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GSE58827: Dynamics of the Mouse Liver

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Results for Gzf1

Z-value: 0.65

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Transcription factors associated with Gzf1

Gene Symbol Gene ID Gene Info
Gzf1
ENSMUSG00000027439.9 GDNF-inducible zinc finger protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gzf1mm10_v2_chr2_+_148681199_148681218-0.019.4e-01Click!

Activity profile of Gzf1 motif

Sorted Z-values of Gzf1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_109540979 6.89 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
Meg3
maternally expressed 3
chr4_-_134128707 3.04 ENSMUST00000105879.1
ENSMUST00000030651.8
Sh3bgrl3
SH3 domain binding glutamic acid-rich protein-like 3
chr14_+_11227511 2.90 ENSMUST00000080237.3
Rpl21-ps4
ribosomal protein L21, pseudogene 4
chr17_+_47594629 2.84 ENSMUST00000182846.1
Ccnd3
cyclin D3
chr17_-_55915870 2.35 ENSMUST00000074828.4
Rpl21-ps6
ribosomal protein L21, pseudogene 6
chr7_-_30612731 2.34 ENSMUST00000006476.4
Upk1a
uroplakin 1A
chr14_+_55854115 2.31 ENSMUST00000168479.1
Nynrin
NYN domain and retroviral integrase containing
chr17_+_48462355 2.10 ENSMUST00000162132.1
Unc5cl
unc-5 homolog C (C. elegans)-like
chr11_-_33163072 2.00 ENSMUST00000093201.6
ENSMUST00000101375.4
ENSMUST00000109354.3
ENSMUST00000075641.3
Npm1
nucleophosmin 1
chr14_+_55853997 2.00 ENSMUST00000100529.3
Nynrin
NYN domain and retroviral integrase containing
chr8_+_121127827 1.54 ENSMUST00000181609.1
Foxl1
forkhead box L1
chr6_-_52204415 1.44 ENSMUST00000048794.6
Hoxa5
homeobox A5
chr4_+_154960915 1.41 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr2_+_162931520 1.20 ENSMUST00000130411.1
Srsf6
serine/arginine-rich splicing factor 6
chr8_-_70792392 1.09 ENSMUST00000166004.1
Mast3
microtubule associated serine/threonine kinase 3
chr8_-_78508876 1.09 ENSMUST00000049245.7
Rbmxl1
RNA binding motif protein, X linked-like-1
chr14_+_19751257 0.41 ENSMUST00000022340.3
Nid2
nidogen 2
chr7_-_29168647 0.36 ENSMUST00000048923.6
Spred3
sprouty-related, EVH1 domain containing 3
chr10_+_82699007 0.33 ENSMUST00000020478.7
Hcfc2
host cell factor C2
chr4_-_129542710 0.31 ENSMUST00000102597.4
Hdac1
histone deacetylase 1
chr6_-_52012476 0.25 ENSMUST00000078214.5
Skap2
src family associated phosphoprotein 2
chr13_-_55415166 0.25 ENSMUST00000054146.3
Pfn3
profilin 3
chr9_-_123978297 0.20 ENSMUST00000071404.3
Ccr1l1
chemokine (C-C motif) receptor 1-like 1
chr8_+_105855086 0.12 ENSMUST00000040445.7
Thap11
THAP domain containing 11
chr4_-_124862171 0.06 ENSMUST00000064444.7
Maneal
mannosidase, endo-alpha-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Gzf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0006407 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) rRNA export from nucleus(GO:0006407)
0.5 4.3 GO:0015074 DNA integration(GO:0015074)
0.5 1.4 GO:0060435 bronchiole development(GO:0060435) intestinal epithelial cell maturation(GO:0060574)
0.5 1.4 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.4 1.5 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.2 6.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 2.8 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 1.2 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 0.3 GO:2000676 fungiform papilla formation(GO:0061198) positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 3.0 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.0 1.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 2.1 GO:0046330 positive regulation of JNK cascade(GO:0046330)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0001652 granular component(GO:0001652)
0.2 1.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 2.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 3.0 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 3.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.1 0.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 2.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID BARD1 PATHWAY BARD1 signaling events
0.0 2.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.4 PID CDC42 PATHWAY CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 2.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.2 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions