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GSE58827: Dynamics of the Mouse Liver

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Results for GAGAACU

Z-value: 0.09

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miRNA associated with seed GAGAACU

NamemiRBASE accession
mmu-miR-146a-5p
MIMAT0000158
mmu-miR-146b-5p
MIMAT0003475

Activity profile of GAGAACU motif

Sorted Z-values of GAGAACU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_109010955 0.22 ENSMUST00000105276.1
ENSMUST00000064054.7
Syt1
synaptotagmin I
chr10_+_107271827 0.10 ENSMUST00000020057.8
ENSMUST00000105280.3
Lin7a
lin-7 homolog A (C. elegans)
chr7_-_38227975 0.08 ENSMUST00000098513.4
Plekhf1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr1_-_15892657 0.07 ENSMUST00000040695.4
Sbspon
somatomedin B and thrombospondin, type 1 domain containing
chr1_-_170976112 0.07 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
Fcgr2b
Fc receptor, IgG, low affinity IIb
chr17_-_12507704 0.07 ENSMUST00000024595.2
Slc22a3
solute carrier family 22 (organic cation transporter), member 3
chr15_+_55112317 0.06 ENSMUST00000096433.3
Deptor
DEP domain containing MTOR-interacting protein
chr7_-_7299492 0.05 ENSMUST00000000619.6
Clcn4-2
chloride channel 4-2
chr19_+_4231899 0.04 ENSMUST00000025773.3
Pold4
polymerase (DNA-directed), delta 4
chr7_-_19796789 0.04 ENSMUST00000108449.2
ENSMUST00000043822.7
Cblc
Casitas B-lineage lymphoma c
chr2_+_15055274 0.04 ENSMUST00000069870.3
Arl5b
ADP-ribosylation factor-like 5B
chr4_+_131921771 0.04 ENSMUST00000094666.3
Tmem200b
transmembrane protein 200B
chr3_-_58692391 0.04 ENSMUST00000070368.7
Siah2
seven in absentia 2
chr2_+_101678403 0.04 ENSMUST00000004949.7
Traf6
TNF receptor-associated factor 6
chr10_-_86498836 0.04 ENSMUST00000120638.1
Syn3
synapsin III
chr2_+_163547148 0.04 ENSMUST00000109411.1
ENSMUST00000018094.6
Hnf4a
hepatic nuclear factor 4, alpha
chr11_-_23770953 0.03 ENSMUST00000102864.3
Rel
reticuloendotheliosis oncogene
chr2_+_33216051 0.03 ENSMUST00000004208.5
Angptl2
angiopoietin-like 2
chr19_-_34527396 0.03 ENSMUST00000049572.8
ENSMUST00000178114.1
Lipa
lysosomal acid lipase A
chr7_-_34654342 0.03 ENSMUST00000108069.1
Kctd15
potassium channel tetramerisation domain containing 15
chr15_-_53902472 0.03 ENSMUST00000078673.6
Samd12
sterile alpha motif domain containing 12
chrX_+_98149666 0.03 ENSMUST00000052837.7
Ar
androgen receptor
chr11_+_72607221 0.03 ENSMUST00000021148.6
ENSMUST00000138247.1
Ube2g1
ubiquitin-conjugating enzyme E2G 1
chr11_-_5542177 0.03 ENSMUST00000020776.4
Ccdc117
coiled-coil domain containing 117
chr6_+_147091379 0.02 ENSMUST00000036003.7
Klhl42
kelch-like 42
chr1_-_16519284 0.02 ENSMUST00000162751.1
ENSMUST00000027052.6
ENSMUST00000149320.2
Stau2
staufen (RNA binding protein) homolog 2 (Drosophila)
chr18_+_11839220 0.02 ENSMUST00000171109.1
ENSMUST00000046948.8
Cables1
CDK5 and Abl enzyme substrate 1
chr12_-_83921899 0.02 ENSMUST00000117217.1
Numb
numb gene homolog (Drosophila)
chr14_-_16575456 0.02 ENSMUST00000063750.6
Rarb
retinoic acid receptor, beta
chr16_+_72663143 0.02 ENSMUST00000023600.7
Robo1
roundabout homolog 1 (Drosophila)
chr12_-_111377705 0.02 ENSMUST00000041965.3
Cdc42bpb
CDC42 binding protein kinase beta
chr11_-_76763550 0.02 ENSMUST00000010536.8
Gosr1
golgi SNAP receptor complex member 1
chr16_-_56886131 0.02 ENSMUST00000023435.5
Tmem45a
transmembrane protein 45a
chr18_+_38250240 0.02 ENSMUST00000025314.5
0610009O20Rik
RIKEN cDNA 0610009O20 gene
chr7_-_66388286 0.02 ENSMUST00000015277.7
Lrrk1
leucine-rich repeat kinase 1
chr7_+_112023469 0.02 ENSMUST00000106653.2
Usp47
ubiquitin specific peptidase 47
chr13_+_63014934 0.02 ENSMUST00000091560.4
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr2_-_26503814 0.02 ENSMUST00000028288.4
Notch1
notch 1
chr7_+_89632689 0.02 ENSMUST00000032856.6
Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr12_+_85110833 0.02 ENSMUST00000053811.8
Dlst
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr2_-_30474199 0.01 ENSMUST00000065134.2
Ier5l
immediate early response 5-like
chr6_+_127015542 0.01 ENSMUST00000000187.5
Fgf6
fibroblast growth factor 6
chr5_-_144358103 0.01 ENSMUST00000055190.7
Baiap2l1
BAI1-associated protein 2-like 1
chr6_+_113638467 0.01 ENSMUST00000059286.7
ENSMUST00000089023.4
ENSMUST00000089022.4
Irak2
interleukin-1 receptor-associated kinase 2
chr1_+_178798438 0.01 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr17_+_24470393 0.01 ENSMUST00000053024.6
Pgp
phosphoglycolate phosphatase
chr13_-_111490111 0.01 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr5_-_96161990 0.01 ENSMUST00000155901.1
Cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr19_+_10389068 0.01 ENSMUST00000169121.1
ENSMUST00000076968.3
ENSMUST00000073899.4
Syt7
synaptotagmin VII
chr2_+_163994960 0.01 ENSMUST00000018470.3
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr9_-_99568849 0.01 ENSMUST00000035043.5
Armc8
armadillo repeat containing 8
chr3_-_26133734 0.01 ENSMUST00000108308.3
ENSMUST00000075054.4
Nlgn1
neuroligin 1
chr9_+_40269430 0.01 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr16_+_4639941 0.01 ENSMUST00000038770.3
Vasn
vasorin
chr2_+_26916360 0.01 ENSMUST00000015017.7
Surf2
surfeit gene 2
chrX_-_165327376 0.01 ENSMUST00000058787.8
Glra2
glycine receptor, alpha 2 subunit
chr18_-_73703739 0.01 ENSMUST00000025393.7
Smad4
SMAD family member 4
chr1_+_60746358 0.01 ENSMUST00000027165.2
Cd28
CD28 antigen
chr7_-_111082997 0.01 ENSMUST00000161051.1
ENSMUST00000160132.1
ENSMUST00000106666.3
ENSMUST00000162415.1
Eif4g2
eukaryotic translation initiation factor 4, gamma 2
chr2_-_104494400 0.00 ENSMUST00000028600.7
Hipk3
homeodomain interacting protein kinase 3
chr12_+_86241848 0.00 ENSMUST00000071106.4
Gpatch2l
G patch domain containing 2 like
chr14_-_26971232 0.00 ENSMUST00000036570.4
Appl1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr3_+_108284089 0.00 ENSMUST00000102632.4
Sort1
sortilin 1
chr11_-_5381734 0.00 ENSMUST00000172492.1
Znrf3
zinc and ring finger 3
chr17_-_35046539 0.00 ENSMUST00000007250.7
Msh5
mutS homolog 5 (E. coli)
chr10_+_85928491 0.00 ENSMUST00000170396.1
Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr1_+_180568913 0.00 ENSMUST00000027777.6
Parp1
poly (ADP-ribose) polymerase family, member 1
chr2_-_34826071 0.00 ENSMUST00000113077.1
ENSMUST00000028220.3
Fbxw2
F-box and WD-40 domain protein 2
chr16_+_84835070 0.00 ENSMUST00000009120.7
Gabpa
GA repeat binding protein, alpha
chr2_-_181592733 0.00 ENSMUST00000108789.2
ENSMUST00000153998.1
Znf512b
zinc finger protein 512B
chr2_+_130450259 0.00 ENSMUST00000028769.6
Ptpra
protein tyrosine phosphatase, receptor type, A
chr2_+_37516618 0.00 ENSMUST00000065441.6
Gpr21
G protein-coupled receptor 21

Network of associatons between targets according to the STRING database.

First level regulatory network of GAGAACU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0002884 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) negative regulation of hypersensitivity(GO:0002884)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.0 GO:0042977 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.0 GO:0070540 stearic acid binding(GO:0070540)
0.0 0.1 GO:0005329 dopamine transmembrane transporter activity(GO:0005329)
0.0 0.0 GO:0004771 sterol esterase activity(GO:0004771)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle