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GSE58827: Dynamics of the Mouse Liver
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Results for Cebpe
Z-value: 2.96
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Transcription factors associated with Cebpe
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cebpe | mm10_v2_chr14_-_54712139_54712174 | -0.77 | 5.0e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_128960965 Show fit | 36.79 |
ENSMUST00000026398.3
|
methyltransferase like 7B |
|
| chr5_-_87337165 Show fit | 32.14 |
ENSMUST00000031195.2
|
UDP glucuronosyltransferase 2 family, polypeptide A3 |
|
| chr4_-_60499332 Show fit | 31.88 |
ENSMUST00000135953.1
|
major urinary protein 1 |
|
| chr1_-_139781236 Show fit | 31.43 |
ENSMUST00000027612.8
ENSMUST00000111989.2 ENSMUST00000111986.2 |
predicted gene 4788 |
|
| chr19_-_39463067 Show fit | 29.98 |
ENSMUST00000035488.2
|
cytochrome P450, family 2, subfamily c, polypeptide 38 |
|
| chr19_+_39510844 Show fit | 29.23 |
ENSMUST00000025968.4
|
cytochrome P450, family 2, subfamily c, polypeptide 39 |
|
| chr19_+_39287074 Show fit | 28.02 |
ENSMUST00000003137.8
|
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
| chr15_+_9335550 Show fit | 24.29 |
ENSMUST00000072403.6
|
UDP glycosyltransferases 3 family, polypeptide A2 |
|
| chr8_-_72212837 Show fit | 20.39 |
ENSMUST00000098630.3
|
calcium and integrin binding family member 3 |
|
| chr6_-_55175019 Show fit | 18.94 |
ENSMUST00000003569.5
|
indolethylamine N-methyltransferase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Cebpe
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 146.0 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 3.0 | 78.5 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 4.6 | 77.7 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 3.9 | 54.4 | GO:0015747 | urate transport(GO:0015747) |
| 4.7 | 47.3 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 4.2 | 21.2 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 0.1 | 19.5 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.1 | 18.6 | GO:0009636 | response to toxic substance(GO:0009636) |
| 1.3 | 18.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 17.2 | GO:0032259 | methylation(GO:0032259) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 128.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 84.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 38.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 37.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 35.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 25.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.8 | 23.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.4 | 21.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 1.3 | 17.2 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 1.2 | 15.4 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 182.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 14.7 | 88.1 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 1.9 | 58.3 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 3.6 | 54.4 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.2 | 40.3 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 1.6 | 32.8 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 10.6 | 31.9 | GO:0005186 | insulin-activated receptor activity(GO:0005009) pheromone activity(GO:0005186) |
| 0.6 | 27.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.7 | 24.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.4 | 22.3 | GO:0016776 | phosphotransferase activity, phosphate group as acceptor(GO:0016776) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 17.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 13.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 12.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 11.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 11.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 10.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 10.6 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.2 | 10.5 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.5 | 10.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 40.8 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 2.2 | 28.2 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 1.8 | 25.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.0 | 22.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.3 | 20.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 18.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 18.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.3 | 17.3 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.9 | 16.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.9 | 16.0 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |