Project
GSE58827: Dynamics of the Mouse Liver
Navigation
Downloads
Results for Ets2
Z-value: 1.52
Motif logo
Transcription factors associated with Ets2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ets2 | mm10_v2_chr16_+_95702044_95702094 | -0.32 | 5.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ets2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.4 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 1.4 | 23.7 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.9 | 20.1 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.1 | 18.9 | GO:0055088 | lipid homeostasis(GO:0055088) |
| 1.6 | 9.6 | GO:0018992 | germ-line sex determination(GO:0018992) |
| 1.5 | 8.9 | GO:1904073 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 1.4 | 7.1 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 1.4 | 7.0 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.4 | 6.8 | GO:0071501 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 2.2 | 6.7 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 35.1 | GO:0016604 | nuclear body(GO:0016604) |
| 3.0 | 23.7 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 18.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 16.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 10.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.0 | 9.3 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.0 | 8.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 6.8 | GO:0000791 | euchromatin(GO:0000791) |
| 0.2 | 6.6 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 6.5 | GO:0031901 | early endosome membrane(GO:0031901) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.8 | 26.4 | GO:0052870 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) |
| 0.1 | 20.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 11.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 11.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 8.9 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 8.3 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.0 | 7.5 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.0 | 7.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.3 | 7.2 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 1.4 | 7.1 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 13.7 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 8.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 7.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 6.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 6.4 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 6.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 5.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 4.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.4 | 7.0 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.3 | 6.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.3 | 6.0 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.4 | 5.8 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.1 | 5.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 5.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.3 | 4.5 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 4.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 4.2 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |