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GSE58827: Dynamics of the Mouse Liver

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Results for Foxl1

Z-value: 0.57

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Transcription factors associated with Foxl1

Gene Symbol Gene ID Gene Info
Foxl1
ENSMUSG00000097084.1 forkhead box L1
Foxl1
ENSMUSG00000043867.5 forkhead box L1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxl1mm10_v2_chr8_+_121127827_1211279400.591.5e-04Click!

Activity profile of Foxl1 motif

Sorted Z-values of Foxl1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_40811089 5.07 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr4_-_99654983 4.19 ENSMUST00000136525.1
Gm12688
predicted gene 12688
chr10_+_79879614 4.02 ENSMUST00000006679.8
Prtn3
proteinase 3
chr13_+_23763660 2.83 ENSMUST00000055770.1
Hist1h1a
histone cluster 1, H1a
chr4_+_11191726 2.60 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2
cyclin E2
chr3_-_123034943 2.50 ENSMUST00000029761.7
Myoz2
myozenin 2
chr8_+_15057646 2.28 ENSMUST00000033842.3
Myom2
myomesin 2
chr13_+_23575753 2.07 ENSMUST00000105105.1
Hist1h3d
histone cluster 1, H3d
chr10_+_88091070 2.05 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr9_+_121777607 1.48 ENSMUST00000098272.2
Klhl40
kelch-like 40
chr18_-_15151427 1.48 ENSMUST00000025992.6
Kctd1
potassium channel tetramerisation domain containing 1
chr11_+_31872100 1.43 ENSMUST00000020543.6
ENSMUST00000109412.2
Cpeb4
cytoplasmic polyadenylation element binding protein 4
chr9_+_71215779 1.21 ENSMUST00000034723.5
Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr13_-_23622502 1.14 ENSMUST00000062045.2
Hist1h1e
histone cluster 1, H1e
chr7_+_91090728 1.06 ENSMUST00000074273.3
Dlg2
discs, large homolog 2 (Drosophila)
chrX_+_133850980 1.06 ENSMUST00000033602.8
Tnmd
tenomodulin
chr7_+_91090697 1.01 ENSMUST00000107196.2
Dlg2
discs, large homolog 2 (Drosophila)
chr12_+_69963452 0.97 ENSMUST00000110560.1
Gm3086
predicted gene 3086
chr2_-_59948155 0.94 ENSMUST00000153136.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr13_+_23555023 0.83 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chrX_+_112604274 0.81 ENSMUST00000071814.6
Zfp711
zinc finger protein 711
chr18_+_34409415 0.79 ENSMUST00000166156.1
ENSMUST00000014647.7
Pkd2l2
polycystic kidney disease 2-like 2
chr13_+_23738804 0.72 ENSMUST00000040914.1
Hist1h1c
histone cluster 1, H1c
chr7_-_119479249 0.70 ENSMUST00000033263.4
Umod
uromodulin
chr1_+_66386968 0.68 ENSMUST00000145419.1
Map2
microtubule-associated protein 2
chr5_-_83355120 0.63 ENSMUST00000053543.4
Tecrl
trans-2,3-enoyl-CoA reductase-like
chr7_+_122289297 0.63 ENSMUST00000064989.5
ENSMUST00000064921.4
Prkcb
protein kinase C, beta
chr6_-_142804390 0.58 ENSMUST00000111768.1
Gm766
predicted gene 766
chr4_-_121017201 0.51 ENSMUST00000043200.7
Smap2
small ArfGAP 2
chr5_+_33018816 0.37 ENSMUST00000019109.7
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr6_+_42286676 0.28 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr15_+_43477213 0.26 ENSMUST00000022962.6
Emc2
ER membrane protein complex subunit 2
chrX_-_94123087 0.25 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr7_+_84853573 0.25 ENSMUST00000078172.4
Olfr291
olfactory receptor 291
chr5_-_83354946 0.25 ENSMUST00000146669.1
Tecrl
trans-2,3-enoyl-CoA reductase-like
chr15_-_11905609 0.20 ENSMUST00000066529.3
Npr3
natriuretic peptide receptor 3
chrX_+_18162575 0.15 ENSMUST00000044484.6
ENSMUST00000052368.8
Kdm6a
lysine (K)-specific demethylase 6A
chr2_+_18055203 0.14 ENSMUST00000028076.8
Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr6_+_42286709 0.14 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr10_+_56377300 0.08 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr5_-_87699414 0.06 ENSMUST00000082370.5
Csn2
casein beta
chr1_-_144249134 0.05 ENSMUST00000172388.1
Rgs1
regulator of G-protein signaling 1
chr6_-_14755250 0.03 ENSMUST00000045096.4
Ppp1r3a
protein phosphatase 1, regulatory (inhibitor) subunit 3A

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.8 4.0 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.7 2.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.3 2.7 GO:0016584 nucleosome positioning(GO:0016584)
0.3 1.5 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.2 0.7 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.2 1.2 GO:0042905 ureter maturation(GO:0035799) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 2.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 1.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 2.1 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 0.6 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.4 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.1 2.6 GO:0006270 DNA replication initiation(GO:0006270)
0.1 2.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.9 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.4 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 2.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.5 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.1 GO:0010643 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 2.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 7.6 GO:0000786 nucleosome(GO:0000786)
0.1 2.3 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.5 GO:0031672 A band(GO:0031672)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 2.5 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0051373 FATZ binding(GO:0051373)
0.3 5.1 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.2 1.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 1.1 GO:0032564 dATP binding(GO:0032564)
0.1 2.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.6 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.7 GO:0019864 IgG binding(GO:0019864)
0.1 2.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 2.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.9 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 2.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 3.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 5.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 2.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors