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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxb4

Z-value: 0.52

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Transcription factors associated with Hoxb4

Gene Symbol Gene ID Gene Info
Hoxb4
ENSMUSG00000038692.7 homeobox B4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb4mm10_v2_chr11_+_96316684_96316684-0.231.7e-01Click!

Activity profile of Hoxb4 motif

Sorted Z-values of Hoxb4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_20275659 7.20 ENSMUST00000011607.5
Cpb1
carboxypeptidase B1 (tissue)
chr7_+_131032061 6.62 ENSMUST00000084509.3
Dmbt1
deleted in malignant brain tumors 1
chrX_-_143933089 1.37 ENSMUST00000087313.3
Dcx
doublecortin
chr19_+_4711153 1.35 ENSMUST00000008991.6
Sptbn2
spectrin beta, non-erythrocytic 2
chr10_-_41709297 1.29 ENSMUST00000019955.9
ENSMUST00000099932.3
Ccdc162
coiled-coil domain containing 162
chr2_-_84775388 0.93 ENSMUST00000023994.3
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775420 0.92 ENSMUST00000111641.1
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr6_+_116650674 0.89 ENSMUST00000067354.5
ENSMUST00000178241.1
8430408G22Rik
RIKEN cDNA 8430408G22 gene
chr4_+_43493345 0.80 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107
coiled-coil domain containing 107
chrX_-_8193387 0.67 ENSMUST00000143223.1
ENSMUST00000033509.8
Ebp
phenylalkylamine Ca2+ antagonist (emopamil) binding protein
chr18_-_56562187 0.55 ENSMUST00000171844.2
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr18_-_56562261 0.55 ENSMUST00000066208.6
ENSMUST00000172734.1
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr10_-_59616667 0.53 ENSMUST00000020312.6
Mcu
mitochondrial calcium uniporter
chr18_-_56562215 0.50 ENSMUST00000170309.1
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr10_-_89621253 0.48 ENSMUST00000020102.7
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr7_+_30231884 0.48 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr17_+_43952999 0.42 ENSMUST00000177857.1
Rcan2
regulator of calcineurin 2
chrX_-_143933204 0.42 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx
doublecortin
chr7_+_30232310 0.38 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr4_+_99656299 0.36 ENSMUST00000087285.3
Foxd3
forkhead box D3
chr3_-_54714353 0.35 ENSMUST00000178832.1
Gm21958
predicted gene, 21958
chr16_-_94370450 0.33 ENSMUST00000138514.1
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr1_-_171222508 0.30 ENSMUST00000005817.2
Tomm40l
translocase of outer mitochondrial membrane 40 homolog-like (yeast)
chr1_-_171222435 0.26 ENSMUST00000147246.1
ENSMUST00000111326.1
ENSMUST00000138184.1
Tomm40l
translocase of outer mitochondrial membrane 40 homolog-like (yeast)
chr7_+_30232032 0.25 ENSMUST00000149654.1
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr11_+_85353156 0.23 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3
breast carcinoma amplified sequence 3
chr3_-_30509462 0.22 ENSMUST00000173899.1
Mecom
MDS1 and EVI1 complex locus
chr7_+_66743504 0.21 ENSMUST00000066475.8
Cers3
ceramide synthase 3
chr1_+_146497614 0.19 ENSMUST00000132847.1
ENSMUST00000166814.1
Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr9_+_40187079 0.17 ENSMUST00000062229.5
Olfr986
olfactory receptor 986
chr7_-_30232186 0.17 ENSMUST00000006254.5
Tbcb
tubulin folding cofactor B
chr9_+_39993812 0.16 ENSMUST00000057161.3
Olfr978
olfactory receptor 978
chr16_-_37384940 0.14 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l
syntaxin binding protein 5-like
chr2_-_119156824 0.13 ENSMUST00000135419.1
ENSMUST00000129351.1
ENSMUST00000139519.1
ENSMUST00000094695.5
Rmdn3
regulator of microtubule dynamics 3
chr3_-_39359128 0.13 ENSMUST00000056409.2
Gm9845
predicted pseudogene 9845
chr16_-_37384915 0.13 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l
syntaxin binding protein 5-like
chr13_-_64497792 0.13 ENSMUST00000180282.1
1190003K10Rik
RIKEN cDNA 1190003K10 gene
chr11_-_40755201 0.12 ENSMUST00000020576.7
Ccng1
cyclin G1
chr3_-_145099024 0.11 ENSMUST00000040465.6
Clca5
chloride channel calcium activated 5
chr8_-_105471481 0.10 ENSMUST00000014990.6
Tppp3
tubulin polymerization-promoting protein family member 3
chr7_-_71351485 0.10 ENSMUST00000094315.2
Gm10295
predicted gene 10295
chr12_+_58211772 0.09 ENSMUST00000110671.2
ENSMUST00000044299.2
Sstr1
somatostatin receptor 1
chr16_-_19408078 0.07 ENSMUST00000052516.4
Olfr165
olfactory receptor 165
chr11_-_58529984 0.06 ENSMUST00000062869.2
Olfr330
olfactory receptor 330
chr18_+_61687911 0.04 ENSMUST00000025471.2
Il17b
interleukin 17B
chr1_+_10993452 0.03 ENSMUST00000027056.5
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr9_+_19712829 0.02 ENSMUST00000077023.3
Olfr857
olfactory receptor 857
chr3_-_51277470 0.01 ENSMUST00000108053.2
ENSMUST00000108051.1
Elf2
E74-like factor 2
chr18_+_56562443 0.01 ENSMUST00000130163.1
ENSMUST00000132628.1
Phax
phosphorylated adaptor for RNA export

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.4 1.1 GO:0001192 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.3 6.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.4 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.4 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.2 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 1.4 GO:0008091 spectrin(GO:0008091)
0.1 0.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.5 GO:1990246 uniplex complex(GO:1990246)
0.1 0.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.2 7.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 6.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.7 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.6 GO:0015288 porin activity(GO:0015288)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 1.8 GO:0001848 complement binding(GO:0001848)
0.1 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 6.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.1 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.8 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway