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GSE58827: Dynamics of the Mouse Liver

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Results for Gmeb1

Z-value: 0.94

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Transcription factors associated with Gmeb1

Gene Symbol Gene ID Gene Info
Gmeb1
ENSMUSG00000028901.7 glucocorticoid modulatory element binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261521_1322615720.874.1e-12Click!

Activity profile of Gmeb1 motif

Sorted Z-values of Gmeb1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_23139064 9.58 ENSMUST00000033947.8
Ank1
ankyrin 1, erythroid
chr8_+_23139030 8.57 ENSMUST00000121075.1
Ank1
ankyrin 1, erythroid
chr6_+_113531675 8.29 ENSMUST00000036340.5
ENSMUST00000101051.2
Fancd2
Fanconi anemia, complementation group D2
chr3_+_127553462 6.25 ENSMUST00000043108.4
4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr6_+_90619241 6.21 ENSMUST00000032177.8
Slc41a3
solute carrier family 41, member 3
chr2_-_157007015 5.82 ENSMUST00000146413.1
Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr15_+_99074968 5.13 ENSMUST00000039665.6
Troap
trophinin associated protein
chr2_-_157007039 5.06 ENSMUST00000103129.2
ENSMUST00000103130.1
Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr3_+_40800054 5.05 ENSMUST00000168287.1
Plk4
polo-like kinase 4
chr1_+_175880775 5.03 ENSMUST00000039725.6
Exo1
exonuclease 1
chr3_+_40800013 4.74 ENSMUST00000026858.5
ENSMUST00000170825.1
Plk4
polo-like kinase 4
chr19_-_40588374 4.51 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chrX_-_150814265 4.43 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2
melanoma antigen, family D, 2
chr19_-_40588453 4.39 ENSMUST00000025979.6
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr19_-_40588338 4.08 ENSMUST00000176939.1
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr11_+_69095217 3.25 ENSMUST00000101004.2
Per1
period circadian clock 1
chr8_-_123949201 2.83 ENSMUST00000044795.7
Nup133
nucleoporin 133
chr8_+_23139157 2.78 ENSMUST00000174435.1
Ank1
ankyrin 1, erythroid
chr10_-_81378459 2.57 ENSMUST00000140901.1
Fzr1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr1_-_91459254 2.54 ENSMUST00000069620.8
Per2
period circadian clock 2
chr11_+_69914179 2.46 ENSMUST00000057884.5
Gps2
G protein pathway suppressor 2
chr16_+_49699198 2.34 ENSMUST00000046777.4
ENSMUST00000142682.1
Ift57
intraflagellar transport 57
chr11_-_40733373 2.27 ENSMUST00000020579.8
Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr15_-_58135047 1.96 ENSMUST00000038194.3
Atad2
ATPase family, AAA domain containing 2
chr19_+_43612299 1.78 ENSMUST00000057178.9
Nkx2-3
NK2 homeobox 3
chr2_+_75659253 1.74 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
Hnrnpa3
heterogeneous nuclear ribonucleoprotein A3
chr7_-_83884289 1.73 ENSMUST00000094216.3
Mesdc1
mesoderm development candidate 1
chr16_+_20696175 1.65 ENSMUST00000128273.1
Fam131a
family with sequence similarity 131, member A
chr10_+_80798652 1.52 ENSMUST00000151928.1
Sf3a2
splicing factor 3a, subunit 2
chr4_-_135353126 1.29 ENSMUST00000030613.4
ENSMUST00000131373.1
Srrm1
serine/arginine repetitive matrix 1
chr7_+_35397046 1.28 ENSMUST00000079414.5
Cep89
centrosomal protein 89
chr4_-_126202583 1.23 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
Thrap3
thyroid hormone receptor associated protein 3
chr11_+_86544982 1.20 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
Tubd1
tubulin, delta 1
chr2_+_69723071 1.08 ENSMUST00000040915.8
Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr4_-_135353164 1.08 ENSMUST00000084846.5
ENSMUST00000136342.2
ENSMUST00000105861.1
Srrm1
serine/arginine repetitive matrix 1
chr6_-_87672142 1.06 ENSMUST00000032130.2
ENSMUST00000065997.2
Aplf
aprataxin and PNKP like factor
chr17_+_23679363 1.04 ENSMUST00000024699.2
Cldn6
claudin 6
chr14_+_20694956 1.00 ENSMUST00000048016.1
Fut11
fucosyltransferase 11
chr9_+_108002501 0.97 ENSMUST00000035214.4
ENSMUST00000175874.1
Ip6k1
inositol hexaphosphate kinase 1
chr5_+_93206518 0.96 ENSMUST00000031330.4
2010109A12Rik
RIKEN cDNA 2010109A12 gene
chr17_+_29549783 0.96 ENSMUST00000048677.7
Tbc1d22b
TBC1 domain family, member 22B
chr13_+_23574381 0.92 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr2_+_69722797 0.87 ENSMUST00000090858.3
Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr2_-_180334665 0.83 ENSMUST00000015771.2
Gata5
GATA binding protein 5
chr12_+_4917376 0.77 ENSMUST00000045664.5
Atad2b
ATPase family, AAA domain containing 2B
chr3_-_108086590 0.70 ENSMUST00000102638.1
ENSMUST00000102637.1
Ampd2
adenosine monophosphate deaminase 2
chr11_-_97782377 0.69 ENSMUST00000128801.1
Rpl23
ribosomal protein L23
chr11_+_83302817 0.67 ENSMUST00000142680.1
Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr17_+_84511832 0.63 ENSMUST00000047206.5
Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr19_-_24477356 0.62 ENSMUST00000099556.1
Fam122a
family with sequence similarity 122, member A
chr8_-_94918012 0.60 ENSMUST00000077955.5
Ccdc102a
coiled-coil domain containing 102A
chr7_+_5020561 0.57 ENSMUST00000085427.3
Zfp865
zinc finger protein 865
chr19_+_46075842 0.56 ENSMUST00000165017.1
Nolc1
nucleolar and coiled-body phosphoprotein 1
chr11_-_97782409 0.56 ENSMUST00000103146.4
Rpl23
ribosomal protein L23
chr17_+_83350925 0.54 ENSMUST00000096766.4
ENSMUST00000112363.2
ENSMUST00000049503.8
Eml4
echinoderm microtubule associated protein like 4
chr7_+_5020376 0.53 ENSMUST00000076251.4
Zfp865
zinc finger protein 865
chr4_+_88776922 0.51 ENSMUST00000179158.1
Gm13289
predicted gene 13289
chr17_+_85090647 0.47 ENSMUST00000095188.5
Camkmt
calmodulin-lysine N-methyltransferase
chr4_-_126202757 0.46 ENSMUST00000080919.5
Thrap3
thyroid hormone receptor associated protein 3
chr15_-_79546741 0.42 ENSMUST00000054014.7
Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr6_-_128424883 0.38 ENSMUST00000001559.8
Itfg2
integrin alpha FG-GAP repeat containing 2
chr3_-_19311269 0.33 ENSMUST00000099195.3
Pde7a
phosphodiesterase 7A
chr11_+_22990519 0.29 ENSMUST00000173867.1
ENSMUST00000020562.4
Cct4
chaperonin containing Tcp1, subunit 4 (delta)
chr11_-_74724670 0.26 ENSMUST00000021091.8
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr3_-_127553233 0.26 ENSMUST00000029588.5
Larp7
La ribonucleoprotein domain family, member 7
chr7_-_111082997 0.24 ENSMUST00000161051.1
ENSMUST00000160132.1
ENSMUST00000106666.3
ENSMUST00000162415.1
Eif4g2
eukaryotic translation initiation factor 4, gamma 2
chrX_+_112311334 0.16 ENSMUST00000026599.3
ENSMUST00000113415.1
Apool
apolipoprotein O-like
chr4_+_88779850 0.13 ENSMUST00000179425.1
Gm13272
predicted gene 13272
chr17_-_29549588 0.10 ENSMUST00000114683.2
ENSMUST00000168339.1
Tmem217
transmembrane protein 217
chr11_+_97315716 0.09 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45
mitochondrial ribosomal protein L45
chr10_-_112928974 0.01 ENSMUST00000099276.2
Atxn7l3b
ataxin 7-like 3B
chr15_-_83724979 0.00 ENSMUST00000171496.1
ENSMUST00000043634.5
ENSMUST00000076060.5
ENSMUST00000016907.7
Scube1
signal peptide, CUB domain, EGF-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Gmeb1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0006592 ornithine biosynthetic process(GO:0006592)
2.7 10.9 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
1.4 9.8 GO:0046601 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
1.2 5.8 GO:0097167 circadian regulation of translation(GO:0097167)
0.8 8.3 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.6 4.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.5 20.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.4 5.0 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3 1.8 GO:0002317 plasma cell differentiation(GO:0002317)
0.3 2.8 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.3 2.6 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 1.2 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.2 2.7 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.2 1.1 GO:0051106 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 2.3 GO:0044458 motile cilium assembly(GO:0044458)
0.1 1.0 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.7 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.1 1.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.6 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 2.5 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.8 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.4 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.3 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 1.7 GO:0051028 mRNA transport(GO:0051028)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 1.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.6 GO:1901880 negative regulation of protein depolymerization(GO:1901880)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.9 GO:0000818 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
1.6 9.8 GO:0098536 deuterosome(GO:0098536)
0.9 20.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 2.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 2.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.3 GO:0044292 dendrite terminus(GO:0044292)
0.1 1.3 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 1.5 GO:0071004 U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004)
0.1 1.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0000235 astral microtubule(GO:0000235)
0.0 1.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 8.3 GO:0000793 condensed chromosome(GO:0000793)
0.0 4.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 11.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
2.1 20.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.3 5.0 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.4 2.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.3 1.7 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 7.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 1.0 GO:0052724 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.2 2.5 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 1.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 1.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 2.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 3.2 GO:0070888 E-box binding(GO:0070888)
0.0 1.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 1.0 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 8.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 1.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 8.3 PID BARD1 PATHWAY BARD1 signaling events
0.1 2.3 PID AURORA A PATHWAY Aurora A signaling
0.0 1.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 8.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.5 13.0 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.5 20.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 9.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 5.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 11.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.2 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 3.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation