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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TLX1_NFIC

Z-value: 0.87

Motif logo

Transcription factors associated with TLX1_NFIC

Gene Symbol Gene ID Gene Info
ENSG00000107807.13 TLX1
ENSG00000141905.19 NFIC

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TLX1hg38_v1_chr10_+_101131284_1011313210.374.7e-02Click!
NFIChg38_v1_chr19_+_3314403_3314472-0.183.3e-01Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr8_-_42207557 2.55 ENST00000220809.9
ENST00000429089.6
ENST00000519510.5
ENST00000429710.6
ENST00000524009.5
plasminogen activator, tissue type
chr8_-_42207667 2.54 ENST00000352041.7
ENST00000679151.1
ENST00000679300.1
plasminogen activator, tissue type
chr18_+_23949847 2.29 ENST00000588004.1
laminin subunit alpha 3
chr17_+_76376581 2.27 ENST00000591651.5
ENST00000545180.5
sphingosine kinase 1
chr20_+_59835853 2.23 ENST00000492611.5
phosphatase and actin regulator 3
chr20_+_59676661 2.03 ENST00000355648.8
phosphatase and actin regulator 3
chr7_+_143381907 1.85 ENST00000392910.6
zyxin
chr7_+_143381561 1.77 ENST00000354434.8
zyxin
chr12_-_54419259 1.47 ENST00000293379.9
integrin subunit alpha 5
chr12_+_65824475 1.42 ENST00000403681.7
high mobility group AT-hook 2
chr20_+_35172046 1.33 ENST00000216968.5
protein C receptor
chr7_+_116524984 1.24 ENST00000614113.5
ENST00000393470.1
caveolin 1
chr3_-_98901656 1.22 ENST00000326840.11
discoidin, CUB and LCCL domain containing 2
chr17_+_7440738 1.18 ENST00000575398.5
ENST00000575082.5
fibroblast growth factor 11
chr14_+_85530127 1.15 ENST00000330753.6
fibronectin leucine rich transmembrane protein 2
chr19_+_10286971 1.13 ENST00000340992.4
ENST00000393717.2
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr3_+_187197486 1.12 ENST00000312295.5
receptor transporter protein 1
chr19_+_10286944 1.12 ENST00000380770.5
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr12_+_13196718 1.10 ENST00000431267.2
ENST00000542474.5
ENST00000544053.5
ENST00000256951.10
epithelial membrane protein 1
chr3_-_132037800 1.09 ENST00000617767.4
copine 4
chr12_+_53097656 1.04 ENST00000301464.4
insulin like growth factor binding protein 6
chr14_+_85530163 1.02 ENST00000554746.1
fibronectin leucine rich transmembrane protein 2
chr9_+_133534697 1.02 ENST00000651351.2
ADAMTS like 2
chr9_+_133534807 1.01 ENST00000393060.1
ADAMTS like 2
chr13_+_31945826 0.99 ENST00000647500.1
FRY microtubule binding protein
chr4_+_109912877 0.98 ENST00000265171.10
ENST00000509793.5
ENST00000652245.1
epidermal growth factor
chr1_+_203626813 0.98 ENST00000357681.10
ATPase plasma membrane Ca2+ transporting 4
chr1_+_203626775 0.97 ENST00000367218.7
ATPase plasma membrane Ca2+ transporting 4
chr2_-_191847068 0.97 ENST00000304141.5
caveolae associated protein 2
chr11_-_65558338 0.96 ENST00000301873.11
latent transforming growth factor beta binding protein 3
chr3_+_52316319 0.95 ENST00000420323.7
dynein axonemal heavy chain 1
chr7_+_116525028 0.90 ENST00000341049.7
caveolin 1
chr14_+_75280078 0.89 ENST00000555347.1
Fos proto-oncogene, AP-1 transcription factor subunit
chr1_-_153390976 0.89 ENST00000368732.5
ENST00000368733.4
S100 calcium binding protein A8
chr19_-_42423100 0.81 ENST00000597001.1
lipase E, hormone sensitive type
chr14_+_73237493 0.81 ENST00000340738.9
ENST00000644200.2
papilin, proteoglycan like sulfated glycoprotein
chr11_-_125592448 0.78 ENST00000648911.1
fasciculation and elongation protein zeta 1
chr6_-_43627302 0.77 ENST00000307114.11
GTP binding protein 2
chr12_-_108632073 0.76 ENST00000228463.6
selectin P ligand
chr1_-_161223559 0.74 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
apolipoprotein A2
chrX_-_54496212 0.73 ENST00000375135.4
FYVE, RhoGEF and PH domain containing 1
chr3_+_46701385 0.72 ENST00000643606.3
transmembrane inner ear
chr2_+_6877768 0.71 ENST00000382040.4
radical S-adenosyl methionine domain containing 2
chr11_-_128587551 0.68 ENST00000392668.8
ETS proto-oncogene 1, transcription factor
chr15_+_90184912 0.67 ENST00000561085.1
ENST00000332496.10
semaphorin 4B
chr8_-_10655137 0.65 ENST00000382483.4
RP1 like 1
chr1_-_93585071 0.63 ENST00000539242.5
BCAR3 adaptor protein, NSP family member
chr6_-_34556319 0.61 ENST00000374037.8
ENST00000544425.2
SAM pointed domain containing ETS transcription factor
chr22_-_39244969 0.60 ENST00000331163.11
platelet derived growth factor subunit B
chrX_-_129654946 0.59 ENST00000429967.3
apelin
chr22_+_30396991 0.59 ENST00000617837.4
ENST00000615189.5
ENST00000405717.7
ENST00000402592.7
SEC14 like lipid binding 2
chr7_-_143647646 0.58 ENST00000636941.1
TRPM8 channel associated factor 2C
chr21_-_26845402 0.58 ENST00000284984.8
ENST00000676955.1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr17_+_7308339 0.55 ENST00000416016.2
eukaryotic translation initiation factor 5A
chr17_-_78925376 0.54 ENST00000262768.11
TIMP metallopeptidase inhibitor 2
chr20_-_52105644 0.54 ENST00000371523.8
ZFP64 zinc finger protein
chr10_+_5412542 0.53 ENST00000355029.9
neuroepithelial cell transforming 1
chr1_+_78620432 0.51 ENST00000370751.10
ENST00000459784.6
ENST00000680110.1
ENST00000680295.1
interferon induced protein 44 like
chr11_-_62689523 0.50 ENST00000317449.5
LRRN4 C-terminal like
chr6_-_30075767 0.50 ENST00000244360.8
ENST00000376751.8
ring finger protein 39
chr1_+_112674722 0.50 ENST00000357443.2
Mov10 RISC complex RNA helicase
chr1_+_78620722 0.49 ENST00000679848.1
interferon induced protein 44 like
chr4_-_109801978 0.49 ENST00000510800.1
ENST00000512148.5
ENST00000394634.7
ENST00000394635.8
ENST00000645635.1
complement factor I
novel protein
chr12_+_100473951 0.48 ENST00000648861.1
ENST00000546380.1
nuclear receptor subfamily 1 group H member 4
chr9_-_127854636 0.48 ENST00000344849.4
ENST00000373203.9
endoglin
chr3_-_50303565 0.48 ENST00000266031.8
ENST00000395143.6
ENST00000457214.6
ENST00000447605.2
ENST00000395144.7
ENST00000418723.1
hyaluronidase 1
chr1_+_112674649 0.48 ENST00000369644.5
Mov10 RISC complex RNA helicase
chr2_+_26848093 0.47 ENST00000288699.11
dihydropyrimidinase like 5
chr1_+_109910485 0.47 ENST00000525659.5
colony stimulating factor 1
chr22_-_18518161 0.46 ENST00000619998.1
gamma-glutamyltransferase light chain family member 3
chr12_+_113244261 0.45 ENST00000392569.8
ENST00000552542.5
two pore segment channel 1
chr17_-_50397472 0.45 ENST00000576448.1
ENST00000225972.8
leucine rich repeat containing 59
chr2_+_26848199 0.44 ENST00000401478.5
dihydropyrimidinase like 5
chr14_+_24070837 0.44 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
copine 6
chrX_+_103376488 0.43 ENST00000361298.9
brain expressed X-linked 3
chr20_+_1895365 0.43 ENST00000358771.5
signal regulatory protein alpha
chr12_+_100473708 0.43 ENST00000548884.5
ENST00000392986.8
nuclear receptor subfamily 1 group H member 4
chr2_-_46916020 0.43 ENST00000409800.5
ENST00000409218.5
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr21_-_26843012 0.42 ENST00000517777.6
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr9_-_129753023 0.42 ENST00000340607.5
prostaglandin E synthase
chrX_+_103376389 0.42 ENST00000372645.3
ENST00000372635.1
brain expressed X-linked 3
chr7_-_27147774 0.41 ENST00000222728.3
homeobox A6
chr1_-_160070150 0.41 ENST00000644903.1
potassium inwardly rectifying channel subfamily J member 10
chr1_-_160070102 0.41 ENST00000638728.1
ENST00000637644.1
potassium inwardly rectifying channel subfamily J member 10
chr1_+_112674416 0.41 ENST00000413052.6
ENST00000369645.5
Mov10 RISC complex RNA helicase
chr21_-_26843063 0.41 ENST00000678221.1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chrX_+_100644183 0.41 ENST00000640889.1
ENST00000373004.5
sushi repeat containing protein X-linked 2
chr10_+_122560639 0.40 ENST00000344338.7
ENST00000330163.8
ENST00000652446.2
ENST00000666315.1
ENST00000368955.7
ENST00000368909.7
ENST00000368956.6
ENST00000619379.1
deleted in malignant brain tumors 1
chr2_+_113117889 0.40 ENST00000361779.7
ENST00000259206.9
ENST00000354115.6
interleukin 1 receptor antagonist
chr7_+_22727147 0.40 ENST00000426291.5
ENST00000401651.5
ENST00000258743.10
ENST00000407492.5
ENST00000401630.7
ENST00000406575.1
interleukin 6
chr10_+_122560679 0.40 ENST00000657942.1
deleted in malignant brain tumors 1
chr11_-_10693616 0.39 ENST00000541483.5
inositol 1,4,5-triphosphate receptor associated 1
chr19_-_43656616 0.39 ENST00000593447.5
plasminogen activator, urokinase receptor
chr15_+_88638947 0.38 ENST00000559876.2
interferon stimulated exonuclease gene 20
chr11_-_35420017 0.38 ENST00000643000.1
ENST00000646099.1
ENST00000647372.1
ENST00000642578.1
solute carrier family 1 member 2
chr4_+_143381939 0.37 ENST00000505913.5
GRB2 associated binding protein 1
chr17_+_39738317 0.37 ENST00000394211.7
growth factor receptor bound protein 7
chr10_+_122560751 0.36 ENST00000338354.10
ENST00000664692.1
ENST00000653442.1
ENST00000664974.1
deleted in malignant brain tumors 1
chr11_-_35420050 0.36 ENST00000395753.6
ENST00000395750.6
ENST00000645634.1
solute carrier family 1 member 2
chr6_+_137871208 0.35 ENST00000614035.4
ENST00000621150.3
ENST00000619035.4
ENST00000615468.4
ENST00000620204.3
TNF alpha induced protein 3
chr2_+_227472363 0.35 ENST00000409315.5
ENST00000373671.7
ENST00000409171.5
ArfGAP with FG repeats 1
chr2_-_46915745 0.35 ENST00000649435.1
ENST00000409105.5
ENST00000319466.9
ENST00000409973.5
ENST00000409913.5
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chrX_+_103376887 0.34 ENST00000372634.1
brain expressed X-linked 3
chr17_+_44352109 0.34 ENST00000586242.1
granulin precursor
chr5_+_177357834 0.33 ENST00000408923.8
regulator of G protein signaling 14
chr11_-_111766359 0.32 ENST00000341980.10
ENST00000311129.9
ENST00000393055.6
ENST00000426998.6
ENST00000527614.6
protein phosphatase 2 scaffold subunit Abeta
chr19_-_46714269 0.32 ENST00000600194.5
protein kinase D2
chr1_-_26890237 0.32 ENST00000431781.2
ENST00000374135.9
GPN-loop GTPase 2
chr12_+_119178920 0.31 ENST00000281938.7
heat shock protein family B (small) member 8
chr12_+_119178953 0.31 ENST00000674542.1
heat shock protein family B (small) member 8
chr5_-_177496845 0.31 ENST00000506537.1
PDZ and LIM domain 7
chr7_+_143316105 0.31 ENST00000343257.7
ENST00000650516.1
chloride voltage-gated channel 1
chr17_-_43833137 0.31 ENST00000398389.9
membrane palmitoylated protein 3
chr8_-_22927890 0.31 ENST00000256404.8
phosphatidylethanolamine binding protein 4
chr11_-_57322197 0.30 ENST00000532437.1
tankyrase 1 binding protein 1
chr8_-_140718661 0.30 ENST00000430260.6
protein tyrosine kinase 2
chr7_-_100479142 0.29 ENST00000300181.7
ENST00000393991.5
TSC22 domain family member 4
chr11_+_67023085 0.29 ENST00000527043.6
synaptotagmin 12
chrX_-_129843388 0.29 ENST00000371064.7
zinc finger DHHC-type palmitoyltransferase 9
chrX_+_2828921 0.29 ENST00000398806.8
glycogenin 2
chr2_+_218323148 0.29 ENST00000258362.7
PNKD metallo-beta-lactamase domain containing
chr5_-_177496802 0.29 ENST00000506161.5
PDZ and LIM domain 7
chr2_-_237414157 0.28 ENST00000295550.9
ENST00000353578.9
ENST00000392004.7
ENST00000433762.1
ENST00000392003.6
collagen type VI alpha 3 chain
chr11_+_75151055 0.28 ENST00000532236.5
solute carrier organic anion transporter family member 2B1
chr13_+_112376341 0.28 ENST00000414180.5
ENST00000283550.8
ENST00000443541.5
sperm acrosome associated 7
chr1_-_242449478 0.28 ENST00000427495.5
phospholipase D family member 5
chr15_+_88639009 0.28 ENST00000306072.10
interferon stimulated exonuclease gene 20
chr2_+_184598520 0.28 ENST00000302277.7
zinc finger protein 804A
chr7_-_100468063 0.28 ENST00000423266.5
ENST00000456330.1
TSC22 domain family member 4
chr17_+_7558258 0.28 ENST00000483039.5
ENST00000380535.8
ENST00000396542.5
TNF superfamily member 13
chr17_+_19411220 0.28 ENST00000461366.2
ring finger protein 112
chr3_+_50267606 0.28 ENST00000618865.4
semaphorin 3B
chr1_+_151540299 0.27 ENST00000392712.7
ENST00000368848.6
ENST00000368849.8
ENST00000353024.4
tuftelin 1
chr12_+_6535278 0.27 ENST00000396858.5
glyceraldehyde-3-phosphate dehydrogenase
chr16_-_51151259 0.27 ENST00000251020.9
spalt like transcription factor 1
chr2_+_127535746 0.27 ENST00000428314.5
ENST00000409816.7
myosin VIIB
chr8_-_37965953 0.26 ENST00000647937.1
ADRB3-GOT1L1 readthrough
chr5_+_72956030 0.26 ENST00000430046.7
ENST00000507345.6
ENST00000512348.5
ENST00000287761.7
FCH and mu domain containing endocytic adaptor 2
chr12_+_57128475 0.26 ENST00000243077.8
ENST00000553277.5
LDL receptor related protein 1
chr11_-_35419899 0.26 ENST00000646847.1
ENST00000449068.2
ENST00000643401.1
ENST00000645966.1
ENST00000647104.1
solute carrier family 1 member 2
chr1_-_31704001 0.26 ENST00000373672.8
collagen type XVI alpha 1 chain
chr4_+_54100161 0.26 ENST00000326902.7
ENST00000503800.1
GS homeobox 2
chr17_+_7558465 0.25 ENST00000349228.8
TNF superfamily member 13
chr7_+_86644829 0.25 ENST00000439827.1
ENST00000421579.1
glutamate metabotropic receptor 3
chr17_+_7558296 0.25 ENST00000438470.5
ENST00000436057.5
TNF superfamily member 13
chr3_-_155854375 0.25 ENST00000643144.2
ENST00000359479.7
ENST00000646424.1
solute carrier family 33 member 1
chr7_+_69967464 0.25 ENST00000664521.1
activator of transcription and developmental regulator AUTS2
chrX_+_49269793 0.25 ENST00000055335.11
ENST00000466508.5
ENST00000495799.5
protein phosphatase 1 regulatory subunit 3F
chr2_-_37671633 0.25 ENST00000295324.4
CDC42 effector protein 3
chr11_-_65381951 0.25 ENST00000526432.5
ENST00000527174.5
solute carrier family 25 member 45
chr13_+_27620945 0.25 ENST00000621089.2
RNA polymerase I and III subunit D
chr8_-_143840940 0.24 ENST00000442628.7
nuclear receptor binding protein 2
chr11_+_75151095 0.24 ENST00000289575.10
ENST00000525650.5
ENST00000454962.6
solute carrier organic anion transporter family member 2B1
chr11_-_117316230 0.24 ENST00000313005.11
ENST00000528053.5
beta-secretase 1
chr1_-_41484680 0.24 ENST00000372587.5
endothelin 2
chr11_+_124611420 0.24 ENST00000284288.3
pannexin 3
chr5_+_32531786 0.23 ENST00000512913.5
SUB1 regulator of transcription
chr2_+_68774782 0.23 ENST00000409030.7
ENST00000409220.5
Rho GTPase activating protein 25
chr1_+_168280872 0.23 ENST00000367821.8
T-box transcription factor 19
chrX_+_2828808 0.23 ENST00000381163.7
glycogenin 2
chr11_-_35419542 0.23 ENST00000643305.1
ENST00000644351.1
ENST00000278379.9
ENST00000644779.1
solute carrier family 1 member 2
chr6_+_151807319 0.22 ENST00000443427.5
estrogen receptor 1
chr11_+_18396266 0.22 ENST00000540430.5
ENST00000379412.9
lactate dehydrogenase A
chr8_+_24914942 0.22 ENST00000433454.3
neurofilament medium
chr3_+_135067530 0.22 ENST00000493838.1
EPH receptor B1
chr8_-_13276491 0.22 ENST00000512044.6
DLC1 Rho GTPase activating protein
chr17_+_7558774 0.22 ENST00000396545.4
TNF superfamily member 13
chr17_-_28576882 0.22 ENST00000395319.7
ENST00000581807.5
ENST00000226253.9
ENST00000584086.5
ENST00000395321.6
aldolase, fructose-bisphosphate C
chr1_+_154405326 0.21 ENST00000368485.8
interleukin 6 receptor
chr19_-_11197516 0.21 ENST00000592903.5
ENST00000586659.6
ENST00000589359.5
ENST00000588724.5
KN motif and ankyrin repeat domains 2
chr12_+_100473916 0.21 ENST00000549996.5
nuclear receptor subfamily 1 group H member 4
chr14_+_69484722 0.21 ENST00000322564.9
pleckstrin homology and coiled-coil domain containing D1
chr7_-_81770039 0.21 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
hepatocyte growth factor
chr1_-_230978796 0.21 ENST00000522821.5
ENST00000366662.8
ENST00000366661.9
ENST00000522399.1
tetratricopeptide repeat domain 13
chr1_+_38991239 0.21 ENST00000432648.8
ENST00000446189.6
ENST00000372984.8
akirin 1
chr1_-_119648165 0.20 ENST00000421812.3
zinc finger protein 697
chr16_+_30650728 0.20 ENST00000568754.5
proline rich 14
chr19_+_48755512 0.20 ENST00000593756.6
fibroblast growth factor 21
chr6_+_143843316 0.20 ENST00000367576.6
LTV1 ribosome biogenesis factor
chr16_+_142725 0.20 ENST00000652335.1
hemoglobin subunit zeta
chr17_+_7558712 0.20 ENST00000338784.9
ENST00000625791.2
TNF superfamily member 13
chr12_+_65824403 0.20 ENST00000393578.7
ENST00000425208.6
ENST00000536545.5
ENST00000354636.7
high mobility group AT-hook 2
chr16_+_75148478 0.20 ENST00000568079.5
ENST00000570010.6
ENST00000464850.5
ENST00000332307.4
ENST00000393430.6
ZFP1 zinc finger protein
chr13_+_111115235 0.20 ENST00000375739.6
ENST00000375741.6
Rho guanine nucleotide exchange factor 7
chr15_+_45635017 0.20 ENST00000260324.12
sulfide quinone oxidoreductase
chr17_+_50426242 0.19 ENST00000502667.5
acyl-CoA synthetase family member 2
chr2_-_74507664 0.19 ENST00000233630.11
polycomb group ring finger 1
chrX_-_103064164 0.19 ENST00000372728.4
brain expressed X-linked 1
chr17_+_50426210 0.19 ENST00000506582.5
ENST00000504392.5
ENST00000300441.9
ENST00000427954.6
acyl-CoA synthetase family member 2
chr2_-_218286763 0.19 ENST00000444881.5
transmembrane BAX inhibitor motif containing 1
chr9_-_74952904 0.19 ENST00000376854.6
chromosome 9 open reading frame 40
chr2_-_218671975 0.19 ENST00000295704.7
ring finger protein 25
chr9_+_27109135 0.19 ENST00000519097.5
ENST00000615002.4
TEK receptor tyrosine kinase
chr19_+_39704461 0.19 ENST00000360675.7
ENST00000392052.8
ENST00000601802.1
galectin 14
chr6_+_151807674 0.18 ENST00000406599.5
ENST00000456483.3
ENST00000206249.8
estrogen receptor 1
chr14_+_20469399 0.18 ENST00000361505.10
ENST00000553591.1
purine nucleoside phosphorylase
chr2_-_237414127 0.18 ENST00000472056.5
collagen type VI alpha 3 chain
chr9_+_27109200 0.18 ENST00000380036.10
TEK receptor tyrosine kinase
chr7_-_81770122 0.18 ENST00000423064.7
hepatocyte growth factor
chrX_-_54798253 0.18 ENST00000218436.7
inter-alpha-trypsin inhibitor heavy chain family member 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.7 2.0 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.5 2.1 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.4 1.6 GO:0035978 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.3 1.0 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.3 1.6 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.3 2.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.3 1.1 GO:0090294 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.2 1.0 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.2 0.5 GO:0001300 chronological cell aging(GO:0001300)
0.2 1.4 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 0.9 GO:1903974 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.2 1.9 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 0.6 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.2 0.8 GO:0002384 hepatic immune response(GO:0002384)
0.2 0.8 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.2 0.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 0.8 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.2 5.1 GO:0031639 plasminogen activation(GO:0031639)
0.1 0.4 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.1 1.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 1.4 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.4 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.1 0.7 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.1 0.1 GO:0003057 regulation of the force of heart contraction by chemical signal(GO:0003057)
0.1 0.2 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.1 0.3 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.9 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.3 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 1.4 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.5 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 2.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.8 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.1 1.2 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.5 GO:1900104 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.2 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.1 1.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 0.3 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.1 0.2 GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission(GO:0099557)
0.1 0.2 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.1 0.6 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.3 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1 0.3 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 0.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.7 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1 0.3 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.4 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.3 GO:0090131 mesenchyme migration(GO:0090131)
0.1 1.5 GO:0002544 chronic inflammatory response(GO:0002544)
0.1 0.8 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.2 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 0.3 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.1 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.2 GO:2000349 negative regulation of CD40 signaling pathway(GO:2000349)
0.0 0.2 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 1.0 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.9 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.4 GO:0060750 mammary gland branching involved in pregnancy(GO:0060745) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.1 GO:1901355 response to rapamycin(GO:1901355)
0.0 0.3 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.0 0.2 GO:1904640 response to methionine(GO:1904640)
0.0 0.3 GO:1904970 brush border assembly(GO:1904970)
0.0 0.2 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.0 0.4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.5 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 1.0 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.7 GO:0032060 bleb assembly(GO:0032060)
0.0 1.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:2000620 innate vocalization behavior(GO:0098582) positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.1 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891) sensory perception of sour taste(GO:0050915)
0.0 0.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.0 0.1 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.6 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.0 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.1 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.0 0.2 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 4.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.1 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0048241 epinephrine transport(GO:0048241)
0.0 0.1 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:0015855 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.3 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.1 GO:0046440 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.2 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.1 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.0 0.1 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.3 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 0.9 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.5 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.2 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.9 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.0 0.2 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 0.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.3 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 1.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0090487 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.4 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.0 GO:0042704 uterine wall breakdown(GO:0042704)
0.0 0.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.6 GO:0042461 photoreceptor cell development(GO:0042461)
0.0 0.0 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.3 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.2 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.0 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.0 0.0 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) retinal cell apoptotic process(GO:1990009)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.3 2.3 GO:0005610 laminin-5 complex(GO:0005610)
0.2 1.0 GO:0036156 inner dynein arm(GO:0036156)
0.2 1.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 0.5 GO:0072563 endothelial microparticle(GO:0072563)
0.2 0.5 GO:0036117 hyaluranon cable(GO:0036117)
0.2 0.8 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 2.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.9 GO:0035976 AP1 complex(GO:0035976)
0.1 0.1 GO:0034681 integrin alpha11-beta1 complex(GO:0034681)
0.1 0.3 GO:0036029 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 0.2 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.1 1.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 0.2 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 2.1 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.0 0.8 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.5 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 4.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.3 GO:0097452 GAIT complex(GO:0097452)
0.0 0.2 GO:0034448 EGO complex(GO:0034448)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 1.4 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.6 GO:0042627 chylomicron(GO:0042627)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 3.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 0.3 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.5 2.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.4 2.0 GO:0050436 microfibril binding(GO:0050436)
0.4 1.6 GO:0035501 MH1 domain binding(GO:0035501)
0.4 1.2 GO:0035375 zymogen binding(GO:0035375)
0.3 1.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.3 2.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.3 1.2 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.3 1.1 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.3 0.8 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 0.7 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 0.6 GO:0008431 vitamin E binding(GO:0008431)
0.2 1.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 0.5 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.1 1.5 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1 0.4 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 0.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.4 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 0.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.9 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.4 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 1.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.2 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 4.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.3 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.1 0.3 GO:0030226 apolipoprotein receptor activity(GO:0030226)
0.1 0.3 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 0.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.4 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.5 GO:0005534 galactose binding(GO:0005534)
0.1 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.4 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.9 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.2 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.3 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.0 0.3 GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 1.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0031755 endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755)
0.0 0.1 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967)
0.0 5.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.1 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.3 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.4 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 2.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.2 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.6 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.0 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.0 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.0 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.0 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 2.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 2.9 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 3.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 1.6 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 0.8 ST STAT3 PATHWAY STAT3 Pathway
0.1 2.6 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.4 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 4.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 6.4 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 1.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 2.3 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism