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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ZBTB14
Z-value: 1.74
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Transcription factors associated with ZBTB14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB14 | hg38_v1_chr18_-_5295679_5295737, hg38_v1_chr18_-_5296002_5296046 | 0.44 | 1.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB14
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.5 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 1.3 | 10.7 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.8 | 9.8 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.1 | 9.7 | GO:0046546 | male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546) |
| 0.6 | 9.5 | GO:0070070 | proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.5 | 9.2 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.6 | 9.1 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.6 | 9.0 | GO:0070444 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 3.0 | 8.9 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 2.8 | 8.5 | GO:0019303 | D-ribose catabolic process(GO:0019303) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.2 | GO:0031514 | motile cilium(GO:0031514) |
| 0.6 | 12.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.0 | 9.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.9 | 9.5 | GO:0043291 | RAVE complex(GO:0043291) |
| 1.0 | 9.2 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 1.8 | 9.0 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.1 | 8.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.2 | 7.8 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.2 | 7.6 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.3 | 5.8 | GO:0000786 | nucleosome(GO:0000786) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 15.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 4.1 | 12.4 | GO:0052810 | 1-phosphatidylinositol-5-kinase activity(GO:0052810) |
| 0.8 | 12.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.3 | 10.0 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 1.1 | 9.8 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.2 | 9.5 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 1.0 | 9.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.2 | 7.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 1.2 | 7.3 | GO:0031849 | olfactory receptor binding(GO:0031849) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 13.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 12.6 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 10.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 9.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 5.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 2.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 2.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.6 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.2 | 9.6 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.2 | 7.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.2 | 5.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.4 | 4.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 4.7 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 4.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 4.3 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.2 | 3.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 3.1 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |