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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for WRNIP1
Z-value: 2.78
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Transcription factors associated with WRNIP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| WRNIP1 | hg38_v1_chr6_+_2765361_2765563 | -0.20 | 2.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of WRNIP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 90.3 | GO:0070268 | cornification(GO:0070268) |
| 5.8 | 86.7 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 4.2 | 79.3 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 9.7 | 58.1 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.6 | 42.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 1.3 | 35.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.2 | 32.6 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 10.4 | 31.3 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.2 | 30.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 3.3 | 29.9 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 260.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 178.8 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 8.7 | 61.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.2 | 51.3 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.5 | 49.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.8 | 47.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.4 | 43.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.3 | 41.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 1.6 | 38.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.3 | 38.0 | GO:0005901 | caveola(GO:0005901) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 344.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 93.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.3 | 53.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 50.2 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.4 | 48.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 38.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 34.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 34.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 33.5 | GO:0002020 | protease binding(GO:0002020) |
| 1.0 | 32.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 165.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.5 | 95.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 81.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.9 | 61.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 53.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 44.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.6 | 42.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.7 | 37.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 1.0 | 36.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.6 | 36.0 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 55.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.5 | 50.5 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 1.1 | 42.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.5 | 41.9 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.6 | 39.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.6 | 30.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 28.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.8 | 28.2 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 1.2 | 27.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 26.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |