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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ZNF263
Z-value: 1.78
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Transcription factors associated with ZNF263
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF263 | hg38_v1_chr16_+_3283443_3283544 | -0.61 | 3.7e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF263
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51001668 Show fit | 14.65 |
ENST00000347619.8
ENST00000291726.11 ENST00000320838.9 |
kallikrein related peptidase 8 |
|
| chr19_-_51001591 Show fit | 11.70 |
ENST00000391806.6
|
kallikrein related peptidase 8 |
|
| chr19_-_50983815 Show fit | 10.86 |
ENST00000391807.5
ENST00000593904.1 ENST00000595820.6 |
kallikrein related peptidase 7 |
|
| chr1_+_150508099 Show fit | 10.81 |
ENST00000346569.6
ENST00000369047.9 |
extracellular matrix protein 1 |
|
| chr1_+_150508074 Show fit | 10.02 |
ENST00000369049.8
|
extracellular matrix protein 1 |
|
| chr6_-_30687200 Show fit | 7.90 |
ENST00000399199.7
|
protein phosphatase 1 regulatory subunit 18 |
|
| chr19_-_51002527 Show fit | 7.81 |
ENST00000595238.1
ENST00000600767.5 |
kallikrein related peptidase 8 |
|
| chr19_-_50952942 Show fit | 7.52 |
ENST00000594846.1
ENST00000336334.8 |
kallikrein related peptidase 5 |
|
| chr17_+_72121012 Show fit | 7.03 |
ENST00000245479.3
|
SRY-box transcription factor 9 |
|
| chr6_+_151240368 Show fit | 5.47 |
ENST00000253332.5
|
A-kinase anchoring protein 12 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 33.9 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.7 | 21.0 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 3.1 | 18.4 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.1 | 13.7 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.9 | 11.7 | GO:0021840 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 1.2 | 10.7 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 1.0 | 10.3 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.5 | 9.1 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 1.8 | 8.9 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.1 | 7.8 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 19.8 | GO:0005901 | caveola(GO:0005901) |
| 0.9 | 18.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 2.6 | 18.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.2 | 11.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 11.5 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
| 0.5 | 11.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.7 | 8.9 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 8.1 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.8 | 7.1 | GO:0005587 | collagen type IV trimer(GO:0005587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 57.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 3.3 | 22.8 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 1.4 | 13.7 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.9 | 12.8 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.6 | 11.7 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.1 | 11.6 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 8.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 7.6 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.5 | 7.1 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.4 | 6.9 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 19.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 10.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 10.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 10.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 9.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 8.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 8.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 7.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.3 | 7.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 13.3 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 12.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 11.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 10.2 | REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | Genes involved in Class I MHC mediated antigen processing & presentation |
| 0.3 | 9.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.5 | 7.9 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.4 | 7.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 6.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 5.7 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |