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GSE58827: Dynamics of the Mouse Liver

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Results for Clock

Z-value: 0.68

Motif logo

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Transcription factors associated with Clock

Gene Symbol Gene ID Gene Info
Clock
ENSMUSG00000029238.8 circadian locomotor output cycles kaput

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_763045480.502.1e-03Click!

Activity profile of Clock motif

Sorted Z-values of Clock motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_17463826 1.97 ENSMUST00000140070.1
Met
met proto-oncogene
chr3_-_95882193 1.68 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
Gm129
predicted gene 129
chr16_+_32608973 1.67 ENSMUST00000120680.1
Tfrc
transferrin receptor
chr17_-_26199008 1.46 ENSMUST00000142410.1
ENSMUST00000120333.1
ENSMUST00000039113.7
Pdia2
protein disulfide isomerase associated 2
chr6_+_17463927 1.41 ENSMUST00000115442.1
Met
met proto-oncogene
chr15_+_81811414 1.33 ENSMUST00000023024.7
Tef
thyrotroph embryonic factor
chr19_+_26623419 1.33 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_31887262 1.27 ENSMUST00000138325.1
ENSMUST00000028187.6
Lamc3
laminin gamma 3
chr3_-_95882232 1.27 ENSMUST00000161866.1
Gm129
predicted gene 129
chr11_+_69095217 1.22 ENSMUST00000101004.2
Per1
period circadian clock 1
chr9_+_44067072 1.20 ENSMUST00000177054.1
Usp2
ubiquitin specific peptidase 2
chr9_+_44066993 1.18 ENSMUST00000034508.7
Usp2
ubiquitin specific peptidase 2
chr3_-_95882031 1.14 ENSMUST00000161994.1
Gm129
predicted gene 129
chr5_-_108795352 1.14 ENSMUST00000004943.1
Tmed11
transmembrane emp24 protein transport domain containing
chr5_-_76951560 1.14 ENSMUST00000140076.1
Ppat
phosphoribosyl pyrophosphate amidotransferase
chr16_-_45158453 1.09 ENSMUST00000181750.1
Slc35a5
solute carrier family 35, member A5
chr16_-_45158183 1.03 ENSMUST00000114600.1
Slc35a5
solute carrier family 35, member A5
chr16_-_45158624 0.96 ENSMUST00000180636.1
Slc35a5
solute carrier family 35, member A5
chr19_-_29805507 0.90 ENSMUST00000175726.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr5_-_22344690 0.90 ENSMUST00000062372.7
ENSMUST00000161356.1
Reln
reelin
chr5_+_76951382 0.80 ENSMUST00000141687.1
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr7_-_46795661 0.79 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr15_-_10714612 0.72 ENSMUST00000169385.1
Rai14
retinoic acid induced 14
chr8_+_90828820 0.72 ENSMUST00000109614.2
ENSMUST00000048665.6
Chd9
chromodomain helicase DNA binding protein 9
chr15_+_80671829 0.71 ENSMUST00000023044.5
Fam83f
family with sequence similarity 83, member F
chr16_+_43889896 0.70 ENSMUST00000122014.1
ENSMUST00000178400.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr4_-_82705735 0.68 ENSMUST00000155821.1
Nfib
nuclear factor I/B
chr4_-_133756769 0.67 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr1_-_52499980 0.67 ENSMUST00000164747.1
Nab1
Ngfi-A binding protein 1
chr7_+_66839726 0.63 ENSMUST00000098382.3
Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr3_+_41564880 0.62 ENSMUST00000168086.1
Phf17
PHD finger protein 17
chr13_-_100015562 0.60 ENSMUST00000022148.6
Mccc2
methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
chr12_+_59131473 0.58 ENSMUST00000177162.1
Ctage5
CTAGE family, member 5
chr16_+_43889800 0.57 ENSMUST00000132859.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr5_-_74702891 0.57 ENSMUST00000117388.1
Lnx1
ligand of numb-protein X 1
chr15_+_44787746 0.57 ENSMUST00000181839.1
2310069G16Rik
RIKEN cDNA 2310069G16 gene
chrX_+_36328353 0.57 ENSMUST00000016383.3
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr12_+_76255209 0.56 ENSMUST00000021443.5
Mthfd1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
chr4_+_44756609 0.56 ENSMUST00000143385.1
Zcchc7
zinc finger, CCHC domain containing 7
chr16_-_45158566 0.55 ENSMUST00000181177.1
Slc35a5
solute carrier family 35, member A5
chr2_+_14229390 0.54 ENSMUST00000028045.2
Mrc1
mannose receptor, C type 1
chr12_+_59131286 0.54 ENSMUST00000176464.1
ENSMUST00000170992.2
ENSMUST00000176322.1
Ctage5
CTAGE family, member 5
chr15_-_44788016 0.54 ENSMUST00000090057.4
ENSMUST00000110269.1
Sybu
syntabulin (syntaxin-interacting)
chr14_-_20181773 0.54 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr10_+_69534039 0.52 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr17_-_90455872 0.50 ENSMUST00000174337.1
ENSMUST00000172466.1
Nrxn1
neurexin I
chr7_-_144939823 0.49 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr11_-_106788845 0.49 ENSMUST00000123339.1
Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr6_-_23839137 0.49 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
Cadps2
Ca2+-dependent activator protein for secretion 2
chr16_+_43889936 0.48 ENSMUST00000151183.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr11_-_106789157 0.48 ENSMUST00000129585.1
Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr10_+_116301374 0.47 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr7_+_66839752 0.47 ENSMUST00000107478.1
Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr1_-_55088156 0.46 ENSMUST00000127861.1
ENSMUST00000144077.1
Hspd1
heat shock protein 1 (chaperonin)
chr6_-_23839420 0.46 ENSMUST00000115358.2
ENSMUST00000163871.2
Cadps2
Ca2+-dependent activator protein for secretion 2
chr15_-_102625436 0.45 ENSMUST00000184485.1
ENSMUST00000185070.1
ENSMUST00000184616.1
ENSMUST00000108828.2
ATF7
Cyclic AMP-dependent transcription factor ATF-7
chr11_-_95041335 0.44 ENSMUST00000038431.7
Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr6_+_17463749 0.43 ENSMUST00000115443.1
Met
met proto-oncogene
chr6_+_108660772 0.42 ENSMUST00000163617.1
Bhlhe40
basic helix-loop-helix family, member e40
chr11_+_100860447 0.42 ENSMUST00000107357.2
Stat5a
signal transducer and activator of transcription 5A
chr19_-_29812952 0.40 ENSMUST00000099525.3
Ranbp6
RAN binding protein 6
chr5_+_76951307 0.40 ENSMUST00000031160.9
ENSMUST00000120912.1
ENSMUST00000117536.1
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr5_+_76974683 0.40 ENSMUST00000101087.3
ENSMUST00000120550.1
Srp72
signal recognition particle 72
chr10_+_36974558 0.39 ENSMUST00000105510.1
Hdac2
histone deacetylase 2
chr4_+_57568144 0.37 ENSMUST00000102904.3
Palm2
paralemmin 2
chr6_-_47813512 0.36 ENSMUST00000077290.7
Pdia4
protein disulfide isomerase associated 4
chr10_+_67535465 0.36 ENSMUST00000145754.1
Egr2
early growth response 2
chr4_+_21848039 0.36 ENSMUST00000098238.2
ENSMUST00000108229.1
Sfrs18
serine/arginine-rich splicing factor 18
chr16_-_45158650 0.36 ENSMUST00000023344.3
Slc35a5
solute carrier family 35, member A5
chr3_-_106483435 0.35 ENSMUST00000164330.1
2010016I18Rik
RIKEN cDNA 2010016I18 gene
chr4_-_11386757 0.35 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1
epithelial splicing regulatory protein 1
chr3_+_135825788 0.34 ENSMUST00000167390.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr4_+_44756553 0.34 ENSMUST00000107824.2
Zcchc7
zinc finger, CCHC domain containing 7
chr1_-_186705980 0.34 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr11_-_106216318 0.32 ENSMUST00000002043.3
Ccdc47
coiled-coil domain containing 47
chr2_+_160645881 0.32 ENSMUST00000109468.2
Top1
topoisomerase (DNA) I
chr16_-_43889669 0.32 ENSMUST00000023387.7
Qtrtd1
queuine tRNA-ribosyltransferase domain containing 1
chr4_-_11386679 0.32 ENSMUST00000043781.7
ENSMUST00000108310.1
Esrp1
epithelial splicing regulatory protein 1
chr2_-_130906338 0.31 ENSMUST00000146975.1
4930402H24Rik
RIKEN cDNA 4930402H24 gene
chr16_+_45158725 0.31 ENSMUST00000023343.3
Atg3
autophagy related 3
chr9_+_110333276 0.29 ENSMUST00000125823.1
ENSMUST00000131328.1
Scap
SREBF chaperone
chr11_-_118290167 0.29 ENSMUST00000144153.1
Usp36
ubiquitin specific peptidase 36
chr5_+_45493374 0.29 ENSMUST00000046122.6
Lap3
leucine aminopeptidase 3
chr5_-_45857473 0.29 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
Lcorl
ligand dependent nuclear receptor corepressor-like
chr3_+_135825648 0.28 ENSMUST00000180196.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr3_-_101604580 0.28 ENSMUST00000036493.6
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr11_-_51756378 0.28 ENSMUST00000109092.1
ENSMUST00000064297.4
ENSMUST00000109097.2
Sec24a
Sec24 related gene family, member A (S. cerevisiae)
chr13_+_37826225 0.28 ENSMUST00000128570.1
Rreb1
ras responsive element binding protein 1
chr10_+_44268328 0.28 ENSMUST00000039286.4
Atg5
autophagy related 5
chr4_-_116405986 0.28 ENSMUST00000123072.1
ENSMUST00000144281.1
Mast2
microtubule associated serine/threonine kinase 2
chr12_+_8674681 0.28 ENSMUST00000168361.1
ENSMUST00000169750.1
ENSMUST00000163730.1
Pum2
pumilio 2 (Drosophila)
chr7_-_25658726 0.28 ENSMUST00000071329.6
Bckdha
branched chain ketoacid dehydrogenase E1, alpha polypeptide
chr9_+_110333402 0.27 ENSMUST00000133114.1
ENSMUST00000125759.1
Scap
SREBF chaperone
chr9_-_121495678 0.27 ENSMUST00000035120.4
Cck
cholecystokinin
chr5_+_146231211 0.26 ENSMUST00000161181.1
ENSMUST00000161652.1
ENSMUST00000031640.8
ENSMUST00000159467.1
Cdk8
cyclin-dependent kinase 8
chr7_-_46795881 0.26 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr1_-_153332724 0.26 ENSMUST00000027752.8
Lamc1
laminin, gamma 1
chrX_+_56786527 0.26 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr2_-_38926217 0.25 ENSMUST00000076275.4
ENSMUST00000142130.1
Nr6a1
nuclear receptor subfamily 6, group A, member 1
chr1_-_166409773 0.24 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
Pogk
pogo transposable element with KRAB domain
chr11_-_100759740 0.24 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr10_-_127522428 0.22 ENSMUST00000026470.4
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_+_59684949 0.22 ENSMUST00000027174.3
Nop58
NOP58 ribonucleoprotein
chr18_+_42511496 0.22 ENSMUST00000025375.7
Tcerg1
transcription elongation regulator 1 (CA150)
chr11_+_114851814 0.22 ENSMUST00000053361.5
ENSMUST00000021071.7
ENSMUST00000136785.1
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chrX_-_48208566 0.22 ENSMUST00000037960.4
Zdhhc9
zinc finger, DHHC domain containing 9
chr5_+_93093428 0.22 ENSMUST00000074733.7
Sept11
septin 11
chrX_-_7572843 0.21 ENSMUST00000132788.1
Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr15_-_38078842 0.21 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr12_+_90738201 0.20 ENSMUST00000181874.1
Gm26512
predicted gene, 26512
chr3_+_58692589 0.20 ENSMUST00000181771.1
4930593A02Rik
RIKEN cDNA 4930593A02 gene
chr7_+_46796088 0.19 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1
general transcription factor II H, polypeptide 1
chr2_+_74762980 0.19 ENSMUST00000047793.4
Hoxd1
homeobox D1
chr2_-_130424242 0.18 ENSMUST00000089581.4
Pced1a
PC-esterase domain containing 1A
chr11_+_106789235 0.17 ENSMUST00000103068.3
ENSMUST00000018516.4
Cep95
centrosomal protein 95
chr9_+_58134017 0.17 ENSMUST00000134955.1
ENSMUST00000147134.1
ENSMUST00000170397.1
Stra6
stimulated by retinoic acid gene 6
chr11_-_72489904 0.16 ENSMUST00000045303.3
Spns2
spinster homolog 2
chr3_+_106482427 0.16 ENSMUST00000029508.4
Dennd2d
DENN/MADD domain containing 2D
chr11_+_67798269 0.16 ENSMUST00000168612.1
ENSMUST00000040574.4
Dhrs7c
dehydrogenase/reductase (SDR family) member 7C
chr2_+_18055203 0.16 ENSMUST00000028076.8
Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chrX_-_36864238 0.16 ENSMUST00000115249.3
ENSMUST00000115248.3
C330007P06Rik
RIKEN cDNA C330007P06 gene
chr9_+_58134535 0.16 ENSMUST00000128378.1
ENSMUST00000150820.1
ENSMUST00000167479.1
ENSMUST00000134450.1
Stra6
stimulated by retinoic acid gene 6
chr18_+_32837225 0.16 ENSMUST00000166214.1
ENSMUST00000053663.9
Wdr36
WD repeat domain 36
chr10_+_67535493 0.16 ENSMUST00000145936.1
Egr2
early growth response 2
chr16_+_23429133 0.15 ENSMUST00000038730.6
Rtp1
receptor transporter protein 1
chrX_-_95444789 0.14 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr3_+_40708855 0.14 ENSMUST00000091184.6
Slc25a31
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chr6_+_125096145 0.13 ENSMUST00000112390.1
Chd4
chromodomain helicase DNA binding protein 4
chr2_-_147186389 0.13 ENSMUST00000109970.3
ENSMUST00000067075.5
Nkx2-2
NK2 homeobox 2
chr3_-_129332713 0.13 ENSMUST00000029658.7
Enpep
glutamyl aminopeptidase
chr11_+_17211912 0.13 ENSMUST00000046955.6
Wdr92
WD repeat domain 92
chr12_+_71136848 0.13 ENSMUST00000149564.1
ENSMUST00000045907.8
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr4_+_97777780 0.13 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
Nfia
nuclear factor I/A
chr9_-_57606234 0.12 ENSMUST00000045068.8
Cplx3
complexin 3
chr15_-_43170809 0.11 ENSMUST00000063492.6
Rspo2
R-spondin 2 homolog (Xenopus laevis)
chr9_+_40801235 0.10 ENSMUST00000117870.1
ENSMUST00000117557.1
Hspa8
heat shock protein 8
chr15_+_10714836 0.10 ENSMUST00000180604.1
4930556M19Rik
RIKEN cDNA 4930556M19 gene
chr11_-_100759942 0.10 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr17_-_87265866 0.09 ENSMUST00000145895.1
ENSMUST00000129616.1
ENSMUST00000155904.1
ENSMUST00000151155.1
ENSMUST00000144236.1
ENSMUST00000024963.3
Mcfd2
multiple coagulation factor deficiency 2
chr8_-_45999860 0.09 ENSMUST00000053558.9
Ankrd37
ankyrin repeat domain 37
chr4_-_132075250 0.08 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1
erythrocyte protein band 4.1
chr2_-_32694120 0.08 ENSMUST00000028148.4
Fpgs
folylpolyglutamyl synthetase
chr11_+_74649462 0.08 ENSMUST00000092915.5
ENSMUST00000117818.1
Cluh
clustered mitochondria (cluA/CLU1) homolog
chr6_+_108660616 0.08 ENSMUST00000032194.4
Bhlhe40
basic helix-loop-helix family, member e40
chr12_-_31950170 0.08 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr3_+_145576196 0.08 ENSMUST00000098534.4
Znhit6
zinc finger, HIT type 6
chr11_-_17211504 0.08 ENSMUST00000020317.7
Pno1
partner of NOB1 homolog (S. cerevisiae)
chr4_+_32657107 0.07 ENSMUST00000071642.4
ENSMUST00000178134.1
Mdn1
midasin homolog (yeast)
chr7_-_126695731 0.07 ENSMUST00000144897.1
Slx1b
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr2_+_130906461 0.06 ENSMUST00000028781.8
Atrn
attractin
chr13_-_75943812 0.06 ENSMUST00000022078.5
ENSMUST00000109606.1
Rhobtb3
Rho-related BTB domain containing 3
chr4_+_129960760 0.06 ENSMUST00000139884.1
1700003M07Rik
RIKEN cDNA 1700003M07 gene
chr2_+_32395896 0.06 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr11_-_99089296 0.05 ENSMUST00000017751.2
Tns4
tensin 4
chr11_+_106216926 0.05 ENSMUST00000021046.5
Ddx42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
chr7_-_68749170 0.05 ENSMUST00000118110.1
ENSMUST00000048068.7
Arrdc4
arrestin domain containing 4
chr11_+_76217608 0.05 ENSMUST00000040806.4
Dbil5
diazepam binding inhibitor-like 5
chr10_+_97693053 0.05 ENSMUST00000060703.4
Ccer1
coiled coil glutamate rich protein 1
chr16_+_4036942 0.05 ENSMUST00000137748.1
ENSMUST00000006136.4
ENSMUST00000157044.1
ENSMUST00000120009.1
Dnase1
deoxyribonuclease I
chr15_-_98807910 0.05 ENSMUST00000075444.6
Ddn
dendrin
chr5_+_129941949 0.04 ENSMUST00000051758.7
ENSMUST00000073945.4
Vkorc1l1
vitamin K epoxide reductase complex, subunit 1-like 1
chr16_-_33967032 0.04 ENSMUST00000023510.6
Umps
uridine monophosphate synthetase
chrX_+_6047453 0.04 ENSMUST00000103007.3
Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr17_+_71204647 0.04 ENSMUST00000126681.1
Lpin2
lipin 2
chr1_-_55088024 0.04 ENSMUST00000027123.8
Hspd1
heat shock protein 1 (chaperonin)
chr11_-_55033398 0.04 ENSMUST00000108883.3
ENSMUST00000102727.2
Anxa6
annexin A6
chr5_+_120116480 0.03 ENSMUST00000031590.8
Rbm19
RNA binding motif protein 19
chr5_+_135168283 0.03 ENSMUST00000031692.5
Bcl7b
B cell CLL/lymphoma 7B
chr1_+_181352618 0.03 ENSMUST00000161880.1
ENSMUST00000027795.7
Cnih3
cornichon homolog 3 (Drosophila)
chr2_+_83644435 0.02 ENSMUST00000081591.6
Zc3h15
zinc finger CCCH-type containing 15
chr5_-_74531619 0.02 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2
Sec1 family domain containing 2
chr3_-_108085346 0.02 ENSMUST00000078912.5
Ampd2
adenosine monophosphate deaminase 2
chr12_-_31950210 0.02 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1
high mobility group box transcription factor 1
chr11_-_118290188 0.02 ENSMUST00000106296.2
ENSMUST00000092382.3
Usp36
ubiquitin specific peptidase 36
chr12_-_66284394 0.02 ENSMUST00000081908.6
Rpl10l
ribosomal protein L10-like
chr2_+_115581667 0.01 ENSMUST00000166472.1
ENSMUST00000110918.2
BC052040
cDNA sequence BC052040
chr11_-_60417022 0.01 ENSMUST00000108721.1
Atpaf2
ATP synthase mitochondrial F1 complex assembly factor 2
chr1_-_82291370 0.01 ENSMUST00000069799.2
Irs1
insulin receptor substrate 1
chr4_-_57143437 0.01 ENSMUST00000095076.3
ENSMUST00000030142.3
Epb4.1l4b
erythrocyte protein band 4.1-like 4b
chr5_-_34187670 0.01 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4
Max dimerization protein 4
chr11_-_77489666 0.01 ENSMUST00000037593.7
ENSMUST00000092892.3
Ankrd13b
ankyrin repeat domain 13b
chr11_+_60417238 0.00 ENSMUST00000070681.6
Gid4
GID complex subunit 4, VID24 homolog (S. cerevisiae)
chr4_+_104328252 0.00 ENSMUST00000094945.1
Gm10304
predicted gene 10304

Network of associatons between targets according to the STRING database.

First level regulatory network of Clock

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 1.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.2 1.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 0.9 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.2 1.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 0.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 0.5 GO:0045041 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.5 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 1.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.6 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.5 GO:0021660 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.1 0.5 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 1.7 GO:0033572 transferrin transport(GO:0033572)
0.1 0.9 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 0.3 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.4 GO:0050812 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.1 2.4 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 0.4 GO:0060376 positive regulation of mast cell differentiation(GO:0060376)
0.1 0.3 GO:0035973 aggrephagy(GO:0035973)
0.1 1.0 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1 0.5 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 0.3 GO:1903416 response to glycoside(GO:1903416)
0.1 0.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 0.2 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.6 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.3 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 1.3 GO:0014002 astrocyte development(GO:0014002)
0.0 0.3 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 0.3 GO:0006265 DNA topological change(GO:0006265)
0.0 0.3 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.0 1.5 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0006983 ER overload response(GO:0006983)
0.0 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.3 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 0.3 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.3 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.3 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.2 GO:0048069 sphingosine-1-phosphate signaling pathway(GO:0003376) eye pigmentation(GO:0048069)
0.0 0.6 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.1 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.0 0.1 GO:0072553 terminal button organization(GO:0072553)
0.0 0.1 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.0 0.1 GO:0002003 angiotensin maturation(GO:0002003)
0.0 0.2 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.7 GO:0014037 Schwann cell differentiation(GO:0014037)
0.0 4.0 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.7 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.3 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.0 0.1 GO:0072161 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.3 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.4 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.5 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.0 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.0 GO:0006222 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0072189 ureter development(GO:0072189)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.2 1.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.5 GO:0097433 dense body(GO:0097433)
0.1 2.0 GO:0071564 npBAF complex(GO:0071564)
0.1 0.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.9 GO:0071141 SMAD protein complex(GO:0071141)
0.1 0.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.3 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.3 GO:0005606 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 0.2 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:0001651 dense fibrillar component(GO:0001651)
0.1 4.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.5 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0043203 axon hillock(GO:0043203)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 4.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.9 GO:0042734 presynaptic membrane(GO:0042734)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.6 1.7 GO:0004998 transferrin receptor activity(GO:0004998)
0.3 1.0 GO:0035500 MH2 domain binding(GO:0035500)
0.2 0.6 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 0.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.2 4.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 0.9 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 1.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.4 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.4 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.1 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.5 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.3 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 0.2 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.2 GO:0005118 sevenless binding(GO:0005118)
0.1 0.6 GO:0016421 CoA carboxylase activity(GO:0016421)
0.1 0.4 GO:0008312 signal recognition particle binding(GO:0005047) 7S RNA binding(GO:0008312)
0.1 0.2 GO:2001069 glycogen binding(GO:2001069)
0.0 0.5 GO:0043426 MRF binding(GO:0043426)
0.0 2.4 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 1.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.3 GO:1990239 sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 1.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.5 GO:0005537 mannose binding(GO:0005537)
0.0 0.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 3.7 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.8 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.7 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)