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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxb1

Z-value: 0.60

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Transcription factors associated with Hoxb1

Gene Symbol Gene ID Gene Info
Hoxb1
ENSMUSG00000018973.2 homeobox B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb1mm10_v2_chr11_+_96365752_963657520.173.1e-01Click!

Activity profile of Hoxb1 motif

Sorted Z-values of Hoxb1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_84901928 4.35 ENSMUST00000067060.7
Klf1
Kruppel-like factor 1 (erythroid)
chr14_-_69284982 4.29 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37
solute carrier family 25, member 37
chr14_-_69503316 3.62 ENSMUST00000179116.2
Gm21464
predicted gene, 21464
chr12_+_79208904 3.56 ENSMUST00000021548.5
Rdh12
retinol dehydrogenase 12
chr14_-_69503220 3.52 ENSMUST00000180059.2
Gm21464
predicted gene, 21464
chr12_+_79208928 3.40 ENSMUST00000122227.1
Rdh12
retinol dehydrogenase 12
chr1_-_119053339 3.31 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2
GLI-Kruppel family member GLI2
chr9_+_65890237 2.63 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr15_-_95528702 2.11 ENSMUST00000166170.1
Nell2
NEL-like 2
chr1_-_45503282 1.94 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr1_-_119053619 1.85 ENSMUST00000062483.8
Gli2
GLI-Kruppel family member GLI2
chr10_-_88605017 1.72 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1
myosin binding protein C, slow-type
chr8_-_8639363 1.53 ENSMUST00000152698.1
Efnb2
ephrin B2
chr2_+_84840612 1.50 ENSMUST00000111625.1
Slc43a1
solute carrier family 43, member 1
chr7_+_73391160 1.33 ENSMUST00000128471.1
Rgma
RGM domain family, member A
chr5_+_136967859 1.11 ENSMUST00000001790.5
Cldn15
claudin 15
chr2_+_156475844 1.05 ENSMUST00000103135.1
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr10_+_4266323 1.02 ENSMUST00000045730.5
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr2_+_156475803 1.01 ENSMUST00000029155.8
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr18_+_42511496 0.99 ENSMUST00000025375.7
Tcerg1
transcription elongation regulator 1 (CA150)
chr11_+_97415527 0.98 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chr4_+_103114712 0.95 ENSMUST00000143417.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr17_+_26941420 0.88 ENSMUST00000081285.3
ENSMUST00000177932.1
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
chr11_+_98386450 0.81 ENSMUST00000041301.7
Pnmt
phenylethanolamine-N-methyltransferase
chr19_-_41743665 0.76 ENSMUST00000025993.3
Slit1
slit homolog 1 (Drosophila)
chr5_+_19907502 0.76 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_98022594 0.75 ENSMUST00000103144.3
ENSMUST00000017552.6
ENSMUST00000092736.4
ENSMUST00000107562.1
Cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr9_-_13245741 0.73 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr6_+_125145235 0.72 ENSMUST00000119527.1
ENSMUST00000088276.6
ENSMUST00000051171.7
ENSMUST00000117675.1
Iffo1
intermediate filament family orphan 1
chr12_-_15816762 0.70 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr8_-_105471481 0.70 ENSMUST00000014990.6
Tppp3
tubulin polymerization-promoting protein family member 3
chr3_+_58526303 0.69 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr17_+_29490812 0.67 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr6_-_87533219 0.67 ENSMUST00000113637.2
ENSMUST00000071024.6
Arhgap25
Rho GTPase activating protein 25
chr9_-_108083330 0.66 ENSMUST00000159372.1
ENSMUST00000160249.1
Rnf123
ring finger protein 123
chr8_-_87959560 0.66 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chrX_+_166344692 0.66 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b
glycoprotein m6b
chr1_-_135688094 0.63 ENSMUST00000112103.1
Nav1
neuron navigator 1
chr16_+_25801907 0.62 ENSMUST00000040231.6
ENSMUST00000115306.1
ENSMUST00000115304.1
ENSMUST00000115305.1
Trp63
transformation related protein 63
chr12_+_38780284 0.62 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1
ets variant gene 1
chr5_+_37735519 0.62 ENSMUST00000073554.3
Cytl1
cytokine-like 1
chr2_-_153529941 0.61 ENSMUST00000035346.7
8430427H17Rik
RIKEN cDNA 8430427H17 gene
chr1_-_136006342 0.59 ENSMUST00000166193.2
Igfn1
immunoglobulin-like and fibronectin type III domain containing 1
chr10_+_127677064 0.51 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194
transmembrane protein 194
chr15_+_74516196 0.49 ENSMUST00000042035.9
Bai1
brain-specific angiogenesis inhibitor 1
chr10_+_67185730 0.48 ENSMUST00000173689.1
Jmjd1c
jumonji domain containing 1C
chr4_-_145315143 0.45 ENSMUST00000030339.6
Tnfrsf8
tumor necrosis factor receptor superfamily, member 8
chr11_-_69549108 0.45 ENSMUST00000108659.1
Dnah2
dynein, axonemal, heavy chain 2
chr4_+_103114385 0.43 ENSMUST00000106858.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr6_-_124464772 0.42 ENSMUST00000008297.4
Clstn3
calsyntenin 3
chr18_+_65873478 0.39 ENSMUST00000025395.8
ENSMUST00000173530.1
Grp
gastrin releasing peptide
chr3_-_65958236 0.39 ENSMUST00000029416.7
Ccnl1
cyclin L1
chr11_+_76672456 0.37 ENSMUST00000056184.1
Bhlha9
basic helix-loop-helix family, member a9
chr11_+_75486813 0.37 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
Prpf8
pre-mRNA processing factor 8
chr4_-_103114238 0.34 ENSMUST00000036451.8
ENSMUST00000036557.8
Wdr78
WD repeat domain 78
chr4_-_103114555 0.34 ENSMUST00000106868.3
Wdr78
WD repeat domain 78
chr16_-_56024628 0.34 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp
PEST proteolytic signal containing nuclear protein
chr3_+_58525821 0.32 ENSMUST00000029387.8
Eif2a
eukaryotic translation initiation factor 2A
chr10_-_63421739 0.28 ENSMUST00000054760.4
Gm7075
predicted gene 7075
chr9_-_20336094 0.28 ENSMUST00000086473.3
Olfr18
olfactory receptor 18
chr8_-_83458386 0.26 ENSMUST00000081506.3
Scoc
short coiled-coil protein
chr2_+_124610573 0.26 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr6_+_142413441 0.25 ENSMUST00000088263.4
B230216G23Rik
RIKEN cDNA B230216G23 gene
chr5_-_124354671 0.24 ENSMUST00000031341.4
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr7_+_102774495 0.23 ENSMUST00000098217.2
Olfr561
olfactory receptor 561
chr7_-_78577771 0.22 ENSMUST00000039438.7
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr7_-_45466894 0.22 ENSMUST00000033093.8
Bax
BCL2-associated X protein
chr12_-_27160498 0.20 ENSMUST00000182592.1
Gm9866
predicted gene 9866
chr2_+_65845767 0.18 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr19_-_43388292 0.18 ENSMUST00000099428.3
Hpse2
heparanase 2
chr5_-_107289561 0.16 ENSMUST00000031224.8
Tgfbr3
transforming growth factor, beta receptor III
chr8_-_117082449 0.15 ENSMUST00000098375.4
ENSMUST00000109093.2
Pkd1l2
polycystic kidney disease 1 like 2
chr1_+_153665274 0.13 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8
regulator of G-protein signaling 8
chrX_+_20617503 0.13 ENSMUST00000115375.1
ENSMUST00000115374.1
ENSMUST00000084383.3
Rbm10
RNA binding motif protein 10
chr12_-_27160311 0.12 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
Gm9866
predicted gene 9866
chr3_-_37232565 0.11 ENSMUST00000161015.1
ENSMUST00000029273.1
Il21
interleukin 21
chr2_+_124610278 0.10 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr4_+_58285930 0.09 ENSMUST00000081919.5
ENSMUST00000102893.3
ENSMUST00000084578.5
ENSMUST00000098057.3
ENSMUST00000179951.1
ENSMUST00000098059.3
ENSMUST00000177951.1
Musk
muscle, skeletal, receptor tyrosine kinase
chr15_-_95830072 0.08 ENSMUST00000168960.1
Gm17546
predicted gene, 17546
chrX_+_105764262 0.01 ENSMUST00000033581.3
Fgf16
fibroblast growth factor 16

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0060032 notochord regression(GO:0060032)
0.5 1.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 7.0 GO:0042572 retinol metabolic process(GO:0042572)
0.3 0.6 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.3 4.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 0.7 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.2 1.5 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.2 1.0 GO:1990928 response to amino acid starvation(GO:1990928)
0.2 0.8 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 2.1 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.2 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1 1.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 1.4 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.1 0.4 GO:1900738 psychomotor behavior(GO:0036343) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 0.8 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 1.3 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.1 1.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.7 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.1 4.3 GO:0006826 iron ion transport(GO:0006826)
0.1 0.7 GO:2000138 vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.1 0.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.6 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.2 GO:0048691 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.0 0.5 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.4 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.4 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 1.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.5 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.6 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 0.7 GO:0003341 cilium movement(GO:0003341)
0.0 0.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.9 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.4 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0005588 collagen type V trimer(GO:0005588)
0.4 5.2 GO:0097542 ciliary tip(GO:0097542)
0.1 1.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.7 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.7 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.7 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.8 GO:0043196 varicosity(GO:0043196)
0.0 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.6 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.9 GO:0043204 perikaryon(GO:0043204)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.0 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.3 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.3 7.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 4.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.8 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.3 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 1.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.7 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 1.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.7 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 1.4 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 1.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 4.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.5 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.0 PID CONE PATHWAY Visual signal transduction: Cones
0.2 5.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.3 PID BMP PATHWAY BMP receptor signaling
0.0 1.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 2.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions