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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZFHX3

Z-value: 0.35

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.17 ZFHX3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg38_v1_chr16_-_73048104_730481360.374.6e-02Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_735026 1.50 ENST00000592155.5
ENST00000590161.2
PALM
paralemmin
chr4_-_148444674 1.16 ENST00000344721.8
NR3C2
nuclear receptor subfamily 3 group C member 2
chr20_-_7940444 0.67 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chr5_-_35195236 0.58 ENST00000509839.5
PRLR
prolactin receptor
chr1_-_247758680 0.48 ENST00000408896.4
OR1C1
olfactory receptor family 1 subfamily C member 1
chr15_+_76336755 0.43 ENST00000290759.9
ISL2
ISL LIM homeobox 2
chr1_-_197067234 0.39 ENST00000367412.2
F13B
coagulation factor XIII B chain
chr11_-_119196769 0.33 ENST00000415318.2
CCDC153
coiled-coil domain containing 153
chr12_-_7665897 0.32 ENST00000229304.5
APOBEC1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr16_+_56191476 0.31 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr4_-_99435336 0.31 ENST00000437033.7
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr18_+_58341038 0.30 ENST00000679791.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr3_-_114758940 0.30 ENST00000464560.5
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_130716264 0.29 ENST00000643940.1
RIMBP2
RIMS binding protein 2
chr4_-_99435134 0.28 ENST00000476959.5
ENST00000482593.5
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr7_-_100428657 0.28 ENST00000360951.8
ENST00000398027.6
ENST00000684423.1
ENST00000472716.1
ZCWPW1
zinc finger CW-type and PWWP domain containing 1
chrX_-_15600953 0.28 ENST00000679212.1
ENST00000679278.1
ENST00000678046.1
ENST00000252519.8
ACE2
angiotensin I converting enzyme 2
chr3_+_69866217 0.28 ENST00000314589.10
MITF
melanocyte inducing transcription factor
chr6_+_25754699 0.23 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chr7_+_48171451 0.23 ENST00000435803.6
ABCA13
ATP binding cassette subfamily A member 13
chr9_-_121050264 0.23 ENST00000223642.3
C5
complement C5
chr2_-_60553618 0.23 ENST00000643716.1
ENST00000359629.10
ENST00000642384.2
ENST00000335712.11
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr6_-_29045175 0.22 ENST00000377175.2
OR2W1
olfactory receptor family 2 subfamily W member 1
chr14_+_39233908 0.22 ENST00000280082.4
MIA2
MIA SH3 domain ER export factor 2
chr11_-_61920267 0.19 ENST00000531922.2
ENST00000301773.9
RAB3IL1
RAB3A interacting protein like 1
chr19_+_49513353 0.19 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr17_+_4788926 0.19 ENST00000331264.8
GLTPD2
glycolipid transfer protein domain containing 2
chr22_-_30574572 0.17 ENST00000402369.5
GAL3ST1
galactose-3-O-sulfotransferase 1
chr17_-_28406160 0.17 ENST00000618626.1
ENST00000612814.5
SLC46A1
solute carrier family 46 member 1
chr9_-_123184233 0.17 ENST00000447404.6
STRBP
spermatid perinuclear RNA binding protein
chrM_+_9207 0.15 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr17_+_7407838 0.15 ENST00000302926.7
NLGN2
neuroligin 2
chr12_+_53954870 0.15 ENST00000243103.4
HOXC12
homeobox C12
chrX_-_15601077 0.14 ENST00000680121.1
ACE2
angiotensin I converting enzyme 2
chr17_+_42900791 0.14 ENST00000592383.5
ENST00000253801.7
ENST00000585489.1
G6PC1
glucose-6-phosphatase catalytic subunit 1
chr7_-_7535863 0.14 ENST00000399429.8
COL28A1
collagen type XXVIII alpha 1 chain
chr4_+_73481737 0.14 ENST00000226355.5
AFM
afamin
chr11_+_8019193 0.13 ENST00000534099.5
TUB
TUB bipartite transcription factor
chr2_-_60553409 0.12 ENST00000358510.6
ENST00000643004.1
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chrY_+_18546691 0.12 ENST00000309834.8
ENST00000307393.3
ENST00000382856.2
HSFY1
heat shock transcription factor Y-linked 1
chr1_-_46551647 0.12 ENST00000481882.7
KNCN
kinocilin
chr18_-_55422306 0.12 ENST00000566777.5
ENST00000626584.2
TCF4
transcription factor 4
chr5_+_141245384 0.11 ENST00000623671.1
ENST00000231173.6
PCDHB15
protocadherin beta 15
chr18_+_34976928 0.11 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
MAPRE2
microtubule associated protein RP/EB family member 2
chr4_-_154590735 0.11 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
FGA
fibrinogen alpha chain
chr8_-_69833338 0.11 ENST00000524945.5
SLCO5A1
solute carrier organic anion transporter family member 5A1
chr17_+_17782108 0.10 ENST00000395774.1
RAI1
retinoic acid induced 1
chr6_-_116126120 0.10 ENST00000452729.1
ENST00000651968.1
ENST00000243222.8
COL10A1
collagen type X alpha 1 chain
chr1_+_76074698 0.09 ENST00000328299.4
ST6GALNAC3
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr3_-_157503574 0.09 ENST00000494677.5
ENST00000468233.5
VEPH1
ventricular zone expressed PH domain containing 1
chr10_-_126521439 0.09 ENST00000284694.11
ENST00000432642.5
C10orf90
chromosome 10 open reading frame 90
chr3_-_157503339 0.09 ENST00000392833.6
VEPH1
ventricular zone expressed PH domain containing 1
chr2_-_2324642 0.09 ENST00000650485.1
ENST00000649207.1
MYT1L
myelin transcription factor 1 like
chr2_+_87748087 0.09 ENST00000359481.9
PLGLB2
plasminogen like B2
chr3_-_157503375 0.08 ENST00000362010.7
VEPH1
ventricular zone expressed PH domain containing 1
chr3_+_77039836 0.08 ENST00000461745.5
ROBO2
roundabout guidance receptor 2
chr17_-_69244846 0.08 ENST00000269081.8
ABCA10
ATP binding cassette subfamily A member 10
chr7_+_33904911 0.08 ENST00000297161.6
BMPER
BMP binding endothelial regulator
chr7_+_100428782 0.07 ENST00000414441.5
MEPCE
methylphosphate capping enzyme
chr6_-_32407123 0.07 ENST00000374993.4
ENST00000544175.2
ENST00000454136.7
ENST00000446536.2
BTNL2
butyrophilin like 2
chr2_-_2324323 0.06 ENST00000648339.1
ENST00000647694.1
MYT1L
myelin transcription factor 1 like
chr6_-_154430495 0.06 ENST00000424998.3
CNKSR3
CNKSR family member 3
chr1_-_160579439 0.06 ENST00000368054.8
ENST00000368048.7
ENST00000311224.8
ENST00000368051.3
ENST00000534968.5
CD84
CD84 molecule
chr12_-_2835018 0.05 ENST00000337508.9
NRIP2
nuclear receptor interacting protein 2
chrX_-_123623155 0.05 ENST00000618150.4
THOC2
THO complex 2
chr12_-_68159732 0.05 ENST00000229135.4
IFNG
interferon gamma
chr11_-_102705737 0.04 ENST00000260229.5
MMP27
matrix metallopeptidase 27
chr15_-_84654270 0.04 ENST00000434634.7
WDR73
WD repeat domain 73
chr6_-_116060859 0.04 ENST00000606080.2
FRK
fyn related Src family tyrosine kinase
chr12_+_64497968 0.03 ENST00000676593.1
ENST00000677093.1
TBK1
ENSG00000288665.1
TANK binding kinase 1
novel transcript
chr20_-_37178966 0.03 ENST00000422138.1
MROH8
maestro heat like repeat family member 8
chr1_-_244860376 0.03 ENST00000638716.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr7_-_44541262 0.03 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr1_+_159587817 0.03 ENST00000255040.3
APCS
amyloid P component, serum
chr2_-_60553558 0.03 ENST00000642439.1
ENST00000356842.9
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr3_-_165078480 0.03 ENST00000264382.8
SI
sucrase-isomaltase
chr4_-_52020332 0.02 ENST00000682860.1
LRRC66
leucine rich repeat containing 66
chr19_+_53962925 0.02 ENST00000270458.4
CACNG8
calcium voltage-gated channel auxiliary subunit gamma 8
chr12_-_55296569 0.02 ENST00000358433.3
OR6C6
olfactory receptor family 6 subfamily C member 6
chr12_+_53441724 0.02 ENST00000551003.5
ENST00000429243.7
ENST00000549068.5
ENST00000549740.5
ENST00000546581.5
ENST00000549581.5
ENST00000547368.5
ENST00000379786.8
ENST00000551945.5
ENST00000547717.1
PRR13
ENSG00000257379.1
proline rich 13
novel transcript
chrM_+_8489 0.02 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase membrane subunit 6
chrX_+_85003863 0.01 ENST00000373173.7
APOOL
apolipoprotein O like
chr14_+_94561435 0.01 ENST00000557004.6
ENST00000555095.5
ENST00000298841.5
ENST00000554220.5
ENST00000553780.5
SERPINA4
SERPINA5
serpin family A member 4
serpin family A member 5
chr4_+_99574812 0.01 ENST00000422897.6
ENST00000265517.10
MTTP
microsomal triglyceride transfer protein
chr2_+_132416795 0.01 ENST00000329321.4
GPR39
G protein-coupled receptor 39
chrM_+_10055 0.01 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
chrX_-_18672101 0.01 ENST00000379984.4
RS1
retinoschisin 1
chr20_+_43558968 0.01 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
SGK2
serum/glucocorticoid regulated kinase 2
chr4_-_53591477 0.01 ENST00000263925.8
LNX1
ligand of numb-protein X 1
chr12_-_101407727 0.00 ENST00000539055.5
ENST00000551688.1
ENST00000551671.5
ENST00000261636.13
ARL1
ADP ribosylation factor like GTPase 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.1 0.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 0.4 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.6 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.3 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310) regulation of mRNA modification(GO:0090365)
0.1 0.4 GO:1904799 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1 0.7 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.4 GO:0002005 angiotensin catabolic process in blood(GO:0002005) angiotensin-mediated drinking behavior(GO:0003051)
0.1 0.2 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.0 0.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.2 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.0 0.2 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:2000309 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.1 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.3 1.3 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.1 0.6 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 0.4 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway