Project

GSE58827: Dynamics of the Mouse Liver

Navigation
Downloads

Results for Irx4

Z-value: 0.29

Motif logo

logo of

Transcription factors associated with Irx4

Gene Symbol Gene ID Gene Info
Irx4
ENSMUSG00000021604.9 Iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx4mm10_v2_chr13_+_73260473_732604970.281.0e-01Click!

Activity profile of Irx4 motif

Sorted Z-values of Irx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_11970540 2.83 ENSMUST00000109653.1
Grb10
growth factor receptor bound protein 10
chr6_-_83317589 1.31 ENSMUST00000005810.6
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr16_+_17146937 1.24 ENSMUST00000115706.1
ENSMUST00000069064.4
Ydjc
YdjC homolog (bacterial)
chr1_-_174250976 0.95 ENSMUST00000061990.4
Olfr419
olfactory receptor 419
chr8_-_24725762 0.94 ENSMUST00000171438.1
ENSMUST00000171611.1
ENSMUST00000033958.7
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
chr18_+_44334062 0.88 ENSMUST00000025349.5
ENSMUST00000115498.1
Myot
myotilin
chr12_-_111980751 0.84 ENSMUST00000170525.1
BC048943
cDNA sequence BC048943
chr2_+_24345282 0.79 ENSMUST00000114485.2
Il1rn
interleukin 1 receptor antagonist
chr2_+_24345305 0.75 ENSMUST00000114482.1
Il1rn
interleukin 1 receptor antagonist
chr4_+_48663502 0.71 ENSMUST00000030033.4
Murc
muscle-related coiled-coil protein
chr3_+_88376023 0.60 ENSMUST00000179946.1
Gm21956
predicted gene, 21956
chr3_+_88381004 0.49 ENSMUST00000107540.2
Gm6821
predicted gene 6821
chr8_+_84872105 0.40 ENSMUST00000136026.1
ENSMUST00000170296.1
Syce2
synaptonemal complex central element protein 2
chr3_+_59925214 0.35 ENSMUST00000049476.2
C130079G13Rik
RIKEN cDNA C130079G13 gene
chr4_+_147150494 0.33 ENSMUST00000151022.1
Gm13139
predicted gene 13139
chr18_-_37178493 0.23 ENSMUST00000181887.1
ENSMUST00000180516.1
Gm10544
predicted gene 10544
chr6_-_3494587 0.16 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr14_-_50299330 0.15 ENSMUST00000163469.1
Olfr733
olfactory receptor 733
chr3_+_84925476 0.12 ENSMUST00000107675.1
Fbxw7
F-box and WD-40 domain protein 7
chr7_+_106814135 0.09 ENSMUST00000075414.1
ENSMUST00000166880.1
Olfr701
olfactory receptor 701
chr9_-_58202281 0.05 ENSMUST00000163897.1
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr2_-_79908389 0.02 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr1_-_59003443 0.01 ENSMUST00000054653.6
Als2cr11
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (human)

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 2.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.1 1.3 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 0.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.4 GO:0007130 synaptonemal complex assembly(GO:0007130)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0045353 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
0.4 1.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.8 PID IGF1 PATHWAY IGF1 pathway
0.0 1.5 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling