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GSE58827: Dynamics of the Mouse Liver

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Results for Foxo4

Z-value: 0.62

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Transcription factors associated with Foxo4

Gene Symbol Gene ID Gene Info
Foxo4
ENSMUSG00000042903.7 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_101254574-0.163.6e-01Click!

Activity profile of Foxo4 motif

Sorted Z-values of Foxo4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102107822 1.62 ENSMUST00000177304.1
ENSMUST00000017455.8
Pyy
peptide YY
chr10_-_109010955 1.57 ENSMUST00000105276.1
ENSMUST00000064054.7
Syt1
synaptotagmin I
chr18_-_38918642 1.30 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr13_-_106547060 1.12 ENSMUST00000076359.2
Dph3b-ps
DPH3B, KTI11 homolog B (S. cerevisiae), pseudogene
chr19_-_5796924 1.02 ENSMUST00000174808.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr2_-_175931051 1.00 ENSMUST00000108949.2
ENSMUST00000109018.2
Gm8898
predicted gene 8898
chr7_-_4524229 0.99 ENSMUST00000154913.1
Tnni3
troponin I, cardiac 3
chr4_-_61835185 0.97 ENSMUST00000082287.2
Mup5
major urinary protein 5
chr6_+_56714891 0.93 ENSMUST00000031805.8
Avl9
AVL9 homolog (S. cerevisiase)
chr10_-_83337440 0.92 ENSMUST00000126617.1
Slc41a2
solute carrier family 41, member 2
chr8_-_45410539 0.89 ENSMUST00000034056.4
ENSMUST00000167106.1
Tlr3
toll-like receptor 3
chr2_-_177840318 0.83 ENSMUST00000108939.2
ENSMUST00000150650.1
Gm14325
predicted gene 14325
chr2_-_175141999 0.76 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
Gm14399
predicted gene 14399
chr2_+_177000956 0.74 ENSMUST00000108975.2
ENSMUST00000156844.1
Gm14419
predicted gene 14419
chr4_-_59960659 0.71 ENSMUST00000075973.2
Mup4
major urinary protein 4
chr2_+_175372436 0.68 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723
predicted gene 4723
chr17_+_26202946 0.68 ENSMUST00000122058.1
ENSMUST00000025020.5
Rgs11
regulator of G-protein signaling 11
chr11_-_77078404 0.67 ENSMUST00000102494.1
Ccdc55
coiled-coil domain containing 55
chr2_+_178023284 0.63 ENSMUST00000108925.3
ENSMUST00000108926.2
Etohi1
ethanol induced 1
chr8_+_26119361 0.63 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
Rnf170
ring finger protein 170
chr2_+_175869219 0.63 ENSMUST00000109011.1
Gm6710
predicted gene 6710
chr2_+_176798612 0.62 ENSMUST00000118012.2
Gm14295
predicted gene 14295
chr2_+_175469985 0.61 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923
predicted gene 8923
chr9_+_37539255 0.60 ENSMUST00000002008.5
Vsig2
V-set and immunoglobulin domain containing 2
chr2_-_176486773 0.59 ENSMUST00000120959.1
ENSMUST00000120521.1
Gm14434
predicted gene 14434
chr2_+_176708328 0.58 ENSMUST00000108981.2
ENSMUST00000108980.2
Gm14305
predicted gene 14305
chr9_+_45319072 0.58 ENSMUST00000034597.7
Tmprss13
transmembrane protease, serine 13
chr7_-_4778141 0.56 ENSMUST00000094892.5
Il11
interleukin 11
chr5_+_92392585 0.56 ENSMUST00000126281.1
Art3
ADP-ribosyltransferase 3
chr8_+_79639618 0.55 ENSMUST00000173078.1
ENSMUST00000173286.1
Otud4
OTU domain containing 4
chr2_-_176636318 0.55 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
Gm14308
predicted gene 14308
chr2_-_175206899 0.55 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
Gm14391
predicted gene 14391
chr2_+_176670522 0.54 ENSMUST00000121956.1
ENSMUST00000108985.2
Gm14306
predicted gene 14306
chr2_-_175435782 0.52 ENSMUST00000152941.1
ENSMUST00000109045.2
Gm4724
predicted gene 4724
chr2_-_175338197 0.52 ENSMUST00000121393.2
Gm4631
predicted gene 4631
chr2_-_178078425 0.52 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
Zfp931
zinc finger protein 931
chr2_+_176521056 0.51 ENSMUST00000108997.2
ENSMUST00000178443.1
Gm14431
predicted gene 14431
chr10_+_79973737 0.48 ENSMUST00000149148.1
Grin3b
glutamate receptor, ionotropic, NMDA3B
chrX_+_134601271 0.48 ENSMUST00000050331.6
ENSMUST00000059297.5
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
chr2_+_176226569 0.47 ENSMUST00000099009.2
ENSMUST00000136719.1
2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr2_-_75938407 0.46 ENSMUST00000099996.3
Ttc30b
tetratricopeptide repeat domain 30B
chr6_+_95117740 0.46 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8
kelch repeat and BTB (POZ) domain containing 8
chr2_-_175703646 0.44 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245
predicted gene 4245
chr2_-_176927809 0.44 ENSMUST00000099007.2
Gm14296
predicted gene 14296
chr8_+_26119611 0.44 ENSMUST00000140819.1
Rnf170
ring finger protein 170
chr2_-_177206421 0.43 ENSMUST00000108964.1
Gm14410
predicted gene 14410
chr10_-_127263346 0.42 ENSMUST00000099172.3
Kif5a
kinesin family member 5A
chr15_-_35938009 0.42 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chr15_-_78204228 0.42 ENSMUST00000005860.9
Pvalb
parvalbumin
chr14_+_32028989 0.41 ENSMUST00000022460.4
Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr7_-_89517576 0.40 ENSMUST00000041761.5
Prss23
protease, serine, 23
chrX_+_134601179 0.39 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
chr14_+_53469756 0.38 ENSMUST00000103643.2
Trav8-1
T cell receptor alpha variable 8-1
chr2_-_177957239 0.35 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
Gm14326
predicted gene 14326
chr2_-_45110336 0.35 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2
zinc finger E-box binding homeobox 2
chr2_+_175965331 0.35 ENSMUST00000109007.1
ENSMUST00000174416.1
Gm2026
predicted gene 2026
chr6_+_42286676 0.34 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr6_-_31218421 0.33 ENSMUST00000115107.1
AB041803
cDNA sequence AB041803
chr6_+_42286709 0.33 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr17_+_78508063 0.32 ENSMUST00000024880.9
Vit
vitrin
chr1_+_171214013 0.32 ENSMUST00000111328.1
Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr1_+_171213969 0.32 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr14_-_18331855 0.28 ENSMUST00000022296.6
Ube2e1
ubiquitin-conjugating enzyme E2E 1
chr8_+_121544378 0.28 ENSMUST00000181133.1
ENSMUST00000181679.1
1700030M09Rik
RIKEN cDNA 1700030M09 gene
chr2_+_130012336 0.27 ENSMUST00000110299.2
Tgm3
transglutaminase 3, E polypeptide
chr5_+_139543889 0.27 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx
UNC homeobox
chr14_+_52778447 0.26 ENSMUST00000103580.2
Trav8d-1
T cell receptor alpha variable 8D-1
chr16_-_64771146 0.25 ENSMUST00000076991.6
4930453N24Rik
RIKEN cDNA 4930453N24 gene
chr15_-_35938186 0.25 ENSMUST00000014457.8
Cox6c
cytochrome c oxidase subunit VIc
chr11_-_85139939 0.24 ENSMUST00000108075.2
Usp32
ubiquitin specific peptidase 32
chr5_+_37185897 0.24 ENSMUST00000094840.3
Gm1043
predicted gene 1043
chr1_-_171437288 0.21 ENSMUST00000181499.1
Gm26641
predicted gene, 26641
chr9_-_119322421 0.21 ENSMUST00000040853.4
Oxsr1
oxidative-stress responsive 1
chr15_-_77596110 0.20 ENSMUST00000089465.4
Apol10b
apolipoprotein L 10B
chr13_-_91223955 0.18 ENSMUST00000022119.4
Atg10
autophagy related 10
chr10_-_40257648 0.18 ENSMUST00000019982.7
Gtf3c6
general transcription factor IIIC, polypeptide 6, alpha
chr13_+_40704005 0.16 ENSMUST00000069457.1
Gm9979
predicted gene 9979
chr4_-_97778042 0.16 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_-_149636164 0.15 ENSMUST00000076410.4
Hsph1
heat shock 105kDa/110kDa protein 1
chr12_+_75308308 0.14 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj
ras homolog gene family, member J
chr7_-_19280032 0.13 ENSMUST00000032560.4
Ppm1n
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr11_-_102579461 0.13 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr4_+_45972233 0.12 ENSMUST00000102929.1
Tdrd7
tudor domain containing 7
chr14_+_32085804 0.12 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1
oxidoreductase NAD-binding domain containing 1
chr12_-_69892989 0.12 ENSMUST00000110567.1
ENSMUST00000171211.1
Map4k5
mitogen-activated protein kinase kinase kinase kinase 5
chr17_-_23745829 0.12 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr17_+_87078255 0.10 ENSMUST00000090731.5
Gm5499
predicted pseudogene 5499
chr9_+_57076343 0.09 ENSMUST00000168678.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr9_+_57076395 0.08 ENSMUST00000168177.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr11_+_105589970 0.08 ENSMUST00000168598.1
ENSMUST00000100330.3
Tanc2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr17_+_80944611 0.07 ENSMUST00000025092.4
Tmem178
transmembrane protein 178
chrX_-_73037103 0.07 ENSMUST00000114540.3
ENSMUST00000051569.6
Pnma5
paraneoplastic antigen family 5
chr4_+_136284658 0.06 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr7_+_15882617 0.06 ENSMUST00000125993.1
ENSMUST00000130566.1
Crxos1
Crx opposite strand transcript 1
chr9_+_8900459 0.06 ENSMUST00000098986.3
ENSMUST00000070463.3
Pgr
progesterone receptor
chr12_+_69893105 0.05 ENSMUST00000021466.8
Atl1
atlastin GTPase 1
chr8_-_94012120 0.05 ENSMUST00000143265.1
Amfr
autocrine motility factor receptor
chr15_-_102625061 0.04 ENSMUST00000184077.1
ENSMUST00000184906.1
ENSMUST00000169033.1
ATF7
Cyclic AMP-dependent transcription factor ATF-7
chr8_-_121544315 0.04 ENSMUST00000182460.1
1700018B08Rik
RIKEN cDNA 1700018B08 gene
chr8_-_47352348 0.03 ENSMUST00000110367.2
Stox2
storkhead box 2
chr8_-_105943382 0.02 ENSMUST00000038896.7
Lcat
lecithin cholesterol acyltransferase
chr1_+_6487231 0.01 ENSMUST00000140079.1
ENSMUST00000131494.1
St18
suppression of tumorigenicity 18
chr2_-_26864943 0.01 ENSMUST00000102900.1
Abo
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)
chr12_-_17329348 0.01 ENSMUST00000153090.1
ENSMUST00000143131.1
Atp6v1c2
ATPase, H+ transporting, lysosomal V1 subunit C2
chr14_-_70153811 0.00 ENSMUST00000035612.5
Ccar2
cell cycle activator and apoptosis regulator 2
chr6_+_87009836 0.00 ENSMUST00000032060.8
ENSMUST00000117583.1
ENSMUST00000144776.1
Nfu1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 1.0 GO:0035063 nuclear speck organization(GO:0035063)
0.2 0.9 GO:0002282 microglial cell activation involved in immune response(GO:0002282) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.2 1.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 1.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.4 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 1.6 GO:0032096 negative regulation of response to food(GO:0032096)
0.1 0.2 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 0.7 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.6 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.1 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.5 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 0.2 GO:0006983 ER overload response(GO:0006983)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.7 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 1.0 GO:0030172 troponin C binding(GO:0030172)
0.1 1.3 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 1.7 GO:0005550 pheromone binding(GO:0005550)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0016594 glycine binding(GO:0016594)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.3 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 0.9 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 2.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events