
ENST00000265036.10
DEP domain containing 1B
chr5_+_69167216 2.41 ENST00000508407.5
ENST00000505500.5
cyclin B1
chr5_+_69167117 2.28 ENST00000506572.5
ENST00000256442.10
cyclin B1
chr7_-_76627240 2.21 ENST00000275569.8
ENST00000310842.9
POM121 and ZP3 fusion
chr12_-_6851245 2.21 ENST00000540683.1
ENST00000229265.10
ENST00000535406.5
ENST00000422785.7
ENST00000538862.7
cell division cycle associated 3
chr18_+_23949847 2.20 ENST00000588004.1
laminin subunit alpha 3
chr11_+_33039561 2.11 ENST00000334274.9
t-complex 11 like 1
chr11_-_61816985 2.02 ENST00000350997.12
fatty acid desaturase 1
chr11_+_33039996 2.00 ENST00000432887.5
ENST00000528898.1
ENST00000531632.6
t-complex 11 like 1
chr12_-_57767057 1.78 ENST00000228606.9
cytochrome P450 family 27 subfamily B member 1
chr18_+_24155938 1.77 ENST00000582229.1
calcium binding tyrosine phosphorylation regulated
chr11_+_125626229 1.72 ENST00000532449.6
ENST00000534070.5
checkpoint kinase 1
chr11_-_88175432 1.72 ENST00000531138.1
ENST00000526372.1
ENST00000243662.11
RAB38, member RAS oncogene family
chr2_-_233854566 1.69 ENST00000432087.5
ENST00000441687.5
ENST00000414924.5
Holliday junction recognition protein
chr9_+_122375286 1.66 ENST00000373698.7
prostaglandin-endoperoxide synthase 1
chr2_-_233854506 1.60 ENST00000411486.7
Holliday junction recognition protein
chr8_+_25459190 1.58 ENST00000380665.3
ENST00000330560.8
cell division cycle associated 2
chr4_+_8229170 1.54 ENST00000511002.6
SH3 domain and tetratricopeptide repeats 1
chr15_-_74203172 1.50 ENST00000616000.4
signaling receptor and transporter of retinol STRA6
chr12_-_52192007 1.44 ENST00000394815.3
keratin 80
chr15_+_40695423 1.37 ENST00000526763.6
ENST00000532743.6
RAD51 recombinase
chr12_-_52191981 1.34 ENST00000313234.9
keratin 80
chr20_-_54173516 1.34 ENST00000395955.7
cytochrome P450 family 24 subfamily A member 1
chr16_+_56336727 1.31 ENST00000568375.2
G protein subunit alpha o1
chr14_-_106374129 1.30 ENST00000390616.2
immunoglobulin heavy variable 4-34
chr15_+_89243945 1.29 ENST00000674831.1
ENST00000300027.12
ENST00000567891.5
ENST00000310775.12
ENST00000676003.1
ENST00000564920.5
ENST00000565255.5
ENST00000567996.5
ENST00000563250.5
FA complementation group I
chr15_+_63048535 1.28 ENST00000560959.5
tropomyosin 1
chr19_+_6531018 1.27 ENST00000245817.5
TNF superfamily member 9
chr12_+_12891554 1.24 ENST00000014914.6
G protein-coupled receptor class C group 5 member A
chr11_+_47248924 1.22 ENST00000481889.6
ENST00000436778.5
ENST00000531660.5
ENST00000407404.5
nuclear receptor subfamily 1 group H member 3
chr14_+_23630109 1.20 ENST00000432832.6
dehydrogenase/reductase 2
chr1_+_153628393 1.19 ENST00000368696.3
ENST00000292169.6
ENST00000436839.1
S100 calcium binding protein A1
chr1_-_6490564 1.19 ENST00000377725.5
ENST00000340850.10
pleckstrin homology and RhoGEF domain containing G5
chr15_+_63048576 1.18 ENST00000559281.6
tropomyosin 1
chr19_+_11541125 1.14 ENST00000587087.5
calponin 1
chr6_-_30690968 1.08 ENST00000376420.9
ENST00000376421.7
nurim
chr1_+_204073104 1.07 ENST00000367204.6
SRY-box transcription factor 13
chr19_-_14112641 1.06 ENST00000536649.5
protein kinase cAMP-activated catalytic subunit alpha
chr15_+_92904447 1.06 ENST00000626782.2
chromodomain helicase DNA binding protein 2
chr17_+_4833331 1.04 ENST00000355280.11
ENST00000347992.11
misshapen like kinase 1
chr7_-_100100716 1.03 ENST00000354230.7
ENST00000425308.5
minichromosome maintenance complex component 7
chr1_-_63523175 1.00 ENST00000371092.7
ENST00000271002.15
integrin subunit beta 3 binding protein
chrX_+_17737443 0.98 ENST00000398080.5
ENST00000380045.7
ENST00000380043.7
ENST00000380041.8
Scm polycomb group protein like 1
chr5_+_136028979 0.98 ENST00000442011.7
transforming growth factor beta induced
chr11_+_47248885 0.98 ENST00000395397.7
ENST00000405576.5
nuclear receptor subfamily 1 group H member 3
chr15_+_63048436 0.97 ENST00000334895.10
ENST00000404484.9
ENST00000558910.3
ENST00000317516.12
tropomyosin 1
chrX_-_107717054 0.97 ENST00000503515.1
ENST00000372397.6
TSC22 domain family member 3
chr10_-_29634964 0.96 ENST00000375398.6
ENST00000355867.8
supervillin
chr2_-_17800195 0.94 ENST00000402989.5
ENST00000428868.1
structural maintenance of chromosomes 6
chr2_+_64453969 0.94 ENST00000464281.5
galectin like
chr5_-_175968280 0.93 ENST00000513482.1
ENST00000265097.9
ENST00000628318.2
THO complex 3
chr19_-_4535221 0.92 ENST00000381848.7
ENST00000586133.1
perilipin 5
chr17_-_7394800 0.89 ENST00000574401.5
phospholipid scramblase 3
chr15_-_74725370 0.87 ENST00000567032.5
ENST00000564596.5
ENST00000566503.1
ENST00000395049.8
ENST00000379727.8
ENST00000617691.4
ENST00000395048.6
cytochrome P450 family 1 subfamily A member 1
chr6_-_159745186 0.85 ENST00000537657.5
superoxide dismutase 2
chr2_+_64454145 0.83 ENST00000238875.10
galectin like
chr10_-_96359273 0.81 ENST00000393871.5
ENST00000419479.5
ENST00000393870.3
oligodendrocytic myelin paranodal and inner loop protein
chr22_+_20917398 0.81 ENST00000354336.8
CRK like proto-oncogene, adaptor protein
chr5_-_16936231 0.80 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
myosin X
chr10_-_124450027 0.78 ENST00000451024.5
NK1 homeobox 2
chr8_+_66043413 0.77 ENST00000522619.1
DnaJ heat shock protein family (Hsp40) member C5 beta
chr5_+_14143322 0.77 ENST00000344204.9
trio Rho guanine nucleotide exchange factor
chr11_-_102625332 0.76 ENST00000260228.3
matrix metallopeptidase 20
chr12_+_121888751 0.76 ENST00000261817.6
ENST00000538613.5
ENST00000542602.1
ENST00000541212.6
proteasome 26S subunit, non-ATPase 9
chr14_-_50944428 0.75 ENST00000532462.5
glycogen phosphorylase L
chr13_-_49936486 0.75 ENST00000378195.6
SPRY domain containing 7
chr5_-_170389634 0.75 ENST00000521859.1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
chr14_-_81436447 0.74 ENST00000649389.1
ENST00000557055.5
stonin 2
chr3_-_177197248 0.74 ENST00000427349.5
ENST00000352800.10
TBL1X receptor 1
chr20_+_61599755 0.74 ENST00000543233.2
cadherin 4
chr17_-_7394514 0.73 ENST00000571802.1
ENST00000619711.5
ENST00000576201.5
ENST00000573213.1
ENST00000324822.15
phospholipid scramblase 3
chr2_+_33476640 0.73 ENST00000425210.5
ENST00000444784.5
ENST00000423159.5
ENST00000403687.8
RAS guanyl releasing protein 3
chr6_-_11382247 0.73 ENST00000397378.7
ENST00000513989.5
ENST00000508546.5
ENST00000504387.5
neural precursor cell expressed, developmentally down-regulated 9
chr19_-_4831689 0.73 ENST00000248244.6
toll like receptor adaptor molecule 1
chr9_-_110999458 0.72 ENST00000374430.6
lysophosphatidic acid receptor 1
chr11_-_5301946 0.72 ENST00000380224.2
olfactory receptor family 51 subfamily B member 4
chr1_+_11736120 0.71 ENST00000400895.6
ENST00000314340.10
ENST00000376629.8
ENST00000376627.6
ENST00000452018.6
ENST00000510878.1
angiotensin II receptor associated protein
chr1_-_228416626 0.70 ENST00000355586.4
ENST00000520264.1
ENST00000479800.1
ENST00000295033.7
tripartite motif containing 17
chr22_+_21015027 0.70 ENST00000413302.6
ENST00000401443.5
purinergic receptor P2X 6
chr1_-_229342966 0.68 ENST00000284617.7
centriole, cilia and spindle associated protein
chr9_-_120926752 0.67 ENST00000373887.8
TNF receptor associated factor 1
chr1_+_54548217 0.67 ENST00000343744.7
ENST00000371316.3
acyl-CoA thioesterase 11
chr9_+_27109135 0.67 ENST00000519097.5
ENST00000615002.4
TEK receptor tyrosine kinase
chr12_-_104050112 0.67 ENST00000547583.1
ENST00000546851.1
ENST00000360814.9
glycosyltransferase 8 domain containing 2
chr1_-_228416841 0.67 ENST00000366698.7
ENST00000457345.2
tripartite motif containing 17
chr4_-_4542034 0.66 ENST00000306200.7
syntaxin 18
chr19_-_45785659 0.66 ENST00000537879.1
ENST00000596586.5
ENST00000595946.1
DM1 locus, WD repeat containing
novel protein
chr8_-_41665200 0.66 ENST00000335651.6
ankyrin 1
chr15_+_63048658 0.65 ENST00000560615.5
ENST00000651577.1
tropomyosin 1
chr2_+_6877768 0.65 ENST00000382040.4
radical S-adenosyl methionine domain containing 2
chr2_-_88979016 0.64 ENST00000390247.2
immunoglobulin kappa variable 3-7 (non-functional)
chr20_-_1329131 0.64 ENST00000360779.4
syndecan binding protein 2
chr7_-_100101333 0.64 ENST00000303887.10
minichromosome maintenance complex component 7
chr8_+_38231484 0.63 ENST00000533100.5
ENST00000397166.7
ENST00000528358.5
ENST00000529642.1
ENST00000532222.5
ENST00000520272.6
DDHD domain containing 2
chr9_+_27109200 0.63 ENST00000380036.10
TEK receptor tyrosine kinase
chr17_-_3513768 0.63 ENST00000570318.1
ENST00000541913.5
spermatogenesis associated 22
chr22_+_22922594 0.62 ENST00000390331.3
immunoglobulin lambda constant 7
chr16_-_31088963 0.61 ENST00000280606.6
serine protease 53
chr4_-_20984011 0.61 ENST00000382149.9
potassium voltage-gated channel interacting protein 4
chr1_-_149917826 0.61 ENST00000369145.1
ENST00000369146.8
synaptic vesicle glycoprotein 2A
chr3_-_177197429 0.60 ENST00000457928.7
TBL1X receptor 1
chr1_+_11736068 0.60 ENST00000376637.7
angiotensin II receptor associated protein
chr22_-_21952827 0.59 ENST00000397495.8
ENST00000263212.10
protein phosphatase, Mg2+/Mn2+ dependent 1F
chr4_+_37891060 0.59 ENST00000261439.9
ENST00000508802.5
ENST00000402522.1
TBC1 domain family member 1
chr6_-_25830557 0.58 ENST00000468082.1
solute carrier family 17 member 1
chr13_-_49936298 0.58 ENST00000613924.1
ENST00000361840.8
SPRY domain containing 7
chr17_+_19411220 0.58 ENST00000461366.2
ring finger protein 112
chr4_-_88231322 0.58 ENST00000515655.5
ATP binding cassette subfamily G member 2 (Junior blood group)
chr1_-_201469151 0.58 ENST00000367311.5
ENST00000367309.1
pleckstrin homology like domain family A member 3
chr1_-_243163310 0.58 ENST00000492145.1
ENST00000490813.5
ENST00000464936.5
centrosomal protein 170
chr11_+_122655712 0.58 ENST00000284273.6
ubiquitin associated and SH3 domain containing B
chr5_+_115841878 0.58 ENST00000316788.12
adaptor related protein complex 3 subunit sigma 1
chr11_+_59142728 0.57 ENST00000528737.5
FAM111 trypsin like peptidase A
chr16_+_81645352 0.56 ENST00000398040.8
c-Maf inducing protein
chr3_+_101779425 0.56 ENST00000491511.6
neurexophilin and PC-esterase domain family member 3
chr9_-_19102887 0.55 ENST00000380502.8
HAUS augmin like complex subunit 6
chr6_-_27867581 0.54 ENST00000331442.5
H1.5 linker histone, cluster member
chr8_+_38728186 0.54 ENST00000519416.5
ENST00000520615.5
transforming acidic coiled-coil containing protein 1
chr5_-_11589019 0.53 ENST00000511377.5
catenin delta 2
chr6_-_26250625 0.53 ENST00000618052.2
H3 clustered histone 7
chr6_+_31587185 0.52 ENST00000376092.7
ENST00000376086.7
ENST00000303757.12
ENST00000376093.6
leukocyte specific transcript 1
chr3_+_101779182 0.52 ENST00000495842.5
ENST00000273347.10
neurexophilin and PC-esterase domain family member 3
chr9_+_6757633 0.51 ENST00000401787.7
ENST00000381306.7
lysine demethylase 4C
chr1_-_23800402 0.51 ENST00000374497.7
ENST00000425913.5
UDP-galactose-4-epimerase
chr15_-_65115185 0.51 ENST00000559089.6
ubiquitin associated protein 1 like
chr2_+_90234809 0.51 ENST00000443397.5
immunoglobulin kappa variable 3D-7
chr6_+_31587268 0.50 ENST00000396101.7
ENST00000490742.5
leukocyte specific transcript 1
chr21_-_32279012 0.49 ENST00000290130.4
MIS18 kinetochore protein A
chr19_-_39833615 0.49 ENST00000593685.5
ENST00000600611.5
dual specificity tyrosine phosphorylation regulated kinase 1B
chr11_-_14891643 0.49 ENST00000532378.5
cytochrome P450 family 2 subfamily R member 1
chr11_-_89922245 0.48 ENST00000420869.3
tripartite motif containing 49D1
chr11_-_83286377 0.48 ENST00000455220.6
ENST00000529689.5
coiled-coil domain containing 90B
chr2_+_87338511 0.48 ENST00000421835.2
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr11_-_83286328 0.47 ENST00000525503.5
coiled-coil domain containing 90B
chr7_+_151114597 0.47 ENST00000335367.7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr13_+_31945826 0.47 ENST00000647500.1
FRY microtubule binding protein
chr11_-_114559866 0.47 ENST00000534921.2
neurexophilin and PC-esterase domain family member 1
chr8_-_67746348 0.46 ENST00000297770.10
carboxypeptidase A6
chr3_-_177197210 0.46 ENST00000431421.5
ENST00000422066.5
ENST00000413084.5
ENST00000673974.1
ENST00000422442.6
TBL1X receptor 1
chr13_-_52159844 0.45 ENST00000611833.4
NIMA related kinase 3
chr2_-_218671975 0.45 ENST00000295704.7
ring finger protein 25
chr2_-_61018228 0.45 ENST00000316752.11
pseudouridine synthase 10
chr13_-_52159559 0.45 ENST00000620675.4
ENST00000610828.5
NIMA related kinase 3
chr1_-_75611083 0.45 ENST00000370855.5
solute carrier family 44 member 5
chr18_+_158513 0.45 ENST00000400266.7
ENST00000580410.5
ENST00000261601.8
ENST00000383589.6
ubiquitin specific peptidase 14
chr1_-_150876697 0.44 ENST00000515192.5
aryl hydrocarbon receptor nuclear translocator
chr13_-_52159529 0.44 ENST00000618534.4
ENST00000550841.1
NIMA related kinase 3
chr22_+_40346508 0.44 ENST00000636714.1
ENST00000216194.11
ENST00000623978.3
ENST00000636265.1
ENST00000680378.1
adenylosuccinate lyase
chr17_+_7438267 0.44 ENST00000575235.5
fibroblast growth factor 11
chr20_+_56248732 0.43 ENST00000243911.2
melanocortin 3 receptor
chr9_-_101487120 0.43 ENST00000374848.8
post-GPI attachment to proteins GalNAc transferase 4
chr12_+_55932028 0.43 ENST00000394147.5
ENST00000551156.5
ENST00000553783.5
ENST00000557080.5
ENST00000432422.7
ENST00000556001.5
diacylglycerol kinase alpha
chr13_-_77919390 0.42 ENST00000475537.2
ENST00000646605.1
endothelin receptor type B
chr1_+_22001654 0.42 ENST00000290122.8
chymotrypsin like elastase 3A
chr12_+_57434778 0.42 ENST00000309668.3
inhibin subunit beta C
chr18_+_58221535 0.42 ENST00000431212.6
ENST00000586268.5
ENST00000587190.5
NEDD4 like E3 ubiquitin protein ligase
chr2_+_191245473 0.42 ENST00000304164.8
myosin IB
chr11_-_114559847 0.42 ENST00000251921.6
neurexophilin and PC-esterase domain family member 1
chr2_-_224947030 0.41 ENST00000409592.7
dedicator of cytokinesis 10
chr16_+_69424634 0.41 ENST00000515314.6
ENST00000561792.6
ENST00000568237.1
cytochrome b5 type B
chr11_+_89924064 0.41 ENST00000623787.3
tripartite motif containing 49D2
chr2_+_118088432 0.40 ENST00000245787.9
insulin induced gene 2
chr1_+_23743462 0.40 ENST00000609199.1
elongin A
chr5_-_179623659 0.40 ENST00000519056.5
ENST00000506721.5
ENST00000503105.5
ENST00000504348.5
ENST00000508103.5
ENST00000510431.5
ENST00000515158.5
ENST00000393432.8
ENST00000442819.6
heterogeneous nuclear ribonucleoprotein H1
chr11_-_68213828 0.39 ENST00000405515.5
lysine methyltransferase 5B
chr20_+_836052 0.39 ENST00000246100.3
family with sequence similarity 110 member A
chr2_-_174764407 0.39 ENST00000409219.5
ENST00000409542.5
cholinergic receptor nicotinic alpha 1 subunit
chr12_+_8989612 0.38 ENST00000266551.8
killer cell lectin like receptor G1
chr2_+_61017562 0.38 ENST00000401576.1
ENST00000295030.6
ENST00000414712.2
peroxisomal biogenesis factor 13
chr7_+_1709162 0.38 ENST00000561626.3
extracellular leucine rich repeat and fibronectin type III domain containing 1
chr18_-_22417910 0.38 ENST00000391403.4
cutaneous T cell lymphoma-associated antigen 1
chr22_+_40346461 0.38 ENST00000623632.4
ENST00000625194.4
ENST00000637666.2
ENST00000680978.1
ENST00000623063.3
ENST00000679723.1
ENST00000342312.9
adenylosuccinate lyase
chr16_+_56669807 0.38 ENST00000332374.5
metallothionein 1H
chr16_+_1972035 0.38 ENST00000568546.6
ENST00000615855.4
transducin beta like 3
chr4_+_122923067 0.37 ENST00000675612.1
ENST00000274008.5
spermatogenesis associated 5
chr11_-_83285965 0.37 ENST00000529073.5
ENST00000529611.5
coiled-coil domain containing 90B
chr1_-_167553745 0.37 ENST00000370509.5
cellular repressor of E1A stimulated genes 1
chr4_-_152382522 0.37 ENST00000296555.11
F-box and WD repeat domain containing 7
chr20_+_36214373 0.37 ENST00000432603.1
erythrocyte membrane protein band 4.1 like 1
chr18_+_3448456 0.37 ENST00000549780.5
TGFB induced factor homeobox 1
chr9_+_27109393 0.37 ENST00000406359.8
TEK receptor tyrosine kinase
chr5_+_892844 0.37 ENST00000166345.8
thyroid hormone receptor interactor 13
chr20_-_47786553 0.36 ENST00000467815.5
ENST00000359930.8
ENST00000484875.5
sulfatase 2
chr19_+_18340581 0.36 ENST00000604499.6
ENST00000269919.11
ENST00000595066.5
ENST00000252813.5
pyroglutamyl-peptidase I
chr22_+_43955424 0.36 ENST00000350028.5
SAMM50 sorting and assembly machinery component
chr9_+_34646654 0.36 ENST00000378842.8
galactose-1-phosphate uridylyltransferase
chr18_+_57352541 0.36 ENST00000324000.4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr9_+_34646589 0.36 ENST00000450095.6
galactose-1-phosphate uridylyltransferase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0060623 regulation of chromosome condensation(GO:0060623) cellular response to iron(III) ion(GO:0071283)
1.4 4.3 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.1 3.2 GO:0060279 positive regulation of ovulation(GO:0060279)
0.8 4.9 GO:0035803 egg coat formation(GO:0035803)
0.8 4.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.8 3.1 GO:0042369 vitamin D catabolic process(GO:0042369)
0.7 2.2 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.7 3.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.5 3.6 GO:0070995 NADPH oxidation(GO:0070995)
0.4 1.7 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.3 1.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.3 1.3 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.3 0.9 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.3 1.7 GO:1903232 melanosome assembly(GO:1903232)
0.2 1.5 GO:0061143 alveolar primary septum development(GO:0061143)
0.2 0.7 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 0.7 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.2 4.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 1.7 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 0.8 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.2 1.0 GO:1903413 cellular response to bile acid(GO:1903413)
0.2 0.9 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.2 0.9 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.2 0.7 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.2 0.6 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.2 2.6 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 1.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 0.8 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.7 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 1.8 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 1.8 GO:0060613 fat pad development(GO:0060613)
0.1 1.1 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.1 0.4 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.5 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.1 0.8 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 4.7 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.4 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 0.6 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.1 1.0 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.3 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 0.8 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.3 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.4 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 2.0 GO:0036109 alpha-linolenic acid metabolic process(GO:0036109)
0.1 2.8 GO:0048240 sperm capacitation(GO:0048240)
0.1 1.0 GO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034127)
0.1 0.3 GO:0072312 metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313)
0.1 0.8 GO:0060017 parathyroid gland development(GO:0060017)
0.1 0.4 GO:0035645 enteric smooth muscle cell differentiation(GO:0035645)
0.1 1.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 2.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.7 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.7 GO:1902019 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.1 1.0 GO:0033292 T-tubule organization(GO:0033292)
0.1 1.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.1 1.1 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 1.2 GO:0046415 urate metabolic process(GO:0046415)
0.1 1.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.9 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.2 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.2 GO:1904398 positive regulation of neuromuscular junction development(GO:1904398)
0.1 0.6 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.1 1.3 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 0.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.1 0.2 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.2 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.1 0.8 GO:0070166 enamel mineralization(GO:0070166)
0.1 0.9 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 3.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 0.6 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.1 0.7 GO:0019388 galactose catabolic process(GO:0019388)
0.1 3.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 0.2 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 1.0 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.1 0.2 GO:0036216 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.1 0.3 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.0 0.6 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0 0.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0006533 aspartate catabolic process(GO:0006533)
0.0 0.2 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.0 0.7 GO:0042407 cristae formation(GO:0042407)
0.0 1.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.3 GO:0019086 late viral transcription(GO:0019086)
0.0 0.2 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.1 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.3 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 1.9 GO:0043278 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0 0.4 GO:0007144 female meiosis I(GO:0007144)
0.0 1.2 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.2 GO:0034227 tRNA thio-modification(GO:0034227)
0.0 1.1 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.1 GO:0042946 glucoside transport(GO:0042946) glycoside transport(GO:1901656)
0.0 0.6 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.0 0.2 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.4 GO:0015871 choline transport(GO:0015871)
0.0 0.3 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.2 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.1 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.4 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.4 GO:0045176 apical protein localization(GO:0045176)
0.0 1.2 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 3.1 GO:0070268 cornification(GO:0070268)
0.0 0.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 1.6 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.1 GO:0032661 regulation of interleukin-18 production(GO:0032661) positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.0 0.3 GO:0032060 bleb assembly(GO:0032060)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.1 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.0 1.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0070543 response to linoleic acid(GO:0070543)
0.0 2.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.3 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.7 GO:0033198 response to ATP(GO:0033198)
0.0 0.0 GO:0061011 hepatic duct development(GO:0061011)
0.0 1.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.2 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 1.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.2 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.1 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.7 GO:0009409 response to cold(GO:0009409)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.4 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.0 0.5 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.4 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.6 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
1.1 3.2 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.4 1.8 GO:0097229 sperm end piece(GO:0097229)
0.3 1.7 GO:0031905 early endosome lumen(GO:0031905)
0.3 2.2 GO:0005610 laminin-5 complex(GO:0005610)
0.3 4.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 3.1 GO:0043203 axon hillock(GO:0043203)
0.2 2.9 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.2 0.9 GO:0035061 interchromatin granule(GO:0035061)
0.1 1.0 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.7 GO:0042555 MCM complex(GO:0042555)
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.0 GO:0070652 HAUS complex(GO:0070652)
0.1 6.3 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.3 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.1 1.4 GO:0000800 lateral element(GO:0000800)
0.1 0.4 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 0.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1 0.4 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.6 GO:0042587 glycogen granule(GO:0042587)
0.0 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 1.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 2.6 GO:0031430 M band(GO:0031430)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.5 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 4.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.4 GO:0070449 elongin complex(GO:0070449)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.7 GO:0097342 ripoptosome(GO:0097342)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 1.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 7.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.7 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 2.1 GO:0045095 keratin filament(GO:0045095)
0.0 1.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 2.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 2.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.0 GO:0005811 lipid particle(GO:0005811)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.5 GO:0031672 A band(GO:0031672)
0.0 0.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 3.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 9.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.2 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.7 2.0 GO:0000248 C-5 sterol desaturase activity(GO:0000248) sterol desaturase activity(GO:0070704)
0.6 3.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.6 3.1 GO:0030395 lactose binding(GO:0030395)
0.6 1.7 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.5 4.9 GO:0032190 acrosin binding(GO:0032190)
0.4 2.2 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.4 2.2 GO:0032810 sterol response element binding(GO:0032810)
0.4 3.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.4 1.7 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.4 3.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 0.5 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.2 1.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.2 0.6 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.2 0.8 GO:0002060 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
0.2 1.3 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.2 2.6 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 0.4 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.5 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.1 4.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.4 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 1.0 GO:0043426 MRF binding(GO:0043426)
0.1 1.4 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.8 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.8 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.9 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.7 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.2 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.1 1.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.7 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.6 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.7 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.2 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.6 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1 0.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 0.2 GO:0055100 adiponectin binding(GO:0055100)
0.1 0.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 2.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.3 GO:0047238 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.6 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 1.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0097604 temperature-gated cation channel activity(GO:0097604)
0.0 0.4 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.7 GO:0031996 thioesterase binding(GO:0031996)
0.0 4.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 2.5 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0042947 glucoside transmembrane transporter activity(GO:0042947)
0.0 0.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.4 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.7 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.0 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.1 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.6 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.3 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 1.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 3.9 GO:0042393 histone binding(GO:0042393)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.0 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 7.8 PID PLK1 PATHWAY PLK1 signaling events
0.1 3.2 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.9 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.0 PID ATR PATHWAY ATR signaling pathway
0.0 1.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 2.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 6.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID SHP2 PATHWAY SHP2 signaling
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.7 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID FOXO PATHWAY FoxO family signaling
0.0 0.4 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.0 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 3.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 4.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 4.0 REACTOME KINESINS Genes involved in Kinesins
0.1 9.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 4.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.8 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 1.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 2.9 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.7 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.7 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins