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GSE58827: Dynamics of the Mouse Liver

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Results for Gata6

Z-value: 0.51

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Transcription factors associated with Gata6

Gene Symbol Gene ID Gene Info
Gata6
ENSMUSG00000005836.8 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata6mm10_v2_chr18_+_11052487_110525100.591.5e-04Click!

Activity profile of Gata6 motif

Sorted Z-values of Gata6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_30639218 4.04 ENSMUST00000031806.9
Cpa1
carboxypeptidase A1, pancreatic
chr4_-_137430517 2.91 ENSMUST00000102522.4
Cela3b
chymotrypsin-like elastase family, member 3B
chr6_-_41035501 2.79 ENSMUST00000031931.5
2210010C04Rik
RIKEN cDNA 2210010C04 gene
chr19_+_58670358 2.67 ENSMUST00000057270.7
Pnlip
pancreatic lipase
chr3_-_75270073 2.65 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr11_-_99322943 2.47 ENSMUST00000038004.2
Krt25
keratin 25
chr4_-_137409777 1.73 ENSMUST00000024200.6
Gm13011
predicted gene 13011
chr4_-_46404224 1.44 ENSMUST00000107764.2
Hemgn
hemogen
chr9_-_95815389 1.43 ENSMUST00000119760.1
Pls1
plastin 1 (I-isoform)
chr6_+_86078070 1.32 ENSMUST00000032069.5
Add2
adducin 2 (beta)
chr4_+_34893772 1.29 ENSMUST00000029975.3
ENSMUST00000135871.1
ENSMUST00000108130.1
Cga
glycoprotein hormones, alpha subunit
chr11_-_102365111 1.23 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr8_-_84044982 1.14 ENSMUST00000061923.4
Rln3
relaxin 3
chr3_-_20242173 1.12 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chr13_-_22219820 0.97 ENSMUST00000057516.1
Vmn1r193
vomeronasal 1 receptor 193
chr6_+_87428986 0.87 ENSMUST00000032125.5
Bmp10
bone morphogenetic protein 10
chr8_-_85365317 0.80 ENSMUST00000034133.7
Mylk3
myosin light chain kinase 3
chr8_-_85365341 0.78 ENSMUST00000121972.1
Mylk3
myosin light chain kinase 3
chr5_+_76840597 0.73 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
C530008M17Rik
RIKEN cDNA C530008M17 gene
chr11_-_99493112 0.70 ENSMUST00000006969.7
Krt23
keratin 23
chr7_-_4397705 0.61 ENSMUST00000108590.2
Gp6
glycoprotein 6 (platelet)
chr1_-_144775419 0.60 ENSMUST00000027603.3
Rgs18
regulator of G-protein signaling 18
chr8_+_45628176 0.59 ENSMUST00000130850.1
Sorbs2
sorbin and SH3 domain containing 2
chr10_+_115817247 0.55 ENSMUST00000035563.7
ENSMUST00000080630.3
ENSMUST00000179196.1
Tspan8
tetraspanin 8
chr18_-_39489157 0.51 ENSMUST00000131885.1
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr5_-_73191848 0.51 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr3_-_59262825 0.50 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr3_+_108364882 0.49 ENSMUST00000090563.5
Mybphl
myosin binding protein H-like
chr8_-_85380964 0.49 ENSMUST00000122452.1
Mylk3
myosin light chain kinase 3
chr1_+_179803376 0.46 ENSMUST00000097454.2
Gm10518
predicted gene 10518
chr2_+_71786923 0.45 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6
integrin alpha 6
chr8_-_38661508 0.43 ENSMUST00000118896.1
Sgcz
sarcoglycan zeta
chr12_+_95692212 0.41 ENSMUST00000057324.3
Flrt2
fibronectin leucine rich transmembrane protein 2
chr2_+_72476225 0.37 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr8_-_36953139 0.37 ENSMUST00000179501.1
Dlc1
deleted in liver cancer 1
chr5_-_30461902 0.36 ENSMUST00000133509.1
ENSMUST00000074171.6
ENSMUST00000114747.2
ENSMUST00000144125.1
Otof
otoferlin
chr17_+_34604819 0.35 ENSMUST00000173242.1
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr2_-_172370506 0.33 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
Aurka
aurora kinase A
chrX_+_10485121 0.30 ENSMUST00000076354.6
ENSMUST00000115526.1
Tspan7
tetraspanin 7
chr10_-_34207551 0.29 ENSMUST00000048010.7
Dse
dermatan sulfate epimerase
chr8_+_45627946 0.28 ENSMUST00000145458.1
Sorbs2
sorbin and SH3 domain containing 2
chr10_-_62342674 0.27 ENSMUST00000143179.1
ENSMUST00000130422.1
Hk1
hexokinase 1
chr15_-_96767141 0.25 ENSMUST00000177677.1
Gm8888
predicted gene 8888
chr5_-_111761697 0.23 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik
RIKEN cDNA E130006D01 gene
chr2_+_68104671 0.22 ENSMUST00000042456.3
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr4_+_150148905 0.20 ENSMUST00000059893.7
Slc2a7
solute carrier family 2 (facilitated glucose transporter), member 7
chr2_+_72476159 0.20 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr11_-_53707269 0.19 ENSMUST00000124352.1
ENSMUST00000020649.7
Rad50
RAD50 homolog (S. cerevisiae)
chr2_+_91118136 0.19 ENSMUST00000169776.1
ENSMUST00000111430.3
ENSMUST00000137942.1
Mybpc3
myosin binding protein C, cardiac
chr7_-_103853199 0.19 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr9_+_65032413 0.19 ENSMUST00000034960.6
Dpp8
dipeptidylpeptidase 8
chr9_-_29963112 0.18 ENSMUST00000075069.4
Ntm
neurotrimin
chr2_-_33087169 0.18 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr16_+_36041184 0.17 ENSMUST00000042203.8
Wdr5b
WD repeat domain 5B
chr2_-_59948155 0.17 ENSMUST00000153136.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr18_+_37300799 0.16 ENSMUST00000051754.1
Pcdhb3
protocadherin beta 3
chr6_+_58831748 0.15 ENSMUST00000126292.1
ENSMUST00000031823.5
Herc3
hect domain and RLD 3
chr9_-_80465429 0.11 ENSMUST00000085289.5
ENSMUST00000185068.1
ENSMUST00000113250.3
Impg1
interphotoreceptor matrix proteoglycan 1
chr11_-_46389454 0.11 ENSMUST00000101306.3
Itk
IL2 inducible T cell kinase
chr7_-_99238564 0.11 ENSMUST00000064231.7
Mogat2
monoacylglycerol O-acyltransferase 2
chr19_-_10678001 0.11 ENSMUST00000025647.5
Pga5
pepsinogen 5, group I
chr10_+_40883469 0.10 ENSMUST00000019975.7
Wasf1
WAS protein family, member 1
chr11_+_87581041 0.09 ENSMUST00000018544.5
ENSMUST00000063156.4
ENSMUST00000107960.1
Sept4
septin 4
chr11_+_3330781 0.09 ENSMUST00000136536.1
ENSMUST00000093399.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr3_-_30140407 0.08 ENSMUST00000108271.3
Mecom
MDS1 and EVI1 complex locus
chr6_+_58833689 0.08 ENSMUST00000041401.8
Herc3
hect domain and RLD 3
chr2_-_7396192 0.07 ENSMUST00000137733.2
Celf2
CUGBP, Elav-like family member 2
chr2_+_74704615 0.07 ENSMUST00000151380.1
Hoxd8
homeobox D8
chr3_+_79885930 0.07 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr11_+_26387194 0.06 ENSMUST00000109509.1
ENSMUST00000136830.1
Fancl
Fanconi anemia, complementation group L
chr5_+_121777929 0.06 ENSMUST00000160821.1
Atxn2
ataxin 2
chr9_+_66350465 0.06 ENSMUST00000042824.6
Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr16_-_46010212 0.05 ENSMUST00000130481.1
Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr1_+_45311538 0.04 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chrX_-_37110257 0.04 ENSMUST00000076265.6
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr11_+_4986824 0.03 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr2_-_77170592 0.03 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141
coiled-coil domain containing 141
chr13_-_106547060 0.03 ENSMUST00000076359.2
Dph3b-ps
DPH3B, KTI11 homolog B (S. cerevisiae), pseudogene
chr19_+_31868754 0.03 ENSMUST00000075838.5
A1cf
APOBEC1 complementation factor
chr11_-_46389471 0.03 ENSMUST00000109237.2
Itk
IL2 inducible T cell kinase
chr2_+_74704861 0.03 ENSMUST00000019749.3
Hoxd8
homeobox D8
chr7_+_28833975 0.03 ENSMUST00000066723.8
Lgals4
lectin, galactose binding, soluble 4
chr9_-_65827544 0.03 ENSMUST00000159109.1
Zfp609
zinc finger protein 609
chr16_+_91647859 0.02 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
Son
Son DNA binding protein
chr2_-_7081207 0.02 ENSMUST00000114923.2
ENSMUST00000182706.1
Celf2
CUGBP, Elav-like family member 2
chr2_-_7395968 0.01 ENSMUST00000002176.6
Celf2
CUGBP, Elav-like family member 2
chr2_+_172370658 0.01 ENSMUST00000151511.1
ENSMUST00000116375.1
Cstf1
cleavage stimulation factor, 3' pre-RNA, subunit 1
chr2_-_33086366 0.01 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr11_+_98026695 0.00 ENSMUST00000092425.4
Rpl19
ribosomal protein L19
chr10_+_117045341 0.00 ENSMUST00000073834.4
Lrrc10
leucine rich repeat containing 10

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:1902896 terminal web assembly(GO:1902896)
0.3 2.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 0.9 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 2.4 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.5 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 1.3 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.1 1.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 0.5 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 2.5 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.3 GO:0060282 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.1 1.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 1.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.5 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.4 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 0.3 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 1.0 GO:0019236 response to pheromone(GO:0019236)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 1.1 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.6 GO:0008203 cholesterol metabolic process(GO:0008203)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:1990357 terminal web(GO:1990357)
0.1 1.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 3.2 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.2 GO:0014704 intercalated disc(GO:0014704)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 5.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.5 GO:0038051 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.9 GO:0031433 telethonin binding(GO:0031433)
0.1 0.4 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.6 GO:0038064 collagen receptor activity(GO:0038064)
0.0 0.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 0.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 1.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.3 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 5.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 1.3 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 1.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 5.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 2.7 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression