ISMARA results: ZBTB6

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZBTB6

Z-value: 1.02

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Transcription factors associated with ZBTB6

Gene Symbol	Gene ID	Gene Info
ZBTB6 Ensembl NCBI GeneCards UniProt	ENSG00000186130.5	ZBTB6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZBTB6	hg38_v1_chr9_-_122913299_122913333	-0.12	5.3e-01	Click!

Activity profile of ZBTB6 motif

Sorted Z-values of ZBTB6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB6

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr21_-_42496186 Show fit	2.95	ENST00000398352.3 ENST00000291536.8	RSPH1 Ensembl NCBI GeneCards UniProt Show fit	radial spoke head component 1
chr16_-_52547113 Show fit	2.68	ENST00000219746.14	TOX3 Ensembl NCBI GeneCards UniProt Show fit	TOX high mobility group box family member 3
chr21_+_34668986 Show fit	2.39	ENST00000349499.3	CLIC6 Ensembl NCBI GeneCards UniProt Show fit	chloride intracellular channel 6
chr14_-_106622837 Show fit	2.37	ENST00000390628.3	IGHV1-58 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1-58
chr13_+_34942263 Show fit	2.10	ENST00000379939.7 ENST00000400445.7	NBEA Ensembl NCBI GeneCards UniProt Show fit	neurobeachin
chr9_+_36136416 Show fit	1.65	ENST00000396613.7	GLIPR2 Ensembl NCBI GeneCards UniProt Show fit	GLI pathogenesis related 2
chr3_-_197959977 Show fit	1.61	ENST00000265239.11	IQCG Ensembl NCBI GeneCards UniProt Show fit	IQ motif containing G
chr10_-_59709842 Show fit	1.49	ENST00000395348.8	SLC16A9 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 16 member 9
chr20_-_34872817 Show fit	1.43	ENST00000427420.1 ENST00000336431.10	GGT7 Ensembl NCBI GeneCards UniProt Show fit	gamma-glutamyltransferase 7
chr15_+_70892809 Show fit	1.39	ENST00000260382.10 ENST00000560755.5	LRRC49 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 49

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	GO:0044458	motile cilium assembly(GO:0044458)
0.0	3.0	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.1	2.9	GO:0035082	axoneme assembly(GO:0035082)
0.9	2.7	GO:0019427	acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
0.0	2.7	GO:0006910	phagocytosis, recognition(GO:0006910)
0.1	2.6	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.1	2.4	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.1	2.2	GO:0007288	sperm axoneme assembly(GO:0007288)
0.0	2.1	GO:0006749	glutathione metabolic process(GO:0006749)
0.0	2.1	GO:0006501	C-terminal protein lipidation(GO:0006501)

Showing 1 to 10 of 224 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	2.7	GO:0031225	anchored component of membrane(GO:0031225)
0.0	2.6	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2	2.4	GO:0072687	meiotic spindle(GO:0072687)
0.0	2.4	GO:0034707	chloride channel complex(GO:0034707)
0.1	2.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	2.1	GO:0097542	ciliary tip(GO:0097542)
0.0	2.0	GO:0034705	potassium channel complex(GO:0034705)
0.3	1.7	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.2	1.6	GO:0002177	manchette(GO:0002177)

Showing 1 to 10 of 78 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.8	GO:0034056	estrogen response element binding(GO:0034056)
0.1	2.8	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.1	2.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.7	2.7	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	2.7	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	2.4	GO:0031489	myosin V binding(GO:0031489)
0.0	2.2	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	1.7	GO:0008028	monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.5	1.6	GO:0052810	1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0	1.6	GO:0030544	Hsp70 protein binding(GO:0030544)

Showing 1 to 10 of 166 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	2.8	PID IFNG PATHWAY	IFN-gamma pathway
0.1	2.4	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	2.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	1.8	PID ALK1 PATHWAY	ALK1 signaling events
0.0	1.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.2	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	1.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	2.7	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	2.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.1	2.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	1.9	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	1.8	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	1.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	1.4	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	1.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	1.2	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus

Showing 1 to 10 of 40 entries

Results for ZBTB6

Z-value: 1.02

Motif logo

Transcription factors associated with ZBTB6

Activity-expression correlation:

Activity profile of ZBTB6 motif

Sorted Z-values of ZBTB6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB6

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: