Project

GSE58827: Dynamics of the Mouse Liver

Navigation
Downloads

Results for Grhl1

Z-value: 1.22

Motif logo

logo of

Transcription factors associated with Grhl1

Gene Symbol Gene ID Gene Info
Grhl1
ENSMUSG00000020656.9 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_24572308-0.076.9e-01Click!

Activity profile of Grhl1 motif

Sorted Z-values of Grhl1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_78347140 10.25 ENSMUST00000034902.5
Gsta2
glutathione S-transferase, alpha 2 (Yc2)
chr9_-_78347162 9.49 ENSMUST00000129247.1
Gsta2
glutathione S-transferase, alpha 2 (Yc2)
chr9_+_78289923 8.30 ENSMUST00000119823.1
ENSMUST00000121273.1
Gm10639
predicted gene 10639
chr11_+_72435565 7.40 ENSMUST00000100903.2
Ggt6
gamma-glutamyltransferase 6
chr5_-_86518578 6.32 ENSMUST00000134179.1
Tmprss11g
transmembrane protease, serine 11g
chr1_+_135818593 5.71 ENSMUST00000038760.8
Lad1
ladinin
chr8_-_93229517 5.62 ENSMUST00000176282.1
ENSMUST00000034173.7
Ces1e
carboxylesterase 1E
chr18_+_56432116 5.62 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chrX_-_38456407 5.55 ENSMUST00000074913.5
ENSMUST00000016678.7
ENSMUST00000061755.8
Lamp2
lysosomal-associated membrane protein 2
chr4_+_141242850 4.74 ENSMUST00000138096.1
ENSMUST00000006618.2
ENSMUST00000125392.1
Arhgef19
Rho guanine nucleotide exchange factor (GEF) 19
chr3_-_85722474 4.67 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr16_+_44173271 3.82 ENSMUST00000088356.4
ENSMUST00000169582.1
Gm608
predicted gene 608
chr15_-_76014318 3.72 ENSMUST00000060807.5
Fam83h
family with sequence similarity 83, member H
chr2_-_30205772 3.71 ENSMUST00000113662.1
Ccbl1
cysteine conjugate-beta lyase 1
chr2_-_30205794 3.70 ENSMUST00000113663.2
ENSMUST00000044038.3
Ccbl1
cysteine conjugate-beta lyase 1
chr19_+_18631927 3.69 ENSMUST00000159572.1
ENSMUST00000042392.7
Nmrk1
nicotinamide riboside kinase 1
chr13_+_8885501 3.50 ENSMUST00000169314.2
Idi1
isopentenyl-diphosphate delta isomerase
chr7_+_101321703 3.20 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
Stard10
START domain containing 10
chr17_+_56005672 3.18 ENSMUST00000133998.1
Mpnd
MPN domain containing
chr7_+_65693447 3.17 ENSMUST00000143508.1
Tm2d3
TM2 domain containing 3
chr17_-_56005566 3.14 ENSMUST00000043785.6
Stap2
signal transducing adaptor family member 2
chr14_-_73385225 3.08 ENSMUST00000022704.7
Itm2b
integral membrane protein 2B
chr16_+_44173239 2.91 ENSMUST00000119746.1
Gm608
predicted gene 608
chr7_+_65693417 2.62 ENSMUST00000032726.7
ENSMUST00000107495.3
Tm2d3
TM2 domain containing 3
chr4_+_108834601 2.20 ENSMUST00000030296.8
Txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr7_+_12927410 1.99 ENSMUST00000045870.4
2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr8_-_71381907 1.98 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr4_+_134065897 1.92 ENSMUST00000137053.1
Aim1l
absent in melanoma 1-like
chr17_+_29268788 1.89 ENSMUST00000064709.5
ENSMUST00000120346.1
BC004004
cDNA sequence BC004004
chr12_+_90738201 1.86 ENSMUST00000181874.1
Gm26512
predicted gene, 26512
chr19_-_18631754 1.72 ENSMUST00000025631.6
Ostf1
osteoclast stimulating factor 1
chr7_+_141338963 1.69 ENSMUST00000143633.1
Eps8l2
EPS8-like 2
chr8_+_45628176 1.68 ENSMUST00000130850.1
Sorbs2
sorbin and SH3 domain containing 2
chr17_-_34628380 1.64 ENSMUST00000167097.2
Ppt2
palmitoyl-protein thioesterase 2
chr3_-_10335650 1.51 ENSMUST00000078748.3
Slc10a5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr11_+_53350783 1.42 ENSMUST00000060945.5
Aff4
AF4/FMR2 family, member 4
chr2_-_127541412 1.42 ENSMUST00000028855.7
Prom2
prominin 2
chr2_-_127541385 1.30 ENSMUST00000103214.2
Prom2
prominin 2
chr4_-_155086271 1.25 ENSMUST00000030914.3
Rer1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
chr1_-_131279544 1.21 ENSMUST00000062108.3
Ikbke
inhibitor of kappaB kinase epsilon
chrX_-_112698642 1.21 ENSMUST00000039887.3
Pof1b
premature ovarian failure 1B
chr17_-_34628005 1.20 ENSMUST00000166040.2
Ppt2
palmitoyl-protein thioesterase 2
chr18_-_25753852 1.20 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4
CUGBP, Elav-like family member 4
chr18_-_64660981 1.16 ENSMUST00000025482.8
Atp8b1
ATPase, class I, type 8B, member 1
chr3_-_103732553 1.16 ENSMUST00000169286.1
BC027582
cDNA sequence BC027582
chr17_+_13760502 1.08 ENSMUST00000139347.1
ENSMUST00000156591.1
ENSMUST00000170827.2
ENSMUST00000139666.1
ENSMUST00000137784.1
ENSMUST00000137708.1
ENSMUST00000150848.1
Mllt4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr2_+_172550761 1.04 ENSMUST00000099058.3
Tfap2c
transcription factor AP-2, gamma
chr5_-_86676346 0.99 ENSMUST00000038448.6
Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr4_-_19570073 0.95 ENSMUST00000029885.4
Cpne3
copine III
chr7_-_102065044 0.85 ENSMUST00000130074.1
ENSMUST00000131104.1
ENSMUST00000096639.5
Rnf121
ring finger protein 121
chr14_-_57133268 0.82 ENSMUST00000160703.1
Gjb6
gap junction protein, beta 6
chr3_+_92288566 0.82 ENSMUST00000090872.4
Sprr2a3
small proline-rich protein 2A3
chr17_+_7324646 0.82 ENSMUST00000095726.4
ENSMUST00000128533.1
ENSMUST00000129709.1
ENSMUST00000147803.1
ENSMUST00000140192.1
ENSMUST00000138222.1
ENSMUST00000144861.1
Tcp10a
t-complex protein 10a
chr6_-_113377510 0.79 ENSMUST00000099118.2
Tada3
transcriptional adaptor 3
chr9_-_107541816 0.78 ENSMUST00000041459.3
Cyb561d2
cytochrome b-561 domain containing 2
chr4_+_155086577 0.75 ENSMUST00000030915.4
ENSMUST00000155775.1
ENSMUST00000127457.1
Morn1
MORN repeat containing 1
chr11_-_22860467 0.74 ENSMUST00000055549.3
B3gnt2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr2_-_30967859 0.74 ENSMUST00000028200.8
Tor1a
torsin family 1, member A (torsin A)
chr5_+_136057138 0.70 ENSMUST00000111137.1
Upk3bl
uroplakin 3B-like
chr4_+_109676568 0.69 ENSMUST00000102724.4
Faf1
Fas-associated factor 1
chr8_+_123477859 0.67 ENSMUST00000001520.7
Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr5_-_86518562 0.65 ENSMUST00000140095.1
Tmprss11g
transmembrane protease, serine 11g
chr2_-_180289879 0.63 ENSMUST00000038529.1
Rbbp8nl
RBBP8 N-terminal like
chr9_-_44268156 0.62 ENSMUST00000169651.1
Nlrx1
NLR family member X1
chr3_-_88548249 0.62 ENSMUST00000131775.1
ENSMUST00000008745.6
Rab25
RAB25, member RAS oncogene family
chr5_-_137600650 0.59 ENSMUST00000111007.1
ENSMUST00000133705.1
Mospd3
motile sperm domain containing 3
chr8_-_95853501 0.57 ENSMUST00000040481.3
Slc38a7
solute carrier family 38, member 7
chr12_-_54656496 0.55 ENSMUST00000056228.6
Sptssa
serine palmitoyltransferase, small subunit A
chr2_+_24276909 0.53 ENSMUST00000028360.1
ENSMUST00000168941.1
ENSMUST00000123053.1
Il1f5
interleukin 1 family, member 5 (delta)
chr7_+_29519158 0.45 ENSMUST00000141713.1
4932431P20Rik
RIKEN cDNA 4932431P20 gene
chr17_+_43389436 0.41 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr17_+_13354572 0.37 ENSMUST00000097403.3
Tcp10c
t-complex protein 10c
chr19_+_3958803 0.35 ENSMUST00000179433.1
1700055N04Rik
RIKEN cDNA 1700055N04 gene
chr9_-_7873016 0.31 ENSMUST00000013949.8
Birc3
baculoviral IAP repeat-containing 3
chr16_-_55822128 0.30 ENSMUST00000114458.1
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr17_+_36837123 0.29 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26
tripartite motif-containing 26
chr2_-_25546872 0.25 ENSMUST00000114234.1
ENSMUST00000028311.6
Traf2
TNF receptor-associated factor 2
chr4_+_135728116 0.24 ENSMUST00000102546.3
Il22ra1
interleukin 22 receptor, alpha 1
chr12_-_20900867 0.21 ENSMUST00000079237.5
Zfp125
zinc finger protein 125
chr9_-_7872983 0.20 ENSMUST00000115672.1
Birc3
baculoviral IAP repeat-containing 3
chr9_+_15239045 0.15 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr15_-_63808747 0.14 ENSMUST00000110125.2
Gsdmc
gasdermin C
chr6_-_113377376 0.06 ENSMUST00000043333.2
Tada3
transcriptional adaptor 3
chr2_-_144332146 0.06 ENSMUST00000037423.3
Ovol2
ovo-like 2 (Drosophila)
chr4_+_88754868 0.03 ENSMUST00000094992.1
Gm13271
predicted gene 13271
chr2_+_149830894 0.03 ENSMUST00000137280.1
ENSMUST00000149705.1
Syndig1
synapse differentiation inducing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Grhl1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.8 23.2 GO:0035634 response to stilbenoid(GO:0035634)
0.7 2.7 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.5 7.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.4 3.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.4 3.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.3 1.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 1.9 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.2 1.2 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.2 0.7 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.2 3.7 GO:0019363 pyridine nucleotide biosynthetic process(GO:0019363)
0.2 0.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 1.7 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.7 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.1 0.6 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 1.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 1.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 0.5 GO:0019732 antifungal humoral response(GO:0019732)
0.1 0.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 2.0 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 3.7 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.1 2.2 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.7 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 1.2 GO:0010884 positive regulation of lipid storage(GO:0010884)
0.0 0.3 GO:1903719 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.6 GO:0031268 pseudopodium organization(GO:0031268)
0.0 1.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 4.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.2 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.9 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0097636 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.7 2.7 GO:0044393 microspike(GO:0044393)
0.2 3.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.7 GO:0005745 m-AAA complex(GO:0005745)
0.1 3.7 GO:0045095 keratin filament(GO:0045095)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 5.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 3.1 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 0.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.9 GO:0000124 SAGA complex(GO:0000124)
0.0 2.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.2 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.2 GO:0032420 stereocilium(GO:0032420)
0.0 3.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.9 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0001533 cornified envelope(GO:0001533)
0.0 1.2 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.7 3.7 GO:1990254 keratin filament binding(GO:1990254)
0.7 2.2 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.7 19.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.6 7.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.3 8.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 5.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.3 2.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 0.7 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.2 1.2 GO:0008384 NF-kappaB-inducing kinase activity(GO:0004704) IkappaB kinase activity(GO:0008384)
0.2 1.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.6 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 0.5 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 1.2 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.5 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 6.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 2.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.7 GO:0051787 misfolded protein binding(GO:0051787)
0.0 7.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 3.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 4.5 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 19.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 7.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 3.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 3.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 5.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway