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GSE58827: Dynamics of the Mouse Liver

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Results for Irx5

Z-value: 0.67

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Transcription factors associated with Irx5

Gene Symbol Gene ID Gene Info
Irx5
ENSMUSG00000031737.10 Iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_92357801-0.447.2e-03Click!

Activity profile of Irx5 motif

Sorted Z-values of Irx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_87254804 5.53 ENSMUST00000075858.3
Ugt2b37
UDP glucuronosyltransferase 2 family, polypeptide B37
chr5_-_86926521 5.33 ENSMUST00000031183.2
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
chr5_-_87337165 5.12 ENSMUST00000031195.2
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr7_-_14438538 3.97 ENSMUST00000168252.2
2810007J24Rik
RIKEN cDNA 2810007J24 gene
chr19_-_7802578 3.83 ENSMUST00000120522.1
ENSMUST00000065634.7
Slc22a26
solute carrier family 22 (organic cation transporter), member 26
chr4_+_43632185 3.46 ENSMUST00000107874.2
Npr2
natriuretic peptide receptor 2
chr4_+_43631935 3.00 ENSMUST00000030191.8
Npr2
natriuretic peptide receptor 2
chr15_-_82394022 2.13 ENSMUST00000170255.1
Cyp2d11
cytochrome P450, family 2, subfamily d, polypeptide 11
chr3_+_19957037 1.92 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
Cp
ceruloplasmin
chr2_+_173153048 1.90 ENSMUST00000029017.5
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr19_+_26623419 1.88 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chrX_+_20549780 1.83 ENSMUST00000023832.6
Rgn
regucalcin
chr4_+_104766334 1.61 ENSMUST00000065072.6
C8b
complement component 8, beta polypeptide
chr4_+_104766308 1.60 ENSMUST00000031663.3
C8b
complement component 8, beta polypeptide
chr14_+_48120841 1.55 ENSMUST00000073150.4
Peli2
pellino 2
chrX_+_38772671 1.53 ENSMUST00000050744.5
6030498E09Rik
RIKEN cDNA 6030498E09 gene
chr12_-_99393010 1.51 ENSMUST00000177451.1
Foxn3
forkhead box N3
chr1_+_13668739 1.45 ENSMUST00000088542.3
Xkr9
X Kell blood group precursor related family member 9 homolog
chr2_-_160872552 1.41 ENSMUST00000103111.2
Zhx3
zinc fingers and homeoboxes 3
chr3_+_19957088 1.40 ENSMUST00000108328.1
Cp
ceruloplasmin
chr12_+_85288591 1.34 ENSMUST00000059341.4
Zc2hc1c
zinc finger, C2HC-type containing 1C
chr3_+_63963631 1.19 ENSMUST00000181653.1
Gm26850
predicted gene, 26850
chr3_+_19957240 1.18 ENSMUST00000108325.2
Cp
ceruloplasmin
chr5_+_23787691 1.05 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
Rint1
RAD50 interactor 1
chr2_+_104027721 1.02 ENSMUST00000028603.3
Fbxo3
F-box protein 3
chr13_+_24943144 0.98 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr3_-_88762244 0.97 ENSMUST00000183267.1
Syt11
synaptotagmin XI
chr2_-_101621033 0.93 ENSMUST00000090513.4
B230118H07Rik
RIKEN cDNA B230118H07 gene
chr12_-_85288419 0.91 ENSMUST00000121930.1
Acyp1
acylphosphatase 1, erythrocyte (common) type
chr5_+_138255608 0.88 ENSMUST00000062067.6
Lamtor4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr6_+_50110837 0.85 ENSMUST00000167628.1
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr12_+_55598917 0.80 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr5_-_88675190 0.78 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1
G-rich RNA sequence binding factor 1
chr1_-_169969143 0.77 ENSMUST00000027989.6
ENSMUST00000111353.3
Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
chr16_-_22811399 0.75 ENSMUST00000040592.4
Crygs
crystallin, gamma S
chr14_+_48446340 0.74 ENSMUST00000111735.2
Tmem260
transmembrane protein 260
chr11_-_46389454 0.72 ENSMUST00000101306.3
Itk
IL2 inducible T cell kinase
chr1_-_132707304 0.72 ENSMUST00000043189.7
Nfasc
neurofascin
chr4_-_43653542 0.66 ENSMUST00000084646.4
Spag8
sperm associated antigen 8
chr11_-_69395333 0.65 ENSMUST00000108660.1
ENSMUST00000051620.4
Cyb5d1
cytochrome b5 domain containing 1
chr18_+_76944384 0.62 ENSMUST00000156454.1
ENSMUST00000150990.1
ENSMUST00000026485.7
ENSMUST00000148955.1
Hdhd2
haloacid dehalogenase-like hydrolase domain containing 2
chr14_+_14820765 0.62 ENSMUST00000112631.2
ENSMUST00000178538.1
ENSMUST00000112630.2
Nek10
NIMA (never in mitosis gene a)- related kinase 10
chr4_-_89311021 0.61 ENSMUST00000097981.4
Cdkn2b
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr7_-_103840427 0.60 ENSMUST00000106866.1
Hbb-bh2
hemoglobin beta, bh2
chr4_-_43653560 0.59 ENSMUST00000107870.2
Spag8
sperm associated antigen 8
chr11_-_28339867 0.58 ENSMUST00000042595.6
Gm6685
predicted pseudogene 6685
chr11_-_121519326 0.58 ENSMUST00000092298.5
Zfp750
zinc finger protein 750
chr5_-_100429503 0.56 ENSMUST00000181873.1
ENSMUST00000180779.1
5430416N02Rik
RIKEN cDNA 5430416N02 gene
chr16_-_55838827 0.56 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr3_-_79737794 0.55 ENSMUST00000078527.6
Rxfp1
relaxin/insulin-like family peptide receptor 1
chr2_+_104027823 0.53 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
Fbxo3
F-box protein 3
chr12_-_108893197 0.49 ENSMUST00000161154.1
ENSMUST00000161410.1
Wars
tryptophanyl-tRNA synthetase
chr16_-_19408078 0.48 ENSMUST00000052516.4
Olfr165
olfactory receptor 165
chr1_+_58278309 0.48 ENSMUST00000114366.1
Aox2
aldehyde oxidase 2
chr12_-_67222549 0.47 ENSMUST00000037181.8
Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr5_+_87666200 0.44 ENSMUST00000094641.4
Csn1s1
casein alpha s1
chrX_+_134187492 0.44 ENSMUST00000064476.4
Arl13a
ADP-ribosylation factor-like 13A
chr11_+_78176711 0.41 ENSMUST00000098545.5
Tlcd1
TLC domain containing 1
chr16_+_30065333 0.39 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr18_-_35215008 0.39 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr11_+_69395647 0.38 ENSMUST00000144531.1
Lsmd1
LSM domain containing 1
chr4_-_43700807 0.38 ENSMUST00000055545.3
Olfr70
olfactory receptor 70
chr5_+_139543889 0.36 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx
UNC homeobox
chr6_+_121183667 0.36 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
Pex26
peroxisomal biogenesis factor 26
chr13_-_106547060 0.36 ENSMUST00000076359.2
Dph3b-ps
DPH3B, KTI11 homolog B (S. cerevisiae), pseudogene
chr17_-_35643684 0.36 ENSMUST00000095467.3
Dpcr1
diffuse panbronchiolitis critical region 1 (human)
chr3_+_87357874 0.33 ENSMUST00000015998.6
Cd5l
CD5 antigen-like
chr12_+_69893105 0.32 ENSMUST00000021466.8
Atl1
atlastin GTPase 1
chr12_+_71048338 0.31 ENSMUST00000135709.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr17_+_87025550 0.31 ENSMUST00000024959.3
ENSMUST00000160269.1
Cript
cysteine-rich PDZ-binding protein
chr17_+_21657582 0.26 ENSMUST00000039726.7
3110052M02Rik
RIKEN cDNA 3110052M02 gene
chr4_-_132144486 0.26 ENSMUST00000056336.1
Oprd1
opioid receptor, delta 1
chr7_+_56239743 0.25 ENSMUST00000032633.5
ENSMUST00000156886.1
Oca2
oculocutaneous albinism II
chr11_-_99285260 0.25 ENSMUST00000017255.3
Krt24
keratin 24
chr14_-_14120904 0.23 ENSMUST00000022256.3
Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr7_+_102803480 0.23 ENSMUST00000061096.6
Olfr564
olfactory receptor 564
chr14_-_59142886 0.21 ENSMUST00000022548.3
ENSMUST00000162674.1
ENSMUST00000159858.1
ENSMUST00000162271.1
1700129C05Rik
RIKEN cDNA 1700129C05 gene
chr3_+_139205887 0.19 ENSMUST00000062306.6
Stpg2
sperm tail PG rich repeat containing 2
chr9_+_78051938 0.18 ENSMUST00000024104.7
Gcm1
glial cells missing homolog 1 (Drosophila)
chr9_+_32393963 0.17 ENSMUST00000172015.1
Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
chr8_+_4240105 0.16 ENSMUST00000110994.1
ENSMUST00000110995.1
Map2k7
mitogen-activated protein kinase kinase 7
chr15_+_102990576 0.13 ENSMUST00000001703.6
Hoxc8
homeobox C8
chr17_-_22007301 0.13 ENSMUST00000075018.3
Gm9772
predicted gene 9772
chr9_-_7835255 0.12 ENSMUST00000074246.6
Birc2
baculoviral IAP repeat-containing 2
chr10_-_130112788 0.11 ENSMUST00000081469.1
Olfr823
olfactory receptor 823
chr16_-_56024628 0.10 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp
PEST proteolytic signal containing nuclear protein
chr6_+_40442863 0.10 ENSMUST00000038907.8
ENSMUST00000141490.1
Wee2
WEE1 homolog 2 (S. pombe)
chr8_+_85171322 0.09 ENSMUST00000076896.5
Gm6531
predicted gene 6531
chr5_-_144026596 0.08 ENSMUST00000031622.6
ENSMUST00000110702.1
Ocm
oncomodulin
chr9_-_110624361 0.08 ENSMUST00000035069.9
Nradd
neurotrophin receptor associated death domain
chr7_+_34095431 0.05 ENSMUST00000108083.1
ENSMUST00000174820.1
Scgb1b30
secretoglobin, family 1B, member 30
chr2_-_79908428 0.05 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr1_-_173982842 0.04 ENSMUST00000000266.7
Ifi202b
interferon activated gene 202B
chr3_+_92352141 0.04 ENSMUST00000068399.1
Sprr2e
small proline-rich protein 2E
chr13_+_94173992 0.03 ENSMUST00000121618.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr7_+_45785331 0.02 ENSMUST00000120005.1
ENSMUST00000123585.1
Lmtk3
lemur tyrosine kinase 3
chr13_-_64497792 0.02 ENSMUST00000180282.1
1190003K10Rik
RIKEN cDNA 1190003K10 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0018879 biphenyl metabolic process(GO:0018879)
0.7 6.6 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.6 1.9 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.5 1.8 GO:0051344 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) positive regulation of calcium-transporting ATPase activity(GO:1901896) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.3 1.0 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.3 5.1 GO:0006063 uronic acid metabolic process(GO:0006063) glucuronate metabolic process(GO:0019585) cellular glucuronidation(GO:0052695)
0.3 1.0 GO:0006507 GPI anchor release(GO:0006507)
0.3 1.0 GO:1990927 calcium ion regulated lysosome exocytosis(GO:1990927)
0.3 3.8 GO:0015747 urate transport(GO:0015747)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 3.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.6 GO:0060618 nipple development(GO:0060618)
0.2 0.5 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.6 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 4.5 GO:0046688 response to copper ion(GO:0046688)
0.1 0.4 GO:0042668 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1 0.5 GO:0009115 xanthine catabolic process(GO:0009115)
0.1 1.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 0.3 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.1 0.3 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.4 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.6 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.0 0.1 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.9 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 1.9 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.2 GO:1901979 renal sodium ion absorption(GO:0070294) regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.0 1.4 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.2 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.8 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.3 GO:0032092 positive regulation of protein binding(GO:0032092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0070939 Dsl1p complex(GO:0070939)
0.3 3.2 GO:0005579 membrane attack complex(GO:0005579)
0.2 5.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 0.7 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.9 GO:0071986 Ragulator complex(GO:0071986)
0.1 1.9 GO:0071564 npBAF complex(GO:0071564)
0.1 1.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 4.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 5.5 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 4.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 16.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.3 0.8 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.3 3.8 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.9 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 0.5 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.4 GO:0071820 N-box binding(GO:0071820)
0.1 1.0 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.5 GO:0016623 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1 0.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 1.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 2.1 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 1.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 4.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription