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GSE58827: Dynamics of the Mouse Liver

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Results for GAUAUGU

Z-value: 0.15

Motif logo

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miRNA associated with seed GAUAUGU

NamemiRBASE accession
mmu-miR-190a-5p
MIMAT0000220
mmu-miR-190b-5p
MIMAT0004852

Activity profile of GAUAUGU motif

Sorted Z-values of GAUAUGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_78226627 0.34 ENSMUST00000110388.2
ENSMUST00000052472.4
Gphn
gephyrin
chr6_-_119417479 0.21 ENSMUST00000032272.6
Adipor2
adiponectin receptor 2
chr4_+_11156411 0.17 ENSMUST00000029865.3
Trp53inp1
transformation related protein 53 inducible nuclear protein 1
chr1_+_106171752 0.16 ENSMUST00000061047.6
Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
chr6_+_114643094 0.16 ENSMUST00000032457.10
Atg7
autophagy related 7
chr10_+_107271827 0.13 ENSMUST00000020057.8
ENSMUST00000105280.3
Lin7a
lin-7 homolog A (C. elegans)
chr7_+_35119285 0.13 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr2_+_49451486 0.13 ENSMUST00000092123.4
Epc2
enhancer of polycomb homolog 2 (Drosophila)
chr9_-_108263887 0.12 ENSMUST00000166905.1
ENSMUST00000080435.2
Dag1
dystroglycan 1
chrX_+_82948861 0.12 ENSMUST00000114000.1
Dmd
dystrophin, muscular dystrophy
chr6_-_149101674 0.12 ENSMUST00000111557.1
Dennd5b
DENN/MADD domain containing 5B
chr14_-_124677089 0.10 ENSMUST00000095529.3
Fgf14
fibroblast growth factor 14
chrX_-_141725181 0.10 ENSMUST00000067841.7
Irs4
insulin receptor substrate 4
chr2_-_167188787 0.08 ENSMUST00000059826.8
Kcnb1
potassium voltage gated channel, Shab-related subfamily, member 1
chr6_+_14901344 0.08 ENSMUST00000115477.1
Foxp2
forkhead box P2
chr10_-_115251407 0.08 ENSMUST00000020339.8
Tbc1d15
TBC1 domain family, member 15
chr13_+_117602439 0.07 ENSMUST00000006991.7
Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
chr2_+_105668888 0.06 ENSMUST00000111086.4
ENSMUST00000111087.3
Pax6
paired box gene 6
chr3_+_16183177 0.06 ENSMUST00000108345.2
ENSMUST00000108346.2
Ythdf3
YTH domain family 3
chr18_-_25753852 0.06 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4
CUGBP, Elav-like family member 4
chr5_-_76304474 0.05 ENSMUST00000075159.1
Clock
circadian locomotor output cycles kaput
chr5_-_143180721 0.05 ENSMUST00000164068.1
ENSMUST00000049861.4
ENSMUST00000165318.1
Rbak
RB-associated KRAB repressor
chr2_+_129800451 0.05 ENSMUST00000165413.2
ENSMUST00000166282.2
Stk35
serine/threonine kinase 35
chr3_-_26133734 0.04 ENSMUST00000108308.3
ENSMUST00000075054.4
Nlgn1
neuroligin 1
chr18_-_79109391 0.04 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1
SET binding protein 1
chr11_+_117654798 0.03 ENSMUST00000106344.1
Tnrc6c
trinucleotide repeat containing 6C
chr5_+_122284365 0.02 ENSMUST00000053426.8
Pptc7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr1_-_25228814 0.02 ENSMUST00000126626.1
Bai3
brain-specific angiogenesis inhibitor 3
chr9_+_3532295 0.02 ENSMUST00000115733.1
Gucy1a2
guanylate cyclase 1, soluble, alpha 2
chr1_-_156303585 0.01 ENSMUST00000141760.3
ENSMUST00000121146.3
Tdrd5
tudor domain containing 5
chr12_+_111538101 0.00 ENSMUST00000166123.1
Eif5
eukaryotic translation initiation factor 5
chr18_+_69345721 0.00 ENSMUST00000078486.6
ENSMUST00000114982.1
Tcf4
transcription factor 4

Network of associatons between targets according to the STRING database.

First level regulatory network of GAUAUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0007529 establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.1 0.2 GO:0036446 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.1 0.2 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.0 0.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.1 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.2 GO:0061042 vascular wound healing(GO:0061042)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.0 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:1904937 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.0 0.1 GO:0000050 urea cycle(GO:0000050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0098855 HCN channel complex(GO:0098855)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.1 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008940 nitrate reductase activity(GO:0008940)
0.1 0.2 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.1 0.2 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network