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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for THRB

Z-value: 0.37

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.20 THRB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg38_v1_chr3_-_24165548_241655950.374.6e-02Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_5596627 1.29 ENST00000380097.8
TRIM6
tripartite motif containing 6
chr11_+_5596745 1.06 ENST00000445329.5
TRIM6
tripartite motif containing 6
chr13_-_23433676 0.90 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
SACS
sacsin molecular chaperone
chr1_-_112956063 0.83 ENST00000538576.5
ENST00000369626.8
ENST00000458229.6
SLC16A1
solute carrier family 16 member 1
chr13_-_23433735 0.81 ENST00000423156.2
ENST00000683210.1
ENST00000682775.1
ENST00000684497.1
ENST00000682944.1
ENST00000683489.1
ENST00000684385.1
ENST00000683680.1
SACS
sacsin molecular chaperone
chr15_-_100544677 0.55 ENST00000284382.8
CERS3
ceramide synthase 3
chr10_+_60778331 0.54 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
CDK1
cyclin dependent kinase 1
chr10_+_60778490 0.48 ENST00000448257.6
ENST00000614696.4
CDK1
cyclin dependent kinase 1
chr3_+_50569470 0.46 ENST00000455834.5
ENST00000232854.9
HEMK1
HemK methyltransferase family member 1
chr15_-_100544341 0.46 ENST00000394113.5
CERS3
ceramide synthase 3
chr17_-_75844334 0.42 ENST00000592386.5
ENST00000412096.6
ENST00000586147.1
ENST00000207549.9
UNC13D
unc-13 homolog D
chr6_-_99394164 0.41 ENST00000254759.8
COQ3
coenzyme Q3, methyltransferase
chr15_-_100544243 0.41 ENST00000538112.6
ENST00000559639.1
ENST00000558884.6
CERS3
ceramide synthase 3
chr8_-_123025627 0.39 ENST00000519018.5
DERL1
derlin 1
chr15_-_35546146 0.38 ENST00000256538.9
ENST00000561411.1
ENST00000440392.3
DPH6
diphthamine biosynthesis 6
chr6_-_39322540 0.37 ENST00000425054.6
ENST00000373227.8
ENST00000373229.9
KCNK16
potassium two pore domain channel subfamily K member 16
chr3_+_50569145 0.35 ENST00000434410.5
HEMK1
HemK methyltransferase family member 1
chr8_-_130016622 0.32 ENST00000518283.5
ENST00000519110.5
CYRIB
CYFIP related Rac1 interactor B
chr8_-_130016414 0.31 ENST00000401979.6
ENST00000517654.5
ENST00000522361.1
ENST00000518167.5
CYRIB
CYFIP related Rac1 interactor B
chr19_+_34994778 0.30 ENST00000599564.5
GRAMD1A
GRAM domain containing 1A
chr2_-_74465162 0.30 ENST00000649854.1
ENST00000650523.1
ENST00000649601.1
ENST00000448666.7
ENST00000409065.5
ENST00000414701.1
ENST00000452063.7
ENST00000649075.1
ENST00000648810.1
ENST00000462443.2
MOGS
mannosyl-oligosaccharide glucosidase
chr2_-_9423340 0.26 ENST00000484735.5
ENST00000456913.6
ITGB1BP1
integrin subunit beta 1 binding protein 1
chr11_-_64246907 0.22 ENST00000309318.8
PPP1R14B
protein phosphatase 1 regulatory inhibitor subunit 14B
chr22_+_19950896 0.22 ENST00000412786.5
COMT
catechol-O-methyltransferase
chr20_+_408030 0.22 ENST00000640614.1
ENST00000475269.5
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1
chr7_+_107580454 0.21 ENST00000379117.6
ENST00000473124.1
BCAP29
B cell receptor associated protein 29
chr1_-_160647287 0.19 ENST00000235739.6
SLAMF1
signaling lymphocytic activation molecule family member 1
chrX_-_135868069 0.17 ENST00000604569.1
CT45A9
cancer/testis antigen family 45 member A9
chr11_+_57542641 0.16 ENST00000527972.5
ENST00000399154.3
SMTNL1
smoothelin like 1
chrX_-_135850791 0.15 ENST00000611438.1
CT45A8
cancer/testis antigen family 45 member A8
chr9_-_21350956 0.15 ENST00000259555.5
IFNA6
interferon alpha 6
chr21_-_36542600 0.14 ENST00000399136.5
CLDN14
claudin 14
chr17_+_7630094 0.14 ENST00000441599.6
ENST00000380450.9
ENST00000416273.7
ENST00000575903.5
ENST00000571153.5
ENST00000575618.5
ENST00000576152.1
ENST00000576830.5
SHBG
sex hormone binding globulin
chr12_-_21657831 0.13 ENST00000450584.5
ENST00000350669.5
ENST00000673047.2
LDHB
lactate dehydrogenase B
chr11_+_73787853 0.12 ENST00000310614.12
ENST00000497094.6
ENST00000411840.6
ENST00000535277.5
ENST00000398483.7
ENST00000542303.5
MRPL48
mitochondrial ribosomal protein L48
chr19_-_52139904 0.12 ENST00000597013.5
ENST00000596290.5
ENST00000600228.6
ZNF616
zinc finger protein 616
chr12_-_21657792 0.11 ENST00000396076.5
LDHB
lactate dehydrogenase B
chr11_+_5596721 0.11 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chrX_-_135764444 0.10 ENST00000597510.6
CT45A3
cancer/testis antigen family 45 member A3
chrX_-_135833541 0.10 ENST00000620885.1
CT45A7
cancer/testis antigen family 45 member A7
chr7_-_100656384 0.09 ENST00000461605.1
ENST00000160382.10
ACTL6B
actin like 6B
chr22_+_22395005 0.09 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43
chr8_+_22245125 0.08 ENST00000306433.9
ENST00000519237.5
ENST00000397802.8
POLR3D
RNA polymerase III subunit D
chr11_-_18726187 0.08 ENST00000513874.6
IGSF22
immunoglobulin superfamily member 22
chr20_+_408147 0.08 ENST00000441733.5
ENST00000353660.7
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1
chrX_-_135816265 0.07 ENST00000605791.7
CT45A2
cancer/testis antigen family 45 member A2
chr19_+_54573781 0.07 ENST00000391738.8
ENST00000251376.7
ENST00000391737.3
ENST00000629481.1
LILRA2
leukocyte immunoglobulin like receptor A2
chr4_+_113292838 0.07 ENST00000672411.1
ENST00000673231.1
ANK2
ankyrin 2
chr4_+_113292925 0.07 ENST00000673353.1
ENST00000505342.6
ENST00000672915.1
ENST00000509550.5
ANK2
ankyrin 2
chr1_-_154192058 0.07 ENST00000271850.11
ENST00000368530.7
ENST00000651641.1
TPM3
tropomyosin 3
chr10_+_35167516 0.07 ENST00000361599.8
CREM
cAMP responsive element modulator
chr7_+_103297425 0.04 ENST00000428154.5
ENST00000249269.9
PMPCB
peptidase, mitochondrial processing subunit beta
chr1_-_10964201 0.04 ENST00000418570.6
C1orf127
chromosome 1 open reading frame 127
chr1_+_3752441 0.02 ENST00000294600.7
CCDC27
coiled-coil domain containing 27
chr6_+_150721073 0.02 ENST00000358517.6
PLEKHG1
pleckstrin homology and RhoGEF domain containing G1
chr8_-_99893697 0.01 ENST00000518171.5
ENST00000520468.7
COX6C
cytochrome c oxidase subunit 6C

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 1.0 GO:0014038 regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166)
0.1 0.8 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.1 1.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.4 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.2 GO:0035744 T-helper 1 cell cytokine production(GO:0035744)
0.0 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.3 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.2 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.4 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.4 GO:0043320 natural killer cell degranulation(GO:0043320)
0.0 0.4 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.2 GO:0006089 lactate metabolic process(GO:0006089)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 1.7 GO:0070852 cell body fiber(GO:0070852)
0.1 0.4 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.0 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.4 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.7 GO:0070628 proteasome binding(GO:0070628)
0.0 1.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 2.3 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.3 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle