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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Z-value: 4.56
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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000065978.19 | YBX1 | |
| ENSG00000170345.10 | FOS | |
| ENSG00000066136.20 | NFYC | |
| ENSG00000001167.15 | NFYA | |
| ENSG00000120837.8 | NFYB | |
| ENSG00000115816.15 | CEBPZ |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOS | hg38_v1_chr14_+_75278820_75278977 | 0.70 | 1.9e-05 | Click! |
| NFYA | hg38_v1_chr6_+_41072939_41072984 | 0.41 | 2.4e-02 | Click! |
| YBX1 | hg38_v1_chr1_+_42682388_42682440 | 0.36 | 4.9e-02 | Click! |
| NFYC | hg38_v1_chr1_+_40691998_40692022 | -0.28 | 1.3e-01 | Click! |
| CEBPZ | hg38_v1_chr2_-_37231549_37231603 | -0.19 | 3.2e-01 | Click! |
| NFYB | hg38_v1_chr12_-_104138007_104138035 | 0.06 | 7.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 147.2 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 1.3 | 91.9 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 1.9 | 75.8 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.5 | 65.7 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.6 | 49.2 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 4.4 | 44.4 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 2.6 | 41.9 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.9 | 37.9 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 1.4 | 34.8 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 2.0 | 33.2 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 74.4 | GO:0005829 | cytosol(GO:0005829) |
| 0.9 | 72.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 1.8 | 72.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.6 | 68.4 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 7.6 | 68.1 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.3 | 45.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 44.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 7.2 | 43.0 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 3.3 | 36.7 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 8.9 | 35.4 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 84.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 84.3 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.5 | 82.4 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.2 | 59.6 | GO:0042393 | histone binding(GO:0042393) |
| 1.0 | 56.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 47.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 5.1 | 46.1 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 7.5 | 45.1 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 2.7 | 38.0 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.8 | 31.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 191.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.9 | 128.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.2 | 62.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.4 | 45.8 | PID E2F PATHWAY | E2F transcription factor network |
| 1.0 | 38.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.5 | 28.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.4 | 26.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.4 | 24.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 18.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.4 | 17.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 138.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 1.4 | 131.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.3 | 95.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.9 | 68.8 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 1.5 | 58.6 | REACTOME KINESINS | Genes involved in Kinesins |
| 3.2 | 54.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 2.0 | 51.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.4 | 39.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 1.3 | 31.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 1.4 | 30.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |