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GSE58827: Dynamics of the Mouse Liver

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Results for Foxo3

Z-value: 0.47

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Transcription factors associated with Foxo3

Gene Symbol Gene ID Gene Info
Foxo3
ENSMUSG00000048756.5 forkhead box O3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_42276763-0.192.8e-01Click!

Activity profile of Foxo3 motif

Sorted Z-values of Foxo3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_107230608 3.05 ENSMUST00000179399.1
A630076J17Rik
RIKEN cDNA A630076J17 gene
chr11_+_101367542 1.81 ENSMUST00000019469.2
G6pc
glucose-6-phosphatase, catalytic
chr11_-_68386974 1.23 ENSMUST00000135141.1
Ntn1
netrin 1
chr3_+_63295815 1.20 ENSMUST00000029400.1
Mme
membrane metallo endopeptidase
chr14_-_51913393 1.10 ENSMUST00000004673.7
ENSMUST00000111632.3
Ndrg2
N-myc downstream regulated gene 2
chr3_-_27896360 1.00 ENSMUST00000058077.3
Tmem212
transmembrane protein 212
chr9_-_71163224 0.91 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr4_-_49549523 0.81 ENSMUST00000029987.9
Aldob
aldolase B, fructose-bisphosphate
chr15_-_78468620 0.80 ENSMUST00000017086.3
Tmprss6
transmembrane serine protease 6
chr8_-_25038875 0.74 ENSMUST00000084031.4
Htra4
HtrA serine peptidase 4
chr11_-_68386821 0.71 ENSMUST00000021284.3
Ntn1
netrin 1
chr4_-_119415494 0.68 ENSMUST00000063642.2
Ccdc30
coiled-coil domain containing 30
chr15_-_89379246 0.67 ENSMUST00000049968.7
Odf3b
outer dense fiber of sperm tails 3B
chr1_+_172698046 0.62 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr1_-_140183283 0.61 ENSMUST00000111977.1
Cfh
complement component factor h
chr4_+_105157339 0.60 ENSMUST00000064139.7
Ppap2b
phosphatidic acid phosphatase type 2B
chr1_-_140183404 0.58 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh
complement component factor h
chr19_-_7802578 0.56 ENSMUST00000120522.1
ENSMUST00000065634.7
Slc22a26
solute carrier family 22 (organic cation transporter), member 26
chr8_+_105269788 0.56 ENSMUST00000036127.2
ENSMUST00000163734.2
Hsf4
heat shock transcription factor 4
chr9_-_48835932 0.55 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr10_-_89533550 0.52 ENSMUST00000105297.1
Nr1h4
nuclear receptor subfamily 1, group H, member 4
chr11_-_100354040 0.51 ENSMUST00000173630.1
Hap1
huntingtin-associated protein 1
chr7_-_34655500 0.50 ENSMUST00000032709.1
Kctd15
potassium channel tetramerisation domain containing 15
chr19_-_58455903 0.48 ENSMUST00000131877.1
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr11_+_3332426 0.45 ENSMUST00000136474.1
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr14_+_30879257 0.45 ENSMUST00000040715.6
Mustn1
musculoskeletal, embryonic nuclear protein 1
chr15_+_102966794 0.44 ENSMUST00000001699.7
Hoxc10
homeobox C10
chr5_-_151190154 0.44 ENSMUST00000062015.8
ENSMUST00000110483.2
Stard13
StAR-related lipid transfer (START) domain containing 13
chr19_-_34879452 0.40 ENSMUST00000036584.5
Pank1
pantothenate kinase 1
chr7_+_130692532 0.38 ENSMUST00000033141.6
Tacc2
transforming, acidic coiled-coil containing protein 2
chr5_+_65131184 0.36 ENSMUST00000031089.5
ENSMUST00000101191.3
Klhl5
kelch-like 5
chr2_-_164389095 0.35 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr11_-_60352869 0.33 ENSMUST00000095254.5
ENSMUST00000102683.4
ENSMUST00000093048.6
ENSMUST00000093046.6
ENSMUST00000064019.8
ENSMUST00000102682.4
Tom1l2
target of myb1-like 2 (chicken)
chr1_+_24005505 0.32 ENSMUST00000181961.1
Gm26524
predicted gene, 26524
chr9_+_114731177 0.32 ENSMUST00000035007.8
Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr11_-_101785252 0.31 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4
ets variant gene 4 (E1A enhancer binding protein, E1AF)
chr13_-_95478655 0.30 ENSMUST00000022186.3
S100z
S100 calcium binding protein, zeta
chr1_+_171225054 0.29 ENSMUST00000111321.1
ENSMUST00000005824.5
ENSMUST00000111320.1
ENSMUST00000111319.1
Apoa2
apolipoprotein A-II
chr2_+_4718145 0.29 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr2_-_148046896 0.29 ENSMUST00000172928.1
ENSMUST00000047315.3
Foxa2
forkhead box A2
chr13_+_60602182 0.28 ENSMUST00000044083.7
Dapk1
death associated protein kinase 1
chr6_+_14901440 0.28 ENSMUST00000128567.1
Foxp2
forkhead box P2
chrX_-_48208870 0.27 ENSMUST00000088935.3
Zdhhc9
zinc finger, DHHC domain containing 9
chr4_-_155345696 0.27 ENSMUST00000103178.4
Prkcz
protein kinase C, zeta
chr3_-_145649970 0.27 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr2_-_91710519 0.26 ENSMUST00000028678.8
ENSMUST00000076803.5
Atg13
autophagy related 13
chr2_+_10370494 0.26 ENSMUST00000114862.1
ENSMUST00000114861.1
Sfmbt2
Scm-like with four mbt domains 2
chr11_+_7197780 0.26 ENSMUST00000020704.7
Igfbp1
insulin-like growth factor binding protein 1
chr6_+_24733241 0.25 ENSMUST00000031690.5
Hyal6
hyaluronoglucosaminidase 6
chr2_+_155517948 0.25 ENSMUST00000029135.8
ENSMUST00000065973.2
ENSMUST00000103142.5
Acss2
acyl-CoA synthetase short-chain family member 2
chr13_+_119606650 0.25 ENSMUST00000178948.1
Gm21967
predicted gene, 21967
chr7_+_82175156 0.24 ENSMUST00000180243.1
Sh3gl3
SH3-domain GRB2-like 3
chr7_-_90129339 0.23 ENSMUST00000181189.1
2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr10_+_96616998 0.23 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr7_+_29309429 0.23 ENSMUST00000137848.1
Dpf1
D4, zinc and double PHD fingers family 1
chr2_+_124610573 0.23 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr18_-_74961252 0.23 ENSMUST00000066532.4
Lipg
lipase, endothelial
chr11_+_82911253 0.22 ENSMUST00000164945.1
ENSMUST00000018989.7
Unc45b
unc-45 homolog B (C. elegans)
chr8_+_71568866 0.22 ENSMUST00000034267.4
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr8_-_84773381 0.21 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr14_-_121698417 0.21 ENSMUST00000040700.7
Dock9
dedicator of cytokinesis 9
chr7_+_30291941 0.21 ENSMUST00000144508.1
Clip3
CAP-GLY domain containing linker protein 3
chr8_-_41016749 0.20 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr2_+_76675265 0.20 ENSMUST00000111920.1
Plekha3
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
chr17_+_24840108 0.19 ENSMUST00000164251.1
Hagh
hydroxyacyl glutathione hydrolase
chr7_-_109616548 0.18 ENSMUST00000077909.1
ENSMUST00000084738.3
St5
suppression of tumorigenicity 5
chr18_-_62756275 0.18 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik
RIKEN cDNA 2700046A07 gene
chr7_-_65371210 0.18 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr17_+_43389436 0.16 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr2_+_136713444 0.16 ENSMUST00000028727.4
ENSMUST00000110098.3
Snap25
synaptosomal-associated protein 25
chr2_+_91710852 0.16 ENSMUST00000128140.1
ENSMUST00000140183.1
Harbi1
harbinger transposase derived 1
chr1_+_75142775 0.16 ENSMUST00000097694.4
Fam134a
family with sequence similarity 134, member A
chr2_+_127854628 0.16 ENSMUST00000028859.1
Acoxl
acyl-Coenzyme A oxidase-like
chr2_+_91710900 0.15 ENSMUST00000142692.1
ENSMUST00000090608.5
Harbi1
harbinger transposase derived 1
chr2_+_164486856 0.15 ENSMUST00000109349.2
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr2_+_164486455 0.14 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr3_+_5218589 0.14 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr16_+_93683184 0.14 ENSMUST00000039620.6
Cbr3
carbonyl reductase 3
chr2_+_143546144 0.13 ENSMUST00000028905.9
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr1_+_74284930 0.13 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd
paroxysmal nonkinesiogenic dyskinesia
chr12_+_71016658 0.13 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr19_+_5877794 0.13 ENSMUST00000145200.1
ENSMUST00000025732.7
ENSMUST00000125114.1
ENSMUST00000155697.1
Slc25a45
solute carrier family 25, member 45
chr1_+_36511867 0.12 ENSMUST00000001166.7
ENSMUST00000097776.3
Cnnm3
cyclin M3
chr10_+_88201158 0.12 ENSMUST00000171151.2
Ccdc53
coiled-coil domain containing 53
chr11_+_60353324 0.11 ENSMUST00000070805.6
ENSMUST00000094140.2
ENSMUST00000108723.2
ENSMUST00000108722.4
Lrrc48
leucine rich repeat containing 48
chr8_-_41016295 0.11 ENSMUST00000131965.1
Mtus1
mitochondrial tumor suppressor 1
chr4_-_91376433 0.10 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr19_+_22692613 0.10 ENSMUST00000099564.2
ENSMUST00000099566.3
Trpm3
transient receptor potential cation channel, subfamily M, member 3
chr2_-_104493690 0.10 ENSMUST00000111124.1
Hipk3
homeodomain interacting protein kinase 3
chr4_-_137785371 0.10 ENSMUST00000133473.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr3_+_5218516 0.10 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr7_-_65370908 0.10 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr10_+_88201223 0.09 ENSMUST00000182619.1
Ccdc53
coiled-coil domain containing 53
chr18_+_37513652 0.09 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr2_+_124610278 0.09 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr4_-_91376490 0.09 ENSMUST00000107124.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr3_+_5218546 0.08 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chrX_+_7878298 0.08 ENSMUST00000033495.8
Pim2
proviral integration site 2
chr10_-_93310963 0.08 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr3_-_146770218 0.08 ENSMUST00000106137.1
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr8_-_25785154 0.08 ENSMUST00000038498.8
Bag4
BCL2-associated athanogene 4
chr9_-_58741543 0.08 ENSMUST00000098674.4
2410076I21Rik
RIKEN cDNA 2410076I21 gene
chr19_-_43986552 0.08 ENSMUST00000026210.4
Cpn1
carboxypeptidase N, polypeptide 1
chr7_+_30458280 0.08 ENSMUST00000126297.1
Nphs1
nephrosis 1, nephrin
chr7_-_70360593 0.07 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr1_-_58695944 0.06 ENSMUST00000055313.7
Als2cr12
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 (human)
chr11_-_99422252 0.06 ENSMUST00000017741.3
Krt12
keratin 12
chr11_+_85353156 0.06 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3
breast carcinoma amplified sequence 3
chr10_-_93311073 0.06 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr2_+_143915273 0.05 ENSMUST00000103172.3
Dstn
destrin
chr6_-_142278836 0.05 ENSMUST00000111825.3
Slco1a5
solute carrier organic anion transporter family, member 1a5
chr16_-_56712825 0.05 ENSMUST00000136394.1
Tfg
Trk-fused gene
chr2_-_51973219 0.05 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr16_-_22439719 0.05 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr4_-_134915010 0.05 ENSMUST00000105863.1
ENSMUST00000030626.5
Tmem50a
transmembrane protein 50A
chr11_+_96133786 0.05 ENSMUST00000167258.1
Ttll6
tubulin tyrosine ligase-like family, member 6
chr5_-_137531204 0.04 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr9_+_65361049 0.04 ENSMUST00000147185.1
Gm514
predicted gene 514
chr11_+_19924403 0.04 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr11_+_98446826 0.04 ENSMUST00000019456.4
Grb7
growth factor receptor bound protein 7
chr18_-_39489880 0.04 ENSMUST00000152853.1
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr16_-_38433145 0.04 ENSMUST00000002926.6
Pla1a
phospholipase A1 member A
chr6_-_83831736 0.03 ENSMUST00000058383.8
Paip2b
poly(A) binding protein interacting protein 2B
chr11_-_48946148 0.03 ENSMUST00000104958.1
Psme2b
protease (prosome, macropain) activator subunit 2B
chr10_-_53647080 0.03 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr18_-_66022580 0.03 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr1_-_163403627 0.03 ENSMUST00000045138.4
Gorab
golgin, RAB6-interacting
chr8_-_122476036 0.03 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr10_+_40349265 0.03 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19
cyclin-dependent kinase 19
chr3_-_30793549 0.02 ENSMUST00000180833.1
4933429H19Rik
RIKEN cDNA 4933429H19 gene
chr6_+_34863130 0.02 ENSMUST00000074949.3
Tmem140
transmembrane protein 140
chr5_-_17888884 0.02 ENSMUST00000169095.1
Cd36
CD36 antigen
chr14_-_57133585 0.02 ENSMUST00000039380.8
Gjb6
gap junction protein, beta 6
chr10_-_5069044 0.02 ENSMUST00000095899.3
Syne1
spectrin repeat containing, nuclear envelope 1
chr5_+_66968559 0.02 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr11_-_99543158 0.01 ENSMUST00000107443.1
ENSMUST00000074253.3
Krt40
keratin 40
chr19_-_19111181 0.01 ENSMUST00000112832.1
Rorb
RAR-related orphan receptor beta
chr12_+_72761211 0.01 ENSMUST00000021514.8
Ppm1a
protein phosphatase 1A, magnesium dependent, alpha isoform
chr7_+_141476374 0.01 ENSMUST00000117634.1
Tspan4
tetraspanin 4
chr15_+_25752860 0.01 ENSMUST00000022882.5
ENSMUST00000135173.1
Myo10
myosin X
chr6_+_15196949 0.01 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2
forkhead box P2

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.3 1.8 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 1.1 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.2 1.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 0.9 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.2 0.8 GO:0006116 fructose catabolic process(GO:0006001) NADH oxidation(GO:0006116) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.2 0.5 GO:0034971 histone H3-R17 methylation(GO:0034971)
0.1 1.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.4 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.5 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.1 0.3 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 0.2 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.4 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.1 0.6 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.3 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) diacylglycerol catabolic process(GO:0046340)
0.1 0.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.8 GO:0097264 self proteolysis(GO:0097264)
0.1 0.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.2 GO:0030070 insulin processing(GO:0030070)
0.1 0.3 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.3 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.1 GO:0042376 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0 0.2 GO:0006083 acetate metabolic process(GO:0006083) short-chain fatty acid biosynthetic process(GO:0051790)
0.0 0.6 GO:0015747 urate transport(GO:0015747)
0.0 0.3 GO:2000667 positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.3 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.6 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.4 GO:0030953 astral microtubule organization(GO:0030953)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.2 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.2 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.3 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 0.1 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.1 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.4 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.2 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.3 GO:0043203 axon hillock(GO:0043203) apical cortex(GO:0045179)
0.0 1.9 GO:0005604 basement membrane(GO:0005604)
0.0 1.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.2 0.9 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.2 1.2 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.5 GO:0038181 bile acid receptor activity(GO:0038181)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 1.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.6 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.3 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.2 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 2.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 1.8 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.9 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)