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GSE58827: Dynamics of the Mouse Liver

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Results for Klf7

Z-value: 0.73

Motif logo

Transcription factors associated with Klf7

Gene Symbol Gene ID Gene Info
ENSMUSG00000025959.7 Kruppel-like factor 7 (ubiquitous)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121456_641214910.289.2e-02Click!

Activity profile of Klf7 motif

Sorted Z-values of Klf7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102107822 7.24 ENSMUST00000177304.1
ENSMUST00000017455.8
peptide YY
chrX_+_136270253 4.17 ENSMUST00000178632.1
ENSMUST00000053540.4
nerve growth factor receptor (TNFRSF16) associated protein 1
chr8_+_84901928 3.02 ENSMUST00000067060.7
Kruppel-like factor 1 (erythroid)
chr2_+_119047116 2.81 ENSMUST00000152380.1
ENSMUST00000099542.2
cancer susceptibility candidate 5
chr15_+_99074968 2.52 ENSMUST00000039665.6
trophinin associated protein
chr5_-_137741601 2.36 ENSMUST00000119498.1
ENSMUST00000061789.7
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chr6_-_88875035 2.35 ENSMUST00000145944.1
podocalyxin-like 2
chr5_+_33658123 2.18 ENSMUST00000074849.6
ENSMUST00000079534.4
transforming, acidic coiled-coil containing protein 3
chr2_+_119047129 2.18 ENSMUST00000153300.1
ENSMUST00000028799.5
cancer susceptibility candidate 5
chr5_+_137761680 1.93 ENSMUST00000110983.2
ENSMUST00000031738.4
TSC22 domain family, member 4
chr11_-_61494173 1.89 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
mitogen-activated protein kinase 7
chr7_-_127993831 1.72 ENSMUST00000033056.3
PYD and CARD domain containing
chr13_+_21722057 1.68 ENSMUST00000110476.3
histone cluster 1, H2bm
chr6_-_88874597 1.65 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
podocalyxin-like 2
chr3_+_51224447 1.63 ENSMUST00000023849.8
ENSMUST00000167780.1
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr7_-_132776855 1.52 ENSMUST00000106168.1
family with sequence similarity 53, member B
chrX_-_74428871 1.51 ENSMUST00000143521.1
glucose-6-phosphate dehydrogenase X-linked
chr19_-_4059295 1.48 ENSMUST00000076451.6
cDNA sequence BC021614
chr7_-_139978748 1.48 ENSMUST00000097970.2
RIKEN cDNA 6430531B16 gene
chr5_-_136135989 1.43 ENSMUST00000150406.1
ENSMUST00000006301.4
leucine-rich repeats and WD repeat domain containing 1
chr8_+_119992438 1.40 ENSMUST00000132583.1
ENSMUST00000034282.9
cysteine-rich secretory protein LCCL domain containing 2
chr12_-_4592927 1.37 ENSMUST00000170816.1
predicted gene 3625
chr5_+_44100442 1.35 ENSMUST00000072800.4
predicted gene 16401
chr7_-_74013676 1.32 ENSMUST00000026896.4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr8_+_70152754 1.32 ENSMUST00000072500.6
ENSMUST00000164040.1
ENSMUST00000110146.2
ENSMUST00000110143.1
ENSMUST00000110141.2
ENSMUST00000110140.1
RIKEN cDNA 2310045N01 gene
myocyte enhancer factor 2B
chr7_-_139978709 1.23 ENSMUST00000121412.1
RIKEN cDNA 6430531B16 gene
chr6_+_120093348 1.17 ENSMUST00000112711.2
ninjurin 2
chr15_+_92344359 1.14 ENSMUST00000181901.1
predicted gene, 26760
chr9_-_32344237 1.14 ENSMUST00000034533.5
potassium inwardly-rectifying channel, subfamily J, member 5
chr4_+_107830958 1.08 ENSMUST00000106731.2
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr4_+_63558748 1.03 ENSMUST00000077709.4
RIKEN cDNA 6330416G13 gene
chr1_+_63176818 1.02 ENSMUST00000129339.1
eukaryotic translation elongation factor 1 beta 2
chr5_+_140607334 0.85 ENSMUST00000031555.1
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_58658181 0.84 ENSMUST00000168747.1
ATPase, class V, type 10A
chr17_-_46202576 0.84 ENSMUST00000024749.7
polymerase (DNA directed), eta (RAD 30 related)
chr11_+_68432112 0.82 ENSMUST00000021283.7
phosphoinositide-3-kinase, regulatory subunit 5, p101
chr14_+_30479565 0.77 ENSMUST00000022535.7
DCP1 decapping enzyme homolog A (S. cerevisiae)
chr7_-_19404082 0.72 ENSMUST00000108458.3
kinesin light chain 3
chr14_+_79451791 0.70 ENSMUST00000100359.1
kelch repeat and BTB (POZ) domain containing 6
chr10_+_127677064 0.70 ENSMUST00000118612.1
ENSMUST00000048099.4
transmembrane protein 194
chr15_-_98953541 0.67 ENSMUST00000097014.5
tubulin, alpha 1A
chr5_+_136136137 0.63 ENSMUST00000136634.1
ENSMUST00000041100.3
alkB, alkylation repair homolog 4 (E. coli)
chr18_+_88971790 0.62 ENSMUST00000023828.7
rotatin
chr9_-_45936049 0.61 ENSMUST00000034590.2
transgelin
chr5_+_136136202 0.58 ENSMUST00000143229.1
alkB, alkylation repair homolog 4 (E. coli)
chr8_+_105860634 0.57 ENSMUST00000008594.7
nuclear transport factor 2
chr7_-_126976092 0.54 ENSMUST00000181859.1
RIKEN cDNA D830044I16 gene
chr8_-_3621270 0.51 ENSMUST00000159548.1
ENSMUST00000019614.6
XPA binding protein 2
chr17_+_46202740 0.50 ENSMUST00000087031.5
exportin 5
chr2_-_151973387 0.49 ENSMUST00000109863.1
family with sequence similarity 110, member A
chr14_+_50807915 0.49 ENSMUST00000036126.5
poly (ADP-ribose) polymerase family, member 2
chr5_+_115631902 0.47 ENSMUST00000031492.8
RAB35, member RAS oncogene family
chr3_+_28263205 0.47 ENSMUST00000159236.2
TRAF2 and NCK interacting kinase
chr17_+_35916541 0.46 ENSMUST00000087211.2
protein phosphatase 1, regulatory subunit 10
chr11_-_40733373 0.43 ENSMUST00000020579.8
hyaluronan mediated motility receptor (RHAMM)
chr12_-_79296266 0.43 ENSMUST00000021547.6
zinc finger, FYVE domain containing 26
chr7_+_28350652 0.42 ENSMUST00000082134.4
ribosomal protein S16
chr11_-_78176619 0.42 ENSMUST00000148154.2
ENSMUST00000017549.6
NIMA (never in mitosis gene a)-related expressed kinase 8
chr17_+_35916977 0.42 ENSMUST00000151664.1
protein phosphatase 1, regulatory subunit 10
chr19_+_8723478 0.40 ENSMUST00000180819.1
ENSMUST00000181422.1
small nucleolar RNA host gene (non-protein coding) 1
chr7_-_68749170 0.40 ENSMUST00000118110.1
ENSMUST00000048068.7
arrestin domain containing 4
chr9_+_55541148 0.38 ENSMUST00000034869.4
insulin related protein 2 (islet 2)
chr7_+_28071230 0.37 ENSMUST00000138392.1
ENSMUST00000076648.7
Fc fragment of IgG binding protein
chr1_+_171329015 0.37 ENSMUST00000111300.1
death effector domain-containing
chr11_-_120991039 0.34 ENSMUST00000070575.7
casein kinase 1, delta
chr12_-_11436607 0.31 ENSMUST00000072299.5
visinin-like 1
chr3_-_103791075 0.26 ENSMUST00000106845.2
ENSMUST00000029438.8
ENSMUST00000121324.1
homeodomain interacting protein kinase 1
chr11_+_80383279 0.25 ENSMUST00000165565.1
ENSMUST00000017567.7
zinc finger protein 207
chr8_-_126945841 0.24 ENSMUST00000179857.1
translocase of outer mitochondrial membrane 20 homolog (yeast)
chr16_+_36694024 0.23 ENSMUST00000119464.1
immunoglobulin-like domain containing receptor 1
chr16_+_36693972 0.22 ENSMUST00000023617.6
ENSMUST00000089618.3
immunoglobulin-like domain containing receptor 1
chr5_-_124187150 0.22 ENSMUST00000161938.1
phosphatidylinositol transfer protein, membrane-associated 2
chr9_-_36767595 0.21 ENSMUST00000120381.2
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
chr2_-_156312470 0.21 ENSMUST00000079125.6
SCAN domain-containing 1
chr9_-_71485893 0.17 ENSMUST00000034720.5
polymerase (RNA) II (DNA directed) polypeptide M
chr6_+_125039760 0.17 ENSMUST00000140131.1
ENSMUST00000032480.7
inhibitor of growth family, member 4
chr8_+_71367210 0.16 ENSMUST00000019169.7
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr15_-_102722120 0.15 ENSMUST00000171838.1
calcium binding and coiled coil domain 1
chr17_-_84466186 0.13 ENSMUST00000047524.8
thyroid adenoma associated
chr8_-_84966008 0.12 ENSMUST00000109738.3
ENSMUST00000065049.8
ENSMUST00000128972.1
ribonuclease H2, large subunit
chr2_-_32775378 0.10 ENSMUST00000091059.5
tetratricopeptide repeat domain 16
chr15_-_102722150 0.10 ENSMUST00000023818.3
calcium binding and coiled coil domain 1
chr11_+_70166696 0.08 ENSMUST00000178567.1
C-type lectin domain family 10, member A
chr11_-_70654624 0.08 ENSMUST00000018437.2
profilin 1
chr17_+_24488773 0.06 ENSMUST00000024958.7
CASK interacting protein 1
chr15_-_50889043 0.06 ENSMUST00000183997.1
ENSMUST00000183757.1
trichorhinophalangeal syndrome I (human)
chr9_+_98955525 0.05 ENSMUST00000051312.2
forkhead box L2
chr13_-_14613017 0.05 ENSMUST00000015816.3
mitochondrial ribosomal protein L32
chr15_+_30172570 0.04 ENSMUST00000081728.5
catenin (cadherin associated protein), delta 2
chr12_+_49383007 0.02 ENSMUST00000021333.3
forkhead box G1
chr2_-_32775625 0.01 ENSMUST00000161958.1
tetratricopeptide repeat domain 16
chr19_+_5637475 0.01 ENSMUST00000025867.5
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr5_+_45520221 0.01 ENSMUST00000156481.1
ENSMUST00000119579.1
ENSMUST00000118833.1
mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0070375 ERK5 cascade(GO:0070375)
0.6 1.7 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277) positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.5 1.5 GO:1904879 pentose-phosphate shunt, oxidative branch(GO:0009051) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.4 7.2 GO:0032096 negative regulation of response to food(GO:0032096)
0.4 1.2 GO:0036090 cleavage furrow ingression(GO:0036090)
0.2 3.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 1.9 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.6 GO:1904046 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.2 1.3 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.2 0.8 GO:0007386 compartment pattern specification(GO:0007386)
0.2 1.1 GO:1990573 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) potassium ion import across plasma membrane(GO:1990573)
0.2 4.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 2.2 GO:0030953 astral microtubule organization(GO:0030953)
0.1 0.4 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.5 GO:1900368 regulation of RNA interference(GO:1900368)
0.1 1.1 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 1.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.8 GO:0006290 pyrimidine dimer repair(GO:0006290) cellular response to UV-C(GO:0071494)
0.1 0.5 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.1 0.8 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.4 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.2 GO:0043686 co-translational protein modification(GO:0043686)
0.1 0.5 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.2 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.0 0.6 GO:0006273 lagging strand elongation(GO:0006273)
0.0 0.2 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.0 0.4 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 1.5 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 1.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 1.2 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.8 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.3 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.1 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.9 GO:0006414 translational elongation(GO:0006414)
0.0 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.7 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.4 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 0.8 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.2 1.4 GO:0031933 telomeric heterochromatin(GO:0031933)
0.2 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 0.5 GO:0042272 nucleocytoplasmic shuttling complex(GO:0031074) nuclear RNA export factor complex(GO:0042272)
0.1 0.9 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 0.2 GO:1990047 spindle matrix(GO:1990047)
0.1 1.2 GO:0070938 contractile ring(GO:0070938)
0.1 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.6 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.7 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0044233 mitochondrial outer membrane translocase complex(GO:0005742) ER-mitochondrion membrane contact site(GO:0044233)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.1 GO:0030315 T-tubule(GO:0030315)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.3 1.5 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.3 7.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 0.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 1.1 GO:0038025 reelin receptor activity(GO:0038025)
0.2 1.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 1.7 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.5 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.9 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.5 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 0.2 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 1.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.5 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.3 GO:0033613 activating transcription factor binding(GO:0033613)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID AURORA A PATHWAY Aurora A signaling
0.0 1.9 ST GA12 PATHWAY G alpha 12 Pathway
0.0 3.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.9 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 6.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 7.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 3.9 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 1.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 1.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases