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GSE58827: Dynamics of the Mouse Liver

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Results for Aire

Z-value: 0.65

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Transcription factors associated with Aire

Gene Symbol Gene ID Gene Info
Aire
ENSMUSG00000000731.9 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Airemm10_v2_chr10_-_78043580_78043611-0.048.3e-01Click!

Activity profile of Aire motif

Sorted Z-values of Aire motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39287074 2.57 ENSMUST00000003137.8
Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
chr4_+_44943727 2.20 ENSMUST00000154177.1
Gm12678
predicted gene 12678
chr5_+_130369420 2.07 ENSMUST00000086029.3
Caln1
calneuron 1
chr5_-_87091150 1.74 ENSMUST00000154455.1
Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chr12_+_84052114 1.53 ENSMUST00000120927.1
Acot3
acyl-CoA thioesterase 3
chr1_+_88200601 1.46 ENSMUST00000049289.8
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
chr6_+_42245907 1.42 ENSMUST00000031897.5
Gstk1
glutathione S-transferase kappa 1
chr8_-_25038875 1.28 ENSMUST00000084031.4
Htra4
HtrA serine peptidase 4
chr19_+_3323301 1.18 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr12_-_104865076 1.16 ENSMUST00000109937.1
ENSMUST00000109936.1
Clmn
calmin
chr10_-_107123585 1.10 ENSMUST00000165067.1
ENSMUST00000044668.4
Acss3
acyl-CoA synthetase short-chain family member 3
chr5_+_7960445 1.09 ENSMUST00000115421.1
Steap4
STEAP family member 4
chr5_-_105343929 1.07 ENSMUST00000183149.1
Gbp11
guanylate binding protein 11
chr17_+_56628118 0.89 ENSMUST00000112979.2
Catsperd
catsper channel auxiliary subunit delta
chrM_+_7005 0.87 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr5_+_137981512 0.85 ENSMUST00000035390.5
Azgp1
alpha-2-glycoprotein 1, zinc
chr14_-_18894255 0.84 ENSMUST00000124353.1
Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr7_-_127895578 0.81 ENSMUST00000033074.6
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr5_+_30921825 0.78 ENSMUST00000117435.1
Khk
ketohexokinase
chr11_-_69696058 0.77 ENSMUST00000180587.1
ENSMUST00000094070.4
Tnfsf12
BC096441
tumor necrosis factor (ligand) superfamily, member 12
cDNA sequence BC096441
chr15_+_10981747 0.72 ENSMUST00000070877.5
Amacr
alpha-methylacyl-CoA racemase
chr16_+_23058250 0.69 ENSMUST00000039492.6
ENSMUST00000023589.8
ENSMUST00000089902.6
Kng1
kininogen 1
chr9_-_108263706 0.66 ENSMUST00000171412.1
Dag1
dystroglycan 1
chr15_+_10358525 0.66 ENSMUST00000110540.1
ENSMUST00000110541.1
ENSMUST00000110542.1
Agxt2
alanine-glyoxylate aminotransferase 2
chr7_-_141434532 0.62 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr15_+_10358556 0.62 ENSMUST00000022858.7
Agxt2
alanine-glyoxylate aminotransferase 2
chr3_-_116968969 0.60 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd
palmdelphin
chr11_+_105975204 0.57 ENSMUST00000001964.7
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr16_-_23029062 0.56 ENSMUST00000115349.2
Kng2
kininogen 2
chr5_+_30921867 0.56 ENSMUST00000123885.1
Khk
ketohexokinase
chr16_-_23029080 0.55 ENSMUST00000100046.2
Kng2
kininogen 2
chr18_+_37400845 0.55 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr9_+_85312773 0.54 ENSMUST00000113205.1
Gm11114
predicted gene 11114
chr11_-_69695802 0.54 ENSMUST00000108649.1
ENSMUST00000174159.1
ENSMUST00000181810.1
BC096441
Tnfsf12
cDNA sequence BC096441
tumor necrosis factor (ligand) superfamily, member 12
chr11_+_70166696 0.54 ENSMUST00000178567.1
Clec10a
C-type lectin domain family 10, member A
chr9_-_53610329 0.53 ENSMUST00000034547.5
Acat1
acetyl-Coenzyme A acetyltransferase 1
chr2_+_147364989 0.53 ENSMUST00000109968.2
Pax1
paired box gene 1
chrM_-_14060 0.51 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chrM_+_14138 0.51 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chrM_+_7759 0.50 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr7_-_19665005 0.49 ENSMUST00000055242.9
Clptm1
cleft lip and palate associated transmembrane protein 1
chrM_+_11734 0.49 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr19_-_28963863 0.49 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr10_+_53337686 0.47 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln
phospholamban
chr2_+_128591205 0.47 ENSMUST00000155430.1
Gm355
predicted gene 355
chr17_-_59013264 0.46 ENSMUST00000174122.1
ENSMUST00000025065.5
Nudt12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr7_-_126922887 0.45 ENSMUST00000134134.1
ENSMUST00000119781.1
ENSMUST00000121612.2
Tmem219
transmembrane protein 219
chr15_+_101266839 0.45 ENSMUST00000023779.6
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr3_+_57425314 0.42 ENSMUST00000029377.7
Tm4sf4
transmembrane 4 superfamily member 4
chr5_+_43672289 0.40 ENSMUST00000156034.1
Cc2d2a
coiled-coil and C2 domain containing 2A
chr12_+_37242030 0.40 ENSMUST00000160390.1
Agmo
alkylglycerol monooxygenase
chr17_-_73950172 0.37 ENSMUST00000024866.4
Xdh
xanthine dehydrogenase
chr1_-_128359610 0.37 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr11_+_70166623 0.37 ENSMUST00000102571.3
ENSMUST00000178945.1
ENSMUST00000000327.6
Clec10a
C-type lectin domain family 10, member A
chrY_-_38800793 0.36 ENSMUST00000180177.1
Gm20901
predicted gene, 20901
chr18_+_37725706 0.35 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr17_+_35236556 0.33 ENSMUST00000068261.8
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chrM_+_8600 0.32 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr3_-_89411781 0.31 ENSMUST00000107429.3
ENSMUST00000129308.2
ENSMUST00000107426.1
ENSMUST00000050398.4
ENSMUST00000162701.1
Flad1
RFad1, flavin adenine dinucleotide synthetase, homolog (yeast)
chr1_-_66863265 0.31 ENSMUST00000027153.5
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
chr9_+_109054839 0.29 ENSMUST00000154184.1
Shisa5
shisa homolog 5 (Xenopus laevis)
chr6_+_134396316 0.27 ENSMUST00000032321.4
Bcl2l14
BCL2-like 14 (apoptosis facilitator)
chr16_-_8425104 0.27 ENSMUST00000023400.2
Cldn26
claudin 26
chr6_+_40628824 0.27 ENSMUST00000071535.6
Mgam
maltase-glucoamylase
chr5_+_121660528 0.26 ENSMUST00000031414.8
Brap
BRCA1 associated protein
chr1_-_65186456 0.26 ENSMUST00000169032.1
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr10_+_79960145 0.26 ENSMUST00000045247.7
Wdr18
WD repeat domain 18
chr13_+_49504774 0.25 ENSMUST00000051504.7
Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_-_6951680 0.25 ENSMUST00000076071.2
Gm10115
predicted gene 10115
chr7_+_29170345 0.25 ENSMUST00000033886.7
Ggn
gametogenetin
chr13_-_110280103 0.24 ENSMUST00000167824.1
Rab3c
RAB3C, member RAS oncogene family
chr14_-_70524068 0.24 ENSMUST00000022692.3
Sftpc
surfactant associated protein C
chr14_+_76476913 0.23 ENSMUST00000140251.2
Tsc22d1
TSC22 domain family, member 1
chr17_-_35516780 0.23 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19
transcription factor 19
chr17_-_56036546 0.23 ENSMUST00000003268.9
Sh3gl1
SH3-domain GRB2-like 1
chr14_+_21481428 0.22 ENSMUST00000182996.1
Kat6b
K(lysine) acetyltransferase 6B
chr7_-_84409959 0.22 ENSMUST00000085077.3
Arnt2
aryl hydrocarbon receptor nuclear translocator 2
chr10_+_57650990 0.22 ENSMUST00000175852.1
Pkib
protein kinase inhibitor beta, cAMP dependent, testis specific
chr11_-_67052563 0.21 ENSMUST00000116363.1
Adprm
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
chr8_-_4216912 0.21 ENSMUST00000177491.1
BC068157
cDNA sequence BC068157
chr2_-_9883993 0.21 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr5_-_100373484 0.21 ENSMUST00000182433.1
Sec31a
Sec31 homolog A (S. cerevisiae)
chr9_+_109816618 0.20 ENSMUST00000118732.1
Spink8
serine peptidase inhibitor, Kazal type 8
chr6_-_3399545 0.19 ENSMUST00000120087.3
Samd9l
sterile alpha motif domain containing 9-like
chr1_-_90843916 0.19 ENSMUST00000130846.2
ENSMUST00000097653.4
ENSMUST00000056925.9
Col6a3
collagen, type VI, alpha 3
chr5_+_140735526 0.19 ENSMUST00000120630.2
Amz1
archaelysin family metallopeptidase 1
chr8_-_109962127 0.18 ENSMUST00000001722.7
ENSMUST00000051430.6
Marveld3
MARVEL (membrane-associating) domain containing 3
chr5_-_108795352 0.17 ENSMUST00000004943.1
Tmed11
transmembrane emp24 protein transport domain containing
chr10_+_3872667 0.17 ENSMUST00000136671.1
ENSMUST00000042438.6
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr5_-_50058908 0.16 ENSMUST00000030971.5
Gpr125
G protein-coupled receptor 125
chr9_+_13662460 0.16 ENSMUST00000177755.1
Maml2
mastermind like 2 (Drosophila)
chr8_+_111643425 0.15 ENSMUST00000077791.6
Zfp1
zinc finger protein 1
chr11_-_99521336 0.15 ENSMUST00000107445.1
Krt39
keratin 39
chr17_-_17883920 0.15 ENSMUST00000061516.7
Fpr1
formyl peptide receptor 1
chr10_+_57650977 0.14 ENSMUST00000066028.6
Pkib
protein kinase inhibitor beta, cAMP dependent, testis specific
chr6_-_91515878 0.14 ENSMUST00000032182.3
Xpc
xeroderma pigmentosum, complementation group C
chr17_+_22689771 0.13 ENSMUST00000055305.8
Gm9805
predicted gene 9805
chr7_-_121981669 0.13 ENSMUST00000057576.7
Cog7
component of oligomeric golgi complex 7
chr3_-_92827239 0.12 ENSMUST00000072363.4
Kprp
keratinocyte expressed, proline-rich
chr5_-_113310697 0.12 ENSMUST00000154248.1
Sgsm1
small G protein signaling modulator 1
chr17_-_42692244 0.12 ENSMUST00000170723.1
ENSMUST00000164524.1
ENSMUST00000024711.4
ENSMUST00000167993.1
Gpr115
G protein-coupled receptor 115
chr10_-_130280218 0.12 ENSMUST00000061571.3
Neurod4
neurogenic differentiation 4
chr11_+_67052641 0.12 ENSMUST00000108690.3
ENSMUST00000092996.4
Sco1
SCO cytochrome oxidase deficient homolog 1 (yeast)
chr8_-_54529951 0.11 ENSMUST00000067476.8
Spcs3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr7_+_45896941 0.10 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143
transmembrane protein 143
chr10_-_81014902 0.10 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7
guanine nucleotide binding protein (G protein), gamma 7
chr3_-_33082004 0.10 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr2_-_92540967 0.10 ENSMUST00000142249.2
Gm13817
predicted gene 13817
chr5_+_114896936 0.10 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr8_-_19114830 0.10 ENSMUST00000062113.7
Defb12
defensin beta 12
chr14_-_50681645 0.09 ENSMUST00000078075.4
Olfr747
olfactory receptor 747
chr12_+_87200524 0.09 ENSMUST00000182869.1
Samd15
sterile alpha motif domain containing 15
chr11_-_96111962 0.08 ENSMUST00000097162.5
ENSMUST00000068686.6
Calcoco2
calcium binding and coiled-coil domain 2
chr1_+_44119952 0.08 ENSMUST00000114709.2
Bivm
basic, immunoglobulin-like variable motif containing
chr11_-_115627948 0.08 ENSMUST00000154623.1
ENSMUST00000106503.3
ENSMUST00000141614.1
Slc25a19
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
chr9_+_109816571 0.07 ENSMUST00000055821.5
Spink8
serine peptidase inhibitor, Kazal type 8
chr16_+_44820728 0.07 ENSMUST00000114626.3
Cd200r4
CD200 receptor 4
chr12_+_36157124 0.07 ENSMUST00000041640.3
Ankmy2
ankyrin repeat and MYND domain containing 2
chr14_-_63037833 0.07 ENSMUST00000111207.1
ENSMUST00000100490.2
Defb30
defensin beta 30
chr3_+_94443315 0.07 ENSMUST00000029786.7
ENSMUST00000098876.3
Mrpl9
mitochondrial ribosomal protein L9
chr16_+_34651188 0.07 ENSMUST00000023530.4
Ropn1
ropporin, rhophilin associated protein 1
chr2_-_94010807 0.07 ENSMUST00000111240.1
Alkbh3
alkB, alkylation repair homolog 3 (E. coli)
chr15_+_22549022 0.07 ENSMUST00000163361.1
Cdh18
cadherin 18
chrY_-_79149787 0.07 ENSMUST00000179922.1
Gm20917
predicted gene, 20917
chr10_+_37139558 0.06 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr7_+_45897429 0.06 ENSMUST00000140243.1
Tmem143
transmembrane protein 143
chr6_-_148896150 0.06 ENSMUST00000072324.5
ENSMUST00000111569.2
Caprin2
caprin family member 2
chr14_+_51114455 0.06 ENSMUST00000100645.3
Eddm3b
epididymal protein 3B
chrX_-_92016183 0.05 ENSMUST00000099471.2
ENSMUST00000072269.1
Mageb1
melanoma antigen, family B, 1
chr3_+_83026147 0.05 ENSMUST00000166581.1
ENSMUST00000029630.9
Fga
fibrinogen alpha chain
chr7_+_28863831 0.05 ENSMUST00000138272.1
Lgals7
lectin, galactose binding, soluble 7
chr18_+_77375065 0.04 ENSMUST00000123410.1
Loxhd1
lipoxygenase homology domains 1
chr7_-_104164812 0.04 ENSMUST00000154555.1
ENSMUST00000051137.8
E030002O03Rik
RIKEN cDNA E030002O03 gene
chr8_-_4217133 0.03 ENSMUST00000175906.1
BC068157
cDNA sequence BC068157
chr1_+_21349598 0.03 ENSMUST00000088407.3
Khdc1a
KH domain containing 1A
chr9_-_110989611 0.03 ENSMUST00000084922.5
Rtp3
receptor transporter protein 3
chrX_-_7041619 0.03 ENSMUST00000115752.1
Ccnb3
cyclin B3
chr12_+_10390756 0.03 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr8_-_15046047 0.02 ENSMUST00000050493.3
ENSMUST00000123331.1
BB014433
expressed sequence BB014433
chr19_+_46707443 0.02 ENSMUST00000003655.7
As3mt
arsenic (+3 oxidation state) methyltransferase
chrY_-_88953082 0.02 ENSMUST00000179463.1
Gm21720
predicted gene, 21720
chr19_+_34217588 0.02 ENSMUST00000119603.1
Stambpl1
STAM binding protein like 1
chr1_+_189728264 0.02 ENSMUST00000097442.2
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr7_+_11005722 0.01 ENSMUST00000131379.2
Zscan4c
zinc finger and SCAN domain containing 4C
chr6_-_40900368 0.01 ENSMUST00000063523.3
Prss58
protease, serine 58
chr15_-_98165560 0.01 ENSMUST00000123922.1
Asb8
ankyrin repeat and SOCS box-containing 8
chr14_-_79223876 0.01 ENSMUST00000040802.4
Zfp957
zinc finger protein 957
chr16_-_91618986 0.01 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
Dnajc28
DnaJ (Hsp40) homolog, subfamily C, member 28
chr15_-_98165613 0.00 ENSMUST00000143400.1
Asb8
ankyrin repeat and SOCS box-containing 8
chr3_-_95217877 0.00 ENSMUST00000136139.1
Gabpb2
GA repeat binding protein, beta 2
chr12_+_4843303 0.00 ENSMUST00000053034.4
BC068281
cDNA sequence BC068281

Network of associatons between targets according to the STRING database.

First level regulatory network of Aire

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0042853 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) L-alanine catabolic process(GO:0042853)
0.4 1.5 GO:0032789 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.3 1.3 GO:0061625 fructose catabolic process(GO:0006001) response to sucrose(GO:0009744) response to disaccharide(GO:0034285) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.3 0.8 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 0.6 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.2 0.5 GO:0006550 isoleucine catabolic process(GO:0006550)
0.2 0.7 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 0.9 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248)
0.1 1.5 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.5 GO:0006742 NADP catabolic process(GO:0006742)
0.1 1.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.3 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.1 1.5 GO:0009437 carnitine metabolic process(GO:0009437)
0.1 0.3 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.5 GO:0061056 sclerotome development(GO:0061056)
0.1 0.5 GO:0033762 response to glucagon(GO:0033762)
0.1 2.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.5 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.4 GO:0009115 xanthine catabolic process(GO:0009115)
0.1 0.7 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.1 0.4 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.5 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 1.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 1.0 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.3 GO:1902572 regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 1.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.6 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.6 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.1 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.0 1.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.1 GO:0035553 oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.5 GO:2000398 regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0036128 CatSper complex(GO:0036128)
0.1 0.7 GO:0016011 dystroglycan complex(GO:0016011)
0.1 2.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 1.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.1 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 4.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.1 GO:0033647 host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.9 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0004454 ketohexokinase activity(GO:0004454)
0.4 2.6 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.4 1.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 1.2 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.2 1.3 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.1 0.6 GO:0031711 tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
0.1 0.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 1.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.4 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
0.1 0.5 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 0.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 3.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.5 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.3 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466) palmitoyl-CoA oxidase activity(GO:0016401)
0.1 1.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.4 GO:0016726 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1 0.7 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 1.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.3 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.8 GO:0048038 quinone binding(GO:0048038)
0.0 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.7 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 1.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 0.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC