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GSE58827: Dynamics of the Mouse Liver
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Results for Hoxb13
Z-value: 1.57
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Transcription factors associated with Hoxb13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxb13 | mm10_v2_chr11_+_96194299_96194316 | -0.36 | 3.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxb13
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 44.1 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.2 | 27.0 | GO:0007586 | digestion(GO:0007586) |
| 2.2 | 24.1 | GO:0006569 | tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189) |
| 1.6 | 22.5 | GO:0015747 | urate transport(GO:0015747) |
| 1.7 | 18.8 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 1.0 | 17.0 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.4 | 15.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.4 | 11.9 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.6 | 9.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.6 | 9.1 | GO:0052695 | cellular glucuronidation(GO:0052695) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 57.4 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 31.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 30.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 22.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 18.0 | GO:0043235 | receptor complex(GO:0043235) |
| 2.0 | 15.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 14.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 13.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 12.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 8.5 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 45.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 8.6 | 43.2 | GO:0008390 | testosterone 16-alpha-hydroxylase activity(GO:0008390) |
| 1.5 | 22.5 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 1.0 | 21.9 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 7.2 | 21.6 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 0.6 | 21.6 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.2 | 21.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.5 | 15.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 5.0 | 14.9 | GO:0005186 | pheromone activity(GO:0005186) |
| 3.3 | 13.2 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 10.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 7.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 6.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 5.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 4.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 4.2 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 3.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 26.5 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 13.9 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.4 | 13.0 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 1.3 | 11.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 10.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 9.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 9.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 8.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.6 | 7.7 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.4 | 6.0 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |