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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZNF8

Z-value: 0.44

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000278129.2 ZNF8
ZNF8
ENSG00000278129.2 ZNF8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF8hg38_v1_chr19_+_58278948_582789920.514.2e-03Click!

Activity profile of ZNF8 motif

Sorted Z-values of ZNF8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_87407965 2.13 ENST00000369562.9
CFAP206
cilia and flagella associated protein 206
chr4_+_185426234 1.97 ENST00000511138.5
ENST00000511581.5
ENST00000378850.5
C4orf47
chromosome 4 open reading frame 47
chr7_+_48035511 1.96 ENST00000420324.5
ENST00000539619.5
ENST00000435376.5
ENST00000430738.5
ENST00000348904.4
C7orf57
chromosome 7 open reading frame 57
chr2_+_119431846 1.80 ENST00000306406.5
TMEM37
transmembrane protein 37
chr3_-_9952337 1.23 ENST00000411976.2
ENST00000412055.6
PRRT3
proline rich transmembrane protein 3
chr3_+_113838772 1.12 ENST00000358160.9
GRAMD1C
GRAM domain containing 1C
chr6_+_29723340 1.03 ENST00000334668.8
HLA-F
major histocompatibility complex, class I, F
chr6_+_29723421 1.00 ENST00000259951.12
ENST00000434407.6
HLA-F
major histocompatibility complex, class I, F
chr6_+_18155399 0.79 ENST00000650836.2
ENST00000449850.2
ENST00000297792.9
KDM1B
lysine demethylase 1B
chr9_+_1050330 0.60 ENST00000382255.7
ENST00000382251.7
ENST00000412350.6
ENST00000358146.7
DMRT2
doublesex and mab-3 related transcription factor 2
chr13_+_36819214 0.51 ENST00000255476.3
RFXAP
regulatory factor X associated protein
chr6_-_26056460 0.50 ENST00000343677.4
H1-2
H1.2 linker histone, cluster member
chr16_+_29962049 0.34 ENST00000279396.11
ENST00000575829.6
ENST00000561899.6
TMEM219
transmembrane protein 219
chr9_+_93263948 0.33 ENST00000448251.5
WNK2
WNK lysine deficient protein kinase 2
chr20_+_38748448 0.33 ENST00000243903.6
ACTR5
actin related protein 5
chr5_-_94111627 0.30 ENST00000505869.5
ENST00000395965.8
ENST00000509163.5
FAM172A
family with sequence similarity 172 member A
chr11_-_46617170 0.30 ENST00000326737.3
HARBI1
harbinger transposase derived 1
chr1_-_186375671 0.28 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr4_+_169620527 0.27 ENST00000360642.7
ENST00000512813.5
ENST00000513761.6
CLCN3
chloride voltage-gated channel 3
chr5_-_138575359 0.25 ENST00000297185.9
ENST00000678300.1
ENST00000677425.1
ENST00000677064.1
ENST00000507115.6
HSPA9
heat shock protein family A (Hsp70) member 9
chr4_+_169620509 0.25 ENST00000347613.8
CLCN3
chloride voltage-gated channel 3
chr2_+_171434196 0.24 ENST00000375255.8
ENST00000539783.5
DCAF17
DDB1 and CUL4 associated factor 17
chr5_+_103120264 0.24 ENST00000358359.8
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr22_-_38656353 0.23 ENST00000535113.7
FAM227A
family with sequence similarity 227 member A
chr13_+_52652828 0.20 ENST00000310528.9
ENST00000343788.10
SUGT1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr1_-_54801161 0.19 ENST00000371274.8
TTC22
tetratricopeptide repeat domain 22
chr6_-_18155053 0.18 ENST00000309983.5
TPMT
thiopurine S-methyltransferase
chr2_-_239400991 0.17 ENST00000543185.6
HDAC4
histone deacetylase 4
chr2_-_239400949 0.16 ENST00000345617.7
HDAC4
histone deacetylase 4
chr2_+_32357009 0.15 ENST00000421745.6
BIRC6
baculoviral IAP repeat containing 6
chr1_+_186375813 0.15 ENST00000419367.8
ENST00000287859.11
ENST00000367470.8
ODR4
odr-4 GPCR localization factor homolog
chr22_+_29767351 0.15 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chrX_+_129779930 0.12 ENST00000356892.4
SASH3
SAM and SH3 domain containing 3
chr9_-_37576365 0.11 ENST00000432825.7
FBXO10
F-box protein 10
chr2_+_197500398 0.11 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr16_+_68539213 0.11 ENST00000570495.5
ENST00000564323.5
ENST00000562156.5
ENST00000573685.5
ENST00000563169.7
ENST00000611381.4
ZFP90
ZFP90 zinc finger protein
chr1_-_54801290 0.11 ENST00000371276.9
TTC22
tetratricopeptide repeat domain 22
chr9_-_32552553 0.09 ENST00000379858.1
ENST00000360538.7
ENST00000681750.1
ENST00000680198.1
TOPORS
ENSG00000288684.1
TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
novel protein
chr19_-_18281612 0.09 ENST00000252818.5
JUND
JunD proto-oncogene, AP-1 transcription factor subunit
chr22_-_29766934 0.08 ENST00000344318.4
ZMAT5
zinc finger matrin-type 5
chr2_+_197500371 0.08 ENST00000409468.1
ENST00000233893.10
HSPE1
heat shock protein family E (Hsp10) member 1
chr5_+_139341875 0.08 ENST00000511706.5
PAIP2
poly(A) binding protein interacting protein 2
chr19_+_37507129 0.08 ENST00000586138.5
ENST00000588578.5
ENST00000587986.5
ZNF793
zinc finger protein 793
chr17_-_58514617 0.08 ENST00000682306.1
MTMR4
myotubularin related protein 4
chr1_+_25338294 0.07 ENST00000374358.5
TMEM50A
transmembrane protein 50A
chr3_+_49199477 0.07 ENST00000452691.7
ENST00000366429.2
IHO1
interactor of HORMAD1 1
chr17_+_77185210 0.07 ENST00000431431.6
SEC14L1
SEC14 like lipid binding 1
chr5_+_139341826 0.07 ENST00000265192.9
PAIP2
poly(A) binding protein interacting protein 2
chr12_-_122266425 0.07 ENST00000643696.1
ENST00000267199.9
VPS33A
VPS33A core subunit of CORVET and HOPS complexes
chr16_+_21953341 0.06 ENST00000268379.9
ENST00000561553.5
ENST00000565331.5
UQCRC2
ubiquinol-cytochrome c reductase core protein 2
chr1_+_70205680 0.05 ENST00000370951.5
SRSF11
serine and arginine rich splicing factor 11
chr16_-_53503192 0.04 ENST00000568596.5
ENST00000394657.12
ENST00000570004.5
ENST00000564497.1
ENST00000300245.8
AKTIP
AKT interacting protein
chr13_+_21176629 0.03 ENST00000309594.5
MRPL57
mitochondrial ribosomal protein L57
chr17_+_50508384 0.03 ENST00000436259.6
ENST00000652471.1
ENST00000323776.11
ENST00000419930.2
MYCBPAP
MYCBP associated protein
chr6_+_44246166 0.02 ENST00000620073.4
HSP90AB1
heat shock protein 90 alpha family class B member 1
chr1_+_70205708 0.02 ENST00000370950.7
SRSF11
serine and arginine rich splicing factor 11
chr12_+_52069967 0.02 ENST00000336854.9
ENST00000550604.1
ENST00000553049.5
ENST00000548915.1
ATG101
autophagy related 101
chr1_-_228109255 0.01 ENST00000483159.1
ENST00000366744.5
ENST00000348259.9
ENST00000495434.1
ENST00000295008.8
ENST00000366731.9
ENST00000366746.7
ENST00000366747.7
ENST00000336520.8
ENST00000391867.8
ENST00000457264.5
ENST00000464148.2
ENST00000336300.9
ENST00000430433.5
MRPL55
mitochondrial ribosomal protein L55
chr17_+_35809474 0.01 ENST00000604879.5
ENST00000603427.5
ENST00000603777.5
ENST00000605844.6
ENST00000604841.5
TAF15
TATA-box binding protein associated factor 15
chr2_-_105329685 0.01 ENST00000393359.7
TGFBRAP1
transforming growth factor beta receptor associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.6 GO:0061055 myotome development(GO:0061055)
0.1 0.5 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.3 GO:0031445 regulation of heterochromatin assembly(GO:0031445) positive regulation of heterochromatin assembly(GO:0031453)
0.1 0.8 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.4 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 2.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0052203 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.3 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.0 0.3 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.3 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0001534 radial spoke(GO:0001534) axonemal outer doublet(GO:0097545)
0.2 2.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.8 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway