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GSE58827: Dynamics of the Mouse Liver

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Results for Irf5_Irf6

Z-value: 0.64

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Transcription factors associated with Irf5_Irf6

Gene Symbol Gene ID Gene Info
Irf5
ENSMUSG00000029771.6 interferon regulatory factor 5
Irf6
ENSMUSG00000026638.9 interferon regulatory factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf6mm10_v2_chr1_+_193153107_1931531160.492.3e-03Click!
Irf5mm10_v2_chr6_+_29526625_295266850.057.8e-01Click!

Activity profile of Irf5_Irf6 motif

Sorted Z-values of Irf5_Irf6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_141010759 4.59 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr1_+_130826676 3.62 ENSMUST00000027675.7
Pigr
polymeric immunoglobulin receptor
chr1_+_130826762 3.49 ENSMUST00000133792.1
Pigr
polymeric immunoglobulin receptor
chr17_-_34862122 3.37 ENSMUST00000154526.1
Cfb
complement factor B
chr17_+_31433054 2.75 ENSMUST00000136384.1
Pde9a
phosphodiesterase 9A
chr9_+_55326913 2.45 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078
expressed sequence AI118078
chr17_-_34862473 1.68 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb
complement factor B
chr4_-_40239779 1.65 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_124911636 1.62 ENSMUST00000032217.1
Lag3
lymphocyte-activation gene 3
chr2_-_77170534 1.53 ENSMUST00000111833.2
Ccdc141
coiled-coil domain containing 141
chr9_+_45042425 1.48 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr6_+_113471481 1.42 ENSMUST00000113062.1
Il17rc
interleukin 17 receptor C
chrM_+_9452 1.39 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr6_+_113471427 1.33 ENSMUST00000058300.7
Il17rc
interleukin 17 receptor C
chr1_-_105356658 1.19 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152
ring finger protein 152
chr10_+_80249441 1.18 ENSMUST00000020361.6
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr3_-_142395661 1.17 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5
PDZ and LIM domain 5
chr6_-_39118211 0.99 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr4_-_46536134 0.98 ENSMUST00000046897.6
Trim14
tripartite motif-containing 14
chr16_+_35938972 0.98 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr4_-_46536096 0.96 ENSMUST00000102924.2
Trim14
tripartite motif-containing 14
chr13_-_100552442 0.93 ENSMUST00000159515.1
ENSMUST00000160859.1
ENSMUST00000069756.4
Ocln
occludin
chr7_+_128523576 0.89 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr16_-_35871544 0.89 ENSMUST00000042665.8
Parp14
poly (ADP-ribose) polymerase family, member 14
chr5_-_91402905 0.88 ENSMUST00000121044.2
Btc
betacellulin, epidermal growth factor family member
chr1_+_175631996 0.88 ENSMUST00000040250.8
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr6_-_13608011 0.87 ENSMUST00000031554.2
Tmem168
transmembrane protein 168
chr1_+_175632169 0.86 ENSMUST00000097458.3
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr13_-_100552704 0.85 ENSMUST00000022140.5
Ocln
occludin
chr5_-_24447587 0.85 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
Tmub1
transmembrane and ubiquitin-like domain containing 1
chr2_-_69586021 0.84 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
Lrp2
low density lipoprotein receptor-related protein 2
chr10_+_80249106 0.84 ENSMUST00000105364.1
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr5_-_45857473 0.83 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
Lcorl
ligand dependent nuclear receptor corepressor-like
chr7_-_141266415 0.81 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
Irf7
interferon regulatory factor 7
chr9_+_20868628 0.79 ENSMUST00000043911.7
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr17_-_32189457 0.78 ENSMUST00000087721.3
ENSMUST00000162117.1
Ephx3
epoxide hydrolase 3
chr13_-_100552598 0.78 ENSMUST00000159459.1
Ocln
occludin
chr7_-_44375006 0.78 ENSMUST00000107933.1
1700008O03Rik
RIKEN cDNA 1700008O03 gene
chr7_+_49246131 0.67 ENSMUST00000064395.6
Nav2
neuron navigator 2
chr3_+_142496924 0.67 ENSMUST00000090127.2
Gbp5
guanylate binding protein 5
chr9_-_123851855 0.67 ENSMUST00000184082.1
ENSMUST00000167595.2
Fyco1
FYVE and coiled-coil domain containing 1
chr4_-_116651644 0.65 ENSMUST00000030455.8
Akr1a1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr11_+_72301613 0.64 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
Xaf1
XIAP associated factor 1
chr11_-_78984946 0.61 ENSMUST00000108268.3
Lgals9
lectin, galactose binding, soluble 9
chr11_-_78984831 0.60 ENSMUST00000073001.4
ENSMUST00000108269.3
Lgals9
lectin, galactose binding, soluble 9
chr2_-_77519565 0.60 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr16_+_23609895 0.58 ENSMUST00000038423.5
Rtp4
receptor transporter protein 4
chr16_-_35939082 0.57 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l
deltex 3-like (Drosophila)
chrX_+_77511002 0.57 ENSMUST00000088217.5
Tbl1x
transducin (beta)-like 1 X-linked
chr19_+_44756049 0.55 ENSMUST00000174490.2
Pax2
paired box gene 2
chr4_-_40239700 0.55 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_77170592 0.55 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141
coiled-coil domain containing 141
chr1_+_52119438 0.54 ENSMUST00000070968.7
Stat1
signal transducer and activator of transcription 1
chr5_+_139543889 0.52 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx
UNC homeobox
chr19_-_7295394 0.52 ENSMUST00000025921.8
Mark2
MAP/microtubule affinity-regulating kinase 2
chr16_+_35938470 0.50 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr12_-_31950170 0.50 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr16_-_5255923 0.49 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86
family with sequence similarity 86
chr3_+_135438722 0.47 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr15_-_76243401 0.46 ENSMUST00000165738.1
ENSMUST00000075689.6
Parp10
poly (ADP-ribose) polymerase family, member 10
chrM_+_8600 0.46 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr8_+_61928081 0.45 ENSMUST00000154398.1
ENSMUST00000093485.2
ENSMUST00000156980.1
ENSMUST00000070631.7
Ddx60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr16_-_67620805 0.44 ENSMUST00000120594.1
Cadm2
cell adhesion molecule 2
chr5_+_92809372 0.44 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr3_+_138065052 0.40 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr17_+_34203527 0.40 ENSMUST00000025197.5
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_-_31950210 0.39 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1
high mobility group box transcription factor 1
chr6_-_38354243 0.35 ENSMUST00000114900.1
Zc3hav1
zinc finger CCCH type, antiviral 1
chr16_-_55838827 0.32 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr7_-_65370908 0.32 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr9_-_123862023 0.31 ENSMUST00000182350.1
ENSMUST00000078755.2
Xcr1
chemokine (C motif) receptor 1
chr11_+_88999376 0.27 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25
tripartite motif-containing 25
chr17_+_34644764 0.23 ENSMUST00000036720.8
Fkbpl
FK506 binding protein-like
chr2_+_58470116 0.19 ENSMUST00000167423.1
Gm17409
predicted gene, 17409
chr17_+_34644805 0.18 ENSMUST00000174796.1
Fkbpl
FK506 binding protein-like
chr16_-_67620880 0.18 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2
cell adhesion molecule 2
chr12_-_31950535 0.12 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr4_-_58911902 0.08 ENSMUST00000134848.1
ENSMUST00000107557.2
ENSMUST00000149301.1
AI314180
expressed sequence AI314180
chr19_+_47937648 0.04 ENSMUST00000066308.7
Ccdc147
coiled-coil domain containing 147
chr11_+_29130733 0.03 ENSMUST00000020756.8
Pnpt1
polyribonucleotide nucleotidyltransferase 1
chr10_-_43174521 0.03 ENSMUST00000040275.7
Sobp
sine oculis-binding protein homolog (Drosophila)
chr1_-_163313661 0.03 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1
paired related homeobox 1
chr1_-_75316998 0.01 ENSMUST00000113605.3
Dnpep
aspartyl aminopeptidase
chr16_+_11313812 0.00 ENSMUST00000023140.5
Tnfrsf17
tumor necrosis factor receptor superfamily, member 17

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf5_Irf6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.4 2.2 GO:0009597 detection of virus(GO:0009597)
0.3 1.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.3 1.6 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.3 5.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 1.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.3 6.5 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 1.2 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.2 0.5 GO:2000595 optic nerve formation(GO:0021634) optic chiasma development(GO:0061360) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597)
0.2 2.6 GO:0070673 response to interleukin-18(GO:0070673)
0.2 0.7 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.2 0.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.2 2.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 3.4 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.7 GO:0021564 vagus nerve development(GO:0021564)
0.1 0.4 GO:0046968 positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591) peptide antigen transport(GO:0046968)
0.1 0.7 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.5 GO:0034238 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239)
0.1 1.5 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 1.0 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 1.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.9 GO:0035810 positive regulation of urine volume(GO:0035810)
0.1 0.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 2.0 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.8 GO:0045056 transcytosis(GO:0045056)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 2.1 GO:0021799 cerebral cortex radially oriented cell migration(GO:0021799)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.4 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.8 GO:0034340 response to type I interferon(GO:0034340)
0.0 1.2 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.7 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 1.2 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.9 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 3.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.5 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 4.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.8 GO:0043204 perikaryon(GO:0043204)
0.0 2.1 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 7.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.3 2.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 1.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 0.8 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.2 1.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 1.2 GO:0016936 galactoside binding(GO:0016936)
0.1 0.6 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 3.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 3.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.4 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.5 GO:0050664 superoxide-generating NADPH oxidase activity(GO:0016175) oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.1 1.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 8.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.0 PID MYC PATHWAY C-MYC pathway
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 3.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 2.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 5.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 2.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions