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GSE58827: Dynamics of the Mouse Liver

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Results for Egr3

Z-value: 0.91

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Transcription factors associated with Egr3

Gene Symbol Gene ID Gene Info
Egr3
ENSMUSG00000033730.3 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.105.7e-01Click!

Activity profile of Egr3 motif

Sorted Z-values of Egr3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_81975742 9.73 ENSMUST00000029645.8
Tdo2
tryptophan 2,3-dioxygenase
chr13_-_41847626 5.52 ENSMUST00000121404.1
Adtrp
androgen dependent TFPI regulating protein
chr13_-_41847599 4.95 ENSMUST00000179758.1
Adtrp
androgen dependent TFPI regulating protein
chr13_-_41847482 4.92 ENSMUST00000072012.3
Adtrp
androgen dependent TFPI regulating protein
chr10_-_68278713 4.33 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr2_-_148045891 3.50 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr6_-_124542281 3.20 ENSMUST00000159463.1
ENSMUST00000162844.1
ENSMUST00000160505.1
ENSMUST00000162443.1
C1s
complement component 1, s subcomponent
chr11_-_98775333 2.87 ENSMUST00000064941.6
Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr3_-_138131356 2.50 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr2_-_173119402 2.24 ENSMUST00000094287.3
ENSMUST00000179693.1
Ctcfl
CCCTC-binding factor (zinc finger protein)-like
chr6_+_91684061 2.23 ENSMUST00000032185.7
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr4_-_57300362 2.23 ENSMUST00000153926.1
Ptpn3
protein tyrosine phosphatase, non-receptor type 3
chr8_-_124751808 2.13 ENSMUST00000055257.5
Fam89a
family with sequence similarity 89, member A
chr19_-_38124801 2.10 ENSMUST00000112335.2
Rbp4
retinol binding protein 4, plasma
chr7_+_80246529 2.10 ENSMUST00000107381.1
Ttll13
tubulin tyrosine ligase-like family, member 13
chr7_+_80246375 2.05 ENSMUST00000058266.6
Ttll13
tubulin tyrosine ligase-like family, member 13
chr2_+_116067213 2.04 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr17_-_87282793 1.89 ENSMUST00000146560.2
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr11_-_109722214 1.85 ENSMUST00000020938.7
Fam20a
family with sequence similarity 20, member A
chr10_+_29143996 1.85 ENSMUST00000092629.2
Soga3
SOGA family member 3
chr1_-_157412576 1.70 ENSMUST00000078308.6
ENSMUST00000139470.1
Rasal2
RAS protein activator like 2
chr7_+_128523576 1.68 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr18_-_39490649 1.59 ENSMUST00000115567.1
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr2_+_32395896 1.55 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr10_+_59221945 1.55 ENSMUST00000182161.1
Sowahc
sosondowah ankyrin repeat domain family member C
chr16_+_64851991 1.53 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr6_-_144209558 1.53 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5
SRY-box containing gene 5
chr7_-_19023538 1.41 ENSMUST00000036018.5
Foxa3
forkhead box A3
chr5_+_102481546 1.41 ENSMUST00000112854.1
Arhgap24
Rho GTPase activating protein 24
chr4_-_41695935 1.40 ENSMUST00000145379.1
Cntfr
ciliary neurotrophic factor receptor
chr18_-_37935403 1.40 ENSMUST00000080033.6
ENSMUST00000115631.1
Diap1
diaphanous homolog 1 (Drosophila)
chr18_-_37935378 1.40 ENSMUST00000025337.7
Diap1
diaphanous homolog 1 (Drosophila)
chr5_-_62766153 1.40 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_+_98937669 1.37 ENSMUST00000107475.2
ENSMUST00000068133.3
Rara
retinoic acid receptor, alpha
chr2_+_121413775 1.37 ENSMUST00000028683.7
Pdia3
protein disulfide isomerase associated 3
chr18_-_37935429 1.36 ENSMUST00000115634.1
Diap1
diaphanous homolog 1 (Drosophila)
chr9_-_75409951 1.35 ENSMUST00000049355.10
Mapk6
mitogen-activated protein kinase 6
chr9_+_44499126 1.30 ENSMUST00000074989.5
Bcl9l
B cell CLL/lymphoma 9-like
chr7_-_119184374 1.28 ENSMUST00000084650.4
Gpr139
G protein-coupled receptor 139
chr7_-_141539784 1.28 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
Chid1
chitinase domain containing 1
chr17_-_87282771 1.26 ENSMUST00000161759.1
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr7_+_48959089 1.25 ENSMUST00000183659.1
Nav2
neuron navigator 2
chr1_+_120340569 1.24 ENSMUST00000037286.8
C1ql2
complement component 1, q subcomponent-like 2
chr9_+_75410145 1.17 ENSMUST00000180533.1
ENSMUST00000180574.1
4933433G15Rik
RIKEN cDNA 4933433G15 gene
chr3_+_135438722 1.16 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr5_-_62765618 1.14 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_+_3693602 1.10 ENSMUST00000123088.1
ENSMUST00000038521.7
ENSMUST00000108629.1
ENSMUST00000142713.1
Tsen34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr1_-_9299238 1.10 ENSMUST00000140295.1
Sntg1
syntrophin, gamma 1
chr4_+_57637816 1.09 ENSMUST00000150412.1
Gm20459
predicted gene 20459
chrX_+_143664365 1.08 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr6_+_42261957 1.07 ENSMUST00000095987.3
Tmem139
transmembrane protein 139
chr17_-_79715034 1.07 ENSMUST00000024894.1
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr7_-_144939823 1.06 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr5_+_64970069 1.05 ENSMUST00000031080.8
Fam114a1
family with sequence similarity 114, member A1
chr8_+_19194319 0.98 ENSMUST00000052601.3
Defb14
defensin beta 14
chr18_-_84086379 0.97 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr11_+_71750980 0.96 ENSMUST00000108511.1
Wscd1
WSC domain containing 1
chr5_-_134747241 0.90 ENSMUST00000015138.9
Eln
elastin
chrX_+_143664290 0.88 ENSMUST00000112868.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr19_-_47157764 0.85 ENSMUST00000178630.1
Calhm3
calcium homeostasis modulator 3
chr4_+_40948401 0.82 ENSMUST00000030128.5
Chmp5
charged multivesicular body protein 5
chr6_-_83572429 0.81 ENSMUST00000068054.7
Stambp
STAM binding protein
chr10_-_59221757 0.79 ENSMUST00000165971.1
Sept10
septin 10
chr11_+_71750680 0.79 ENSMUST00000021168.7
Wscd1
WSC domain containing 1
chr13_+_59585259 0.77 ENSMUST00000168367.1
ENSMUST00000022038.7
ENSMUST00000166923.1
Naa35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr12_-_67221221 0.75 ENSMUST00000178814.1
ENSMUST00000179345.2
Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr10_-_77799133 0.73 ENSMUST00000178581.1
Gm19668
predicted gene, 19668
chr10_-_18023229 0.71 ENSMUST00000020002.7
Abracl
ABRA C-terminal like
chr18_+_65698253 0.70 ENSMUST00000115097.1
ENSMUST00000117694.1
Oacyl
O-acyltransferase like
chr18_+_32163073 0.69 ENSMUST00000096575.3
Map3k2
mitogen-activated protein kinase kinase kinase 2
chr10_+_38965515 0.68 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr12_+_49382791 0.67 ENSMUST00000179669.1
Foxg1
forkhead box G1
chrX_-_162159717 0.65 ENSMUST00000087085.3
Nhs
Nance-Horan syndrome (human)
chrX_-_48513518 0.63 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
chr11_-_33276334 0.62 ENSMUST00000183831.1
Gm12117
predicted gene 12117
chr7_-_110061319 0.62 ENSMUST00000098110.2
AA474408
expressed sequence AA474408
chr19_-_38224096 0.60 ENSMUST00000067167.5
Fra10ac1
FRA10AC1 homolog (human)
chr4_+_99955715 0.60 ENSMUST00000102783.4
Pgm2
phosphoglucomutase 2
chr9_-_78481724 0.59 ENSMUST00000042235.8
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr7_-_45510400 0.57 ENSMUST00000033096.7
Nucb1
nucleobindin 1
chr10_-_128645784 0.56 ENSMUST00000065334.3
Ikzf4
IKAROS family zinc finger 4
chr17_-_46327949 0.55 ENSMUST00000047970.7
Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr10_+_40883819 0.55 ENSMUST00000105509.1
Wasf1
WAS protein family, member 1
chr6_+_103510874 0.54 ENSMUST00000066905.6
Chl1
cell adhesion molecule with homology to L1CAM
chr1_+_74236479 0.53 ENSMUST00000113820.2
ENSMUST00000006467.7
ENSMUST00000113819.1
Arpc2
actin related protein 2/3 complex, subunit 2
chr2_-_63184253 0.53 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr17_-_46327990 0.53 ENSMUST00000167360.1
Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr1_+_86526688 0.53 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr17_-_33760306 0.51 ENSMUST00000173860.1
Rab11b
RAB11B, member RAS oncogene family
chr5_+_143403819 0.50 ENSMUST00000110731.2
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr4_-_40948196 0.48 ENSMUST00000030125.4
ENSMUST00000108089.1
Bag1
BCL2-associated athanogene 1
chr3_+_97901190 0.48 ENSMUST00000029476.2
ENSMUST00000122288.1
Sec22b
SEC22 vesicle trafficking protein homolog B (S. cerevisiae)
chr11_-_23895208 0.47 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg
poly(A) polymerase gamma
chr7_+_3645267 0.47 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr10_-_40883073 0.46 ENSMUST00000044166.7
Cdc40
cell division cycle 40
chr10_-_5922385 0.45 ENSMUST00000131996.1
ENSMUST00000064225.7
Rgs17
regulator of G-protein signaling 17
chr13_-_85288999 0.44 ENSMUST00000109552.2
Rasa1
RAS p21 protein activator 1
chr14_-_21740395 0.43 ENSMUST00000120984.2
Dusp13
dual specificity phosphatase 13
chr10_+_40883469 0.40 ENSMUST00000019975.7
Wasf1
WAS protein family, member 1
chr11_-_99422252 0.40 ENSMUST00000017741.3
Krt12
keratin 12
chr3_+_93393696 0.39 ENSMUST00000045912.2
Rptn
repetin
chr5_+_129715488 0.37 ENSMUST00000119576.1
ENSMUST00000042191.5
ENSMUST00000118420.1
ENSMUST00000154358.1
ENSMUST00000121339.1
ENSMUST00000119604.1
ENSMUST00000136108.1
ENSMUST00000121813.1
ENSMUST00000119985.1
ENSMUST00000138812.1
Mrps17
mitochondrial ribosomal protein S17
chr17_+_87282880 0.33 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7
tetratricopeptide repeat domain 7
chr8_+_62951361 0.33 ENSMUST00000119068.1
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chrX_+_36195968 0.32 ENSMUST00000115256.1
Zcchc12
zinc finger, CCHC domain containing 12
chr11_-_77489666 0.31 ENSMUST00000037593.7
ENSMUST00000092892.3
Ankrd13b
ankyrin repeat domain 13b
chr14_+_15437623 0.30 ENSMUST00000181388.1
B230110C06Rik
RIKEN cDNA B230110C06 gene
chr16_-_94370994 0.30 ENSMUST00000113914.1
ENSMUST00000113905.1
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr7_-_100371889 0.29 ENSMUST00000032963.8
Ppme1
protein phosphatase methylesterase 1
chr1_-_164307443 0.21 ENSMUST00000027866.4
ENSMUST00000120447.1
ENSMUST00000086032.3
Blzf1
basic leucine zipper nuclear factor 1
chr1_-_161788489 0.21 ENSMUST00000000834.2
Fasl
Fas ligand (TNF superfamily, member 6)
chr17_-_29078953 0.21 ENSMUST00000133221.1
Trp53cor1
tumor protein p53 pathway corepressor 1
chr10_-_111010001 0.19 ENSMUST00000099285.3
ENSMUST00000041723.7
Zdhhc17
zinc finger, DHHC domain containing 17
chr10_+_69534208 0.18 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
Ank3
ankyrin 3, epithelial
chr15_+_43477213 0.18 ENSMUST00000022962.6
Emc2
ER membrane protein complex subunit 2
chr7_+_80860909 0.14 ENSMUST00000132163.1
ENSMUST00000147125.1
Zscan2
zinc finger and SCAN domain containing 2
chr12_+_49383007 0.14 ENSMUST00000021333.3
Foxg1
forkhead box G1
chr8_+_104170513 0.13 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
Bean1
brain expressed, associated with Nedd4, 1
chr10_+_69533803 0.11 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
Ank3
ankyrin 3, epithelial
chr10_-_5922341 0.11 ENSMUST00000117676.1
ENSMUST00000019909.7
Rgs17
regulator of G-protein signaling 17
chr4_-_129696579 0.11 ENSMUST00000137640.1
Tmem39b
transmembrane protein 39b
chr4_-_129662442 0.08 ENSMUST00000003828.4
Kpna6
karyopherin (importin) alpha 6
chr17_-_83631892 0.05 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr10_+_69533761 0.04 ENSMUST00000182884.1
Ank3
ankyrin 3, epithelial
chr4_-_126968124 0.03 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr7_+_126759601 0.02 ENSMUST00000050201.4
ENSMUST00000057669.9
Mapk3
mitogen-activated protein kinase 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
1.2 3.5 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.6 2.9 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.5 2.1 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.5 4.3 GO:0060613 fat pad development(GO:0060613)
0.5 1.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.5 1.4 GO:1903334 positive regulation of protein folding(GO:1903334)
0.4 2.5 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.4 1.1 GO:0071603 dibenzo-p-dioxin metabolic process(GO:0018894) endothelial cell-cell adhesion(GO:0071603)
0.4 1.4 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
0.4 1.4 GO:0003360 brainstem development(GO:0003360)
0.3 1.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.3 1.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.3 0.8 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.3 0.8 GO:0021852 pyramidal neuron migration(GO:0021852)
0.3 1.6 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 1.3 GO:0021564 vagus nerve development(GO:0021564)
0.2 2.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.2 1.0 GO:0060023 soft palate development(GO:0060023)
0.2 0.5 GO:2000812 response to rapamycin(GO:1901355) regulation of barbed-end actin filament capping(GO:2000812)
0.2 1.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 1.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 1.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 1.9 GO:0070166 enamel mineralization(GO:0070166)
0.1 0.9 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.5 GO:0045054 constitutive secretory pathway(GO:0045054)
0.1 1.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 2.2 GO:0043046 regulation of gene expression by genetic imprinting(GO:0006349) DNA methylation involved in gamete generation(GO:0043046)
0.1 0.6 GO:0019388 galactose catabolic process(GO:0019388)
0.1 0.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 2.0 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 0.3 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.1 0.6 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.1 1.6 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 2.2 GO:0072348 sulfur compound transport(GO:0072348)
0.0 2.9 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.4 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.2 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.8 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 1.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 1.3 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 0.5 GO:0043486 histone exchange(GO:0043486)
0.0 0.6 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 1.4 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.5 GO:0035640 exploration behavior(GO:0035640)
0.0 1.3 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 0.7 GO:0050873 brown fat cell differentiation(GO:0050873)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.3 0.8 GO:0031417 NatC complex(GO:0031417)
0.2 0.9 GO:0071953 elastic fiber(GO:0071953)
0.2 1.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.2 1.4 GO:0042825 TAP complex(GO:0042825)
0.1 2.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.6 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 2.5 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.9 GO:0031209 SCAR complex(GO:0031209)
0.1 1.4 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.7 2.2 GO:0030977 taurine binding(GO:0030977)
0.5 1.4 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.4 1.6 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.3 1.3 GO:0004568 chitinase activity(GO:0004568)
0.3 1.6 GO:0004883 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.2 2.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 1.4 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 1.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.1 2.1 GO:0016918 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.1 0.6 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 2.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.4 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.1 2.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 1.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 3.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 1.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 2.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.1 GO:0070330 aromatase activity(GO:0070330)
0.0 1.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.0 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 4.1 GO:0016874 ligase activity(GO:0016874)
0.0 0.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 5.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0032183 SUMO binding(GO:0032183)
0.0 0.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 6.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.6 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.7 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.4 3.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 4.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 1.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 3.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 3.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)