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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZIC1

Z-value: 0.65

Motif logo

Transcription factors associated with ZIC1

Gene Symbol Gene ID Gene Info
ENSG00000152977.10 ZIC1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC1hg38_v1_chr3_+_147409357_1474093810.412.3e-02Click!

Activity profile of ZIC1 motif

Sorted Z-values of ZIC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_41047267 1.44 ENST00000542137.1
ENST00000391419.3
keratin associated protein 2-1
chr17_-_41055211 1.24 ENST00000542910.1
ENST00000398477.1
keratin associated protein 2-2
chr6_-_35688907 1.12 ENST00000539068.5
ENST00000357266.9
FKBP prolyl isomerase 5
chr14_+_32934383 1.04 ENST00000551634.6
neuronal PAS domain protein 3
chr17_-_17836997 1.00 ENST00000395757.6
sterol regulatory element binding transcription factor 1
chr14_-_68979076 0.94 ENST00000538545.6
ENST00000684639.1
actinin alpha 1
chr14_-_68979436 0.94 ENST00000193403.10
actinin alpha 1
chr19_+_44905785 0.93 ENST00000446996.5
ENST00000252486.9
ENST00000434152.5
apolipoprotein E
chr14_-_68979274 0.93 ENST00000394419.9
actinin alpha 1
chr14_-_68979251 0.92 ENST00000438964.6
ENST00000679147.1
actinin alpha 1
chr14_-_68979314 0.90 ENST00000684713.1
ENST00000683198.1
ENST00000684598.1
ENST00000682331.1
ENST00000682291.1
ENST00000683342.1
actinin alpha 1
chr22_+_43923755 0.89 ENST00000423180.2
ENST00000216180.8
patatin like phospholipase domain containing 3
chr11_+_66011994 0.87 ENST00000312134.3
cystatin E/M
chr19_-_35501878 0.83 ENST00000593342.5
ENST00000601650.1
ENST00000408915.6
dermokine
chr19_-_42427379 0.78 ENST00000244289.9
lipase E, hormone sensitive type
chr1_-_111449209 0.76 ENST00000235090.10
WD repeat domain 77
chr12_-_54588516 0.73 ENST00000547431.5
protein phosphatase 1 regulatory inhibitor subunit 1A
chr21_+_30396030 0.71 ENST00000355459.4
keratin associated protein 13-1
chr2_-_1744442 0.71 ENST00000433670.5
ENST00000425171.1
ENST00000252804.9
peroxidasin
chr12_+_4809176 0.67 ENST00000280684.3
potassium voltage-gated channel subfamily A member 6
chr15_+_73683938 0.66 ENST00000567189.5
CD276 molecule
chr4_+_24795560 0.66 ENST00000382120.4
superoxide dismutase 3
chr9_-_35103178 0.62 ENST00000452248.6
ENST00000619795.4
stomatin like 2
chr16_-_31088963 0.61 ENST00000280606.6
serine protease 53
chr17_-_17836973 0.61 ENST00000261646.11
ENST00000355815.8
sterol regulatory element binding transcription factor 1
chr10_-_33334898 0.61 ENST00000395995.5
neuropilin 1
chr11_+_116830529 0.60 ENST00000630701.1
apolipoprotein C3
chr10_-_33335074 0.60 ENST00000432372.6
neuropilin 1
chr10_-_33334625 0.60 ENST00000374875.5
ENST00000374822.8
ENST00000374867.7
neuropilin 1
chr9_-_35103108 0.59 ENST00000356493.10
stomatin like 2
chr1_+_65147657 0.58 ENST00000546702.5
adenylate kinase 4
chr1_-_20119527 0.55 ENST00000375105.8
ENST00000617227.1
phospholipase A2 group IID
chr18_+_63752935 0.55 ENST00000425392.5
ENST00000336429.6
serpin family B member 7
chr4_-_55636259 0.54 ENST00000505262.5
ENST00000507338.1
neuromedin U
chr20_+_33031648 0.53 ENST00000349552.1
BPI fold containing family B member 6
chr17_-_41060109 0.52 ENST00000391418.3
keratin associated protein 2-3
chr17_-_41350824 0.51 ENST00000007735.4
keratin 33A
chr17_-_979726 0.50 ENST00000336868.8
nucleoredoxin
chr6_+_31571957 0.50 ENST00000454783.5
lymphotoxin alpha
chr2_+_11539833 0.49 ENST00000263834.9
growth regulating estrogen receptor binding 1
chr4_+_88523810 0.48 ENST00000512194.2
ENST00000598772.1
ENST00000597259.2
HECT and RLD domain containing E3 ubiquitin protein ligase 3
PIGY divergent transcript
chr6_+_31572279 0.48 ENST00000418386.3
lymphotoxin alpha
chr22_-_30591850 0.48 ENST00000335214.8
ENST00000406208.7
ENST00000402284.7
ENST00000354694.12
pescadillo ribosomal biogenesis factor 1
chrX_-_79367307 0.47 ENST00000373298.7
integral membrane protein 2A
chr6_-_34248989 0.47 ENST00000481533.5
ENST00000468145.1
ENST00000476320.6
ENST00000394990.8
small integral membrane protein 29
chr7_+_150567347 0.46 ENST00000461940.5
GTPase, IMAP family member 4
chr17_+_38428456 0.46 ENST00000622683.5
ENST00000620417.4
Rho GTPase activating protein 23
chr16_+_55479188 0.44 ENST00000219070.9
matrix metallopeptidase 2
chr9_-_124500986 0.44 ENST00000373587.3
nuclear receptor subfamily 5 group A member 1
chr1_+_65147514 0.43 ENST00000545314.5
adenylate kinase 4
chr17_+_62627628 0.43 ENST00000303375.10
mannose receptor C type 2
chr4_-_55636284 0.43 ENST00000511469.5
ENST00000264218.7
neuromedin U
chr11_+_67056805 0.43 ENST00000308831.7
ras homolog family member D
chr10_-_62268837 0.41 ENST00000373789.8
rhotekin 2
chr6_-_34249102 0.41 ENST00000636500.1
small integral membrane protein 29
chr19_+_33796846 0.41 ENST00000590771.5
ENST00000589786.5
ENST00000284006.10
ENST00000683859.1
ENST00000588881.5
potassium channel tetramerization domain containing 15
chr11_-_62921339 0.40 ENST00000306960.4
cholinergic receptor muscarinic 1
chr19_-_45639104 0.40 ENST00000586770.5
ENST00000591721.5
ENST00000245925.8
ENST00000590043.5
ENST00000589876.5
EMAP like 2
chr1_+_16021871 0.40 ENST00000375692.5
chloride voltage-gated channel Ka
chr5_-_141673160 0.40 ENST00000513878.5
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr17_-_55732074 0.39 ENST00000575734.5
transmembrane protein 100
chr3_-_86991135 0.39 ENST00000398399.7
vestigial like family member 3
chr1_+_16022030 0.39 ENST00000331433.5
chloride voltage-gated channel Ka
chr16_+_788614 0.39 ENST00000262315.14
ENST00000455171.6
ENST00000317063.10
chromosome transmission fidelity factor 18
chr19_+_46303599 0.38 ENST00000300862.7
hypoxia inducible factor 3 subunit alpha
chr17_+_45999250 0.37 ENST00000537309.1
saitohin
chr2_+_169069537 0.37 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
dehydrogenase/reductase 9
chr3_+_50155024 0.37 ENST00000414301.5
ENST00000450338.5
ENST00000413852.5
semaphorin 3F
chr17_+_77453993 0.36 ENST00000592951.5
septin 9
chr9_-_16870702 0.36 ENST00000380667.6
ENST00000545497.5
ENST00000486514.5
basonuclin 2
chr14_-_64942720 0.36 ENST00000557049.1
ENST00000389614.6
glutathione peroxidase 2
chr14_+_103385450 0.36 ENST00000416682.6
microtubule affinity regulating kinase 3
chr14_+_54567100 0.35 ENST00000554335.6
sterile alpha motif domain containing 4A
chrX_-_154751017 0.35 ENST00000369575.7
ENST00000369568.8
ENST00000424127.3
GRB2 associated binding protein 3
chr14_-_64942783 0.35 ENST00000612794.1
glutathione peroxidase 2
chr1_-_161118024 0.35 ENST00000368010.4
prefoldin subunit 2
chr8_+_25184668 0.35 ENST00000276440.12
ENST00000410074.5
dedicator of cytokinesis 5
chr15_+_73684373 0.35 ENST00000558689.5
ENST00000560786.6
ENST00000318443.10
ENST00000561213.5
CD276 molecule
chr1_-_110607425 0.34 ENST00000633222.1
potassium voltage-gated channel subfamily A member 2
chr10_-_62268685 0.34 ENST00000395260.3
rhotekin 2
chr11_-_2171805 0.33 ENST00000381178.5
ENST00000381175.5
ENST00000333684.9
ENST00000352909.8
tyrosine hydroxylase
chr2_+_238158926 0.33 ENST00000546354.6
erythroferrone
chr16_-_695946 0.33 ENST00000562563.1
F-box and leucine rich repeat protein 16
chr11_+_67056875 0.32 ENST00000532559.1
ras homolog family member D
chrX_-_154805516 0.32 ENST00000413259.7
membrane palmitoylated protein 1
chr11_+_75815180 0.32 ENST00000356136.8
UV radiation resistance associated
chr7_+_150567382 0.31 ENST00000255945.4
ENST00000479232.1
GTPase, IMAP family member 4
chr11_+_62242232 0.31 ENST00000244926.4
secretoglobin family 1D member 2
chr2_+_218710821 0.30 ENST00000392102.6
ENST00000457313.5
ENST00000415717.5
tubulin tyrosine ligase like 4
chr1_-_110607816 0.30 ENST00000485317.6
potassium voltage-gated channel subfamily A member 2
chrX_+_69616067 0.29 ENST00000338901.4
ENST00000525810.5
ENST00000527388.5
ENST00000374553.6
ENST00000374552.9
ENST00000524573.5
ectodysplasin A
chr11_-_2161158 0.29 ENST00000421783.1
ENST00000397262.5
ENST00000381330.5
ENST00000250971.7
ENST00000397270.1
insulin
INS-IGF2 readthrough
chrX_-_154805386 0.29 ENST00000393531.5
ENST00000369534.8
ENST00000453245.5
ENST00000428488.1
ENST00000369531.1
membrane palmitoylated protein 1
chr2_-_29074515 0.29 ENST00000331664.6
photoreceptor cilium actin regulator
chr12_-_10884244 0.28 ENST00000543626.4
proline rich protein HaeIII subfamily 1
chr5_+_153491174 0.28 ENST00000521843.6
glutamate ionotropic receptor AMPA type subunit 1
chr7_+_38977904 0.27 ENST00000518318.7
ENST00000403058.6
POU class 6 homeobox 2
chr2_+_218710931 0.27 ENST00000442769.5
ENST00000424644.1
tubulin tyrosine ligase like 4
chr12_+_5432101 0.26 ENST00000423158.4
neurotrophin 3
chr5_+_157743703 0.25 ENST00000286307.6
LSM11, U7 small nuclear RNA associated
chr1_-_89175997 0.25 ENST00000294671.3
ENST00000650452.1
guanylate binding protein 7
chr1_-_110607970 0.24 ENST00000638532.1
potassium voltage-gated channel subfamily A member 2
chr6_-_116765709 0.24 ENST00000368557.6
family with sequence similarity 162 member B
chr4_-_108168950 0.24 ENST00000379951.6
lymphoid enhancer binding factor 1
chr17_+_41226648 0.23 ENST00000377721.3
keratin associated protein 9-2
chr15_+_81296913 0.23 ENST00000394652.6
interleukin 16
chr1_-_43367956 0.23 ENST00000372458.8
ELOVL fatty acid elongase 1
chr10_-_69416323 0.22 ENST00000619173.4
tachykinin receptor 2
chr6_+_31762996 0.22 ENST00000415669.3
ENST00000425424.4
suppressor APC domain containing 1
chr5_-_132011580 0.21 ENST00000651250.1
ENST00000434099.6
ENST00000296869.9
ENST00000651356.1
ENST00000651883.2
acyl-CoA synthetase long chain family member 6
chr22_+_21015027 0.21 ENST00000413302.6
ENST00000401443.5
purinergic receptor P2X 6
chr4_-_108168919 0.21 ENST00000265165.6
lymphoid enhancer binding factor 1
chr11_-_59845496 0.21 ENST00000257248.3
cobalamin binding intrinsic factor
chr15_+_73684204 0.21 ENST00000537340.6
ENST00000318424.9
CD276 molecule
chr17_-_41041447 0.20 ENST00000306271.5
keratin associated protein 1-1
chr17_-_5468951 0.20 ENST00000225296.8
DEAH-box helicase 33
chr1_+_61952283 0.19 ENST00000307297.8
PATJ crumbs cell polarity complex component
chr21_-_38498415 0.19 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ETS transcription factor ERG
chr1_+_226223618 0.19 ENST00000542034.5
ENST00000366810.6
Mix paired-like homeobox
chr14_+_103385506 0.18 ENST00000303622.13
microtubule affinity regulating kinase 3
chr2_+_88885397 0.18 ENST00000390243.2
immunoglobulin kappa variable 4-1
chr1_-_153616289 0.18 ENST00000368701.5
ENST00000344616.4
S100 calcium binding protein A14
chr10_-_48493641 0.18 ENST00000417247.6
Rho GTPase activating protein 22
chr12_-_52520371 0.17 ENST00000549420.1
ENST00000252242.9
ENST00000551275.1
ENST00000546577.1
keratin 5
chr3_-_58577367 0.17 ENST00000464064.5
ENST00000360997.7
family with sequence similarity 107 member A
chr7_-_124929938 0.17 ENST00000668382.1
ENST00000655761.1
ENST00000393329.5
protection of telomeres 1
chr8_-_119673368 0.17 ENST00000427067.6
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr2_-_89010515 0.16 ENST00000493819.1
immunoglobulin kappa variable 1-9
chr1_-_43367689 0.16 ENST00000621943.4
ELOVL fatty acid elongase 1
chr17_-_19042485 0.16 ENST00000395635.5
GRB2 related adaptor protein
chr10_-_79949098 0.16 ENST00000372292.8
surfactant protein D
chr3_+_149129610 0.16 ENST00000460120.5
ENST00000296051.7
HPS3 biogenesis of lysosomal organelles complex 2 subunit 1
chr15_+_40953463 0.15 ENST00000617768.5
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr1_+_206865620 0.15 ENST00000367098.6
interleukin 20
chr15_+_80060113 0.15 ENST00000618205.4
zinc finger AN1-type containing 6
chr9_+_121567057 0.14 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2 interacting protein
chr6_-_127918540 0.14 ENST00000368250.5
thymocyte selection associated
chr1_-_211133945 0.14 ENST00000640044.1
ENST00000640566.1
potassium voltage-gated channel subfamily H member 1
chrX_+_154542194 0.14 ENST00000618670.4
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
chr7_-_108240049 0.14 ENST00000379022.8
neuronal cell adhesion molecule
chr1_+_16043776 0.14 ENST00000375679.9
chloride voltage-gated channel Kb
chr1_+_16022004 0.13 ENST00000439316.6
chloride voltage-gated channel Ka
chr1_+_16043736 0.13 ENST00000619181.4
chloride voltage-gated channel Kb
chr17_-_44968263 0.13 ENST00000253407.4
complement C1q like 1
chrX_+_71144818 0.13 ENST00000536169.5
ENST00000358741.4
ENST00000395855.6
ENST00000374051.7
neuroligin 3
chr6_-_127918604 0.13 ENST00000537166.5
thymocyte selection associated
chr7_-_124929801 0.13 ENST00000653241.1
ENST00000664366.1
ENST00000446993.6
ENST00000654766.1
ENST00000357628.8
ENST00000609702.5
protection of telomeres 1
chr1_-_43368039 0.12 ENST00000413844.3
ELOVL fatty acid elongase 1
chr22_+_39014249 0.12 ENST00000361441.5
apolipoprotein B mRNA editing enzyme catalytic subunit 3C
chr1_-_211134061 0.12 ENST00000639602.1
ENST00000638498.1
ENST00000367007.5
novel protein
potassium voltage-gated channel subfamily H member 1
chr7_-_150800533 0.12 ENST00000434545.5
transmembrane protein 176B
chr19_-_14475307 0.12 ENST00000292513.4
prostaglandin E receptor 1
chr17_-_41065879 0.11 ENST00000394015.3
keratin associated protein 2-4
chr1_-_211134135 0.11 ENST00000638983.1
ENST00000271751.10
ENST00000639952.1
novel protein
potassium voltage-gated channel subfamily H member 1
chr14_+_103385374 0.11 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
microtubule affinity regulating kinase 3
chr19_+_55476575 0.11 ENST00000598519.2
zinc finger protein 628
chr17_+_8339837 0.11 ENST00000328248.7
ENST00000584943.1
outer dense fiber of sperm tails 4
chr13_+_101452629 0.11 ENST00000622834.4
ENST00000545560.6
ENST00000376180.8
integrin subunit beta like 1
chr12_+_56996151 0.10 ENST00000556850.1
G protein-coupled receptor 182
chr2_-_74553049 0.10 ENST00000409549.5
lysyl oxidase like 3
chr3_-_50292404 0.10 ENST00000417626.8
interferon related developmental regulator 2
chr3_+_32817990 0.10 ENST00000383763.6
tripartite motif containing 71
chr8_+_25184758 0.10 ENST00000481100.5
dedicator of cytokinesis 5
chr8_-_63038788 0.10 ENST00000518113.2
ENST00000260118.7
ENST00000677482.1
gamma-glutamyl hydrolase
chr9_-_16870662 0.09 ENST00000380672.9
basonuclin 2
chrX_+_13689171 0.09 ENST00000618931.2
RAB9A, member RAS oncogene family
chr19_-_49665603 0.09 ENST00000596756.5
interferon regulatory factor 3
chr11_-_46121397 0.09 ENST00000676320.1
PHD finger protein 21A
chr3_+_141386862 0.09 ENST00000513258.5
zinc finger and BTB domain containing 38
chr22_+_39014282 0.09 ENST00000381568.9
novel protein
chr12_-_102478539 0.09 ENST00000424202.6
insulin like growth factor 1
chr5_-_127073467 0.09 ENST00000607731.5
ENST00000509733.7
ENST00000296662.10
ENST00000535381.6
chromosome 5 open reading frame 63
chr12_+_26938454 0.09 ENST00000229395.8
ENST00000544111.5
ENST00000546072.5
ENST00000327214.5
FGFR1 oncogene partner 2
chr22_-_23580223 0.09 ENST00000249053.3
ENST00000330377.3
ENST00000438703.1
immunoglobulin lambda like polypeptide 1
chr21_+_44646414 0.08 ENST00000334670.9
keratin associated protein 10-11
chr17_-_41168219 0.07 ENST00000391356.4
keratin associated protein 4-3
chr10_+_116590956 0.07 ENST00000358834.9
ENST00000528052.5
pancreatic lipase related protein 1
chr14_+_64504574 0.07 ENST00000358738.3
zinc finger and BTB domain containing 1
chr3_+_178536407 0.07 ENST00000452583.6
potassium calcium-activated channel subfamily M regulatory beta subunit 2
chr15_+_84980440 0.07 ENST00000310298.8
ENST00000557957.5
phosphodiesterase 8A
chr11_+_15073562 0.07 ENST00000533448.1
ENST00000324229.11
calcitonin related polypeptide beta
chr19_-_42255119 0.07 ENST00000222329.9
ENST00000594664.1
ETS2 repressor factor
novel protein
chr6_+_41787651 0.07 ENST00000398884.7
ENST00000398881.4
translocase of outer mitochondrial membrane 6
chr2_+_79120474 0.06 ENST00000233735.2
regenerating family member 1 alpha
chr15_+_80059568 0.06 ENST00000613266.4
ENST00000561060.5
zinc finger AN1-type containing 6
chr4_-_174829212 0.06 ENST00000340217.5
ENST00000274093.8
glycine receptor alpha 3
chr12_-_54588636 0.06 ENST00000257905.13
protein phosphatase 1 regulatory inhibitor subunit 1A
chr22_+_22375984 0.06 ENST00000390296.2
immunoglobulin lambda variable 5-45
chr12_+_13044371 0.06 ENST00000197268.13
family with sequence similarity 234 member B
chrX_+_13689116 0.06 ENST00000464506.2
ENST00000243325.6
RAB9A, member RAS oncogene family
chr15_+_80059635 0.06 ENST00000559157.5
zinc finger AN1-type containing 6
chr6_-_87095059 0.06 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
glycoprotein hormones, alpha polypeptide
chr7_-_135728177 0.06 ENST00000682651.1
ENST00000354042.8
solute carrier family 13 member 4
chr13_+_101452569 0.05 ENST00000618057.4
integrin subunit beta like 1
chrX_-_130165664 0.05 ENST00000535724.6
ENST00000346424.6
ENST00000676436.1
apoptosis inducing factor mitochondria associated 1
chr7_-_100896123 0.05 ENST00000428317.7
acetylcholinesterase (Cartwright blood group)
chr16_-_11392065 0.04 ENST00000599216.5
novel lipoprotein amino terminal region containing protein
chr11_-_134253248 0.04 ENST00000392595.6
ENST00000352327.5
ENST00000341541.8
ENST00000392594.7
thymocyte nuclear protein 1
chrX_-_47574738 0.04 ENST00000640721.1
synapsin I
chr17_-_41027198 0.04 ENST00000361883.6
keratin associated protein 1-5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0061552 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.4 1.2 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.3 1.0 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.3 0.9 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.2 0.8 GO:1903575 cornified envelope assembly(GO:1903575)
0.2 0.8 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 0.8 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.2 4.6 GO:0051639 actin filament network formation(GO:0051639)
0.2 0.6 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982) negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.7 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 1.6 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.1 0.4 GO:0035290 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1 0.6 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.1 0.4 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.3 GO:0052314 phthalate metabolic process(GO:0018963) epinephrine biosynthetic process(GO:0042418) phytoalexin metabolic process(GO:0052314)
0.1 0.4 GO:0007538 primary sex determination(GO:0007538)
0.1 0.5 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 0.3 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.1 0.3 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.5 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 0.3 GO:0048867 stem cell fate determination(GO:0048867)
0.1 0.9 GO:0021633 optic nerve structural organization(GO:0021633)
0.1 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.1 1.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 1.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.9 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.1 0.7 GO:2000252 negative regulation of feeding behavior(GO:2000252)
0.1 0.4 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.4 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.2 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1 0.4 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056) adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.5 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.3 GO:0051684 maintenance of Golgi location(GO:0051684) double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.2 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624)
0.0 0.2 GO:0035106 operant conditioning(GO:0035106)
0.0 0.4 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.4 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 0.1 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.4 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.2 GO:2000504 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.2 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.1 GO:1904045 cellular response to aldosterone(GO:1904045)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 4.5 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.5 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 1.2 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.7 GO:0046688 response to copper ion(GO:0046688)
0.0 0.1 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.3 GO:2000193 positive regulation of fatty acid transport(GO:2000193)
0.0 0.5 GO:0043586 tongue development(GO:0043586)
0.0 0.6 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.3 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.8 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.1 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.0 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 1.2 GO:0098869 cellular oxidant detoxification(GO:0098869)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.2 1.8 GO:0097443 sorting endosome(GO:0097443)
0.2 4.6 GO:0005916 fascia adherens(GO:0005916)
0.1 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.1 0.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.5 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.3 GO:0044301 climbing fiber(GO:0044301)
0.1 0.3 GO:0044308 axonal spine(GO:0044308)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.9 GO:0033010 paranodal junction(GO:0033010)
0.0 0.8 GO:0034709 methylosome(GO:0034709)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 3.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0070187 telosome(GO:0070187)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 1.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.7 GO:0005811 lipid particle(GO:0005811)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 2.1 GO:0043679 axon terminus(GO:0043679)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0032810 sterol response element binding(GO:0032810)
0.3 0.8 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 1.8 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 1.0 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 0.9 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.2 4.6 GO:0017166 vinculin binding(GO:0017166)
0.1 0.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 0.9 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.2 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 1.2 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.2 GO:0016497 substance K receptor activity(GO:0016497)
0.1 0.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.6 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) tetrahydrobiopterin binding(GO:0034617)
0.0 0.5 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.8 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 1.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 1.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 4.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.6 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.8 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex