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GSE58827: Dynamics of the Mouse Liver

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Results for Hnf1a

Z-value: 1.69

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Transcription factors associated with Hnf1a

Gene Symbol Gene ID Gene Info
Hnf1a
ENSMUSG00000029556.6 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1amm10_v2_chr5_-_114971056_1149710790.473.5e-03Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_10215955 15.57 ENSMUST00000130720.1
Prlr
prolactin receptor
chr11_+_101367542 13.92 ENSMUST00000019469.2
G6pc
glucose-6-phosphatase, catalytic
chr7_+_140763739 13.68 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr1_-_130661584 13.38 ENSMUST00000137276.2
C4bp
complement component 4 binding protein
chr1_-_130661613 12.99 ENSMUST00000027657.7
C4bp
complement component 4 binding protein
chr5_+_90518932 12.66 ENSMUST00000113179.2
ENSMUST00000128740.1
Afm
afamin
chr11_-_84167466 11.62 ENSMUST00000050771.7
Gm11437
predicted gene 11437
chr5_-_89457763 11.41 ENSMUST00000049209.8
Gc
group specific component
chr5_-_87337165 10.70 ENSMUST00000031195.2
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_88211956 10.61 ENSMUST00000073049.6
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr6_+_141629499 10.48 ENSMUST00000042812.6
Slco1b2
solute carrier organic anion transporter family, member 1b2
chr12_-_103773592 9.26 ENSMUST00000078869.5
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr4_+_138967112 9.04 ENSMUST00000116094.2
Rnf186
ring finger protein 186
chr12_-_103904887 9.00 ENSMUST00000074051.5
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr10_+_87859255 8.60 ENSMUST00000105300.2
Igf1
insulin-like growth factor 1
chr5_-_87092546 8.59 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chr10_+_87859062 8.37 ENSMUST00000095360.4
Igf1
insulin-like growth factor 1
chr2_-_35100677 8.19 ENSMUST00000045776.4
ENSMUST00000113050.3
AI182371
expressed sequence AI182371
chr17_+_12584183 7.94 ENSMUST00000046959.7
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
chr3_+_129836729 7.78 ENSMUST00000077918.5
Cfi
complement component factor i
chr2_-_91636394 7.77 ENSMUST00000111335.1
ENSMUST00000028681.8
F2
coagulation factor II
chr1_+_88138364 7.51 ENSMUST00000014263.4
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr17_+_12378603 7.12 ENSMUST00000014578.5
Plg
plasminogen
chr12_-_103863551 6.93 ENSMUST00000085056.6
ENSMUST00000072876.5
ENSMUST00000124717.1
Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr9_-_71163224 6.90 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr5_+_33104219 6.87 ENSMUST00000011178.2
Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr5_+_90460889 6.65 ENSMUST00000031314.8
Alb
albumin
chr12_-_103738158 6.23 ENSMUST00000095450.4
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr19_+_42045792 6.18 ENSMUST00000172244.1
ENSMUST00000081714.4
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr8_-_121944886 5.96 ENSMUST00000057653.7
Car5a
carbonic anhydrase 5a, mitochondrial
chr2_-_62412219 5.89 ENSMUST00000047812.7
Dpp4
dipeptidylpeptidase 4
chr11_-_78422217 5.83 ENSMUST00000001122.5
Slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr18_+_33464163 5.73 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr2_-_35061431 5.56 ENSMUST00000028233.3
Hc
hemolytic complement
chr4_-_140617062 5.54 ENSMUST00000154979.1
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr12_-_103657159 5.50 ENSMUST00000044159.6
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr1_+_88070765 5.39 ENSMUST00000073772.4
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr11_-_11898092 5.07 ENSMUST00000178704.1
Ddc
dopa decarboxylase
chr11_-_11898044 5.03 ENSMUST00000066237.3
Ddc
dopa decarboxylase
chr3_+_94398517 4.86 ENSMUST00000050975.3
Lingo4
leucine rich repeat and Ig domain containing 4
chr2_+_163547148 4.68 ENSMUST00000109411.1
ENSMUST00000018094.6
Hnf4a
hepatic nuclear factor 4, alpha
chr1_-_20617992 4.63 ENSMUST00000088448.5
Pkhd1
polycystic kidney and hepatic disease 1
chr5_+_31297551 4.49 ENSMUST00000072228.5
Gckr
glucokinase regulatory protein
chr5_+_24428208 4.38 ENSMUST00000115049.2
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr2_-_134554348 4.36 ENSMUST00000028704.2
Hao1
hydroxyacid oxidase 1, liver
chr4_+_150853919 4.26 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr11_+_70519619 4.25 ENSMUST00000179000.1
Gltpd2
glycolipid transfer protein domain containing 2
chr5_+_35041539 4.16 ENSMUST00000030985.6
Hgfac
hepatocyte growth factor activator
chr12_-_103657095 3.98 ENSMUST00000152517.1
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr19_+_56287943 3.95 ENSMUST00000166049.1
Habp2
hyaluronic acid binding protein 2
chr5_+_102845007 3.93 ENSMUST00000070000.4
Arhgap24
Rho GTPase activating protein 24
chr2_-_32424005 3.92 ENSMUST00000113307.2
Slc25a25
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr1_+_172698046 3.68 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr19_+_56287911 3.66 ENSMUST00000095948.4
Habp2
hyaluronic acid binding protein 2
chr13_+_55152640 3.58 ENSMUST00000005452.5
Fgfr4
fibroblast growth factor receptor 4
chr2_-_86347764 3.57 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chrX_+_101377267 3.47 ENSMUST00000052130.7
Gjb1
gap junction protein, beta 1
chr7_-_79842287 3.38 ENSMUST00000049004.6
Anpep
alanyl (membrane) aminopeptidase
chr6_+_21986887 3.27 ENSMUST00000151315.1
Cped1
cadherin-like and PC-esterase domain containing 1
chr10_+_63061582 3.16 ENSMUST00000020266.8
ENSMUST00000178684.1
Pbld1
phenazine biosynthesis-like protein domain containing 1
chr2_+_163506808 2.95 ENSMUST00000143911.1
Hnf4a
hepatic nuclear factor 4, alpha
chr9_+_21835506 2.90 ENSMUST00000058777.6
Gm6484
predicted gene 6484
chr2_+_162987330 2.88 ENSMUST00000018012.7
Sgk2
serum/glucocorticoid regulated kinase 2
chr8_-_95142477 2.87 ENSMUST00000034240.7
ENSMUST00000169748.1
Kifc3
kinesin family member C3
chr2_+_162987502 2.84 ENSMUST00000117123.1
Sgk2
serum/glucocorticoid regulated kinase 2
chr11_+_118428203 2.83 ENSMUST00000124861.1
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr16_+_24448082 2.63 ENSMUST00000078988.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr12_-_103956891 2.60 ENSMUST00000085054.4
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr11_+_70519183 2.57 ENSMUST00000057685.2
Gltpd2
glycolipid transfer protein domain containing 2
chrX_+_101376359 2.54 ENSMUST00000119080.1
Gjb1
gap junction protein, beta 1
chr12_+_76533540 2.41 ENSMUST00000075249.4
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr15_+_54952939 2.37 ENSMUST00000181704.1
Gm26684
predicted gene, 26684
chr14_-_36919314 2.29 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr10_+_34483400 2.20 ENSMUST00000019913.7
ENSMUST00000170771.1
Frk
fyn-related kinase
chr7_-_119895446 2.17 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr4_-_139968026 2.16 ENSMUST00000105031.2
Klhdc7a
kelch domain containing 7A
chr3_-_75270073 2.15 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr14_-_36919513 2.12 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr1_+_133309778 2.12 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
Golt1a
Kiss1
GOLT1A
golgi transport 1 homolog A (S. cerevisiae)
KiSS-1 metastasis-suppressor
KISS1 isoform e
chr12_+_59095653 2.07 ENSMUST00000021384.4
Mia2
melanoma inhibitory activity 2
chr9_+_109096659 1.97 ENSMUST00000130366.1
Plxnb1
plexin B1
chr9_-_70934808 1.88 ENSMUST00000034731.8
Lipc
lipase, hepatic
chr7_+_141216626 1.86 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr7_-_45062393 1.77 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr16_-_38433145 1.71 ENSMUST00000002926.6
Pla1a
phospholipase A1 member A
chr12_-_103631404 1.69 ENSMUST00000121625.1
ENSMUST00000044231.5
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chrX_-_43167817 1.46 ENSMUST00000115058.1
ENSMUST00000115059.1
Tenm1
teneurin transmembrane protein 1
chr3_+_90537242 1.45 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr7_-_144751968 1.30 ENSMUST00000155175.1
Ano1
anoctamin 1, calcium activated chloride channel
chr5_-_114444036 1.28 ENSMUST00000031560.7
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chrX_-_139085230 1.25 ENSMUST00000152457.1
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_106158109 1.23 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk
glycerate kinase
chr2_+_91265252 1.22 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr5_-_114443993 1.15 ENSMUST00000112245.1
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr18_-_33464007 1.15 ENSMUST00000168890.1
Nrep
neuronal regeneration related protein
chr3_+_83026147 1.03 ENSMUST00000166581.1
ENSMUST00000029630.9
Fga
fibrinogen alpha chain
chr11_+_83852135 1.02 ENSMUST00000146786.1
Hnf1b
HNF1 homeobox B
chr18_-_33463747 1.01 ENSMUST00000171533.1
Nrep
neuronal regeneration related protein
chr17_-_35132050 0.99 ENSMUST00000025249.6
Apom
apolipoprotein M
chr3_+_90537306 0.99 ENSMUST00000107335.1
S100a16
S100 calcium binding protein A16
chr6_-_52183828 0.96 ENSMUST00000134831.1
Hoxa3
homeobox A3
chr5_+_7304128 0.92 ENSMUST00000160634.1
ENSMUST00000159546.1
4921511H03Rik
RIKEN cDNA 4921511H03 gene
chr3_-_83049797 0.92 ENSMUST00000048246.3
Fgb
fibrinogen beta chain
chr14_+_43957069 0.92 ENSMUST00000066719.4
Ang5
angiogenin, ribonuclease A family, member 5
chr7_+_141215852 0.90 ENSMUST00000046890.5
ENSMUST00000133763.1
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr2_+_74727074 0.89 ENSMUST00000111980.2
Hoxd3
homeobox D3
chrX_-_139085211 0.80 ENSMUST00000033626.8
ENSMUST00000060824.3
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_-_122984404 0.77 ENSMUST00000090379.2
Usp53
ubiquitin specific peptidase 53
chr3_+_14480692 0.68 ENSMUST00000037321.7
ENSMUST00000120484.1
ENSMUST00000120801.1
Slc7a12
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr16_-_52296924 0.65 ENSMUST00000167115.1
Alcam
activated leukocyte cell adhesion molecule
chr11_+_115912001 0.54 ENSMUST00000132961.1
Smim6
small integral membrane protein 6
chr4_-_97778042 0.52 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_94650134 0.45 ENSMUST00000053419.2
Lrrc19
leucine rich repeat containing 19
chr11_+_43035746 0.43 ENSMUST00000069051.1
Gm9972
predicted gene 9972
chr3_-_69859875 0.42 ENSMUST00000051239.7
ENSMUST00000171529.1
Sptssb
serine palmitoyltransferase, small subunit B
chr8_+_64947177 0.24 ENSMUST00000079896.7
ENSMUST00000026595.5
Tmem192
transmembrane protein 192
chr2_+_110597298 0.24 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr5_-_114658414 0.23 ENSMUST00000112225.1
ENSMUST00000071968.2
Trpv4
transient receptor potential cation channel, subfamily V, member 4
chr2_-_68472138 0.21 ENSMUST00000102715.3
Stk39
serine/threonine kinase 39
chr5_+_88487982 0.20 ENSMUST00000031222.8
Enam
enamelin
chr5_+_122391878 0.19 ENSMUST00000102525.4
Arpc3
actin related protein 2/3 complex, subunit 3
chr13_-_84064772 0.18 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr6_+_29859374 0.14 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr8_-_93535707 0.10 ENSMUST00000077816.6
Ces5a
carboxylesterase 5A
chr7_+_45062429 0.04 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip
nitric oxide synthase interacting protein
chr11_+_78178105 0.00 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 GO:0018879 biphenyl metabolic process(GO:0018879)
2.8 17.0 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
2.6 15.6 GO:0038161 prolactin signaling pathway(GO:0038161)
2.5 7.6 GO:0010534 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
2.3 13.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
2.2 6.7 GO:0051659 maintenance of mitochondrion location(GO:0051659)
2.0 5.9 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
1.9 7.8 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
1.7 6.9 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
1.6 23.6 GO:0052695 cellular glucuronidation(GO:0052695)
1.5 6.2 GO:0009436 glyoxylate catabolic process(GO:0009436)
1.4 10.1 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
1.4 7.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.4 6.9 GO:0001951 intestinal D-glucose absorption(GO:0001951)
1.2 3.6 GO:0061144 alveolar secondary septum development(GO:0061144)
1.1 4.5 GO:0009750 response to fructose(GO:0009750)
1.1 5.6 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
1.1 4.4 GO:0009441 glycolate metabolic process(GO:0009441)
1.1 3.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.9 4.3 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.8 37.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.7 2.1 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.7 2.1 GO:0033189 response to vitamin A(GO:0033189)
0.6 11.4 GO:0042359 vitamin D metabolic process(GO:0042359)
0.5 6.0 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.5 13.7 GO:0017144 drug metabolic process(GO:0017144)
0.5 2.0 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.5 2.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 2.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.5 7.9 GO:0051608 histamine transport(GO:0051608)
0.4 10.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.4 3.9 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.3 2.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 1.0 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.3 9.5 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.3 2.8 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.3 1.8 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.3 1.0 GO:0035565 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.2 5.5 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.2 3.4 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.2 1.9 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.2 9.4 GO:0051180 vitamin transport(GO:0051180)
0.1 3.9 GO:0014823 response to activity(GO:0014823)
0.1 1.3 GO:0015705 iodide transport(GO:0015705)
0.1 2.2 GO:0010225 response to UV-C(GO:0010225)
0.1 13.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 4.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 4.6 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.1 2.1 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 0.2 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.1 0.2 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 15.4 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 0.4 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.2 GO:0042488 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) regulation of enamel mineralization(GO:0070173)
0.0 4.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 4.4 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 5.7 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 4.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 2.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.8 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 3.5 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 1.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 2.2 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
0.0 3.6 GO:0007608 sensory perception of smell(GO:0007608)
0.0 2.8 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.7 GO:0008045 motor neuron axon guidance(GO:0008045)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 17.0 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
1.8 7.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.0 1.0 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.8 10.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.7 5.9 GO:0071438 invadopodium membrane(GO:0071438)
0.6 5.6 GO:0005579 membrane attack complex(GO:0005579)
0.3 3.4 GO:0031983 vesicle lumen(GO:0031983)
0.3 2.9 GO:0005915 zonula adherens(GO:0005915)
0.3 40.4 GO:0072562 blood microparticle(GO:0072562)
0.3 6.0 GO:0005922 connexon complex(GO:0005922)
0.2 27.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 1.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 2.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.7 GO:0002080 acrosomal membrane(GO:0002080)
0.1 20.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 4.6 GO:0072686 mitotic spindle(GO:0072686)
0.0 10.1 GO:0008021 synaptic vesicle(GO:0008021)
0.0 4.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.9 GO:0030175 filopodium(GO:0030175)
0.0 6.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.6 GO:0030133 transport vesicle(GO:0030133)
0.0 2.8 GO:0005581 collagen trimer(GO:0005581)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 4.4 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 9.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 24.7 GO:0005794 Golgi apparatus(GO:0005794)
0.0 5.7 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.9 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
4.2 12.7 GO:0008431 vitamin E binding(GO:0008431)
3.8 11.4 GO:1902271 D3 vitamins binding(GO:1902271)
3.1 15.6 GO:0004925 prolactin receptor activity(GO:0004925)
2.6 7.9 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
2.5 7.6 GO:0070540 stearic acid binding(GO:0070540)
2.5 10.1 GO:0004058 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
1.5 6.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.4 6.9 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
1.3 7.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.1 42.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
1.1 4.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.7 5.9 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.6 3.6 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.6 4.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.5 7.1 GO:1990405 protein antigen binding(GO:1990405)
0.5 5.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.5 3.7 GO:0001849 complement component C1q binding(GO:0001849)
0.4 17.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.4 6.7 GO:0015643 toxic substance binding(GO:0015643)
0.4 13.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.4 3.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 6.0 GO:0005243 gap junction channel activity(GO:0005243)
0.4 49.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 6.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 3.9 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 5.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 4.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.3 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 7.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 3.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 2.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.4 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 2.2 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.2 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 13.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 5.6 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 7.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.6 GO:0005549 odorant binding(GO:0005549)
0.0 2.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 2.8 GO:0005518 collagen binding(GO:0005518)
0.0 2.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.0 GO:0015293 symporter activity(GO:0015293)
0.0 4.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.0 GO:0016209 antioxidant activity(GO:0016209)
0.0 2.0 GO:0030674 protein binding, bridging(GO:0030674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.4 22.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 13.9 PID FOXO PATHWAY FoxO family signaling
0.2 9.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 15.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 7.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 22.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 3.6 PID FGF PATHWAY FGF signaling pathway
0.1 7.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.5 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 REACTOME XENOBIOTICS Genes involved in Xenobiotics
1.2 16.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.8 15.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.7 6.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.6 9.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.6 7.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.6 7.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.6 6.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 10.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.5 3.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 5.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.4 18.4 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.3 11.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.3 6.0 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 5.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 7.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 6.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 3.6 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 6.9 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.1 1.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 4.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 4.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 3.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases