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GSE58827: Dynamics of the Mouse Liver

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Results for Cbfb

Z-value: 0.49

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Transcription factors associated with Cbfb

Gene Symbol Gene ID Gene Info
Cbfb
ENSMUSG00000031885.7 core binding factor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cbfbmm10_v2_chr8_+_105170668_1051706860.676.9e-06Click!

Activity profile of Cbfb motif

Sorted Z-values of Cbfb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_40515362 3.16 ENSMUST00000027237.5
Il18rap
interleukin 18 receptor accessory protein
chr11_-_17008647 2.59 ENSMUST00000102881.3
Plek
pleckstrin
chr2_+_164948219 2.55 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr2_+_172393900 2.13 ENSMUST00000109136.2
Cass4
Cas scaffolding protein family member 4
chr16_-_92826004 1.98 ENSMUST00000023673.7
Runx1
runt related transcription factor 1
chr2_-_58160495 1.73 ENSMUST00000028175.6
Cytip
cytohesin 1 interacting protein
chr11_-_83649349 1.42 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr15_-_66801577 1.42 ENSMUST00000168589.1
Sla
src-like adaptor
chr7_-_67803489 1.40 ENSMUST00000181235.1
4833412C05Rik
RIKEN cDNA 4833412C05 gene
chr5_-_147400352 1.15 ENSMUST00000049324.8
ENSMUST00000176456.1
ENSMUST00000110549.1
Flt3
FMS-like tyrosine kinase 3
chr19_-_50678642 1.15 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1
VPS10 domain receptor protein SORCS 1
chr17_+_12119274 1.15 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr6_-_136781718 1.12 ENSMUST00000078095.6
ENSMUST00000032338.7
Gucy2c
guanylate cyclase 2c
chr15_-_9529868 0.87 ENSMUST00000003981.4
Il7r
interleukin 7 receptor
chr11_+_20631956 0.79 ENSMUST00000109586.2
Sertad2
SERTA domain containing 2
chr10_+_118441044 0.74 ENSMUST00000068592.3
Ifng
interferon gamma
chr1_+_63176818 0.74 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr16_-_58718724 0.70 ENSMUST00000089318.3
Gpr15
G protein-coupled receptor 15
chr19_-_50678485 0.62 ENSMUST00000111756.3
Sorcs1
VPS10 domain receptor protein SORCS 1
chr2_+_153938218 0.61 ENSMUST00000109757.1
Bpifb4
BPI fold containing family B, member 4
chr7_-_115824699 0.61 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr2_+_172393794 0.46 ENSMUST00000099061.2
ENSMUST00000103073.2
Cass4
Cas scaffolding protein family member 4
chr3_-_146651304 0.45 ENSMUST00000149825.1
ENSMUST00000049703.5
4930503B20Rik
RIKEN cDNA 4930503B20 gene
chr6_-_99726392 0.39 ENSMUST00000032152.8
ENSMUST00000101120.4
ENSMUST00000008273.6
Prok2
prokineticin 2
chr4_-_117891994 0.37 ENSMUST00000030265.3
Dph2
DPH2 homolog (S. cerevisiae)
chr15_-_101370125 0.35 ENSMUST00000077196.4
Krt80
keratin 80
chr5_+_24364804 0.32 ENSMUST00000030834.4
ENSMUST00000115090.1
Nos3
nitric oxide synthase 3, endothelial cell
chr11_-_74724670 0.28 ENSMUST00000021091.8
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr19_+_12798574 0.26 ENSMUST00000025601.6
Lpxn
leupaxin
chr6_+_129408854 0.23 ENSMUST00000058352.8
ENSMUST00000164513.2
ENSMUST00000088075.5
Clec9a
C-type lectin domain family 9, member a
chr9_-_66126559 0.22 ENSMUST00000137542.1
Snx1
sorting nexin 1
chr4_+_10874498 0.21 ENSMUST00000080517.7
ENSMUST00000101504.2
2610301B20Rik
RIKEN cDNA 2610301B20 gene
chr14_-_101729690 0.19 ENSMUST00000066461.3
Gm9922
predicted gene 9922
chr12_+_95692212 0.17 ENSMUST00000057324.3
Flrt2
fibronectin leucine rich transmembrane protein 2
chr4_+_83417715 0.15 ENSMUST00000030206.3
ENSMUST00000071544.4
Snapc3
small nuclear RNA activating complex, polypeptide 3
chr4_+_108847827 0.15 ENSMUST00000102738.2
Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr15_+_62039216 0.14 ENSMUST00000183297.1
Pvt1
plasmacytoma variant translocation 1
chr2_+_35132194 0.13 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
Cep110
centrosomal protein 110
chr14_+_64950037 0.12 ENSMUST00000043914.5
Ints9
integrator complex subunit 9
chr8_+_27260327 0.08 ENSMUST00000033880.5
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr1_-_16656843 0.04 ENSMUST00000115352.3
Tceb1
transcription elongation factor B (SIII), polypeptide 1
chr4_-_6990774 0.03 ENSMUST00000039987.3
Tox
thymocyte selection-associated high mobility group box
chr7_-_46795661 0.01 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)

Network of associatons between targets according to the STRING database.

First level regulatory network of Cbfb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.7 2.0 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
0.5 2.6 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560)
0.3 1.2 GO:0002572 pro-T cell differentiation(GO:0002572)
0.2 0.7 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.4 GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983)
0.1 1.4 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.4 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.3 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 1.1 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.2 GO:0009301 snRNA transcription(GO:0009301)
0.0 1.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.3 GO:0000235 astral microtubule(GO:0000235)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.0 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.3 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.1 2.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.1 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.1 1.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.4 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 2.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation