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GSE58827: Dynamics of the Mouse Liver
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Results for Bptf
Z-value: 2.42
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Transcription factors associated with Bptf
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bptf | mm10_v2_chr11_-_107132114_107132166 | -0.43 | 9.0e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Bptf
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 43.0 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 0.5 | 24.0 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.6 | 18.5 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 3.3 | 16.6 | GO:0001692 | histamine metabolic process(GO:0001692) |
| 0.2 | 12.8 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 2.0 | 12.3 | GO:0008355 | olfactory learning(GO:0008355) |
| 0.8 | 12.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.4 | 10.5 | GO:0051639 | actin filament network formation(GO:0051639) |
| 2.4 | 9.4 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.7 | 8.9 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.1 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 23.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.4 | 13.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.2 | 13.2 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 12.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.4 | 11.6 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 11.0 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 8.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 2.0 | 8.0 | GO:0044218 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.1 | 7.7 | GO:0000502 | proteasome complex(GO:0000502) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 29.5 | GO:0005550 | pheromone binding(GO:0005550) |
| 8.5 | 25.5 | GO:0005186 | pheromone activity(GO:0005186) |
| 0.1 | 22.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 21.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 16.6 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.4 | 12.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.3 | 11.5 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 1.6 | 11.0 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.3 | 10.6 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.4 | 9.8 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 12.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 12.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 12.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 6.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 5.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 4.5 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.2 | 4.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.6 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 16.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 10.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.5 | 9.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 8.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 8.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 7.6 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.4 | 7.5 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.4 | 6.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.4 | 6.6 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 6.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |