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GSE58827: Dynamics of the Mouse Liver

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Results for Bbx

Z-value: 0.31

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Transcription factors associated with Bbx

Gene Symbol Gene ID Gene Info
Bbx
ENSMUSG00000022641.9 bobby sox HMG box containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bbxmm10_v2_chr16_-_50330987_50331017-0.221.9e-01Click!

Activity profile of Bbx motif

Sorted Z-values of Bbx motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_7966000 1.94 ENSMUST00000182102.1
ENSMUST00000075619.4
Slc22a27
solute carrier family 22, member 27
chr19_-_11081088 1.35 ENSMUST00000025636.6
Ms4a8a
membrane-spanning 4-domains, subfamily A, member 8A
chr8_+_45658666 1.06 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
Sorbs2
sorbin and SH3 domain containing 2
chr2_+_58754910 1.03 ENSMUST00000059102.6
Upp2
uridine phosphorylase 2
chr6_+_124304646 1.02 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163
CD163 antigen
chr1_-_13660476 0.97 ENSMUST00000027071.5
Lactb2
lactamase, beta 2
chr15_-_3303521 0.95 ENSMUST00000165386.1
Ccdc152
coiled-coil domain containing 152
chr8_+_45658273 0.91 ENSMUST00000153798.1
Sorbs2
sorbin and SH3 domain containing 2
chr7_+_51880312 0.77 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chr5_-_108675569 0.70 ENSMUST00000051757.7
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr8_+_45658731 0.68 ENSMUST00000143820.1
ENSMUST00000132139.1
Sorbs2
sorbin and SH3 domain containing 2
chr18_+_37421418 0.60 ENSMUST00000053073.4
Pcdhb11
protocadherin beta 11
chr7_+_127800604 0.57 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
Hsd3b7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr2_-_134554348 0.48 ENSMUST00000028704.2
Hao1
hydroxyacid oxidase 1, liver
chr8_-_41054771 0.43 ENSMUST00000093534.4
Mtus1
mitochondrial tumor suppressor 1
chr7_-_127708886 0.38 ENSMUST00000061468.8
Bcl7c
B cell CLL/lymphoma 7C
chr15_-_101892916 0.36 ENSMUST00000100179.1
Krt76
keratin 76
chr3_+_16183177 0.35 ENSMUST00000108345.2
ENSMUST00000108346.2
Ythdf3
YTH domain family 3
chrX_-_75161620 0.34 ENSMUST00000165080.1
Smim9
small integral membrane protein 9
chr6_+_139621888 0.28 ENSMUST00000032353.8
Pik3c2g
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr11_+_105146893 0.27 ENSMUST00000100338.1
Gm10842
predicted gene 10842
chr10_-_107486077 0.25 ENSMUST00000000445.1
Myf5
myogenic factor 5
chr4_+_80910646 0.24 ENSMUST00000055922.3
Lurap1l
leucine rich adaptor protein 1-like
chr7_-_127708738 0.23 ENSMUST00000106282.1
Bcl7c
B cell CLL/lymphoma 7C
chr2_-_155592567 0.22 ENSMUST00000155347.1
ENSMUST00000130881.1
ENSMUST00000079691.6
Gss
glutathione synthetase
chr1_-_156032948 0.19 ENSMUST00000136397.1
Tor1aip1
torsin A interacting protein 1
chrX_-_107816238 0.16 ENSMUST00000120722.1
2610002M06Rik
RIKEN cDNA 2610002M06 gene
chr16_+_88728828 0.16 ENSMUST00000060494.6
Krtap13-1
keratin associated protein 13-1
chr12_+_88027004 0.16 ENSMUST00000178852.1
Gm2056
predicted gene 2056
chr12_-_87919857 0.15 ENSMUST00000180053.1
Gm2035
predicted pseudogene 2035
chr5_-_146585239 0.14 ENSMUST00000036211.6
Gpr12
G-protein coupled receptor 12
chr2_+_136892168 0.12 ENSMUST00000099311.2
Slx4ip
SLX4 interacting protein
chr1_-_163725123 0.12 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr5_+_104202609 0.10 ENSMUST00000066708.5
Dmp1
dentin matrix protein 1
chr13_-_91807658 0.09 ENSMUST00000022121.6
Zcchc9
zinc finger, CCHC domain containing 9
chr11_+_59306920 0.08 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a
wingless-type MMTV integration site 9A
chr13_+_49608030 0.08 ENSMUST00000021822.5
Ogn
osteoglycin
chr3_-_37232565 0.08 ENSMUST00000161015.1
ENSMUST00000029273.1
Il21
interleukin 21
chr1_+_180111339 0.04 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr12_+_88329254 0.04 ENSMUST00000091715.1
Gm10264
predicted gene 10264
chr18_-_65970178 0.03 ENSMUST00000025397.5
Cplx4
complexin 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Bbx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0015747 urate transport(GO:0015747)
0.1 0.5 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.7 GO:0019532 oxalate transport(GO:0019532)
0.1 0.6 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 2.7 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.0 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.4 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 1.0 GO:0006953 acute-phase response(GO:0006953)
0.0 0.3 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.4 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.3 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.1 1.9 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.5 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 1.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane