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GSE58827: Dynamics of the Mouse Liver

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Results for Cdx2

Z-value: 0.66

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Transcription factors associated with Cdx2

Gene Symbol Gene ID Gene Info
Cdx2
ENSMUSG00000029646.3 caudal type homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cdx2mm10_v2_chr5_-_147307264_147307281-0.353.8e-02Click!

Activity profile of Cdx2 motif

Sorted Z-values of Cdx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_131032061 8.97 ENSMUST00000084509.3
Dmbt1
deleted in malignant brain tumors 1
chr8_-_105933832 4.25 ENSMUST00000034368.6
Ctrl
chymotrypsin-like
chr7_+_140763739 3.40 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr11_-_99438143 2.84 ENSMUST00000017743.2
Krt20
keratin 20
chr9_-_65422773 2.67 ENSMUST00000065894.5
Slc51b
solute carrier family 51, beta subunit
chr1_-_89933290 2.33 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr5_+_146079254 2.31 ENSMUST00000035571.8
Cyp3a59
cytochrome P450, family 3, subfamily a, polypeptide 59
chr3_-_90695706 1.96 ENSMUST00000069960.5
ENSMUST00000117167.1
S100a9
S100 calcium binding protein A9 (calgranulin B)
chrX_+_164090187 1.61 ENSMUST00000015545.3
Tmem27
transmembrane protein 27
chr14_+_80000292 1.33 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr17_+_80307396 1.13 ENSMUST00000068175.5
Arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr4_-_64046925 1.11 ENSMUST00000107377.3
Tnc
tenascin C
chr6_-_49214954 1.03 ENSMUST00000031838.7
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr11_-_99244058 0.96 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chrX_+_96455359 0.85 ENSMUST00000033553.7
Heph
hephaestin
chr1_-_144249134 0.82 ENSMUST00000172388.1
Rgs1
regulator of G-protein signaling 1
chr5_+_13399309 0.76 ENSMUST00000030714.7
ENSMUST00000141968.1
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr11_+_96323253 0.76 ENSMUST00000093944.3
Hoxb3
homeobox B3
chr18_+_65582239 0.70 ENSMUST00000182684.1
Zfp532
zinc finger protein 532
chrX_+_164140447 0.70 ENSMUST00000073973.4
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr19_-_47692042 0.68 ENSMUST00000026045.7
ENSMUST00000086923.5
Col17a1
collagen, type XVII, alpha 1
chr3_+_57425314 0.66 ENSMUST00000029377.7
Tm4sf4
transmembrane 4 superfamily member 4
chr1_-_169747634 0.66 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4
regulator of G-protein signaling 4
chrX_+_13632769 0.61 ENSMUST00000096492.3
Gpr34
G protein-coupled receptor 34
chr15_-_101491509 0.61 ENSMUST00000023718.7
5430421N21Rik
RIKEN cDNA 5430421N21 gene
chr5_-_135744206 0.54 ENSMUST00000153399.1
ENSMUST00000043378.2
Tmem120a
transmembrane protein 120A
chr18_+_65582390 0.53 ENSMUST00000169679.1
ENSMUST00000183326.1
Zfp532
zinc finger protein 532
chr6_-_13839916 0.50 ENSMUST00000060442.7
Gpr85
G protein-coupled receptor 85
chr1_-_163289214 0.48 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr4_-_137118135 0.48 ENSMUST00000154285.1
Gm13001
predicted gene 13001
chr12_-_102878406 0.45 ENSMUST00000045652.6
Btbd7
BTB (POZ) domain containing 7
chr3_-_92485886 0.43 ENSMUST00000054599.7
Sprr1a
small proline-rich protein 1A
chr3_+_126597415 0.43 ENSMUST00000066452.7
ENSMUST00000171289.1
ENSMUST00000106399.1
Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr3_+_118433797 0.39 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
Gm26871
predicted gene, 26871
chr14_-_54686060 0.38 ENSMUST00000125265.1
Acin1
apoptotic chromatin condensation inducer 1
chr13_-_107890059 0.35 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr12_+_85473883 0.35 ENSMUST00000021674.6
Fos
FBJ osteosarcoma oncogene
chr1_-_186705980 0.33 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr9_-_45936049 0.33 ENSMUST00000034590.2
Tagln
transgelin
chr6_+_38918969 0.31 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr5_+_90460889 0.31 ENSMUST00000031314.8
Alb
albumin
chr3_+_95658771 0.31 ENSMUST00000178686.1
Mcl1
myeloid cell leukemia sequence 1
chr2_+_31759932 0.31 ENSMUST00000028190.6
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr12_+_77238093 0.31 ENSMUST00000177595.1
ENSMUST00000171770.2
Fut8
fucosyltransferase 8
chr5_-_122697603 0.30 ENSMUST00000071235.4
Gm10064
predicted gene 10064
chr1_+_12692430 0.29 ENSMUST00000180062.1
ENSMUST00000177608.1
Sulf1
sulfatase 1
chr6_+_17491216 0.27 ENSMUST00000080469.5
Met
met proto-oncogene
chr3_+_126597299 0.25 ENSMUST00000106400.2
ENSMUST00000106401.1
Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr10_+_69787431 0.25 ENSMUST00000183240.1
Ank3
ankyrin 3, epithelial
chr8_-_33843562 0.23 ENSMUST00000183062.1
Rbpms
RNA binding protein gene with multiple splicing
chr18_+_37755718 0.23 ENSMUST00000061279.7
Pcdhga9
protocadherin gamma subfamily A, 9
chr3_-_10208569 0.23 ENSMUST00000029041.4
Fabp4
fatty acid binding protein 4, adipocyte
chr18_+_65582281 0.23 ENSMUST00000183319.1
Zfp532
zinc finger protein 532
chr6_+_71199827 0.21 ENSMUST00000067492.7
Fabp1
fatty acid binding protein 1, liver
chr2_+_31759993 0.18 ENSMUST00000124089.1
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr8_+_54550324 0.18 ENSMUST00000033918.2
Asb5
ankyrin repeat and SOCs box-containing 5
chr17_-_31129602 0.18 ENSMUST00000024827.4
Tff3
trefoil factor 3, intestinal
chr3_+_95658714 0.17 ENSMUST00000037947.8
Mcl1
myeloid cell leukemia sequence 1
chr6_-_71262232 0.16 ENSMUST00000129630.2
ENSMUST00000114186.2
ENSMUST00000074301.3
Smyd1
SET and MYND domain containing 1
chr15_+_3270767 0.13 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1
selenoprotein P, plasma, 1
chrX_-_51205990 0.12 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr5_+_121777929 0.08 ENSMUST00000160821.1
Atxn2
ataxin 2
chr3_-_14778452 0.07 ENSMUST00000094365.4
Car1
carbonic anhydrase 1
chr6_-_99044414 0.07 ENSMUST00000177507.1
ENSMUST00000123992.1
Foxp1
forkhead box P1
chr6_-_122340525 0.06 ENSMUST00000112600.2
Phc1
polyhomeotic-like 1 (Drosophila)
chr19_-_34879452 0.06 ENSMUST00000036584.5
Pank1
pantothenate kinase 1
chr11_-_100105626 0.05 ENSMUST00000107416.2
Krt36
keratin 36
chr2_+_4300462 0.05 ENSMUST00000175669.1
Frmd4a
FERM domain containing 4A
chr18_+_11839220 0.04 ENSMUST00000171109.1
ENSMUST00000046948.8
Cables1
CDK5 and Abl enzyme substrate 1
chr13_+_63282142 0.04 ENSMUST00000159152.1
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr8_+_94386486 0.04 ENSMUST00000034220.7
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr10_+_52391606 0.02 ENSMUST00000067085.4
Nepn
nephrocan
chrX_+_139684980 0.02 ENSMUST00000096313.3
Tbc1d8b
TBC1 domain family, member 8B
chr15_+_23036449 0.02 ENSMUST00000164787.1
Cdh18
cadherin 18
chr8_+_15057646 0.01 ENSMUST00000033842.3
Myom2
myomesin 2
chr16_-_44016387 0.00 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0070488 neutrophil aggregation(GO:0070488)
0.5 9.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 2.7 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.3 2.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.3 1.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 1.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 0.7 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.2 0.5 GO:1990051 negative regulation of phospholipase C activity(GO:1900275) activation of protein kinase C activity(GO:1990051)
0.2 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 0.8 GO:0021824 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 3.4 GO:0017144 drug metabolic process(GO:0017144)
0.1 0.7 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.1 0.3 GO:0035910 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.3 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 2.8 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.5 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.3 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.7 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.3 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.2 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.4 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.2 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.3 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.3 GO:0042581 specific granule(GO:0042581)
0.1 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0061574 ASAP complex(GO:0061574)
0.0 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.9 GO:0043194 axon initial segment(GO:0043194)
0.0 2.8 GO:0005882 intermediate filament(GO:0005882)
0.0 3.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.3 2.3 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.2 2.0 GO:0050786 Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786)
0.2 9.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.1 GO:0045545 syndecan binding(GO:0045545)
0.1 3.4 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.5 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 3.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 1.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 4.3 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 10.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation