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GSE58827: Dynamics of the Mouse Liver

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Results for Klf3

Z-value: 0.23

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Transcription factors associated with Klf3

Gene Symbol Gene ID Gene Info
Klf3
ENSMUSG00000029178.8 Kruppel-like factor 3 (basic)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf3mm10_v2_chr5_+_64803513_64803530-0.038.5e-01Click!

Activity profile of Klf3 motif

Sorted Z-values of Klf3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_102251852 0.56 ENSMUST00000101336.3
ENSMUST00000136277.1
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chrX_-_102252154 0.43 ENSMUST00000050551.3
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr14_+_63046988 0.28 ENSMUST00000067990.1
ENSMUST00000111203.1
Defb42
defensin beta 42
chr10_-_12964252 0.17 ENSMUST00000163425.1
ENSMUST00000042861.5
Stx11
syntaxin 11
chr15_+_76457438 0.17 ENSMUST00000043089.7
Scx
scleraxis
chr1_+_107511416 0.17 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511489 0.17 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_50942710 0.15 ENSMUST00000060650.5
Frmd7
FERM domain containing 7
chr7_-_103827922 0.13 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs
hemoglobin, beta adult s chain
chr15_-_102722120 0.12 ENSMUST00000171838.1
Calcoco1
calcium binding and coiled coil domain 1
chr15_-_102722150 0.12 ENSMUST00000023818.3
Calcoco1
calcium binding and coiled coil domain 1
chr6_-_135254326 0.10 ENSMUST00000111911.2
ENSMUST00000111910.2
Gsg1
germ cell-specific gene 1
chr3_+_135438722 0.09 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chrX_-_74246364 0.07 ENSMUST00000130007.1
Flna
filamin, alpha
chr6_-_135254170 0.07 ENSMUST00000111909.1
Gsg1
germ cell-specific gene 1
chrX_-_74246534 0.06 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna
filamin, alpha
chr5_+_137630116 0.06 ENSMUST00000175968.1
Lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr14_+_123659971 0.06 ENSMUST00000049681.7
Itgbl1
integrin, beta-like 1
chr19_+_10041548 0.05 ENSMUST00000115995.2
Fads3
fatty acid desaturase 3
chr3_+_89266552 0.05 ENSMUST00000040824.1
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr19_-_53390559 0.04 ENSMUST00000025997.5
Smndc1
survival motor neuron domain containing 1
chr1_+_86064619 0.04 ENSMUST00000027432.8
Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr3_+_90080442 0.03 ENSMUST00000127955.1
Tpm3
tropomyosin 3, gamma
chr7_-_4149781 0.03 ENSMUST00000058358.6
Leng9
leukocyte receptor cluster (LRC) member 9
chrX_+_7884321 0.03 ENSMUST00000096514.3
ENSMUST00000123277.1
Slc35a2
solute carrier family 35 (UDP-galactose transporter), member A2
chr3_+_90079540 0.03 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
Tpm3
tropomyosin 3, gamma
chr9_-_67539392 0.02 ENSMUST00000039662.8
Tln2
talin 2
chr3_-_89960562 0.02 ENSMUST00000069805.7
Atp8b2
ATPase, class I, type 8B, member 2
chr13_-_74292297 0.02 ENSMUST00000109640.1
ENSMUST00000022059.7
Ahrr
aryl-hydrocarbon receptor repressor
chr3_-_89089955 0.02 ENSMUST00000166687.1
Rusc1
RUN and SH3 domain containing 1
chr9_-_95815389 0.02 ENSMUST00000119760.1
Pls1
plastin 1 (I-isoform)
chr12_+_33315393 0.02 ENSMUST00000154742.1
Atxn7l1
ataxin 7-like 1
chr11_+_68968107 0.01 ENSMUST00000102606.3
ENSMUST00000018884.5
Slc25a35
solute carrier family 25, member 35
chr3_-_88334428 0.01 ENSMUST00000107552.1
Tmem79
transmembrane protein 79
chr2_+_163547148 0.01 ENSMUST00000109411.1
ENSMUST00000018094.6
Hnf4a
hepatic nuclear factor 4, alpha
chr1_+_131867224 0.01 ENSMUST00000112386.1
ENSMUST00000027693.7
Rab7l1
RAB7, member RAS oncogene family-like 1
chr4_-_41774097 0.00 ENSMUST00000108036.1
ENSMUST00000173865.1
ENSMUST00000108037.2
ENSMUST00000108032.2
Ccl27a
chemokine (C-C motif) ligand 27A
chr11_+_75679542 0.00 ENSMUST00000147718.1
Crk
v-crk sarcoma virus CT10 oncogene homolog (avian)

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0071104 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.2 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0 0.2 GO:0043312 neutrophil degranulation(GO:0043312)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.0 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0031720 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins