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GSE58827: Dynamics of the Mouse Liver

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Results for Gbx2

Z-value: 0.36

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Transcription factors associated with Gbx2

Gene Symbol Gene ID Gene Info
Gbx2
ENSMUSG00000034486.7 gastrulation brain homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_899332900.105.5e-01Click!

Activity profile of Gbx2 motif

Sorted Z-values of Gbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_38132767 1.33 ENSMUST00000025956.5
ENSMUST00000112329.1
Pde6c
phosphodiesterase 6C, cGMP specific, cone, alpha prime
chr12_+_79297345 1.02 ENSMUST00000079533.5
ENSMUST00000171210.1
Rad51b
RAD51 homolog B
chr2_+_84988194 0.87 ENSMUST00000028466.5
Prg3
proteoglycan 3
chr3_+_84666192 0.63 ENSMUST00000107682.1
Tmem154
transmembrane protein 154
chr13_+_23763660 0.54 ENSMUST00000055770.1
Hist1h1a
histone cluster 1, H1a
chr3_-_116129615 0.52 ENSMUST00000029574.8
Vcam1
vascular cell adhesion molecule 1
chrX_-_7741288 0.51 ENSMUST00000033490.6
Ccdc120
coiled-coil domain containing 120
chr16_+_44394771 0.49 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chr7_-_30664986 0.47 ENSMUST00000019697.8
Haus5
HAUS augmin-like complex, subunit 5
chr16_-_36784924 0.40 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr6_+_6248659 0.36 ENSMUST00000181633.1
ENSMUST00000176283.1
ENSMUST00000175814.1
ENSMUST00000181192.1
Gm20619
predicted gene 20619
chr2_+_152754156 0.35 ENSMUST00000010020.5
Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr12_+_109545390 0.34 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr17_-_48432723 0.32 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr11_+_97315716 0.28 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45
mitochondrial ribosomal protein L45
chr16_-_36784784 0.27 ENSMUST00000165531.1
Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr4_+_19280850 0.25 ENSMUST00000102999.1
Cngb3
cyclic nucleotide gated channel beta 3
chrX_+_106920618 0.22 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr3_+_88616133 0.21 ENSMUST00000176500.1
ENSMUST00000177498.1
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chrX_-_43167817 0.20 ENSMUST00000115058.1
ENSMUST00000115059.1
Tenm1
teneurin transmembrane protein 1
chr15_+_103240405 0.20 ENSMUST00000036004.9
ENSMUST00000087351.7
Hnrnpa1
heterogeneous nuclear ribonucleoprotein A1
chr10_+_116177351 0.20 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr
protein tyrosine phosphatase, receptor type, R
chr19_-_39740999 0.19 ENSMUST00000099472.3
Cyp2c68
cytochrome P450, family 2, subfamily c, polypeptide 68
chr10_-_129902726 0.19 ENSMUST00000071557.1
Olfr815
olfactory receptor 815
chr14_-_18893376 0.17 ENSMUST00000151926.1
Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr3_+_57425314 0.17 ENSMUST00000029377.7
Tm4sf4
transmembrane 4 superfamily member 4
chr11_-_5878207 0.16 ENSMUST00000102922.3
Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr5_-_111761697 0.16 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik
RIKEN cDNA E130006D01 gene
chr6_-_145434925 0.16 ENSMUST00000111708.2
Ifltd1
intermediate filament tail domain containing 1
chr11_-_99851608 0.15 ENSMUST00000107437.1
Krtap4-16
keratin associated protein 4-16
chr16_-_19515634 0.15 ENSMUST00000054606.1
Olfr167
olfactory receptor 167
chr14_-_48667508 0.15 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr10_-_116896879 0.15 ENSMUST00000048229.7
Myrfl
myelin regulatory factor-like
chr16_-_22439719 0.15 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr9_+_96258697 0.14 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr3_+_88615367 0.14 ENSMUST00000176539.1
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr4_+_110397661 0.14 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
Agbl4
ATP/GTP binding protein-like 4
chr5_-_5266038 0.14 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
Cdk14
cyclin-dependent kinase 14
chr17_-_36032682 0.13 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr14_+_58893465 0.13 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr1_-_74893109 0.13 ENSMUST00000006721.2
Cryba2
crystallin, beta A2
chr3_-_89998656 0.13 ENSMUST00000079724.4
Hax1
HCLS1 associated X-1
chr10_+_116177217 0.13 ENSMUST00000148731.1
Ptprr
protein tyrosine phosphatase, receptor type, R
chr5_+_115341225 0.12 ENSMUST00000031508.4
Triap1
TP53 regulated inhibitor of apoptosis 1
chr1_-_128102412 0.12 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3
zinc finger, RAN-binding domain containing 3
chr19_-_59170978 0.11 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr2_-_17460610 0.10 ENSMUST00000145492.1
Nebl
nebulette
chr1_+_71652837 0.10 ENSMUST00000097699.2
Apol7d
apolipoprotein L 7d
chr7_+_78783119 0.10 ENSMUST00000032840.4
Mrps11
mitochondrial ribosomal protein S11
chr1_+_24005505 0.09 ENSMUST00000181961.1
Gm26524
predicted gene, 26524
chr4_+_110397764 0.08 ENSMUST00000097920.2
ENSMUST00000080744.6
Agbl4
ATP/GTP binding protein-like 4
chr9_-_20336094 0.08 ENSMUST00000086473.3
Olfr18
olfactory receptor 18
chr11_-_46707059 0.08 ENSMUST00000055102.6
ENSMUST00000125008.1
Timd2
T cell immunoglobulin and mucin domain containing 2
chr5_-_87699414 0.08 ENSMUST00000082370.5
Csn2
casein beta
chr18_+_57354733 0.07 ENSMUST00000025490.8
Prrc1
proline-rich coiled-coil 1
chr4_+_52596270 0.07 ENSMUST00000029995.5
4930547C10Rik
RIKEN cDNA 4930547C10 gene
chr14_-_30353468 0.07 ENSMUST00000112249.1
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr11_-_79504078 0.07 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr7_-_78783026 0.07 ENSMUST00000032841.5
Mrpl46
mitochondrial ribosomal protein L46
chr5_-_31295862 0.06 ENSMUST00000041266.7
ENSMUST00000172435.1
Fndc4
fibronectin type III domain containing 4
chr10_+_128083273 0.06 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr14_+_44988192 0.05 ENSMUST00000046891.5
Ptger2
prostaglandin E receptor 2 (subtype EP2)
chr13_+_49544443 0.05 ENSMUST00000177948.1
ENSMUST00000021820.6
Aspn
asporin
chr14_+_69347587 0.03 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr10_-_95501921 0.03 ENSMUST00000075829.2
Mrpl42
mitochondrial ribosomal protein L42
chr5_+_7304128 0.02 ENSMUST00000160634.1
ENSMUST00000159546.1
4921511H03Rik
RIKEN cDNA 4921511H03 gene
chr5_-_115341142 0.02 ENSMUST00000139167.1
Gatc
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)
chr7_+_28810886 0.02 ENSMUST00000038572.8
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr1_-_24005608 0.02 ENSMUST00000027338.3
1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr5_+_113735782 0.01 ENSMUST00000065698.5
Ficd
FIC domain containing
chr13_-_97747373 0.01 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_13730970 0.01 ENSMUST00000023364.6
Pla2g10
phospholipase A2, group X
chr3_+_93468751 0.01 ENSMUST00000029516.2
Tchhl1
trichohyalin-like 1
chr1_-_161979636 0.01 ENSMUST00000162676.1
4930558K02Rik
RIKEN cDNA 4930558K02 gene
chr4_-_139968026 0.01 ENSMUST00000105031.2
Klhdc7a
kelch domain containing 7A
chr4_+_118961578 0.00 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Gbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0045575 basophil activation(GO:0045575)
0.2 1.0 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.7 GO:0042938 dipeptide transport(GO:0042938)
0.1 1.3 GO:0046549 retinal cone cell development(GO:0046549)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.4 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.2 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.5 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:2000566 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0060762 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 0.1 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.1 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.0 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.1 GO:0042612 MHC class I protein complex(GO:0042612)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0042936 dipeptide transporter activity(GO:0042936)
0.1 1.0 GO:0000150 recombinase activity(GO:0000150)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.6 GO:0030553 cGMP binding(GO:0030553)
0.1 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0070287 ferritin receptor activity(GO:0070287)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand