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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxa3

Z-value: 0.26

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Transcription factors associated with Hoxa3

Gene Symbol Gene ID Gene Info
Hoxa3
ENSMUSG00000079560.7 homeobox A3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa3mm10_v2_chr6_-_52183828_521838550.144.1e-01Click!

Activity profile of Hoxa3 motif

Sorted Z-values of Hoxa3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_7966000 0.88 ENSMUST00000182102.1
ENSMUST00000075619.4
Slc22a27
solute carrier family 22, member 27
chr6_-_136781718 0.64 ENSMUST00000078095.6
ENSMUST00000032338.7
Gucy2c
guanylate cyclase 2c
chr14_+_27000362 0.63 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chr2_-_168767136 0.59 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4
sal-like 4 (Drosophila)
chr2_-_168767029 0.45 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr2_+_173153048 0.39 ENSMUST00000029017.5
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr9_+_119063429 0.33 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill
villin-like
chr16_-_42340595 0.30 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr10_-_37138863 0.30 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr15_-_34356421 0.26 ENSMUST00000179647.1
9430069I07Rik
RIKEN cDNA 9430069I07 gene
chr10_+_37139558 0.23 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr2_-_164171113 0.18 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr2_+_36230426 0.18 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr3_-_86548268 0.16 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr7_-_38019505 0.14 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chr2_-_116067391 0.13 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr3_+_159839729 0.12 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr1_-_172027269 0.11 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr19_-_55241236 0.11 ENSMUST00000069183.6
Gucy2g
guanylate cyclase 2g
chr12_+_59013379 0.11 ENSMUST00000021379.7
Gemin2
gem (nuclear organelle) associated protein 2
chr5_+_90561102 0.10 ENSMUST00000094615.4
5830473C10Rik
RIKEN cDNA 5830473C10 gene
chr3_+_55782500 0.10 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr7_-_45103747 0.09 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr14_+_79515618 0.08 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr6_+_63255971 0.08 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2
glutamate receptor, ionotropic, delta 2
chr10_+_40349265 0.08 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19
cyclin-dependent kinase 19
chr10_+_26772477 0.07 ENSMUST00000039557.7
Arhgap18
Rho GTPase activating protein 18
chr4_-_14621805 0.07 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr5_-_137531952 0.07 ENSMUST00000140139.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr17_+_17402672 0.06 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr17_-_70853482 0.06 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chr5_+_138187485 0.05 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr11_-_99374895 0.05 ENSMUST00000006963.2
Krt28
keratin 28
chr16_-_29544852 0.04 ENSMUST00000039090.8
Atp13a4
ATPase type 13A4
chr9_-_77399308 0.04 ENSMUST00000183878.1
RP23-264N13.2
RP23-264N13.2
chr7_-_116038734 0.04 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr5_+_104202609 0.03 ENSMUST00000066708.5
Dmp1
dentin matrix protein 1
chr12_+_71170589 0.03 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr11_+_95384662 0.02 ENSMUST00000021243.7
ENSMUST00000146556.1
Slc35b1
solute carrier family 35, member B1
chr4_+_108719649 0.02 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr16_-_92400067 0.02 ENSMUST00000023672.8
Rcan1
regulator of calcineurin 1
chr5_-_62766153 0.01 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_116067213 0.01 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chrX_+_16619698 0.01 ENSMUST00000026013.5
Maoa
monoamine oxidase A
chr5_-_137531204 0.01 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr14_+_64589802 0.00 ENSMUST00000180610.1
A930011O12Rik
RIKEN cDNA A930011O12 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.1 0.6 GO:0030916 otic vesicle formation(GO:0030916)
0.1 0.9 GO:0015747 urate transport(GO:0015747)
0.1 1.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.3 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.1 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.0 0.7 GO:0006182 cGMP biosynthetic process(GO:0006182)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine