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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TLX2

Z-value: 0.71

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Transcription factors associated with TLX2

Gene Symbol Gene ID Gene Info
ENSG00000115297.11 TLX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TLX2hg38_v1_chr2_+_74513441_74513559,
hg38_v1_chr2_+_74514442_74514494
0.251.8e-01Click!

Activity profile of TLX2 motif

Sorted Z-values of TLX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_+_10123171 2.39 ENST00000615152.5
ribonucleotide reductase regulatory subunit M2
chr2_+_10122730 2.15 ENST00000304567.10
ribonucleotide reductase regulatory subunit M2
chr14_+_54397021 1.91 ENST00000541304.5
cyclin dependent kinase inhibitor 3
chr14_+_54396949 1.74 ENST00000611205.4
cyclin dependent kinase inhibitor 3
chr14_+_54396964 1.72 ENST00000543789.6
ENST00000442975.6
ENST00000458126.6
ENST00000556102.6
ENST00000335183.11
cyclin dependent kinase inhibitor 3
chr4_+_17810945 1.53 ENST00000251496.7
non-SMC condensin I complex subunit G
chr22_+_31082860 1.49 ENST00000619644.4
smoothelin
chr2_+_102311502 1.43 ENST00000404917.6
ENST00000410040.5
interleukin 1 receptor like 1
interleukin 18 receptor 1
chr16_+_56336727 1.20 ENST00000568375.2
G protein subunit alpha o1
chr7_+_155298561 1.08 ENST00000476756.1
insulin induced gene 1
chr3_-_42702778 1.04 ENST00000457462.5
ENST00000441594.6
hedgehog acyltransferase like
chr1_-_24143112 0.96 ENST00000270800.2
interleukin 22 receptor subunit alpha 1
chr10_-_88952763 0.95 ENST00000224784.10
actin alpha 2, smooth muscle
chr8_+_26577843 0.92 ENST00000311151.9
dihydropyrimidinase like 2
chr1_+_152908538 0.90 ENST00000368764.4
involucrin
chr1_+_152514474 0.90 ENST00000368790.4
cysteine rich C-terminal 1
chr10_-_73641450 0.90 ENST00000359322.5
myozenin 1
chr12_-_95548213 0.86 ENST00000537435.2
ubiquitin specific peptidase 44
chr19_-_11155798 0.86 ENST00000592540.5
SPC24 component of NDC80 kinetochore complex
chr1_-_153057504 0.83 ENST00000392653.3
small proline rich protein 2A
chr22_+_31081310 0.82 ENST00000426927.5
ENST00000482444.5
ENST00000440425.5
ENST00000333137.12
ENST00000358743.5
ENST00000347557.6
smoothelin
chr13_-_60013178 0.81 ENST00000498416.2
ENST00000465066.5
diaphanous related formin 3
chr3_+_122077850 0.76 ENST00000482356.5
ENST00000393627.6
CD86 molecule
chr10_+_86958557 0.73 ENST00000372017.4
ENST00000348795.8
synuclein gamma
chr6_+_24774925 0.71 ENST00000356509.7
ENST00000230056.8
geminin DNA replication inhibitor
chr3_+_122077776 0.70 ENST00000264468.9
CD86 molecule
chr12_-_95548837 0.67 ENST00000393091.6
ubiquitin specific peptidase 44
chr3_+_122055355 0.67 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86 molecule
chr19_+_676385 0.67 ENST00000166139.9
follistatin like 3
chr2_-_55296361 0.66 ENST00000647547.1
coiled-coil domain containing 88A
chr6_+_24775413 0.66 ENST00000378054.6
ENST00000620958.4
ENST00000476555.5
geminin DNA replication inhibitor
chr14_+_64704380 0.64 ENST00000247226.13
ENST00000394691.7
pleckstrin homology and RhoGEF domain containing G3
chr19_+_46601237 0.64 ENST00000597743.5
calmodulin 3
chr1_-_205449924 0.63 ENST00000367154.5
LEM domain containing 1
chr9_+_35673917 0.63 ENST00000617161.1
ENST00000378357.9
carbonic anhydrase 9
chr13_+_108596152 0.63 ENST00000356711.7
ENST00000251041.10
myosin XVI
chr12_-_98644733 0.62 ENST00000299157.5
ENST00000393042.3
IKBKB interacting protein
chr12_+_48978313 0.59 ENST00000293549.4
Wnt family member 1
chr8_+_31640358 0.59 ENST00000523534.5
neuregulin 1
chr2_-_79087986 0.56 ENST00000305089.8
regenerating family member 1 beta
chr1_-_204166334 0.55 ENST00000272190.9
renin
chr15_-_82262660 0.55 ENST00000557844.1
ENST00000359445.7
ENST00000268206.12
elongation factor like GTPase 1
chr8_+_27325516 0.55 ENST00000346049.10
ENST00000420218.3
protein tyrosine kinase 2 beta
chr17_-_78903193 0.54 ENST00000322630.3
ENST00000586713.5
CEP295 N-terminal like
chr4_-_164383986 0.53 ENST00000507270.5
ENST00000514618.5
ENST00000503008.5
membrane associated ring-CH-type finger 1
chr1_-_16978276 0.51 ENST00000375534.7
microfibril associated protein 2
chr17_+_64449037 0.51 ENST00000615220.4
ENST00000619286.5
ENST00000612535.4
ENST00000616498.4
mast cell immunoglobulin like receptor 1
chr2_-_215138603 0.50 ENST00000272895.12
ATP binding cassette subfamily A member 12
chr17_-_41055211 0.49 ENST00000542910.1
ENST00000398477.1
keratin associated protein 2-2
chr8_-_27258414 0.48 ENST00000523048.5
stathmin 4
chr11_-_107858777 0.48 ENST00000525815.6
solute carrier family 35 member F2
chr15_-_70763430 0.47 ENST00000539319.5
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_-_58587033 0.47 ENST00000447756.2
family with sequence similarity 107 member A
chr1_+_119414931 0.46 ENST00000543831.5
ENST00000433745.5
ENST00000369416.4
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_-_151790475 0.46 ENST00000368825.7
ENST00000368823.5
ENST00000368824.8
ENST00000458431.6
ENST00000368827.10
ENST00000440583.6
tudor and KH domain containing
chr2_+_218568865 0.45 ENST00000295701.9
CCR4-NOT transcription complex subunit 9
chr14_-_54489003 0.45 ENST00000554908.5
ENST00000616146.4
glia maturation factor beta
chr14_-_54488940 0.45 ENST00000628554.2
ENST00000358056.8
glia maturation factor beta
chr10_-_44385043 0.44 ENST00000374426.6
ENST00000395794.2
ENST00000374429.6
ENST00000395793.7
ENST00000343575.10
ENST00000395795.5
C-X-C motif chemokine ligand 12
chrX_+_47080855 0.44 ENST00000336169.3
regucalcin
chrX_+_152830991 0.44 ENST00000432467.1
NAD(P) dependent steroid dehydrogenase-like
chr17_-_19386785 0.43 ENST00000497081.6
microfibril associated protein 4
chr19_-_14090963 0.43 ENST00000269724.5
sterile alpha motif domain containing 1
chr4_+_168631597 0.43 ENST00000504519.5
ENST00000512127.5
palladin, cytoskeletal associated protein
chr19_-_19262792 0.42 ENST00000291481.8
hyaluronan and proteoglycan link protein 4
chr2_+_112645930 0.42 ENST00000272542.8
solute carrier family 20 member 1
chr3_+_63443076 0.42 ENST00000295894.9
synaptoporin
chr3_+_63443306 0.42 ENST00000472899.5
ENST00000479198.5
ENST00000460711.5
ENST00000465156.1
synaptoporin
chr10_-_101588126 0.42 ENST00000339310.7
ENST00000299206.8
ENST00000413344.5
ENST00000429502.1
ENST00000430045.1
ENST00000370172.5
ENST00000370162.8
ENST00000628479.2
DNA polymerase lambda
chr1_+_171257930 0.41 ENST00000354841.4
flavin containing dimethylaniline monoxygenase 1
chr16_+_56336767 0.40 ENST00000640469.1
G protein subunit alpha o1
chr1_+_18630839 0.40 ENST00000420770.7
paired box 7
chr10_+_75111476 0.39 ENST00000671730.1
sterile alpha motif domain containing 8
chr17_-_7393404 0.39 ENST00000575434.4
phospholipid scramblase 3
chr19_+_46601296 0.39 ENST00000598871.5
ENST00000291295.14
ENST00000594523.5
calmodulin 3
chr21_-_15064934 0.39 ENST00000400199.5
ENST00000400202.5
ENST00000318948.7
nuclear receptor interacting protein 1
chr6_+_106098933 0.38 ENST00000369089.3
PR/SET domain 1
chr11_+_61248122 0.38 ENST00000451616.6
pepsinogen A5
chr10_+_75111595 0.38 ENST00000671800.1
ENST00000542569.6
ENST00000372687.4
sterile alpha motif domain containing 8
chr16_+_56336805 0.38 ENST00000564727.2
G protein subunit alpha o1
chr11_+_35139162 0.38 ENST00000415148.6
ENST00000263398.11
ENST00000428726.8
ENST00000526669.6
ENST00000433892.6
ENST00000525211.6
ENST00000278386.10
ENST00000434472.6
ENST00000352818.8
ENST00000442151.6
CD44 molecule (Indian blood group)
chr1_-_77979054 0.38 ENST00000370768.7
ENST00000370767.5
ENST00000421641.1
far upstream element binding protein 1
chr5_+_96662046 0.37 ENST00000338252.7
ENST00000508830.5
calpastatin
chr11_+_62419025 0.37 ENST00000278282.3
secretoglobin family 1A member 1
chr7_+_31687208 0.37 ENST00000409146.3
ENST00000342032.8
protein phosphatase 1 regulatory subunit 17
chr1_+_119507203 0.37 ENST00000369413.8
ENST00000528909.1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr14_-_24141570 0.37 ENST00000560403.5
ENST00000419198.6
ENST00000216799.9
ER membrane protein complex subunit 9
chr11_+_8682782 0.37 ENST00000531978.5
ENST00000524496.5
ENST00000532359.5
ENST00000314138.11
ENST00000530022.5
ribosomal protein L27a
chr3_-_28348629 0.37 ENST00000334100.10
5-azacytidine induced 2
chr7_+_24573415 0.37 ENST00000409761.5
ENST00000222644.10
ENST00000396475.6
membrane palmitoylated protein 6
chr2_-_223837553 0.36 ENST00000396654.7
ENST00000396653.2
ENST00000443700.5
adaptor related protein complex 1 subunit sigma 3
chr1_+_15756659 0.36 ENST00000375771.5
filamin binding LIM protein 1
chr3_+_14675128 0.36 ENST00000435614.5
ENST00000253697.8
ENST00000412910.1
chromosome 3 open reading frame 20
chr16_+_30064142 0.36 ENST00000562168.5
ENST00000569545.5
aldolase, fructose-bisphosphate A
chr1_+_156893678 0.35 ENST00000292357.8
ENST00000338302.7
ENST00000455314.5
platelet endothelial aggregation receptor 1
chr21_-_37267511 0.35 ENST00000398998.1
VPS26 endosomal protein sorting factor C
chr16_-_138512 0.35 ENST00000399953.7
NPR3 like, GATOR1 complex subunit
chr5_+_132073782 0.35 ENST00000296871.4
colony stimulating factor 2
chr3_-_28348924 0.34 ENST00000414162.5
ENST00000420543.6
5-azacytidine induced 2
chr2_-_223837484 0.34 ENST00000446015.6
ENST00000409375.1
adaptor related protein complex 1 subunit sigma 3
chr14_-_106374129 0.34 ENST00000390616.2
immunoglobulin heavy variable 4-34
chrX_+_38352573 0.34 ENST00000039007.5
ornithine transcarbamylase
chr16_-_3099228 0.34 ENST00000572431.1
ENST00000572548.1
ENST00000575108.5
ENST00000576985.6
ENST00000576483.1
ENST00000538082.5
zinc finger and SCAN domain containing 10
chr14_-_56805648 0.34 ENST00000554788.5
ENST00000554845.1
ENST00000408990.8
orthodenticle homeobox 2
chr19_-_45406327 0.34 ENST00000593226.5
ENST00000418234.6
protein phosphatase 1 regulatory subunit 13 like
chr18_+_31318144 0.34 ENST00000257192.5
desmoglein 1
chr9_-_112175283 0.33 ENST00000374270.8
ENST00000374263.7
sushi domain containing 1
chr8_+_38901327 0.33 ENST00000519640.5
ENST00000617275.5
pleckstrin homology domain containing A2
chr9_+_123356189 0.33 ENST00000373631.8
crumbs cell polarity complex component 2
chr9_+_136952896 0.33 ENST00000371632.7
lipocalin 12
chr21_-_42350987 0.32 ENST00000291526.5
trefoil factor 2
chr19_+_2389761 0.32 ENST00000648592.1
transmembrane serine protease 9
chr11_-_93741479 0.32 ENST00000448108.7
ENST00000532455.1
TATA-box binding protein associated factor, RNA polymerase I subunit D
chr1_-_44843240 0.32 ENST00000372192.4
patched 2
chr10_-_33334625 0.32 ENST00000374875.5
ENST00000374822.8
ENST00000374867.7
neuropilin 1
chr8_-_130443581 0.32 ENST00000357668.2
ENST00000518721.6
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr11_+_60455839 0.32 ENST00000532491.5
ENST00000532073.5
ENST00000345732.9
ENST00000534668.6
ENST00000528313.1
ENST00000533306.6
ENST00000674194.1
membrane spanning 4-domains A1
chr1_+_86424154 0.31 ENST00000370565.5
chloride channel accessory 2
chr11_+_18599782 0.31 ENST00000634992.1
ENST00000635674.1
ENST00000511927.2
SPTY2D1 opposite strand
chr7_+_77840122 0.31 ENST00000450574.5
ENST00000248550.7
putative homeodomain transcription factor 2
chr6_-_43528867 0.31 ENST00000455285.2
exportin 5
chr8_+_79611727 0.31 ENST00000518491.1
stathmin 2
chr11_+_62856004 0.31 ENST00000680729.1
solute carrier family 3 member 2
chr5_+_96662314 0.31 ENST00000674702.1
calpastatin
chr8_+_133191060 0.31 ENST00000519433.1
ENST00000517423.5
ENST00000220856.6
cellular communication network factor 4
chr7_-_100168602 0.31 ENST00000423751.2
ENST00000360039.9
galactose-3-O-sulfotransferase 4
chr10_+_122271292 0.31 ENST00000260723.6
BTB domain containing 16
chr1_+_52602347 0.30 ENST00000361314.5
glutathione peroxidase 7
chr18_+_57435366 0.30 ENST00000491143.3
one cut homeobox 2
chr11_-_83682414 0.30 ENST00000404783.7
discs large MAGUK scaffold protein 2
chr5_+_96662214 0.30 ENST00000395812.6
calpastatin
chr8_-_104588998 0.30 ENST00000424843.6
LDL receptor related protein 12
chr10_+_62374361 0.29 ENST00000395254.8
zinc finger protein 365
chr19_+_47713412 0.29 ENST00000538399.1
ENST00000263277.8
EH domain containing 2
chr9_+_136665745 0.29 ENST00000371698.3
EGF like domain multiple 7
chr20_+_58309704 0.29 ENST00000244040.4
RAB22A, member RAS oncogene family
chrX_-_133218345 0.29 ENST00000310125.5
transcription factor Dp family member 3
chr16_+_30064274 0.29 ENST00000563060.6
aldolase, fructose-bisphosphate A
chrX_-_15664798 0.29 ENST00000380342.4
collectrin, amino acid transport regulator
chr17_+_44847905 0.29 ENST00000587021.1
HIG1 hypoxia inducible domain family member 1B
chr6_-_32666648 0.29 ENST00000399082.7
ENST00000399079.7
ENST00000374943.8
ENST00000434651.6
major histocompatibility complex, class II, DQ beta 1
chr15_-_65106308 0.29 ENST00000502113.2
ubiquitin associated protein 1 like
chr12_+_56338873 0.29 ENST00000228534.6
interleukin 23 subunit alpha
chr5_+_96662366 0.28 ENST00000675179.1
ENST00000421689.6
ENST00000674984.1
ENST00000512620.5
calpastatin
chr6_-_49744378 0.28 ENST00000371159.8
ENST00000263045.9
cysteine rich secretory protein 3
chr2_-_287687 0.28 ENST00000401489.6
ENST00000619265.4
ALK and LTK ligand 2
chr6_-_49744434 0.28 ENST00000433368.6
ENST00000354620.4
cysteine rich secretory protein 3
chr19_+_4402615 0.28 ENST00000301280.10
chromatin assembly factor 1 subunit A
chr16_+_30064462 0.28 ENST00000412304.6
aldolase, fructose-bisphosphate A
chr9_-_71446835 0.28 ENST00000357533.6
transient receptor potential cation channel subfamily M member 3
chr12_+_12891554 0.28 ENST00000014914.6
G protein-coupled receptor class C group 5 member A
chr5_+_149271848 0.27 ENST00000296721.9
actin filament associated protein 1 like 1
chr1_+_149782671 0.27 ENST00000444948.5
ENST00000369168.5
Fc fragment of IgG receptor Ia
chr16_+_31108294 0.27 ENST00000287507.7
ENST00000394950.7
ENST00000219794.11
ENST00000561755.1
branched chain keto acid dehydrogenase kinase
chr8_-_104589241 0.27 ENST00000276654.10
LDL receptor related protein 12
chr11_+_65576023 0.27 ENST00000533237.5
ENST00000309295.9
ENST00000634639.1
EH domain binding protein 1 like 1
chr2_-_287299 0.27 ENST00000405290.5
ALK and LTK ligand 2
chr19_+_15641280 0.27 ENST00000585846.1
cytochrome P450 family 4 subfamily F member 3
chr2_-_287320 0.26 ENST00000401503.5
ALK and LTK ligand 2
chr12_+_71439976 0.26 ENST00000536515.5
ENST00000540815.2
leucine rich repeat containing G protein-coupled receptor 5
chr2_-_43838832 0.26 ENST00000405322.8
ATP binding cassette subfamily G member 5
chrX_+_49053554 0.26 ENST00000597275.5
coiled-coil domain containing 120
chr18_+_31376777 0.26 ENST00000308128.9
ENST00000359747.4
desmoglein 4
chr8_+_38901757 0.26 ENST00000616834.1
pleckstrin homology domain containing A2
chr17_-_2266131 0.26 ENST00000570606.5
ENST00000354901.8
SMG6 nonsense mediated mRNA decay factor
chr3_-_183162726 0.26 ENST00000265598.8
lysosomal associated membrane protein 3
chr20_+_45207025 0.26 ENST00000372781.4
semenogelin 1
chr1_+_31296989 0.26 ENST00000373714.5
ENST00000344147.10
ENST00000627541.1
zinc finger CCHC-type containing 17
chr11_+_1839452 0.25 ENST00000381906.5
troponin I2, fast skeletal type
chr4_+_119135825 0.25 ENST00000307128.6
myozenin 2
chr4_-_5019437 0.25 ENST00000506508.1
ENST00000509419.1
ENST00000307746.9
cytokine like 1
chr5_+_95646854 0.25 ENST00000311364.8
ENST00000458310.1
Rieske Fe-S domain containing
chr18_+_31498168 0.25 ENST00000261590.13
ENST00000585206.1
ENST00000683654.1
desmoglein 2
chr2_-_203535253 0.25 ENST00000457812.5
ENST00000319170.10
ENST00000630330.2
ENST00000308091.8
ENST00000453034.5
ENST00000420371.2
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr19_+_35292145 0.25 ENST00000595791.5
ENST00000597035.5
ENST00000537831.2
ENST00000392213.8
myelin associated glycoprotein
chr12_-_16606795 0.25 ENST00000447609.5
LIM domain only 3
chr6_+_13272709 0.24 ENST00000379335.8
phosphatase and actin regulator 1
chr3_+_46354072 0.24 ENST00000445132.3
ENST00000421659.1
C-C motif chemokine receptor 2
chr5_+_150497772 0.24 ENST00000523767.5
N-deacetylase and N-sulfotransferase 1
chr18_+_24460655 0.24 ENST00000426880.2
histamine receptor H4
chr7_-_22500152 0.24 ENST00000406890.6
ENST00000678116.1
ENST00000424363.5
STEAP family member 1B
chr1_+_209938169 0.24 ENST00000367019.5
ENST00000537238.5
ENST00000637265.1
synaptotagmin 14
chr5_-_16916400 0.24 ENST00000513882.5
myosin X
chr17_-_7404039 0.24 ENST00000576017.1
ENST00000302422.4
transmembrane protein 256
chr19_+_35292125 0.24 ENST00000600291.5
ENST00000361922.8
myelin associated glycoprotein
chr18_+_24460630 0.24 ENST00000256906.5
histamine receptor H4
chr16_+_30000944 0.24 ENST00000562291.2
INO80 complex subunit E
chr7_-_11832190 0.24 ENST00000423059.9
ENST00000617773.1
thrombospondin type 1 domain containing 7A
chr17_-_81166160 0.23 ENST00000326724.9
apoptosis associated tyrosine kinase
chr5_+_96662969 0.23 ENST00000514845.5
ENST00000675663.1
calpastatin
chr20_+_44355692 0.23 ENST00000316673.8
ENST00000609795.5
ENST00000457232.5
ENST00000609262.5
hepatocyte nuclear factor 4 alpha
chr20_+_36214373 0.23 ENST00000432603.1
erythrocyte membrane protein band 4.1 like 1
chr1_+_209938207 0.23 ENST00000472886.5
synaptotagmin 14
chr12_-_16606102 0.23 ENST00000537304.6
LIM domain only 3
chr7_+_139829242 0.23 ENST00000455353.6
ENST00000458722.6
ENST00000448866.7
ENST00000411653.6
thromboxane A synthase 1
chr5_-_160370619 0.23 ENST00000652664.2
ENST00000393975.4
C1q and TNF related 2
chr1_-_21937300 0.23 ENST00000374695.8
heparan sulfate proteoglycan 2
chr12_-_16605939 0.23 ENST00000541295.5
ENST00000535535.5
LIM domain only 3
chr1_+_155859550 0.23 ENST00000368324.5
synaptotagmin 11
chr21_-_37267300 0.23 ENST00000309117.11
ENST00000476950.5
ENST00000399001.5
VPS26 endosomal protein sorting factor C

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0002665 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.4 1.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.3 1.0 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.3 1.4 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.2 0.2 GO:1905154 negative regulation of membrane invagination(GO:1905154)
0.2 0.9 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.2 1.6 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 0.8 GO:0070378 positive regulation of ERK5 cascade(GO:0070378)
0.2 0.6 GO:0061184 positive regulation of dermatome development(GO:0061184)
0.2 0.9 GO:0072144 glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131)
0.2 0.9 GO:0044565 dendritic cell proliferation(GO:0044565)
0.2 0.5 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.2 4.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.6 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 0.4 GO:1990654 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.1 0.5 GO:0035627 ceramide transport(GO:0035627)
0.1 0.3 GO:0097272 ammonia homeostasis(GO:0097272)
0.1 0.9 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 0.3 GO:0014028 notochord formation(GO:0014028)
0.1 0.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.4 GO:1903627 regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634)
0.1 0.3 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.1 0.7 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.5 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.1 1.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.3 GO:0060301 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.2 GO:0002436 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) negative regulation of eosinophil activation(GO:1902567) positive regulation of monocyte extravasation(GO:2000439)
0.1 0.4 GO:0010193 response to ozone(GO:0010193)
0.1 0.5 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 1.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.3 GO:0070352 positive regulation of white fat cell proliferation(GO:0070352)
0.1 0.3 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.6 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.1 0.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 0.2 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.1 1.5 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 0.3 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.1 0.3 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.1 0.4 GO:0015680 intracellular copper ion transport(GO:0015680)
0.1 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 0.2 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.1 0.3 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.1 0.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 0.2 GO:0036484 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1 0.4 GO:1903237 positive regulation of dopamine secretion(GO:0033603) negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1 0.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.1 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.1 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.3 GO:0060356 leucine import(GO:0060356)
0.1 0.4 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.5 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.2 GO:0051919 activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
0.0 0.8 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.5 GO:2000582 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.2 GO:1902617 late nucleophagy(GO:0044805) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) response to fluoride(GO:1902617)
0.0 0.6 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.3 GO:1901569 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.0 0.5 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.0 0.6 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 5.1 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.2 GO:0003164 His-Purkinje system development(GO:0003164)
0.0 0.5 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.0 0.6 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.7 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.3 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 1.7 GO:0043278 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0 0.1 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) platelet alpha granule organization(GO:0070889) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.2 GO:0042758 long-chain fatty acid catabolic process(GO:0042758)
0.0 0.4 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.2 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.4 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.2 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.2 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.4 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.1 GO:0001807 regulation of type IV hypersensitivity(GO:0001807) negative regulation of type IV hypersensitivity(GO:0001808) negative regulation of hypersensitivity(GO:0002884)
0.0 0.3 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.4 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.3 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 0.4 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.3 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 0.7 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.4 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.4 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.4 GO:0090179 regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.5 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0014813 skeletal muscle satellite cell commitment(GO:0014813)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:2000690 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.2 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.0 0.2 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.1 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 0.0 GO:0061355 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.1 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.1 GO:0007113 endomitotic cell cycle(GO:0007113)
0.0 0.1 GO:0006528 asparagine metabolic process(GO:0006528)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.1 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.0 0.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.0 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 0.2 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.4 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 1.8 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.3 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.0 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 1.8 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.2 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.8 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.1 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.2 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 0.6 GO:0010165 response to X-ray(GO:0010165)
0.0 0.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.2 GO:0048262 negative regulation of JUN kinase activity(GO:0043508) determination of dorsal/ventral asymmetry(GO:0048262)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 1.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 1.5 GO:0000796 condensin complex(GO:0000796)
0.2 0.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.9 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.8 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.3 GO:0042565 RNA nuclear export complex(GO:0042565)
0.1 0.3 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 0.3 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.5 GO:0071547 piP-body(GO:0071547)
0.1 0.4 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 0.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.3 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 1.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 2.3 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0070852 cell body fiber(GO:0070852)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.3 GO:0097443 sorting endosome(GO:0097443)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.9 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0034515 proteasome storage granule(GO:0034515)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 1.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 1.4 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.0 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 1.6 GO:0002113 interleukin-33 binding(GO:0002113)
0.3 0.9 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 0.7 GO:0047012 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity(GO:0047012)
0.2 0.8 GO:0004769 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) steroid delta-isomerase activity(GO:0004769)
0.2 0.8 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 1.0 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 0.8 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.2 1.5 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.4 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 1.1 GO:0051373 FATZ binding(GO:0051373)
0.1 2.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.4 GO:0004341 gluconolactonase activity(GO:0004341)
0.1 0.3 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.1 0.3 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.1 0.4 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 0.4 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.3 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 0.4 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 0.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.5 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.1 0.4 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 5.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 0.3 GO:0005119 smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108)
0.1 0.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.2 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.1 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.6 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.3 GO:0004096 catalase activity(GO:0004096)
0.0 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.6 GO:0016015 morphogen activity(GO:0016015)
0.0 1.0 GO:0048185 activin binding(GO:0048185)
0.0 0.5 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.2 GO:0070404 NADH binding(GO:0070404)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.4 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 1.9 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.2 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.6 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.3 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.1 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.0 0.1 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
0.0 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.0 0.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 0.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 4.3 PID E2F PATHWAY E2F transcription factor network
0.0 1.5 PID AURORA B PATHWAY Aurora B signaling
0.0 0.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 2.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.4 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 2.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.0 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.8 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.6 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.1 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.3 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis