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GSE58827: Dynamics of the Mouse Liver

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Results for E2f7

Z-value: 1.40

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Transcription factors associated with E2f7

Gene Symbol Gene ID Gene Info
E2f7
ENSMUSG00000020185.10 E2F transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.835.3e-10Click!

Activity profile of E2f7 motif

Sorted Z-values of E2f7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_108579445 15.06 ENSMUST00000102744.3
Orc1
origin recognition complex, subunit 1
chr7_-_142578139 11.19 ENSMUST00000136359.1
H19
H19 fetal liver mRNA
chr15_+_102296256 10.13 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr13_-_100775844 9.68 ENSMUST00000075550.3
Cenph
centromere protein H
chr12_+_24708984 8.71 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr10_+_3973086 8.65 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr13_-_21833575 8.13 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr11_+_102248842 8.07 ENSMUST00000100392.4
BC030867
cDNA sequence BC030867
chr13_-_21753851 7.68 ENSMUST00000074752.2
Hist1h2ak
histone cluster 1, H2ak
chr12_+_24708241 7.50 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr4_+_136172367 7.39 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr10_-_69352886 7.12 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1
cyclin-dependent kinase 1
chr3_+_108383829 6.10 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
Psrc1
proline/serine-rich coiled-coil 1
chr9_-_58741543 6.08 ENSMUST00000098674.4
2410076I21Rik
RIKEN cDNA 2410076I21 gene
chr14_-_54641347 5.79 ENSMUST00000067784.6
Cdh24
cadherin-like 24
chr4_+_126556994 5.75 ENSMUST00000147675.1
Clspn
claspin
chr8_+_75109528 5.71 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr4_+_126556935 5.67 ENSMUST00000048391.8
Clspn
claspin
chr2_+_72476159 5.39 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr6_-_88898664 5.11 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr13_-_22042949 4.73 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr13_+_21810428 4.72 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr2_+_72476225 4.63 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr13_+_22043189 4.62 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr18_+_56707725 4.41 ENSMUST00000025486.8
Lmnb1
lamin B1
chr10_+_11281304 4.34 ENSMUST00000129456.1
Fbxo30
F-box protein 30
chr10_+_11281583 4.33 ENSMUST00000070300.4
Fbxo30
F-box protein 30
chr7_-_44548733 3.96 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1
polymerase (DNA directed), delta 1, catalytic subunit
chr12_+_73286868 3.94 ENSMUST00000153941.1
ENSMUST00000122920.1
ENSMUST00000101313.3
Slc38a6
solute carrier family 38, member 6
chr13_-_21783391 3.78 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr11_-_69560186 3.70 ENSMUST00000004036.5
Efnb3
ephrin B3
chr14_-_20388822 3.70 ENSMUST00000022345.6
Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr12_-_11265768 3.58 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr9_+_3017408 3.47 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr6_-_67037399 3.43 ENSMUST00000043098.6
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr13_-_55329723 3.39 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chr1_-_128359610 3.26 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr17_-_35516780 3.11 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19
transcription factor 19
chr7_+_66109474 3.04 ENSMUST00000036372.6
Chsy1
chondroitin sulfate synthase 1
chr13_+_23581563 2.89 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr3_+_88532314 2.81 ENSMUST00000172699.1
Mex3a
mex3 homolog A (C. elegans)
chr4_+_132768325 2.79 ENSMUST00000102561.4
Rpa2
replication protein A2
chr1_-_180813591 2.76 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3f3a
H3 histone, family 3A
chr11_-_87404380 2.69 ENSMUST00000067692.6
Rad51c
RAD51 homolog C
chr9_+_64281575 2.61 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr9_+_3015654 2.60 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr13_+_21716385 2.54 ENSMUST00000070124.3
Hist1h2ai
histone cluster 1, H2ai
chr13_+_23555023 2.48 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chr1_-_156474249 2.46 ENSMUST00000051396.6
Soat1
sterol O-acyltransferase 1
chr13_-_22035589 2.43 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr9_+_3013140 2.43 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr11_-_70410010 2.39 ENSMUST00000019065.3
ENSMUST00000135148.1
Pelp1
proline, glutamic acid and leucine rich protein 1
chr10_-_35711891 2.22 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chrX_+_153006461 2.20 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr14_+_79451791 2.17 ENSMUST00000100359.1
Zbtbd6
kelch repeat and BTB (POZ) domain containing 6
chr7_+_35802593 2.14 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr9_+_3025417 2.10 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr13_+_23574381 2.09 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr13_+_109685994 2.04 ENSMUST00000074103.5
Pde4d
phosphodiesterase 4D, cAMP specific
chrX_-_37085402 1.99 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chr16_+_38346986 1.99 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
Cox17
Gm21987
cytochrome c oxidase assembly protein 17
predicted gene 21987
chr18_+_44104407 1.98 ENSMUST00000081271.5
Spink12
serine peptidase inhibitor, Kazal type 11
chr1_+_172521044 1.97 ENSMUST00000085894.5
ENSMUST00000161140.1
ENSMUST00000162988.1
Ccdc19
coiled-coil domain containing 19
chr7_+_110122299 1.96 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr15_+_82298943 1.81 ENSMUST00000023089.3
Wbp2nl
WBP2 N-terminal like
chr1_+_74506044 1.79 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr1_+_136683375 1.76 ENSMUST00000181524.1
Gm19705
predicted gene, 19705
chr9_+_3037111 1.74 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr5_+_129020069 1.73 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran
RAN, member RAS oncogene family
chr4_+_124714776 1.71 ENSMUST00000030734.4
Sf3a3
splicing factor 3a, subunit 3
chr10_-_117376922 1.55 ENSMUST00000177145.1
ENSMUST00000176670.1
Cpsf6
cleavage and polyadenylation specific factor 6
chr13_+_21754067 1.43 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr5_+_135187251 1.43 ENSMUST00000002825.5
Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr9_+_44334685 1.41 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr15_+_84720052 1.38 ENSMUST00000006029.4
ENSMUST00000172307.2
Arhgap8
Rho GTPase activating protein 8
chr19_+_8723478 1.38 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1
small nucleolar RNA host gene (non-protein coding) 1
chrX_+_68678541 1.34 ENSMUST00000088546.5
Fmr1
fragile X mental retardation syndrome 1
chr3_+_14533817 1.29 ENSMUST00000169079.1
ENSMUST00000091325.3
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr12_-_12941827 1.29 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr7_-_28598140 1.27 ENSMUST00000040531.8
ENSMUST00000108283.1
Samd4b
Pak4
sterile alpha motif domain containing 4B
p21 protein (Cdc42/Rac)-activated kinase 4
chr7_-_45896656 1.26 ENSMUST00000120299.1
Syngr4
synaptogyrin 4
chr17_+_34850373 1.25 ENSMUST00000097343.4
ENSMUST00000173357.1
ENSMUST00000173065.1
ENSMUST00000165953.2
Nelfe
negative elongation factor complex member E, Rdbp
chr2_-_157204483 1.14 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr11_-_106301801 1.13 ENSMUST00000103071.3
Gh
growth hormone
chr1_+_118389058 1.10 ENSMUST00000049404.6
ENSMUST00000070989.7
ENSMUST00000165223.1
ENSMUST00000178710.1
Clasp1
CLIP associating protein 1
chr7_+_28169744 1.08 ENSMUST00000042405.6
Fbl
fibrillarin
chr10_-_117376955 1.05 ENSMUST00000069168.6
ENSMUST00000176686.1
Cpsf6
cleavage and polyadenylation specific factor 6
chr11_+_43681998 1.04 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr4_-_108579330 1.04 ENSMUST00000079213.5
Prpf38a
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr11_+_43682038 1.03 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr3_+_14533788 1.00 ENSMUST00000108370.2
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr11_+_87127267 0.89 ENSMUST00000139532.1
Trim37
tripartite motif-containing 37
chr15_-_81871883 0.88 ENSMUST00000023117.8
Phf5a
PHD finger protein 5A
chr7_+_44816088 0.87 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62
nucleoporin 62
chrX_-_73966329 0.87 ENSMUST00000114372.2
ENSMUST00000033761.6
Hcfc1
host cell factor C1
chr1_-_191183244 0.86 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr13_+_22035821 0.86 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr2_+_179442427 0.85 ENSMUST00000000314.6
Cdh4
cadherin 4
chr17_-_35046726 0.84 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr3_-_57847478 0.79 ENSMUST00000120289.1
ENSMUST00000066882.8
Pfn2
profilin 2
chr12_+_55836365 0.78 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr3_+_14533867 0.77 ENSMUST00000163660.1
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr4_+_136286061 0.75 ENSMUST00000069195.4
ENSMUST00000130658.1
Zfp46
zinc finger protein 46
chr11_-_77513335 0.73 ENSMUST00000060417.4
Trp53i13
transformation related protein 53 inducible protein 13
chr5_-_137533170 0.70 ENSMUST00000168746.1
ENSMUST00000170293.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr7_-_45694369 0.69 ENSMUST00000040636.6
Sec1
secretory blood group 1
chr4_+_94739276 0.62 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek
endothelial-specific receptor tyrosine kinase
chr9_-_121277160 0.59 ENSMUST00000051479.6
ENSMUST00000171923.1
Ulk4
unc-51-like kinase 4
chr17_+_12916329 0.50 ENSMUST00000089024.6
ENSMUST00000151287.1
ENSMUST00000143961.1
Tcp1
t-complex protein 1
chr13_-_21810190 0.49 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq
histone cluster 1, H2bq
chr12_+_112146187 0.48 ENSMUST00000128402.2
Kif26a
kinesin family member 26A
chrX_+_162760388 0.47 ENSMUST00000033720.5
ENSMUST00000112327.1
Rbbp7
retinoblastoma binding protein 7
chr11_+_85311232 0.45 ENSMUST00000020835.9
Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
chrX_+_68678624 0.43 ENSMUST00000114656.1
Fmr1
fragile X mental retardation syndrome 1
chr2_+_147364989 0.42 ENSMUST00000109968.2
Pax1
paired box gene 1
chr19_+_34550664 0.38 ENSMUST00000149829.1
ENSMUST00000102826.3
Ifit2
interferon-induced protein with tetratricopeptide repeats 2
chr17_-_34850162 0.37 ENSMUST00000046022.9
Skiv2l
superkiller viralicidic activity 2-like (S. cerevisiae)
chr11_+_88047693 0.34 ENSMUST00000079866.4
Srsf1
serine/arginine-rich splicing factor 1
chr1_+_180568913 0.34 ENSMUST00000027777.6
Parp1
poly (ADP-ribose) polymerase family, member 1
chr13_-_21716143 0.30 ENSMUST00000091756.1
Hist1h2bl
histone cluster 1, H2bl
chrX_+_71981522 0.29 ENSMUST00000114569.1
Fate1
fetal and adult testis expressed 1
chr6_-_52183828 0.28 ENSMUST00000134831.1
Hoxa3
homeobox A3
chr6_-_30509706 0.24 ENSMUST00000064330.6
ENSMUST00000102991.2
ENSMUST00000115157.1
ENSMUST00000148638.1
Tmem209
transmembrane protein 209
chr15_-_98093245 0.22 ENSMUST00000180657.1
Senp1
SUMO1/sentrin specific peptidase 1
chr13_-_97198351 0.17 ENSMUST00000022169.7
Hexb
hexosaminidase B
chr3_+_60501252 0.16 ENSMUST00000099087.2
Mbnl1
muscleblind-like 1 (Drosophila)
chr17_+_35517100 0.13 ENSMUST00000164242.2
ENSMUST00000045956.7
Cchcr1
coiled-coil alpha-helical rod protein 1
chr5_-_92348871 0.10 ENSMUST00000038816.6
ENSMUST00000118006.1
Cxcl10
chemokine (C-X-C motif) ligand 10
chr17_+_33524170 0.09 ENSMUST00000087623.6
Adamts10
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
chr6_+_113077631 0.09 ENSMUST00000113157.1
Setd5
SET domain containing 5
chr9_+_111271832 0.08 ENSMUST00000060711.5
Epm2aip1
EPM2A (laforin) interacting protein 1
chr2_+_11172080 0.02 ENSMUST00000114853.1
Prkcq
protein kinase C, theta

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 15.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.5 4.4 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.4 8.7 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256) tetrahydrofolate biosynthetic process(GO:0046654)
1.3 4.0 GO:0045004 DNA replication proofreading(GO:0045004)
1.1 7.4 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.0 11.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.9 16.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.9 11.2 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.8 8.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 2.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.7 2.8 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.7 10.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.7 6.1 GO:0090166 Golgi disassembly(GO:0090166)
0.7 2.7 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.7 2.0 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.6 1.8 GO:1901254 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.5 2.6 GO:0000076 DNA replication checkpoint(GO:0000076)
0.4 3.7 GO:0016198 axon choice point recognition(GO:0016198)
0.4 3.6 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.3 5.3 GO:0051382 kinetochore assembly(GO:0051382)
0.3 2.5 GO:0016584 nucleosome positioning(GO:0016584)
0.3 3.0 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.3 0.9 GO:0032954 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.3 0.9 GO:0019046 release from viral latency(GO:0019046)
0.3 3.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 2.5 GO:0042984 very-low-density lipoprotein particle assembly(GO:0034379) amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 5.7 GO:0006270 DNA replication initiation(GO:0006270)
0.2 24.7 GO:0006342 chromatin silencing(GO:0006342)
0.2 1.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.9 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 6.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 1.1 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.2 1.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 6.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.2 0.9 GO:0046600 histone H2A-K119 monoubiquitination(GO:0036353) negative regulation of centriole replication(GO:0046600)
0.2 2.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 2.0 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.8 GO:0007343 egg activation(GO:0007343)
0.1 1.2 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.1 2.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.5 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.5 GO:0010286 heat acclimation(GO:0010286)
0.1 0.3 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.1 1.3 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 3.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 0.5 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.1 3.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.8 GO:0051026 chiasma assembly(GO:0051026)
0.1 1.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 2.2 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.4 GO:0061056 sclerotome development(GO:0061056)
0.1 4.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 2.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 6.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 1.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.3 GO:0010159 specification of organ position(GO:0010159)
0.0 1.1 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0 0.4 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 2.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.1 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.0 0.2 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.6 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 1.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 2.0 GO:0030010 establishment of cell polarity(GO:0030010)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 16.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.5 20.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
1.3 4.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 4.4 GO:0005638 lamin filament(GO:0005638)
0.6 1.7 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.5 2.7 GO:0048476 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.4 1.8 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.4 2.8 GO:0001740 Barr body(GO:0001740)
0.4 5.4 GO:0042555 MCM complex(GO:0042555)
0.4 2.6 GO:0031298 replication fork protection complex(GO:0031298)
0.4 0.4 GO:0055087 Ski complex(GO:0055087)
0.3 2.6 GO:0042382 paraspeckles(GO:0042382)
0.3 1.2 GO:0032021 NELF complex(GO:0032021)
0.3 20.6 GO:0000786 nucleosome(GO:0000786)
0.3 1.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 13.2 GO:0005876 spindle microtubule(GO:0005876)
0.2 1.1 GO:0001651 dense fibrillar component(GO:0001651)
0.2 2.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 3.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 10.5 GO:0005844 polysome(GO:0005844)
0.1 11.0 GO:0072686 mitotic spindle(GO:0072686)
0.1 2.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.4 GO:0043596 nuclear replication fork(GO:0043596)
0.1 0.9 GO:0070461 SAGA-type complex(GO:0070461)
0.1 1.9 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 10.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0070822 Sin3-type complex(GO:0070822)
0.0 5.3 GO:0000776 kinetochore(GO:0000776)
0.0 13.8 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.5 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 16.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.2 8.7 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
2.2 10.8 GO:0043515 kinetochore binding(GO:0043515)
1.9 11.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.0 3.0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.8 6.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.8 10.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 5.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 7.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3 2.2 GO:0019808 polyamine binding(GO:0019808)
0.3 1.7 GO:0070883 pre-miRNA binding(GO:0070883)
0.3 4.0 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.3 1.8 GO:0033592 RNA strand annealing activity(GO:0033592)
0.2 2.0 GO:0016531 copper chaperone activity(GO:0016531)
0.2 0.7 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.2 4.4 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.9 GO:0051425 PTB domain binding(GO:0051425)
0.1 1.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 6.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 10.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.9 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 3.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 3.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 2.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 10.1 GO:0001047 core promoter binding(GO:0001047)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 6.0 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 9.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 3.7 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 3.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.7 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 6.7 GO:0003682 chromatin binding(GO:0003682)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 3.1 GO:0008017 microtubule binding(GO:0008017)
0.0 6.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.1 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 9.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 7.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.5 21.9 PID ATR PATHWAY ATR signaling pathway
0.4 32.4 PID E2F PATHWAY E2F transcription factor network
0.2 2.5 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 5.2 PID AURORA A PATHWAY Aurora A signaling
0.1 2.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 8.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 3.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 1.4 PID ATM PATHWAY ATM pathway
0.1 2.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 22.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.5 7.4 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.2 16.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.1 14.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.8 6.8 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.4 21.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 6.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 2.0 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 6.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 2.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 3.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 3.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 4.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.6 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 1.1 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 2.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 2.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 2.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity