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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for XBP1
Z-value: 0.67
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Transcription factors associated with XBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| XBP1 | hg38_v1_chr22_-_28800042_28800133, hg38_v1_chr22_-_28800558_28800597 | -0.15 | 4.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of XBP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_25248036 Show fit | 1.23 |
ENST00000216962.9
|
glycogen phosphorylase B |
|
| chr10_-_70170466 Show fit | 1.05 |
ENST00000373239.2
ENST00000373241.9 ENST00000373242.6 |
secretion associated Ras related GTPase 1A |
|
| chr17_-_7205116 Show fit | 1.02 |
ENST00000649520.1
ENST00000649186.1 |
discs large MAGUK scaffold protein 4 |
|
| chr19_-_48511793 Show fit | 0.94 |
ENST00000600059.6
|
lemur tyrosine kinase 3 |
|
| chr11_-_64878612 Show fit | 0.93 |
ENST00000320631.8
|
EH domain containing 1 |
|
| chr12_-_27970047 Show fit | 0.88 |
ENST00000395868.7
|
parathyroid hormone like hormone |
|
| chr7_-_128405930 Show fit | 0.88 |
ENST00000470772.5
ENST00000480861.5 ENST00000496200.5 |
inosine monophosphate dehydrogenase 1 |
|
| chr15_-_83284645 Show fit | 0.83 |
ENST00000345382.7
|
basonuclin 1 |
|
| chr2_+_64453969 Show fit | 0.81 |
ENST00000464281.5
|
galectin like |
|
| chr3_-_57597443 Show fit | 0.77 |
ENST00000463880.1
|
ADP ribosylation factor 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 1.7 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 1.6 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 1.3 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.1 | 1.0 | GO:0097688 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.0 | 1.0 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 1.0 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 1.0 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.2 | 0.9 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.1 | 0.9 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 2.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 1.0 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 1.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 1.0 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.2 | 0.9 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.1 | 0.8 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 0.8 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.8 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 0.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.3 | 1.2 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.1 | 1.0 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.0 | 1.0 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.2 | 0.9 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.0 | 0.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.2 | 0.8 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.1 | 0.8 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.2 | 0.7 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.0 | 0.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 1.9 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.0 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 0.9 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.8 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.7 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |