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GSE58827: Dynamics of the Mouse Liver

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Results for Foxg1

Z-value: 0.48

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Transcription factors associated with Foxg1

Gene Symbol Gene ID Gene Info
Foxg1
ENSMUSG00000020950.9 forkhead box G1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxg1mm10_v2_chr12_+_49383007_493831050.115.2e-01Click!

Activity profile of Foxg1 motif

Sorted Z-values of Foxg1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_143005046 1.97 ENSMUST00000009396.6
Tspan32
tetraspanin 32
chr10_-_120476469 1.65 ENSMUST00000072777.7
ENSMUST00000159699.1
Hmga2
high mobility group AT-hook 2
chr3_-_106149761 1.52 ENSMUST00000149836.1
Chi3l3
chitinase 3-like 3
chr15_+_79891631 1.49 ENSMUST00000177350.1
ENSMUST00000177483.1
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr15_-_95528702 1.07 ENSMUST00000166170.1
Nell2
NEL-like 2
chr15_-_95528228 0.90 ENSMUST00000075275.2
Nell2
NEL-like 2
chr3_-_127225917 0.86 ENSMUST00000182064.1
ENSMUST00000182662.1
Ank2
ankyrin 2, brain
chr4_+_154960915 0.86 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr13_-_71963713 0.83 ENSMUST00000077337.8
Irx1
Iroquois related homeobox 1 (Drosophila)
chr2_-_152830615 0.82 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
Bcl2l1
BCL2-like 1
chr7_-_115824699 0.81 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr2_-_152831112 0.80 ENSMUST00000128172.1
Bcl2l1
BCL2-like 1
chr3_-_127225847 0.78 ENSMUST00000182726.1
ENSMUST00000182779.1
Ank2
ankyrin 2, brain
chr1_-_180813534 0.78 ENSMUST00000159789.1
ENSMUST00000081026.4
H3f3a
H3 histone, family 3A
chr1_-_180813591 0.76 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3f3a
H3 histone, family 3A
chr4_+_48585193 0.74 ENSMUST00000107703.1
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr17_+_34377124 0.72 ENSMUST00000080254.5
Btnl1
butyrophilin-like 1
chr4_+_48585276 0.71 ENSMUST00000123476.1
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr2_-_154558834 0.70 ENSMUST00000109716.2
ENSMUST00000000895.6
ENSMUST00000125793.1
Necab3
N-terminal EF-hand calcium binding protein 3
chr1_+_82839449 0.69 ENSMUST00000113444.1
ENSMUST00000063380.4
Agfg1
ArfGAP with FG repeats 1
chr15_+_103240405 0.65 ENSMUST00000036004.9
ENSMUST00000087351.7
Hnrnpa1
heterogeneous nuclear ribonucleoprotein A1
chr4_+_48585135 0.65 ENSMUST00000030032.6
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr11_+_3488275 0.63 ENSMUST00000064265.6
Pla2g3
phospholipase A2, group III
chr18_+_68300351 0.63 ENSMUST00000009679.4
ENSMUST00000131075.1
ENSMUST00000025427.7
ENSMUST00000139111.1
Rnmt
RNA (guanine-7-) methyltransferase
chr19_+_8617991 0.63 ENSMUST00000010250.2
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr6_-_12109583 0.58 ENSMUST00000080891.5
Gm6578
predicted gene 6578
chr1_+_180935022 0.54 ENSMUST00000037361.8
Lefty1
left right determination factor 1
chr2_-_164389095 0.52 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr12_+_112999964 0.50 ENSMUST00000180971.1
9230104M06Rik
RIKEN cDNA 9230104M06 gene
chr15_-_85581809 0.43 ENSMUST00000023015.7
Wnt7b
wingless-related MMTV integration site 7B
chr8_+_92901387 0.42 ENSMUST00000104947.2
Capns2
calpain, small subunit 2
chr9_+_64121501 0.42 ENSMUST00000118215.1
Lctl
lactase-like
chr3_-_50443603 0.41 ENSMUST00000029297.4
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr7_-_41560795 0.40 ENSMUST00000164677.1
ENSMUST00000073410.5
Gm6871
predicted gene 6871
chr5_+_34369909 0.38 ENSMUST00000180376.1
Fam193a
family with sequence similarity 193, member A
chr19_-_4615453 0.38 ENSMUST00000053597.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr9_-_60649793 0.36 ENSMUST00000053171.7
Lrrc49
leucine rich repeat containing 49
chr14_-_24245913 0.35 ENSMUST00000073687.6
ENSMUST00000090398.4
Dlg5
discs, large homolog 5 (Drosophila)
chr3_-_95015416 0.34 ENSMUST00000132195.1
Zfp687
zinc finger protein 687
chr16_-_97504925 0.33 ENSMUST00000049721.7
Fam3b
family with sequence similarity 3, member B
chr13_-_3918157 0.32 ENSMUST00000091853.4
Net1
neuroepithelial cell transforming gene 1
chr2_-_57124003 0.30 ENSMUST00000112629.1
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr18_+_73859366 0.22 ENSMUST00000120033.1
ENSMUST00000179472.1
ENSMUST00000119239.1
Mro
maestro
chr16_-_90284412 0.19 ENSMUST00000039280.7
Scaf4
SR-related CTD-associated factor 4
chr6_-_72345144 0.17 ENSMUST00000070345.3
Usp39
ubiquitin specific peptidase 39
chr12_-_10900296 0.16 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr1_-_72874877 0.15 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr12_-_113000621 0.14 ENSMUST00000011302.7
Brf1
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
chr3_-_95015214 0.14 ENSMUST00000128438.1
ENSMUST00000149747.1
ENSMUST00000019482.1
Zfp687
zinc finger protein 687
chr9_+_54586450 0.12 ENSMUST00000167866.1
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr16_-_90284300 0.10 ENSMUST00000163419.1
Scaf4
SR-related CTD-associated factor 4
chr5_-_121191365 0.10 ENSMUST00000100770.2
ENSMUST00000054547.7
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
chr11_-_28583995 0.09 ENSMUST00000146385.2
Ccdc85a
coiled-coil domain containing 85A
chr10_+_22158566 0.08 ENSMUST00000181645.1
ENSMUST00000105522.2
Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chr15_+_66577536 0.07 ENSMUST00000048188.8
Phf20l1
PHD finger protein 20-like 1
chr2_+_174330006 0.06 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr12_-_104751900 0.06 ENSMUST00000041987.6
Dicer1
dicer 1, ribonuclease type III
chr4_-_155653184 0.06 ENSMUST00000030937.1
Mmp23
matrix metallopeptidase 23
chr11_-_120041774 0.06 ENSMUST00000103019.1
Aatk
apoptosis-associated tyrosine kinase
chr8_+_46163733 0.05 ENSMUST00000110376.1
4933411K20Rik
RIKEN cDNA 4933411K20 gene
chr8_+_46163651 0.05 ENSMUST00000034048.6
ENSMUST00000145229.1
4933411K20Rik
RIKEN cDNA 4933411K20 gene
chr4_+_128058962 0.02 ENSMUST00000184063.1
Csmd2
CUB and Sushi multiple domains 2
chr13_+_34162953 0.00 ENSMUST00000124996.1
ENSMUST00000147632.1
Psmg4
proteasome (prosome, macropain) assembly chaperone 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxg1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0046898 response to cycloheximide(GO:0046898)
0.4 1.5 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.3 0.9 GO:2000978 auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.2 0.7 GO:0045062 extrathymic T cell selection(GO:0045062)
0.2 0.8 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.2 2.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.2 1.6 GO:0060613 fat pad development(GO:0060613)
0.2 1.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.4 GO:0072061 inner medullary collecting duct development(GO:0072061)
0.1 0.5 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 2.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 1.5 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.1 0.6 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.1 0.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.7 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 1.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331) protein localization to adherens junction(GO:0071896)
0.0 0.6 GO:0015747 urate transport(GO:0015747)
0.0 0.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
0.0 0.1 GO:2000850 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0 0.3 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.1 GO:0070173 peripheral nervous system myelin formation(GO:0032290) regulation of enamel mineralization(GO:0070173)
0.0 0.5 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.1 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
0.2 1.5 GO:0001740 Barr body(GO:0001740)
0.2 0.6 GO:0031533 mRNA cap methyltransferase complex(GO:0031533)
0.1 1.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.6 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.1 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 2.0 GO:0043204 perikaryon(GO:0043204)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 0.6 GO:0004482 mRNA (guanine-N7-)-methyltransferase activity(GO:0004482)
0.2 1.6 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.5 GO:0038100 nodal binding(GO:0038100)
0.1 0.4 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.1 1.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.6 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.6 GO:0030507 spectrin binding(GO:0030507)
0.0 2.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.6 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 1.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription